Haloperidol 및 Lithium Chloride가 마우스 세포성 면역에 미치는 영향

서신영,김채원 연세대학교 의과대학 1984 연세의대논문집 Vol.17 No.1

부모의 양육태도와 자아존중감 및 대인관계문제와의 관계

서신영 서울여자대학교 학생생활연구소 2003 학생생활연구 Vol.16 No.-

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월경전기 증후군 여성들에서 분노 및 감정표현불능증

서신영,김미영,이상혁,최태규,김근향,김은경,박선은,김용우,김서영,육근영,Suh, Shin-Young,Kim, Mi-Young,Lee, Sang-Hyuk,Choi, Tae-Kyou,Kim, Keun-Hyang,Kim, Eun-Kyung,Park, Seon-Eun,Kim, Yong-Woo,Kim, Seo-Young,Yook, Keun-Young 한국정신신체의학회 2006 정신신체의학 Vol.14 No.2

연구목적 : 월경전기 증후군은 생리 주기에 따라 가임기 여성의 75%가량이 겪는 흔한 현상으로 생리전에 증상이 시작하여 생리후에 증상이 가라앉는 증후군이다. 이 월경전기 증후군은 월경전 불쾌장애와 더불어 여성의 우울 증상과 연관이 있는 것으로 보고되고 있으며, 최근에는 다른 심리적 요소와의 연관성도 보고되고 있다. 분노와 감정표현불능증(alexithymia)는 일반적으로 정신신체장애와 연관이 있는 것으로 보고되고 있으나 월경전기증후군에서의 연관성은 거의 밝혀진 바가 없다. 이에 저자 등은 월경전기 증후군과 분노, 감정표현불능증과의 관계를 알아보고자 하였다. 방법 : 서울, 경기, 경북지역에 거주하는 여성 377명을 대상으로 하였다. 연구 도구로는 1달 동안 매일 자신의 생리주기에 따라 증상을 보고하도록 하는 Daily record of Severity of Problems (DRSP)와 생리전 시기에 작성하도록 한 Shortened Premenstrual Assessment Form(SPAF), Anger Scale, Toronto Alexithymia Scale 등으로 하였다. DRSP와 SPAE로 평가한 월경전기 증후군 125명과 비월경전기 증후군 여성 58명을 대상으로 분노와 감정표현불능증 수준을 통계적으로 분석하였다. 결과: 월경전기 증후군 여성들이 비월경전기 증후군 여성들보다 분노억제 (t=2.0, p=0.04), 분노전체(t=3.1, p=0.00) 점수가 유의하게 더 높았다. 월경전기 증후군 여성들이 비월경전기 증후군 여성들 보다 유의하게 감정표현불능증증 점수가 더 높았다(t=2.0, p=0.04). 월경전 불쾌장애 의심 환자와 일반 월경전기 증후군 여성, 비월경전기 증후군여성 3군으로 나누어 분노 수준과 감정표현 불능증 수준을 비교한 결과도 월경전 불쾌장애 의심 환자가 비월경전기 증후군 여성보다 유의하게 분노억제수준이 더 높았으며(F=4.6, p=0.01), 월경전 불쾌장애 의심 환자가 일반 월경전기 증후군 여성보다(F=5.1, p=0.01) 그리고 비월경전기 증후군 여성(F=5.1, p=0.03) 보다 유의하게 더 분노전체 점수가 높았다. 사회인구학적 변인 가운데 연령과 임신여부는 각 군간 유의한 차이를 보였으나 SPAF 및 분노, 감정표현불능증과 유의한 상관관계는 보이지 않았다. 결론: 월경전기 증후군여성들이 비월경전기 증후군 여성보다 분노 억압점수 및 분노전체점수(anger total)가 각각 유의하게 더 높았다. 또한 월경전기 증후군 여성들은 비월경전기 증후군 여성들보다 감정표현불능증 점수가 유의하게 더 높았다. 상기 결과는 월경전기 증후군 여성의 증상이 분노와 감정표현 불능증과 연관되어 있을 가능성을 시사한다. Objectives : Objectives of this study was to explore the relationships between anger, alexithymia and premenstrual syndrome(PMS). Methods The subjects included 125 women with PMS and 58 women with non-PMS assessed by Daily record of Severity of Problems(DRSP) and Shortened Premestrual Assessment Form(SPAE). Anger level was assessed by anger expression scale. The level of alexithymia was assessed by Toronto alexithymia scale. We compared the scores of anger, alexithymia between PMS group and no-PMS group. Results : The mean scores of anger in(p=0.04), anger total(p=0.01) were significantly higher in women with PMS compared to control subjects. and the mean scores of alexithymia(p=0.04) were also significantly higher in women with PMS compared to control subjects. Conclusions : This study showed that the level of anger and alexithymia could be higher in women with PMS compared to control subjects, and that symptoms of PMS could be associated with anger and alexithymia. therefore, It would be better to consider the level of anger and alexithymia in treating and evaluating women with PMS.

Bromazepam이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

서신영 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.3

Bromazepam is one of the new benzodiazepine antianxiety agents, Chemically, it is 7-bromo-5-(2-pyridl)-2H-1.4-benzodiazepine-2(1H)-one and contains bromine in the structure. In the animal experiments, it was found to have taming, muscle relaxing and anticonvulsive effect and many clinical investigators have suggested that bromazepam is a potent antianxiety drug with little side effects. Investigators suggested that any new psychotrophic drugs should be tested for its interaction with alcohol, because they might precipitate the ritk situation in case of consuming them concurrently. In view of these reports, the author concucted an animal experiment to investigate the effects of bromazepam on the blood alcohol level in rabbits. Summany of the results are as follows: 1. In the group of alcohol plus bromazepam 3㎎/㎏ of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.01) and 45 minutes (p<0.05) after alcohol administration. 2. In the group of alcohol plus bromazepam 3㎎/㎏ of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 16 (p<0.01) and 45 minutes (p<0.01) after alcohol administration. 3. In the group of alcohol plus bromazepam 6㎎/㎏ of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.001) and 45 minutes (p<0.01) after alcohol administration. 4. In the group of alcohol plus bromazepam 6㎎/㎏ of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.01) and 45 minutes (p<0.01) after alcohol administration. Conclusion Bromazepam, when administered orally in a dosage of 3㎎/㎏ of body weight daily for 5 days or 10 days, it elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. When given in dose of 6㎎/㎏ daily for 5 days or 10 days, it elevated alcohol more significantly at both 15 and 45 minutes after alcohol administration.

히스테리 신경증과 과거 16년간의 증상양상의 변화에 관한 연구

민성길,서신영 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.1

A clinical study, reviewing the chart of 159 inpatients suffering from hysterical neurosis in Yonsei Medical Center during two periods, 1959 to 1962 and 1976 to 1978, was conducted to study the characteristic clinical feature of hysteria and the change in its prevalence and in the pattern of conversion symptoms for last 16 years between the two periods. The results revealed; 1. The frequency of the hysterical neurosis was not changed between two periods. Eighty three of them were females, but numbers of males were increasing. Most patients were in their 20s and 30s and their average age of onset was becoming younger(table 1). 2. Generalized convulsion was the most frequent chief complaint. Others were paralysis, paresthesia, headache, dyspnea, pain and G-I troubles. The dissociation symptoms were rare. No significant change was noted in the pattern of the chief complaints for the past 16 years(Table 2). 3. In average, a patient complained 4 to 5 conversion symptoms. The females complained more than the males did. The average number of symptoms was increasing. Pain was the most frequently complained symptom and also the symptoms of autonomic nervous system, especially gastrointestinal symptoms, were increasing. So it can be reasonably stated that the classical form of hysterical symptom is declining. The male complained more of paralysis and dizziness, while the females complained more of pain, fainting, globus hystericus, aphonia and itching sensation of sex organs. 4. In many patients, other neurotic symptoms such as anxiety, depression, hypochondria or fear were combined, but la belle indifference was rather uncommon. Regarding to In premorbid personality, hysterical personality was most common and also found were obsessivecompulsive an shizoid ones. The most common precipitating factor was considered to be sexual problems and also included were the conflicts with mothering-law and other life stresses. Conflicts with mother in law, financial failure, and failure in college intrance examination were seemingly increasing in number as precipitating stress in the recent years, which was to reflect the recent changes in social values system. 5. It was noted that there was some symbolic correlations between the particular somatic symptoms and the co-existing psychological symptoms, premorbid personality and the precipitating factors, suggesting some dynamic processes involved in patient's selecting of conversion symptom.

Semi-Custom ASIC 기반 16-bit ALU 설계

서신영(Sin-young Seo),박소연(So-yeon Park),용지원(Ji-won Yong),김용우(Yongwoo Kim) 대한전기학회 2022 대한전기학회 워크샵 Vol.2022 No.7

1998학년도 신입생 실태조사

박승호;박경;권세리;서신영;성주은 서울여자대학교 학생생활연구소 1998 학생생활연구 Vol.10 No.-

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한국판 성인용 자기 보고형 및 관찰자 보고형 Young ADHD 척도의 신뢰도 및 타당도 연구

김은경,서신영,김근향 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study is to assess the psychometric properties and to investigate factor structure of the Korean version of the Young ADHD Questionnaire-Self-Report (K-YAQ-S) and the Young ADHD Questionnaire-Informant-Report(K-YAQ-I). Methods : 269 normal college students completed the K-YAQ-S and the Lee Ji-Yeon's adult ADHD scale (1996). 213 in-formants of the subjects completed the K-YAQ-I. Results : The K-YAQ-S and the K-YAQ-I had good internal consistency (Cronbach's =.957, .965). An ADHD symptomatology and emotional problem subscales of the K-YAQ-S showed strong correlation with the Lee Ji-Yeon's adult ADHD scale. The delinquency and social functioning subscales of the K-YAQ-S and all subscales of the K-YAQ-I correlated significantly but were relatively lower. An exploratory factor analysis showed that the K-YAQ-S revealed 4 factors (ADHD symptomatology, emotional problems, delinquency, social functioning) and the K-YAQ-I being composed of 3 factors (ADHD symptomatology/aggressive behavior, emotional problem/social functioning, illegal act). Conclusion : These results suggest that the K-YAQ-S and the K-YAQ-I rating scale is a reliable and a valid test. These scales would be useful in diagnostic evaluation and in measuring the treatment effect for ADHD adult.

화병척도와 연구용 화병진단기준 개발

민성길,서신영,조윤경,허지은,송기준 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The aim of this study was to identify the characteristic symptoms for diagnosis of Hwabyung (HB), a culture-related anger syndrome in Korea; to construct a rating scale for HB and test its validity and reliability; and propose diagnostic criteria for HB. Methods Subjects were male and female Korean patients, who were diagnosed following Structured Clinical Interview (SCID) as having depressive disorders, anxiety disorders and somatoform disorders and who reported as having self-labeled HB. A HB Scale was constructed with 22 of the most common symptoms of HB as identified by previous studies. The HB scale's inter-rated reliability was tested with 60 subjects. Its validity was tested by comparison between a HB only group(n=47) and depressive disorder only group (n=44). Logistic regression analysis was conducted to make a predictive model of HB. Based on these results diagnostic criteria for HB was proposed. Results Inter-rated reliability in each of all the items and the total score of the HB Scale were statistically significant. The HB scale differentiated HB from depressive disorder with statistical significance. In logistic regression analysis, the ability of the HB model to predict symptoms of heat sensation, ukwool/boon (feeling of unfairness), and subjective anger was high with sensitivity of 80.0%, specificity of 88.4% accuracy of 84.1% and area under ROC of 0.92. Based on these results and information from previous research, diagnostic criteria of HB were formulated. Conclusion The HB Scale was found to be reliable and valid. Consequently, diagnostic criteria of HB were proposed, to include subject anger, "kwool/boon" (Feeling of unfairness), expressed anger, heat sensation, hostility, "haan", pushing-up in the chest, epigastric mass, respiratory stuffiness, palpitation, dry mouth, sighing, racing thoughts, and lamentation.

화병 증상에 대한 Paroxetine의 효과

민성길,서신영,전덕인,홍현주,박상진,송기준 대한정신약물학회 2009 대한정신약물학회지 Vol.20 No.2

Objective:This study consists of a single open clinical trial to evaluate the treatment effects of paroxetine on symptoms of hwa-byung, a Korean culture-related anger syndrome. Methods:Eighty-nine patients with depressive disorders, anxiety disorders, somatoform disorders, or self-labeled hwa-byung were treated with paroxetine (Paxil CR) 12.5-37.5 mg/day for 8 weeks. Treatment effects were evaluated using the Hamilton Depression Scale (HAMD), the State and Trait Anger Inventory (STAXI), and the Hwa-byung Scale. Results:Scores on all items;total score on the Hwa-byung Scale;scores on state anger, trait anger, and anger-in;total score on the STAXI;and total score on the HAM-D decreased significantly after eight weeks of paroxetine treatment compared to baseline. Conclusion:Paroxetine was shown to be effective for treating symptoms of hwa-byung, a chronic anger syndrome. 본 연구는 화병 증상에 대한 paroxetine의 치료효과를 알아보기 위한 단일개방성 임상시험이다. 89명의 우울증, 불안장애, 신체형장애, 적응장애 그리고 자가진단의 화병을 가진 환자를 대상으로 paroxetine HCl(팍실CR) 12.5~37.5 mg/day를 4주간 투여하였다. 치료효과는 HAM-D, STAXI 그리고 화병척도로 평가하여 치료전후를 반복측정 자료의 분산분석방식으로 분석하였다. 그 결과, HAM-D 총점, 화병척도의 총점과 모든 항목들의 점수, 그리고 STAXI의 총점, 상태분노, 특성분노, 분노억제 등의 점수에서 치료 전에 비해 치료 후에 통계적으로 유의한 감소가 있었다. 이러한 결과는 paroxetine이 화병 증상에 효과적인 치료약물임을 시사한다.