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정량분무식 에어러졸 사용시 propellant에 의한 기도수축반응
반준우,윤호주,손지웅,조상헌,최동철,민경업,김유영 (Jun Woo Bahn,Ho Joo Yoon,Jee Woong Son,Sang Heon Cho,Dong Chull Choi,Kyung Up Min,Yon Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Background: Bronchoconstriction associated with aerosolized agents delivered by a metered dose inhaler (MDI) is relatively uncommon, but has been of particular interest. Material and Method: In this study, we investigated to what extent the inert ingredients and propellants (freons) influence pulmonary function in 25 asthmatic patients. Forced expiratory volume in one second(FEV,) was measured by spirometry, Autospira HI 498(Chest, Japan) before and 1, 3, 5 and 10 minutes after the inhalation of saline control and MDI-placebo containing freons and inert ingredients. Res ult: Twenty four % (6/25) of asthmatics experienced a decrease in FEV20 by 10% or greater when compared to saline control. Number of positive cases in steroid dependent asthmatics is significantly higher compared to non-steroid dependent asthmatics. (p <0.05) Bronchoconstriction associated with the use of MDI-placebo appeared within 3 to 5 minutes and resolved spontaneouly at 10 minutes after the inhalation. Conclusion: The bronchoconstrictive response induced by MDI might be caused by the pro- pellants and/or the other inert ingredients contained in MDIs.
스테로이드 의존성 천식 환자에서 스테로이드와 β2-아드레날린 수용체 mRNA의 발현양상
반준우 ( Joon Woo Bahn ),오선영 ( Sun Young Oh ),김세훈 ( Sae Hoon Kim ),장윤석 ( Yoon Seok Chang ),김우경 ( Woo Kyung Kim ),김상훈 ( Sang Hoon Kim ),김윤근 ( Yoon Keun Kim ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),김유영 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Background:Steroid-dependency is one of phenotypes of severe asthma. Because steroid- dependent asthmatics require long-term systemic steroids to control their symptoms, they have potentially increased risks to experience serious adverse events caused by
데오필린 , 경구 , 베타교감신경자극제 , 경구 스테로이드제가 피부단자시험에 미치는 영향
이상록,반준우,이병재,손지웅,김우경,김윤근,지영구,조상헌,민경업,김유영 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.4
Skin prick test(SPT) is an economic and sensitive test to detect a specific IgE. Theophylline, oral beta2-agonist. Oral corticosteroids, and antihistamines are the commomly prescribed drugs in patients with allergic diseases but there are many situations that SPT are performed while taking those durgs. It has been suggested that theophylline, oral beta2- agonist, and corticosteroid inhibit the release of mediators from mast cells in vitro. To evaluate the effects of theophylline, oral Salbutamol, and Prednisolone on the results of SPT, we measured skin resgonse to histamine codeine, and allergens before and after the mediestions of therapeutic dosage for 7 days in 10 healthy subjects. The results were as follows. L. In SPT with histamines(lmg/ml), the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistmaine were 4.37+ 0.23 and 4.27+0.20, 4.17 + 0.28 and 3.87 + 0. 28, 4.49 + 0.29 and 3.98 + 0.36, and 4.82 + 0.40 and 1.82+0.35, respectively. Theophylline, bata2-agonist and corticosteroid had no significant effect on the result of SPT with histamine. 2. In SPT with codeine(10mg/ml), the mean wheal sizes(mm+-SE) before and after medications of theophylline, beta2-agonist, corticosteroid, snd antihistamines were 4.00 + 0.37 a,nd 4.05+0.26, 4.51+0.28 and 4.28+0.36 4.31+0.37 and 4.41+0.29, and 4.39+0.30 and 2.05+0.28 respectively. Theophy'Rine, beta2-agonist and corticosteroid had no significant effect on the result of SPT with codeine. 3. In SPT with allergens, the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistamines were 5.86 + 0.65 and 4.95 +0.97, 6.00+0.79 and 5.58+1.17, 5.12+0.70 and 4.09 + 0.60, and 5.72 + 0.67 and 3.05 + 0. 37, respectively. Theophylline, beta2-agonist and corticosteroid had no significant effect on the result of SPT with allergens. In conclusion, it is suggested that theophyl- line, oral Salbutamol, and Prdnisolone have no significant effect on the result of skin prick test with histamine, codeine and allergens.
운동유발성 천식환자에서 운동후 요중 메틸히스타민 및 설피도펩티드 류코트리엔의 농도 변화
박재경,반준우,이병재,손지웅,이상록,김윤근,조상헌,민경업,김유영 (Jae Kyung Park,Jun Woo Bahn,Byung Jae Lee,Jee Woong Son,Sang Rok Lee,Yoon Keun Kim,Sang Heon Cho,Kyung Up Min,You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Background: Exercise can aggravate asthmatic symptoms in many patients with bronchial asthma. It is caused by that inhaled air bypasses nasal cavity and goes directly to the lower airways through open mouth dring exercise. Although the pathogenetic mechanisms of exercise -induced asthma(EIA) have not been clarified yet, there is evidence that chemical mediators, released from the inflammatory cells triggered by airway cooling or drying, might be responsible for induction of bronchoconstriction. However, it has been controversial which chemical mediators or cells are involved in such process. Objectiye . The aim of this study was to evaluate t.he role of activated mast cells in the pathogenesis of EIA and find out whether or not sulfidopeptide leukotrienes (LTC4/d4/E4) are involved in the exercise-induced bronchoconstriction. Material and Method: Eleven asthmatics with documented exercise-induced bronchoconstriction and 10 control subjects were studied. Before and 6 hours after free running for 6 minutes, forced expiratory volume in 1 second (FEV,) and the concentrations of N- methylhistamine, LTE4, and creatinine in unine collected for 6 hours after exercise were determined. Result: Urinary concentrations of N-methylhistamine(mean+SE, ng/mg creatinine) of EIA patients before and after exercise were 159+40 and 450+75, respectively. Those of control subjects were 208+ 54 and 275+ 62, respectively. Uninary N-methylhistamine levels of EIA group increased significantly after exercise, while those of control group did not change. Urinary concentrations of LTE,(mean+SE, pg/mg creatinine) of EIA patients before and after exercise were 15.6 k2.6 and 22.2+5.8, respectively. Those of control subjects were 10.4+ 4.0, 18.2 +7.0, respectively. The concentrations of LTE4 in the urine samples collected before exerise revealed no difference between EIA and control subjects (p=0.07). There was no change after exercise in both groups. Percent fall of FEV, was 29.1+8.0% (mean+SD) in EIA group and 3.4 + 4.0% in control group, respectively. There was no correlation between reduction of FEV, and change in urinary concentrations of N-methyl-histmine after exercise. Conclusion'. Chemical mediators of activated mast cells may be involved in exercise-induced bronchoconstriction, but there is little evidence for enhanced sulfidopeptide leukotriene generation as assessed by urinary LTE4.