Clinical Implications of Systemic Inflammatory Response Markers as Independent Prognostic Factors in Colorectal Cancer Patients

백광열,이인규,이윤석,성나영,권택수 대한암학회 2014 Cancer Research and Treatment Vol.46 No.1

PurposeCancer-related inflammation affects many aspects of malignancy. We confirm theeffects of early postoperative systemic inflammation on cancer prognosis. Materials and MethodsSix hundred consecutive patients underwent surgery for colorectal cancer from 2006to 2009. Measurements of white blood cells, neutrophils, lymphocytes, monocytes,and platelet counts were performed preoperatively, daily until the fourth postoperativeday, and subsequently every two days. Patients were divided into three groups basedon the days spent on the leukocyte count to drop below 10,000/mm3 after surgery. ResultsPreoperative white blood cell (WBC) counts correlated with stage of disease. In univariate survival analyses, tumor, node, metastasis (TNM) stage, and monocytecount were associated with cancer-free survival. In addition, cancer-free survivaloutcomes were worse in patients who required more than four days for the normalizationof WBC count. A TNM stage greater than II and the neutrophil lymphocyte ratiowere associated with the duration of overall survival. In a multivariate analysis ofthese significant variables, TNM stage, an interval longer than four days for normalizationof WBC counts and monocyte count independently associated with cancerfreesurvival. ConclusionPostoperative early inflammatory phase and preoperative monocyte count correlatewith poor colon cancer prognosis. We can conclude that preoperative and postoperativeinflammatory response and period unfavorably affect the metastatic microenvironment

무인항공기의 표적 추적을 위한 실시간 컬러 기반 물체 추적

백광열,방효충 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-

플러그인의 활갯짓

백광열 한국제품안전협회 2000 제품안전 Vol.73 No.-

위장의 점막 연관성 림프조직 림프종(MALT Lymphoma)의 임상적 고찰

백광열,노재형,허진석,손태성,최성호,조재원,김용일,Paik Kwang Yeol,Noh Jae Hyung,Heo Jin Seok,Sohn Tae Sung,Choi Seong Ho,Joh Jae Won,Kim Yong-Il 대한위암학회 2001 대한위암학회지 Vol.1 No.1

Purpose: The aim of this study was to analyze the clinical and the histopathological characteristics of mucosa associated lymphoid tissue (MALT) lymphomas in the stomach. Materials and Methods: We retrospectively reviewed the medical records of 22 patients who had been treated at Samsung Medical Center from Jan. 1995 to Sep. 2000 and who had been pathologically proven to have a MALT lymphoma. The factors we analyzed were operative procedure, tumor stage, and histopathological characteristics. Results: Of 3658 patients with a gastric malignancy, 22 patients proved to have a MALT lymphoma ($0.6\%$). There were 7 men and 15 women whose ages ranged from 25 years to 70 years (mean, 48.8 years). Forteen cases were located in the antrum, 4 ($18\%$) in the body and 4 ($18\%$) in the fundus or the high body. Nineteen of these patients were managed with total gastrectomy and splenectomy and 3 with radical subtotal gastrectomy. Histopathologically the tumor was limited to the mucosa in 3 patients ($1.36\%$), to the submucosa in 13 ($59.1\%$) and extended to the muscularis propria in 6 ($27.3\%$). Lymph node involvement was seen in 12 patients ($54.6\%$). There was no splenic or hepatic involvement. Bone marrow involvement was not seen in any patients. H. pylori was identified in 11 patients (50$\%$). During the mean follow-up period of 32.7 months, there were no reports of tumor recurrence or death. Conclusion: MALT lymphomas rarely disseminate by the time of diagnosis and rarely involve the bone marrow. Lymph node involvement is relatively high and a total gastrectomy is effective in managing patients with a MALT lymphoma.

Laser를 이용한 sapphire wafer의 scribing에 관한 연구

백광열,홍성준,강형식,홍순국 한국통신학회 2002 한국통신학회 기타 간행물 Vol.2002 No.10

Specific and Sensitive Primers Developed by Comparative Genomics to Detect Bacterial Pathogens in Grains

백광열,이현희,손근주,이평안,Nazish Roy,서영수,이선우 한국식물병리학회 2018 Plant Pathology Journal Vol.34 No.2

Accurate and rapid detection of bacterial plant pathogen is the first step toward disease management and prevention of pathogen spread. Bacterial plant pathogens Clavibacter michiganensis subsp. nebraskensis (Cmn), Pantoea stewartii subsp. stewartii (Pss), and Rathayibacter tritici (Rt) cause Goss’s bacterial wilt and blight of maize, Stewart’s wilt of maize and spike blight of wheat and barley, respectively. The bacterial diseases are not globally distributed and not present in Korea. This study adopted comparative genomics approach and aimed to develop specific primer pairs to detect these three bacterial pathogens. Genome comparison among target pathogens and their closely related bacterial species generated 15-20 candidate primer pairs per bacterial pathogen. The primer pairs were assessed by a conventional PCR for specificity against 33 species of Clavibacter, Pantoea, Rathayibacter, Pectobacterium, Curtobacterium. The investigation for specificity and sensitivity of the primer pairs allowed final selection of one or two primer pairs per bacterial pathogens. In our assay condition, a detection limit of Pss and Cmn was 2 pg/μl of genomic DNA per PCR reaction, while the detection limit for Rt primers was higher. The selected primers could also detect bacterial cells up to 8.8 × 103 cfu to 7.84 × 104 cfu per gram of grain seeds artificially infected with corresponding bacterial pathogens. The primer pairs and PCR assay developed in this study provide an accurate and rapid detection method for three bacterial pathogens of grains, which can be used to investigate bacteria contamination in grain seeds and to ultimately prevent pathogen dissemination over countries.

상호작용 다중 모델 알고리즘을 이용한 항공기 충돌 확률 예측

백광열,심상욱,방효충,탁민제 한국항공우주학회 2011 한국항공우주학회 학술발표회 논문집 Vol.2011 No.4

항공기간의 충돌 예측은 항공교통관제에 있어서 중요한 부분을 차지한다. 본 논문에서는 일정 시간후의 충돌확률을 예측하는 기법을 설명한다. 순간충돌확률은 정규분포 적분을 해석적으로 구하는 근사화된 방법을 통해 계산한다. 일정시간 후의 충동확률은 현재 항공기의 상태변수와 비행모드를 바탕으로 예측한다. 항공기의 상태변수와 비행모드는 ADS-B 신호와 상호작용 다중모델 기법을 통해 추정한다. 충돌확률 예측은 상호작용 다중 모델의 각 비행모드로부터 예측된 충돌확률의 조합으로 계산한다. 시뮬레이션을 통해 제안한 기법의 성능을 보인다. Conflict prediction of aircrafts is an important part in air traffic control operations. This paper describes the prediction algorithm of conflict probability after specific time. The instantaneous conflict probability is computed by approximated analytic solution of integral of Gaussian distribution. The conflict probability after specific time is predicted based on aircraft’s state and flight mode at the present time. The aircraft’s state and flight mode are estimated by interacting multiple model(IMM) approach with ADS-B messages. The predicted conflict probability is obtained by combination of predicted conflict probabilities of each flight modes of IMM. The performance of proposed algorithm is demonstrated by simulation study.

족보를 활용한 조선후기 인구현상의 이해— 전주이씨 『선원속보(璿源續譜)』를 중심으로

백광열 한국사회사학회 2022 사회와 역사 Vol.- No.133

This article is an attempt to understand the birth dynamics in the late Joseon Dynasty by utilizing the Jeonju Yi clan’s great companion genealogy, The Seonwon Sokbo (璿源續譜, 1900~1902). Until now, genealogy has not often been used for demographic analysis due to data limitations. However, of the available forms of data for understanding the population of the Joseon society, genealogy offers advantages in terms of size and quality. In this paper, in order to solve the limitations of genealogy as a form of population data, various methods were used to derive and analyze fertility-related indicators. The results have several implications for our understanding of birth Dynamics in the late Joseon Dynasty. Adapting the concept of Total Fertility Rate (TFR), I calculated the Yi clan’s ‘total survival rate’. This is the number of children a woman is expected to give birth to and survive to adulthood. In the Jeonju Yi clan, the ‘total survival rate’ was very low until the first half of the 17th century due to war, but rose from the late 17th to the first half of the 18th century. The total survival rate stayed at a very high level in the first half of the 19th century, a finding which differs from previous observations. This suggests we need to reconsider fertility and population-related phenomena during this period. Although the data was not complete, I also calculated the women’s (recorded) average age at first birth and (recorded) mean age at birth. These values rose through the 17th century and peaked in the 18th century. This process coincided with an increase in the total survival rate. After the 18th century women’s (recorded) average age at first birth dropped sharply while the total survival rate increased. In this regard, an interpretation was attempted through the relation between the infant mortality rate and the fertility rate. The Seonwon Sokbo has an inherent class bias because it is a genealogy of royal descendants, so, in order to compensate for this, the demographic effects for legitimate and illegitimate son were investigated individually. As a result, it was observed that illegitimacy had a negative effect on fertility. In the future, if we add analysis of various variables and comparison with other societies, we may be able to attain a more in-depth history of population and society during this period. 이 글은 전주이씨 대동보인 선원속보 를 활용하여 조선후기의 출산 관련 현상을 이해해 보려는 시도이다. 지금까지 족보는 자료적 한계로 인해 인구학적 분석에 그다지 잘 이용되지 못했다. 그러나 조선시대의 인구 현상을 이해하기 위한 자료 중에 족보는 그 규모나 질적인 면에서 유용한 자료임이 틀림없다. 이 글에서는 족보가 가진 인구 자료로서의 제약을 해결하기 위해 여러 가지 방법을 활용하여 출산 관련 지표를 도출하고 이를 분석하였다. 이 결과 조선후기 출산 현상과 관련하여 몇 가지 함의를 얻을 수 있었다. 합계출산율 개념을 활용하여, 한 여성이 평생동안 출산해서 성인이 될 때까지 생존시킬 것이 기대되는 자녀 수인 ‘합계생존율’을 구해보았다. 전주이씨 집단에 있어 ‘합계생존율’ 값은 17세기 전반기까지 전란으로 인해 매우 낮은 상태이다가 17세기 후반~18세기 전반에 걸쳐 상승하였다. 특히, 종래의 일반적인 관찰과는 다르게 19세기 전반기에 이 값이 매우 높은 수준을 유지하였다. 이것은 이 시기 출산 및 인구동태에 관한 인식 재고의 필요성을 제기한다. 비록 완전한 의미의 것은 아니지만, (기록상의) 초산연령 및 평균출산연령도 구해보았다. 이 값은 17세기까지 상승하다가 18세기에 정점에 도달하였다. 이 과정이 ‘합계생존율’의 상승과 병행했다. 18세기 이후에는 기록상 초산연령이 급격히 하강하고 ‘합계생존율’은 증가하였다. 이에 대해 유아사망율이나 출산율의 관련을 통한 해석을 시도해 보았다. 한편, 선원속보 가 왕실 후손의 족보라는 것에서 오는 계층편의를 보완하기 위해 적파/서파를 구분하여 그 인구학적 영향을 살펴보았다. 이 결과 서파의 영향이 기록상의 출산아 수에 음의 방향으로 작용함을 관찰하였다. 추후, 다양한 변수들에 대한 분석과 다른 사회와의 비교를 가미한다면 인구 및 사회에 관한 보다 심화된 역사상을 가질 수 있으리라 생각된다.

복부둔상에 의한 혈복강으로 시행한 췌미부 절제술 후 발견된 췌미부 췌관선암

백광열,유경탁,송대성,우고운,조영규 대한외과학회 2009 대한외과학회 학술대회 초록집 Vol.2009 No.11

LMT를 이용한 Laser Direct Writing에 관한 연구

백광열,김성한,홍순국,강형식 한국레이저가공학회 2002 학술발표대회 Vol.2002 No.2