Metabolic Syndrome Related with Serum Biochemical Factors Affecting Serum GGT at Transitional Ages in Gumi

Seong Ja Seok(석성자) 대한의생명과학회 2010 Biomedical Science Letters Vol.16 No.4

This study has been done with 1,431 subjects who visited Health Promotion Centers of the hospitals in Gumi for National Health Screening Program for People at Transitional Ages from April to December 2007. Serum biochemical tests related with metabolic syndrome were performed. Among biochemical factors related with metabolic syndrome, the mean values of serum glucose, AST, ALT, triglyceride and HDL cholesterol except LDL cholesterol were significantly higher in males than in females, so a significant difference by sex was observed (P<0.001). AST, ALT, triglyceride and HDL were thought to be significantly affecting serum GGT for males. In contrast, ALT and HDL cholesterol were important factors for females (P<0.001). For both sexes, serum glucose and LDL cholesterol did not produce any meaningful effect on serum GGT. In males AST, ALT and HDL cholesterol were associated with high risk of abnormality of serum GGT and in females AST, ALT and LDL cholesterol were related with high risk of abnormality of serum GGT. Therefore, AST and ALT showed a significant effect on abnormality of serum GGT in both males and females. It was observed that males exhibited significantly high correlation between metabolic syndrome related biochemical factors and serum GGT than females, and their influence on abnormality of serum GGT was also higher in males than in females. Therefore, serum GGT tests performed for health screening are considered to be useful for managements of cardiovascular diseases and metabolic syndrome as well as liver function test.

건강검진자를 대상으로한 혈청지질 분석 -특히 이상지혈증의 빈도를 중심으로-

석성자 ( Seong Ja Seok ),신두만 ( Du Man Shin ) 대한임상검사과학회 2006 대한임상검사과학회지(KJCLS) Vol.38 No.2

This study was carried out to establish the normal values of serum lipids by age and sex for healthy adults and the frequency of dyslipidemia as a risk factor of coronary atherosclerosis. Total cholesterol, triglyceride, and HDL-cholesterol were measured for 14,485 average adults (8,712 males and 5,773 females) aged 20 to 69 years and analyzed using the auto-analyzer Hitach 7600 in enzyme method. Mean values of total cholesterol, LDL-cholesterol and atherogenic index were higher in men than in women at the ages of 20-40 years but significantly higher in women than in men in the age group of 60 years. Theses findings suggest that the mean concentrations of total cholesterol, triglyceride and LDL-cholesterol in men and women vary with age. The frequency of hypercholesterolemia (□200 mg/dL) in men and women was about 31.4% and increased with age.

건강검진자를 대상으로한 갑상선질환의 유병률 조사

석성자 ( Seong Ja Seok ),신두만 ( Du Man Shin ) 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.2

This study was carried out on 14,443 subjects (8,706 men, 5,737 women ; between 20-80 years of age, mean age 41.8 ± 9.16) who visited the health promotion center of one university hospital. Serum T3, T4 and TSH concentrations were measured with CIA using commercial kits on ADVIA Centaur Assay. The prevalence of thyroid disfunction was high in elderly people and women like in western countries. The results were as follows; 1. The prevalence of overt hyperthyroidism was 4.8/1,000 population (men 4.1/1,000, women 5.9/1,000) and was higher in women than in men. 2. The prevalence of subclinical hyperthyroidism was 10.7/1,000 population (men 9.0/1,000, women 13.2/1,000) with peak prevalence at the age group 50, 60 and was higher in women than in men. 3. The prevalence of overt hypothyroidism was 0.5/1,000 population (men 0.5/1,000, women 0.5/1,000). The prevalence increased with age and was significantly higher in women in the age group over 60 years. 4. The prevalence of subclinical hypothyroidism was 12.6/1,000 population (men 6.0/1,000, women 22.7/1,000) and was as high as about 4 times in women than in men. 5. The prevalence of thyroid dysfunction was higher in women than in men in all the age groups, and was higher in the age group 50, 60 years than in any other age group.

불현성 갑상선 기능저하증과 혈청 총 콜레스테롤, 저밀도 콜레스테롤 농도와의 상관성

석성자,유왕근,Seok, Seong-Ja,Yoo, Wang-Keun 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.1

This study was carried out in 14,443 subjects(8,706 men, 5,737 women, mean age $41.8{\pm}9.16$) who visited the health promotion center of one university hospital. Serum $T_3$, $T_4$ and TSH concentrations were measured with CIA using commercial kits on ADVIA Centaur Assay and Serum total cholesterol, triglyceride, and HDL-cholesterol were measured by auto-analyzer Hitach 7600 in enzyme method. 1. The prevalence of subclinical hypothyroidism was 12.6/1,000 population(men 6.0/1,000, women 22.7/1,000) and as high as about 4 times in women than in men. 2. In subclinical hypothyroidism, the values of total cholesterol and LDL-cholesterol were significantly high by 5.5 mg/dL, 4.6 mg/dL compared with normal group(p<0.05). 3. In all the tested hypercholesterolemia and hyperLDL-cholesterolemia, were correlated with TSH. There is higher correlation in women group than men group. These results indicate that the subclinical hypothyroidism and dyslipemia significantly correlated. Especially, it is very important to find that the hypercholesterolemia and hyperLDL-cholesterolemia are the high risk factors of atherosclerosis. Therefore, it is essential for the group of subclinical hypothyroidism to take the cholesterol, LDL-cholesterol and serum lipid test as well as thyroid function test.

경주, 포항, 울산지역 보건.환경성 질환 위해 인자

정종현,최봉욱,문기내,석성자,김현규,손병현,Jung, Jong-Hyeon,Choi, Bong-Wook,Moon, Ki-Nai,Seok, Seong-Ja,Kim, Hyun-Gyu,Shon, Byung-Hyun 한국환경보건학회 2010 한국환경보건학회지 Vol.36 No.2

This study was undertaken in an attempt to provide scientific grounds in explaining the causes of environmental and respiratory diseases resulting from air pollutants in Gyeongju and its neighboring areas. In relation to heavy metals, lead (Pb) was $0.0135{\sim}0.1744\;{\mu}g/m^3$ and high in order of Pohang, Ulsan, and Gyeongju while nickel (Ni) was $0.0023{\sim}0.0115\;{\mu}g/m^3$. The concentrations of heavy metals in the investigated areas did not exceed the environmental standards or Guideline Value of Korea or other countries. However, it is considered necessary to apply intensive control to some heavy metals including cadmium (Cd) that show a relatively high level of hazard. Based on the responses to the survey, measured personal interest in environmental pollution and the basic knowledge of the causes of the respiratory diseases was higher in those with a family history of allergic reactions to metals and bronchial asthma. The incidence of allergic disease was higher in those who are currently in poor health state. In addition, the general knowledge of environmental pollutants was higher in those with higher educational level and those with a higher interest in environmental pollution. Personal interest in environmental pollution was higher in those with higher basic knowledge of environmental pollutants. Therefore, it is necessary to increase the awareness through better education and campaigns on environmental pollution.

구미시에 거주하는 노인들의 건강실태

신윤희 ( Yun Hee Sin ),석성자 ( Seong Ja Seok ),신두만 ( Du Man Sin ) 대한임상검사과학회 2009 대한임상검사과학회지(KJCLS) Vol.41 No.3

This study examined people over 60 years old living in Gumi, Gyeongbuk Province and their health and disease were analyzed. The results are as followings; First, as for seniors`` condition of health, females were worse than males: the older they were and the lower their schooling and income were, they recognized bad health condition. Second, as for seniors`` health care, males cared for themselves better than females: the higher their schooling and income were, the better they cared for themselves. Using the methods of health care such as walking, hiking, diet care, We found out that the low income class did not get the health examination at all. Lastly, as the most seniors in Gumi city suffer a chronic disease, the city office is needed to promote various policies like prevention of age-related disease, early discovery and delay of retrogression at its own initiative.

노인들의 라이프스타일에 따른 건강운동 효과 분석

지병태(Byoung-Tae Ji),석성자(Seong-Ja Seok),신두만(Du-Man Sin),정종현(Jong-Hyeon Jung),김주원(Joo-Won Kim) 한국보건교육건강증진학회 2010 보건교육건강증진학회지 Vol.27 No.2