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건성각결막염 환자에서 스테로이드 점안 후 눈물 신경성장인자의 변화
정승아,이형근,서경률,홍순원,김현창,김응권,Seung Ah Chung,Hyung Keun Lee,Kyoung Yul Seo Soon Won Hong,Hyung Chang Kim,Eung Kweon Kim 대한안과학회 2006 대한안과학회지 Vol.47 No.11
Purpose: To compare nerve growth factor (NGF) levels in tears and on the ocular surface of normal controls with those of non-Sjogren type keratoconjunctivitis sicca (KCS) subjects, and investigate the effect of 0.1% prednisolone eye drops on NGF levels in KCS patients. Methods: Baseline tear NGF levels were measured in 41 KCS patients and 23 healthy control subjects using enzyme-linked immunosorbent assays (ELISA). KCS patients received 0.1% prednisolone drops in one eye, and 0.1% hyaluronic acid drops in the other eye, three times daily for 28 days. Impression cytology (IC) and immunostaining for NGF on conjunctival epithelium was performed for both groups. Results: KCS patients were found to have higher baseline tear NGF concentrations compared to age- and sex- matched healthy control subjects (65.9±14.5 vs. 122.1±45.3, p<0.0001). In KCS patients, prednisolone treatment for 28 days resulted in a decrease in tear NGF levels, symptom scores and IC scores, whereas hyaluronic acid treatment had no such effect (68.2±25.0 pg/μg vs. 108.0±43.4 pg/μg, p<0.0001 for tear NGF/TP ratio; 2.16±1.01 vs. 3.39±1.50, p=0.0014 for symptom scale; 1.05±0.67 vs. 1.61±0.86, p=0.0317 for IC). Measurements taken at both 14 and 28 days indicate that neither prednisolone nor hyaluronic acid treatment affected BUT or Schirmer values. Conclusions: KCS patients showed elevated levels of tear NGF, which were decreased by treatment with 0.1% prednisolone. These data suggest that the ocular surface NGF may play an important role in ocular surface inflammation processes associated with dry eyes.
이승규,김선웅,김태임,이형근,김응권,서경률.Seung Kyu Lee. M.D.. Sun Woong Kim. M.D.. Tae Im Kim. M.D.. Hyung Kuen Lee. M.D.. Eung Kweon Kim. M.D.. Kyoung Yul Seo. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.3
`Purpose: To compare short-term clinical results of LASEK and epi-LASIK. Methods: Fifteen subjects (30 eyes) underwent uncomplicated LASEK on one eye and uncomplicated epi- LASIK on the other eye by a single surgeon, and uncorrected visual acuity, refractive change, postoperative pain, and postoperative satisfaction were compared at postoperative week one, at one month, and at three months. Results: Postoperative uncorrected visual acuities were 0.68±0.20, 0.96±0.22, and 1.05±0.17 for LASEK and 0.75±0.21, 0.92±0.14, and 1.01±0.21 for epi-LASIK at one week, one month, and three months, respectively. Epi-LASIK showed faster improvement in visual acuity at one week, while LASEK showed faster improvement afterward. However, no statistical significance was found. Spherical equivalet of LASEK was -0.66±1.28D and that of epi-LASIK was -0.61±0.92D at postoperative week one, implying faster refractive recovery for epi-LASIK, but after one month, LASEK was faster in refractive recovery and all these changes were not statistically significant. Durations of postoperative pain were 3.13±1.25 days for LASEK and 3.02±1.32 days for epi-LASIK. Pain scores (0~10 point scale), however, were also lower for LASEK by 0.33 point, 0.57 point, and 0.45 point for postoperative day 1, 2, and 3, respectively. No statistical significance was noted in either pain duration or pain score. When asked for overall satisfaction, six subjects preferred LASIK, four subjects preferred epi-LASIK, and five subjects showed no preference. Conclusions: Both LASEK and epi-LASIK are effective for surgical correction of myopia, and no significant difference in visual recovery, refractive change or degree of postoperative pain was noted in this study.`