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방성원,부태성,황규왕,정현,김영근 ( Sung Won Bang,Tai Sung Bu,Chung Hyun,Kyu Uang Whang,Young Keun Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2
Acquired perforating disease(APD) is characterized by hyperkeratotic papules with transepidermal elimination of degenerated material and is associated with renal disease and/or diabetes. Particular attention has been directed to transepidermal elimination because the articles on perforating diseases among patients with chronic renal failure and/or diabetes have been increasingly reported. We describe four patients with chronic renal failure and/or diabetes whose skin biopsy specimens showed transepidermal elimination. (Kor J Dermatol 1997;35(2): 333-338)
수종의 표피종양에서 p53단백발현에 관한 면역조직화학적 연구
이성열,부태성,이종석,김의한 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2
This study was carried out to evaluate the aberrant expression of P 53 protein using immunohistochemical method in 28 basal cell carcinoma, 24 squamous cell carcinoma, 7 keratoacanthoma, and 4 Bowen's disease. Eighteen out of 28(64.3%) and twenty one out of 24(87.5%) showed positive reaction in the nucleus of basal cell carcinoma and squamous cell carcinoma, respectively. Five out of 7(71.4%) and three out of 4(75%) showed positive reaction in the nucleus of keratoacanthoma and Bowen's disease. In conclusion, our results suggest that the aberrant expression of P53 protein is a common and an important part of the pathogenetic sequence in a majority of cases of epidermal neoplasms.