일반연제 발표 : 혈청 Estradiol 농도의 지수극수적 증가률 및 배란직전 혈청 Estradiol 농도가 Human Menopausal Gonadotropin 배란유도 결과에 미치는 영향에 관한 연구

배광범,김정구,문신용,이진용,장윤석 대한산부인과학회 1987 대한산부인과학회 학술대회 Vol.60 No.-

난소적출술 환자에서 Estrogen 단독요법 및 Estrogen-androgen 병합요법에 관한 연구

배광범,Bai, Kwang-Bum 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4

Objective : To evaluate the difference between estrogen only therapy and estrogen-androgen combination therapy in surgical menopause patients. Materials and Method: Surgical menopause patients received 0.625 mg conjugated equine estrogens or 0.625 mg conjugated equine estrogens plus 1.25 mg methyltestosterone for 2 years. Bone mineral density, menopausal symptoms, lipoprotein profiles were measured. Results: Both groups showed increased bone mineral density. In the combination group, total cholestero l, high density lipoprotein cholesterol and triglycerides decreased. In the estrogen only group, low density lipoprotein cholesterol decreased but high density lipoprotein cholesterol increased significantly. In both groups, menopausal symptoms were much improved. Side effects were easily tolerated in both groups. Conclusions: Estrogen-androgen combination therapy had comparable benefits compared with estrogen only therapy.

황체기능 평가에 관한 연구

배광범,김정구,문신용,이진용,장윤석,Bai, Kwang-Bum,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1986 Clinical and Experimental Reproductive Medicine Vol.13 No.2

The present study was designed to assess the relationships between the methods to evaluate adequacy of luteal function. We measured mid-luteal serum progesterone levels by radioimmune assay, luteal phase lengths and mean post-ovulatory basal body temperature rise rates by basal body temperature charts in 40 in-phase-cycle infertile patients and 38 out-of-phase-cycle patients who underwent late-luteal endometrial biopsies at the sterility clinic of Department of Obstetrics and Gynecology, Seoul National University Hospital from Jan. 1986 to Aug. 1986. The results were summarized as follows: 1. No significant differences were found in mean age, mean duration of infertility, mean mid-luteal serum progesterone levels, and mean post-ovulatory temperature rise rate between in-phase-cycle patients and out-of-phase-cycle patients, but significant difference in mean luteal phase length between 2 groups was identified. 2. 91% of total patients sho had luteal phase lengths of less than 11 days showed out-of-phase-cycles. 3. In out-of-phase-cycle group with luteal phase lengths of less than 11 days, 50% had an endometrial lag of at least 4 days, but 10.7% had an endometrial lag of 4 or more days in group with luteal phase lengths of more than 11 days. 4. There was no significant correlation between mid-luteal serum progesterone level and endometrial lag of late luteal phase endometrial biopsy.

혈청 Estradiol 농도의 지수함수적 증가율이 Human Menopausal Gonadotropin 배란유도 결과에 미치는 영향

배광범,김정구,문신용,이진용,장윤석,Bai, K.B.,Kim, J.G.,Moon, S.Y.,Lee, J.Y.,Chang, Y.S. 대한생식의학회 1987 Clinical and Experimental Reproductive Medicine Vol.14 No.2

Exponential rise rate(ERR) of serum estradiol concentrations during active follicular phase was calculated for 49 ovulation induction cycles by human menopausal gonadotropin to know the ovulation induction outcome according to ERR classified into 3 groups with low, moderate and high ERR values(Group I${\leqq}$0.3, 0.3<Group II${\leqq}$0.6,Group III>0.6). The results were summarised as follows : 1. No significant difference in the dosage of human menopausal gonadotropin was identified in each group. 2. The mean serum estradiol concentration at the day of human chorionic gonadotropin injection in Group II and Group ill was significantly higher than that in Group I . 3. The mean diameter of leading follicles at the day of human chorionic gonadotropin injection showed no significant difference in each group. 4. No significant difference in the ovulation rate was observed in relation to ERR. How ever, 20% and 20.8% of pregnancy rate in Group I and Group II were achieved while no pregnancy was occurred in Group III. 5. The ovarian hyperstimulation frequency was significantly higher in Group ill that in Group I and Group II. In conclusion, the study suggests that exponential rise rate of serum estradiol is a useful tool in HMG ovulation induction by preventing ovarian hyperstimulation without reducing pregnancy success rate.

체외수정시술 환자에서 난소 주위 유착이 과배란유도 중의 난소 난포 발달에 미치는 영향에 관한 연구

배광범,김석현,이진용,Bai, Kwang-Bum,Kim, Seok-Hyun,Lee, Jin-Yong 대한생식의학회 1988 Clinical and Experimental Reproductive Medicine Vol.15 No.2

It has been suggested that the presence of periovarian adhesions might impair the ovarian response to gonadotropins. Total 136 patients who underwent IVF-ET from February to June 1988(88-1 and 88-2 series) at SNUH were classified into three groups according to total ovarian access score, sum of each ovarian availability, estimated by diagnostic laparoscopy : group I(N=43,0%-50%), group II(N=49, 50%-150%) and group III(N=44, 150%-200%). To evaluate the effects of periovarian adhesions on follicular development in controlled ovarian yperstimulation for IVF-ET, serum E2 levels on the day of hCG dministration (Day 0) and the day after hCG administration (Day+1), the number of ovarian follicles with mean diameter${\geqq}$12mm on Day 0, and the number of oocytes retrieved by transvaginal aspiration were measured and compared among groups. There were no significant differences in age of patients, cancellation rate due to inadequate ovarian response, serum E2 levels, the number of ovarian follicles, the number of oocytes retrieved, and oocytes retrieval rate per follicle. In the same patients(N=31) in group II in whom the difference in ovarian availability between two ovaries is more than 50%, there was also no significant difference in the number of ovarian follicles between them. These data suggest that pelvic adhesions including periovarian adhesions have no adverse effects on the ovarian response to gonadotropins stimulation and the outcome of IVF-ET.

子宮破裂 2 例

배광범,홍성환,신면우 한국의학사 1984 診斷과治療 Vol.4 No.12

과체중 및 비만 다낭성 난소 증후군 환자에서의 Metformin과 Rosiglitazone의 효용성

배광범,Bai, Kwang Bum 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.4

Objective: The purpose of this study was to evaluate and compare the effects of metformin and rosiglitazone in overweight or obese women with polycystic ovarian syndrome. Methods: Twenty Six overweight or obese patients with polycystic ovarian syndrome were randomly treated with either metformin (500 mg three times daily, n=13) or rosiglitazone (4 mg once daily, n=13) for 6 months. Hormonal studies were performed before and after treatment. Insulin resistances were calculated by computerized HOMA 2 Calculator v2.2. Results: Testosterone decreased while SHBG increased after 6 months treatment in both metformin and rosiglitazone treatment groups. Fasting glucose decreased after metformin or rosiglitazone treatment. HOMA insulin resistance improved after treatment with either drug. There was no differences in hormonal changes and insulin resistance between 2 treatment groups. Conclusions: This study shows that metformin and rosiglitazone are effective in improving insulin sensitivity and ameliorating hyperandrogenism in overweight/obese polycystic ovarian syndrome women.

환자에서의 Chlamydia 항체 양성율에 관한 연구

배광범,신창재,김정구,문신용,이진용,장윤석 대한산부인과학회 1988 대한산부인과학회 학술대회 Vol.61 No.-

호르몬 대체요법 혹은 칼슘 보충제로 치료한 초기 폐경기 여성에서 골밀도 변화에 대한 골대사 생화학적 지표의 유용성

배광범(Kwang Bum Bai) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2

목적 : 생화학적 골지표가 초기 폐경기 여성의 골 소실 혹은 골 생성의 정도를 예측할 수 있는지를 규명하고자 하였다 . 연구방법 : 초기 폐경기 여성 240명을 호르몬 대체요법 혹은 칼슘보충제로 치료하였으며 이들에게서 치료전 및 치료개시 1, 3, 6, 12개월 경과 후 NTx 및 osteocalcin을 측정하였으며 동시에 골밀도 측정을 병행하였다 . 결과 : 호르몬 대체요법을 받은 110명은 요추(+2.6%) 및 대퇴골 경부(+1.1%)에서 골밀도의 증가를 보인 반면 칼슘 보충제만 사용한 130명에서는 감소를 나타냈다. 호르몬 대체요법 여성들에서는 치료기간이 경과함에 따라서 생화학적 골지표값의 감소를 보였으나 칼슘 보충제만 사용한 여성들에서는 변화가 없었다 . 호르몬 치료전 측정한 생화학적 골지표를 크기에 따라 4분하여 상호 비교시에 최고 4분위군에서 최저 4분위군에 비해서 골밀도 증가가 현저하였다(P<0.05). 1년간의 호르몬 치료후 골밀도가 증가한 여성들에서 감소한 여성들에 비하여 치료전 측정한 골대사인자 평균치가 월등히 높았다 ( P<0 . 001 ) . 칼슘보충제만 사용한 경우 생화학적 골지표 크기가 최고 4분위군에서 최저 4분위군에 비해 골밀도 감소가 현저하였다 ( P < 0 . 05 ) . 결론 : 생화학적 골지표들은 초기 폐경기 여성에서 호르몬 치료에 대한 골밀도의 반응을 예측하는데 유용한 지침자라고 사료된다. Objective : To identify the effectiveness of bone turnover indexes for bone loss or gain in early postmenopausal women. Method : This study was performed in 240 menopausal women(mean age, 50 yr), who were randomized to hormone replacement therapy(HRT) or calcium supplementation(CS, 500mg/day) for 1yr. Urinary N-telopeptide(NTx) and osteocalcin(OC), as well as spine and femoral neck bone mineral density(BMD) were measured at baseline and 1, 3, 6, 12 months after treatment. Results : Women receiving HRT(n=110) showed a significant increase in spine BMD(+2.6% ; P<0.0001) and hip BMD(+1.1% ; P<0.05) compared to women receiving CS, who showed a decline at both sites (-1.0% ; P<0.01). Both markers showed time dependent decreases in women receiving HRT(P<0.001) and no change in women receiving calcium alone. When baseline indexes of turnover were divided by quartile, there was a significantly greater increase in BMD among those with the highest NTx, OC levels compared to that in those with the lowest NTx, OC levles(P<0.05). When subjects receiving HRT were compared by their positive or negative skeletal response at 1yr and their baseline turnover marker, initial NTx values were significantly higher in those that gained bone than in those that lost bone (P<0.001). Calcium supplementation women in the highest quartile for NTx at baseline had significantly greater decreases in spine BMD than subjects with the lowest NTx values(P<0.005). Conclusions : For early postmenopausal women there are differential responses of biochemical markers to HRT and calcium supplementation. Baseline urinary NTx and serum osteocalcin were good predictors of change in spine BMD after 1yr of either HRT or calcium supplementation. It is concluded that markers of bone formation and resorption can be used clinically to predict future BMD in early postmenopausal women.

자궁경부에서 발생한 1 예

배광범(KB Bai),서광태(KT Suh),한영란(YR Han),정동건(DG Chung),신명우(MW Shin) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.5

19세의 ㅈ은 여성의 자궁경부에서 기원한 1례를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. Embryonal rhabdomyosarcoma, more commonly called sarcoma botryoides, is the most common malignant tumor arsing from the infant vagina. Eighty-five percent of these tumors arise in girls under 5 years of age. a fewer appear after menarche ; however, a greater percentage of tumors developing in this age group arise in the uterine cervix than arise in the vagina. We present a case of botryoid embryonal rhabdomyosacoma arising from uterine cervix with a review of a literatures.