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전환된 각질형성세포주에 의한 마우스 Dendritic Epidermal T Cell ( V 5/V 1 + T 림프구 ) 의 활성화 반응
서성준(Seong Jun Seo),한은실(Eun Sil Han),김명남(Myung Nam Kim),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.11
Background:Dendritic epidermal T cells(DETC) are skin specific members of the epithelial γδ-T cell family that reside normally in mouse epidermis. Although the mechanisms of antigen recognition by αβ-T cells have become better defined, the physiological role of the γδ-T cells and ligands they recognize are still poorly understood. Object:In the present study we sought to elucidate the antigen specificity and whether the DETC recognize transformed keratinocyte derived antigen. Method:We used a DETC and TCR(-) DETC which were obtained by 1600R γ-irradiation and sorting, in addition to transformed keratinocyte cell lines. We performed coculture experiments of DETC/transformed keratinocyte cell lines to detect direct evidence that DETC recognize the keratinocyte-derived antigen. Result:1. TCR negative variants of DETC do not respond to concanavalin(Con)-A, but respond to phobol myristate acetate(PMA)/ionomycin. 2. PAM 212, UV-irradiated PAM 212 and heat shocked PAM 212 cells stimulate DETC. PAM 212 cells could perform as stimulator of DETC even in the absence of stress signal. 3. UV irradiated XB2 cells stimulate DETC, but XB2 and heat shocked XB2 cells could not stimulate DETC. 4. DETC do not respond to fibroblast, UV-irradiated fibroblast and heat shocked fibroblast 5. TCR negative variants of DETC are no longer stimulated by PAM 212 cells, suggests that PAM 212 cells mediate their effects through the TCR Conclusion:The above results strongly suggest that DETC recognize specific, transformed and stressed keratinocyte-derived antigens and may play a role as an immune surveillant for cellular damage. Therfore, DETC may play critical roles during the induction of immune reaction in the skin. (Korean J Dermatol 2000;38(11):1444~1452)
서성준(Seong Jun Seo),임이석(Ee Seok Lim),홍창권(Chang Kwun Hong),이기룡(Khee Rhyong Lee),송계용(Kye Young Song),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.6
We report herein a case of acral lentiginous melanoma in a 65-year-old female. An about 2x3cm sized erythematous to brownish mass with central ulceration was located on the left heel accompanied by enlargement of the left inguinal lymph nodes. Histopathologic findings showed lentiginous proliferation of atypical melanocytes with pseudoepithliomatous hyperplasia and invasion of tumor cells from the epidermis into the dermis. Focal pigmented melanocytes were also noted. Complete surgical excision and chemotherapy with DTIC were done. Marked edematous swelling on the left lower leg was developed after 8 months and 1 month later she was expired.
서성준(Seong Jun Seo),홍창권(Chang Kwun Hong),송계용(Kye Yong Song),김범준(Beom Joon Kim),김유진(Yu Jin Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.9
Relapsing polychondritis is a rare systemic disorder manifested by recurring episodes of inflammation in cartilagenous tissues including the eye, the audiovascular systems, We describe a 53-year-old oriental woman with a one month history of painful swelling of both accompanied by intermittent hoarseness, dyspnea, impaired visual acuity, and swelling of hands. Both ear were typically uninvolved. Auricle including cartilaginous tissues were histologically examined, which revea1ed loss of basophilic staining, degenerative changes, inflammatory cells infiltrations with eosinophils and neutrophils, and perichon4rial inflammation of the cartilage. Oral prednisolone and colchicine were prescribed and the succid resolulion of both ears swelling were observed. As the disease progressed optic neuritis and chewing difficu1ty by non-erosive motion limit of temporo-mandibular joints developed, (Korean J Dermatol 2002;40(9) : 1111~1115)