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한약 복용이 고혈압에 미치는 영향: 내과학회 학회지 논문에 대한 고찰
백혜기 ( Hye Ki Baek ),안정조 ( Jung Jo An ),조현경 ( Hyun Kyung Jo ),유호룡 ( Ho Ryong Yoo ),김윤식 ( Yoon Sik Yoon ),설인찬 ( In Chan Seol ) 대전대학교 한의학연구소 2009 혜화의학회지 Vol.18 No.2
Background: Almost people know hypertensions treatment is taking western medicine. But korean herbal medicine(KHM) also have an effect of turning down blood pressure. Objectives: This study aims to review the influence of KHM on hypertension in korean internal medicines studies systematically. Additionally, we tried to estimate the change of data of hypertension and let people know a possibility of herbal treatment on hypertension. Methods: Systematic studies searches were performed on one database of korean internal medicine to November 2009. Screening and selection of the studies and extraction of data were performed by one author. Results: Twelve studies were included. All studies were performed retrospectively. Almost studiess object were hypertensive rats. Two studiess object were rabbits and only one studys object was hopitalized patients. Blood pressure and pulse was changed significantly after taking KHM in almost studies, and rest of items, aldosterone, catecholamine, electro, angiotensin converting enzyme inhibitory effect, renin activity were changed significantly after taking KHM. Conclusions: KHM might have an effect of lowering blood pressure, but almost studiess object were animals, so it is necessary to investigate an effect of KHM for people.
가미청열도담탕(加味淸熱導痰湯)이 DOCA-salt로 유발된 고혈압 백서에 미치는 영향
백혜기,안정조,조현경,유호룡,김윤식,설인찬,Baek, Hye-Ki,An, Joung-Jo,Jo, Hyun-Kyung,Yoo, Ho-Ryong,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3
This study was done to investigate the effect of Gamichungyeoldodam-tang (GCDT) in DOCA-salt induced hypertensive rats. The results were obtained as follows : GCDT showed safety against cytotoxicity and toxicity in the liver and the kidney. GCDT showed an inhibitory effect on ACE. GCDT significantly decreased the heart rate and the blood pressure in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of aldosterone in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of dopamine, norepinephrine, and epinephrine in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of chloride in DOCA-salt induced hypertensive rats. These results suggest that GCDT might be effective in treatment of hypertension.
백혜기,고미미,유병찬,방옥선,오영선,김연진,김정현,김윤식,설인찬,Baek, Hye-Ki,Ko, Mi-Mi,Yu, Byeong-Chan,Bang, Ok-Sun,Oh, Yeong-Seon,Kim, Yeon-Jin,Kim, Jung-Hyun,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Background : Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarction or may lead to insidious progressive brain damage resulting in vascular dementia. Known cardiovascular risk factors, such as arterial hypertension, diabetes mellitus, smoking, hyperlipidemia and ischemic heart disease may increase the risk of SCI. This study was designed to evaluate the risk factors of SCI in an apparently normal adult population. Methods : We divided 340 neurologically normal adults (mean age=59.90$\pm$8.30, men:women = 146:194) who underwent brain computed tomography (CT) or magnetic resonance imaging (MRI) at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital in two groups, Silent inf. and Controls,and analyzed risk factors of SCI by interview, physical examination and blood test. Risk factors of SCI were assessed by interview, physical examination and blood test. We performed Pearson's chi-square test and two-sample t-test for univariate analysis and multiple logistic regressions for multivariate analysis to evaluate risk factors of SCI. Results : Old age, diabetes mellitus, and high lactate dehydrogenase (LDH) levels were associated with SCI on univariate analysis. Diabetes mellitus was demonstrated to be an independent risk factor for SCI on multivariate analysis. Conclusions : Advanced age, diabetes mellitus, and LDH levels are associated with SCI.
뇌졸중 위험지표로서의 혈중 지질에 대한 환자;대조군 연구
김정현,강경원,유병찬,최선미,백혜기,임승민,안정조,설인찬,김윤식,Kim, Jung-Hyun,Kang, Kyung-Won,Yu, Byeong-Chan,Choi, Sun-Mi,Baek, Hye-Ki,Lim, Seung-Min,An, Jung-Jo,Seol, In-Chan,Kim, Yoon-Sik 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Background and purpose : Stroke is one of the most deadly diseases and a leading cause of disability. Lipids confer an increased risk for cardiovascular morbidity and mortality. In spite of many studies on the relationship between stroke and lipids, their relationship is not clear. This study was undertaken to determine whether lipids were associated with stroke. Method : We compared the components of blood lipids between stroke patients group (n=217,Cases), non-stroke control group (n=160, Controls) and healthy control group without hypertension, diabetes mellitus, ischemic heart disease, or hyperlipidemia (n=140, Normals). These data were statically analyzed by general linear models and binary logistic regression analysis to get each adjusted odds ratio. Result : The results were as follows. The blood levels of total cholesterol (T-Chol), triglyceride (TG) and low density lipoprotein cholesterol (LDL-Chol) were significantly higher in patients of ischemic stroke, while the blood levels of T-Chol and LDL-Chol were significantly lower, and the blood levels of TG significantly higher in patients of hemorrhagic stroke. The blood level of high density lipoprotein cholesterol (HDL-Chol) was significantly lower in all cases. Conclusion : These results suggest that high TG and low HDL-Chol may be risk factors of hemorrhagic stroke and ischemic stroke, high T-Chol and LDL-Chol may be risk factors of ischemic stroke, and low T-Chol and LDL-Chol may be risk factors of hemorrhagic stroke in Koreans.