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      • Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients

        서종근,이다인,황양하,이호원,정두교,서정규,권순학,박성파 대한신경과학회 2007 Journal of Clinical Neurology Vol.3 No.1

        Background and Purpose: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients. Methods: This retrospective study investigated 60 epilepsy patients undergoing neuropsychological tests who were either newly diagnosed or untreated in the preceding 6 months. The cognitive function in 30 patients receiving LTG monotherapy and 30 age-matched patients receiving OXC monotherapy was compared after 1 year. The neuropsychological scores at baseline and all of the epilepsy-relevant variables except seizure type did not differ between the groups. The mean daily dosages of LTG and OXC at 1 year were 93 mg and 825 mg, respectively. Results: The posttreatment list-learning performance was better in the LTG group than in the OXC group (p<0.05). The incidence of cognitive complaints did not differ between the two groups. The list-learning performance and Trail Making Test scores were better in each group after treatment. Conclusions: LTG and OXC monotherapies have similar, slightly beneficial effects on cognitive function, and are probably not harmful.

      • KCI등재

        Suicidality and Its Risk Factors in Korean People with Epilepsy: A MEPSY Study

        서종근,이장준,조용원,이세진,김지은,문혜진,박성파 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.1

        Background and Purpose People with epilepsy (PWE) are more likely to experience suicidality, with suicidal ideation and attempts, than people without epilepsy (PWoE). The aims of thepresent study were to determine 1) the characteristics of suicidality in Korean PWE, 2) whetherPWE with suicidality receive psychiatric intervention, and 3) the risk factors for suicidality. Methods Patients who consecutively visited epilepsy clinics at secondary- and tertiary-carehospitals were recruited (n=684), along with age- and sex-matched PWoE (n=229). The presenceof current major depressive disorder (MDD), generalized anxiety disorder (GAD), and/or suicidality was established using the Mini International Neuropsychiatric Interview-Plus Version 5.0.0. The Korean version of the Liverpool Adverse Events Profile (K-LAEP) was applied to detectadverse effects of antiepileptic drugs (AEDs). Results Suicidality was present in 208 (30.4%) of the 684 PWE. The rate of suicidality was 4.6times higher among PWE than PWoE, and 108 (15.7%) PWE had suicidal ideation and had attempted suicide. Among those who had attempted suicide, 40.7% had made at least two attempts.The most common method of suicide attempt was drug overdose (34.9%). Unfortunately, of the 208 PWE with suicidality, 136 (65.4%) did not receive psychiatric intervention. The risk factors for suicidality were MDD [odds ratio (OR)=6.448, 95% confidence interval (CI)=3.739–11.120, p<0.001], GAD (OR=3.561, 95% CI=1.966–6.452, p<0.001), item scores of 3 or 4 on the K-LAEP (OR=2.688, 95% CI=1.647–4.387, p<0.001), and a history of febrile convulsion (OR=2.188, 95% CI=1.318–3.632, p=0.002). Conclusions Suicidality is more prevalent in PWE than in PWoE. Clinicians should monitorpsychiatric disorders and the adverse effects of AEDs in PWE in an attempt to reduce the incidence of suicidal ideation or suicide attempts in this patient population.

      • KCI등재

        외국인 노인장기요양보험 이용 특성 분석

        서종근,왕영민,심혜진 한국보건사회연구원 2023 保健社會硏究 Vol.43 No.1

        The purpose of the study is to analyze the utilization of long-term care insurance by foreigners. As various foreign population groups migrated to Korea, changes occurred in the age composition of foreigners, and the proportion of the elderly foreign population is significantly increasing. The demand for long-term care insurance has increased as the number of elderly foreigners has increased, but there is a lack of research and analysis on long-term care insurance. Therefore, this study aimed to analyze the characteristics of foreigners’ long-term care insurance use. This study compared the average amount of use between nationals and foreigners and analyzed the characteristics of use according to the duration between enrollment in the National Health Insurance Service and application for long-term care. Our analysis found that the number of recognized foreigners increased by 52.9% in 2021 compared to 2017, indicating that the demand for long-term care for foreigners significantly increased. The total amount of use by Koreans was higher than that by foreigners, and the same trend was shown in the use of home-based benefits and equipment service. However, the average institution-based benefit for foreigners was higher than that for Koreans. When examined in terms of the duration until application for LTC after NHIS enrollment, the highest percentage of foreigners applied for long-term care immediately after enrollment in the National Health Insurance. Our analysis of the duration until application, divided into 6 sections, showed that the total benefit use was high for short- and long-term applicants. On the other hand, for institution-based benefits, the shorter the duration until application for LTC, the higher the use of benefits. 본 연구는 외국인 노인장기요양보험의 이용 특성 분석을 목적으로 한다. 다양한 외국인 인구집단이 국내 이주하며 외국인 연령 구성에 변화가 발생하였고, 큰 폭으로 고령 외국인 인구 비율이 높아지고 있다. 고령 외국인 증가로 노인장기요양보험 수요가 높아지고 있지만, 외국인 노인장기요양보험에 대한 연구 담론 및 분석이 부재하였다. 이에 본 연구에서는 외국인 노인장기요양보험 급여이용 특성을 분석하고자 하였다. 본 연구는 내국인-외국인 인정자의 급여이용 평균을 비교하고, 외국인 인정신청 기간에 따른 급여이용 특성을 분석하였다. 분석 결과, 외국인 인정자는 2017년 대비 2021년 52.9% 증가하여, 외국인 장기요양 수요가 크게 증가하고 있었다. 전체 급여 이용에 있어 내국인 급여이용 총액이 높았고, 재가급여 및 복지용구 이용에서도 동일한 추세를 보였다. 하지만, 외국인 인정자의 시설급여 평균은 내국인보다 높게 나타났다. 외국인 건강보험 자격 취득 후 장기요양 인정신청 기간(duration until application for LTC after NHIS enrollment) 측정 결과, 건강보험 자격 취득 후 곧바로 장기요양 인정신청을 한 외국인이 가장 높았고, 인정신청 기간이 길어질수록 인정자 수 또한 감소하였다. 자격 취득 후 인정신청 기간을 6구간으로 나눠 분석한 결과, 전체 급여는 단기/장기 기간 인정신청자의 급여이용액이 높았던 반면, 시설급여는 인정신청 기간이 짧을수록 급여이용이 높았다.

      • KCI등재

        편두통 환자에서 자살경향성과 위험인자

        서종근,김병건,주민경,조수진,정필욱,문희수,김병수,안진영,손종희,정재면,최윤주,문혜진,박성파 대한신경과학회 2022 대한신경과학회지 Vol.40 No.3

        Background: Migraine patients have a higher frequency of suicidality than people without migraine. The aim of this study was to identify suicidality and its risk factors in migraine patients. Methods: We enrolled 358 migraine patients from 11 hospitals. We collected data regarding their clinical characteristics and the patients completes the questionnaires. We also interviewed patients with the Mini International Neuropsychiatric Interview (MINI)plus version 5.0.0 to identify their suicidality. The International Classification of Headache Disorders, third edition, beta version was used in headache diagnosis. Results: The frequency of suicidality in migraine patients was 118 (33.0%). Migraine patients with suicidality were more likely to have a major depressive disorder or generalized anxiety disorder than those without suicidality. Among variables, risk factors for suicidality in migraine patients were female (odds ratio [OR], 4.110; 95% confidence interval [CI], 1.55310.878; p=0.004), attack duration (OR, 2.559; 95% CI, 1.2105.413; p=0.011), Patient Health Questionnaire9 (OR, 1.111; 95% CI, 1.0381.189; p=0.002), and Generalized Anxiety Disorder7 (OR, 1.194; 95% CI, 1.1011.294; p<0.001). Conclusions: Suicidality in migraine patients is common. Therefore, clinicians who take care of migraine patients should be concerned about suicidality and its risk factors such as female gender, attack duration, depression or anxiety

      • KCI등재
      • 비전형적인 클라인-레빈 증후군 1예

        서종근,이호원,서승돈,박성파 대한수면연구학회 2013 Journal of sleep medicine Vol.10 No.2

        Kleine-Levin syndrome is characterized by recurrent episodes of hypersomnia and associated cognitive and behavioral impairments. We present a 47-year-old female patient with recurrent hypersomnia and disorder of appetite. During each episode, patient slept more than 24 hours with hyperphagia or anorexia. Physical examinations, laboratory tests, and brain MRI showed no significant abnormality in the patient. Nocturnal polysomnographic study showed high sleep efficiency, reduced sleep latency and REM sleep latency, and increased sleep stage 1 & 2. The multiple sleep latency tests showed one episode of sleep-onset REM periods. This is the first atypical case of Kleine-Levin syndrome in Korea which showed short duration of episodes and hypersomnia combined with anorexia.

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