WKY 랫드의 혈림프절 구조

박철범,성제경,이인세,이흥식,이준섭,윤여성,Park, Cheol-beom,Seong, Je-kyung,Lee, In-se,Lee, Heungshik S.,Lee, Joon-sup,Yoon, Yeo-sung 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.3

It has been known that the hemolymph node is one of the lymphoid organs found normally in ruminants and some rodents, and this organ shares morphological and functional characteristics of lymph node and spleen. To clanify the rigorous definition of morphological structures and functions of the hemolymph node in Wistar Kyoto(WKY)rats, we examined these organs of WKY rats gross anatomically and light microscopically. The hemolymph nodes were normally found in the abdominal cavity and in the neck of WKY rats. This organ was surrounded by a thin connective tissue capsule and there was a hilus. The parenchyma comprised a cortex of lymphatic nodules and diffuse lymphatic tissues, and a medulla of diffuse lymphatic tissues arranged in cords. Afferent and efferent lymph vessels were observed but there was no extensive subcapsular and medullary sinuses. These sinuses were filled with erythrocytes. The stroma of hemolymph nodes was composed of reticular cells and fibers, and many lymphocytes, granulocytes, erythrocytes, plasma cells, macrophages and megakaryocytes were supported by the reticular network. The above findings suggest that the hemolymph nodes of WKY rats may take part in blood formation, blood filtration and immune reaction.

면양의 혈절과 혈림프절의 구조

박철범,성제경,이인세,이흥식,이준섭,윤여성,Park, Cheol-beom,Seong, Je-kyung,Lee, In-se,Lee, Heungshik S.,Lee, Joon-sup,Yoon, Yeo-sung 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.3

This study was performed to investigate the gross anatomical features and microscopical structures of the hemal nodes and the hemolymph nodes in the sheep. The hemal nodes and hemolymph nodes were observed mainly in periphery of the thoracic and abdominal aortae of the animals. The size of hemal nodes was generally smaller than that of the hemolymph nodes, and the shape of the both organs was spherical or ovoid. The color of the hemal nodes was red, while that of the hemolymph nodes was grary with red bands. The hemal nodes were surrounded by a relatively thick connective tissue capsule and there were extensive subcapsular sinuses distended by a great number of erythrocytes. Although a few number of lymphatic nodules and small areas of diffuse lymphatic tissues were observed in the parenchyma, no typical cortex and medulla were defined in the hemal node. Small numbers of blood vessels were found at the connective tissue capsule but lymph vessel was not observed microscopically in this organ. The hemolymph nodes were covered by a relatively thick connective tissue capsule and there was a hilus in each node. The parenchyma was divided into cortex and medulla. The cortex was composed of a few numbers of lymphatic nodules and some diffuse lymphatic tissues. The medulla comprised medullary sinuses and cords. Afferent and efferent lymph vessels were observed at the periphery of the capsule adn the hilus, respectively. The subcapsular and medullary sinuses were not extensive but filled with small numbers of erythrocytes. The stroma of hemal node and hemolymph node was composed of reticular cells and fibers, and the capsule and trabecula consisted of collagenous fibers with smooth muscle fibers.

랫드의 혈림프절 구조

박철범,성제경,이인세,이흥식,이준섭,윤여성,Park, Cheol-beom,Seong, Je-kyung,Lee, In-se,Lee, Heungshik S.,Lee, Joon-sup,Yoon, Yeo-sung 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.4

It has been known that the hemolymph node is one of the lymphoid organs found normally in ruminants and some rodents, and this organ shares morphological and functional characteristics of lymph node and spleen. To clarify the rigorous definition of morphological structures and functions of the hemolymph node in Sprague-Dawley(SD) rats, we examined these organs of SD rats gross anatomically and light microscopically. The hemolymph nodes were normally found in the abdominal cavity and in the neck of SD rats. This organ was surrounded by a thin connective tissue capsule and there was a hilus. The parenchyma comprised a cortex of lymphatic nodules and diffuse lymphatic tissues, and a medulla of diffuse lymphatic tissues arranged in cords. Afferent and efferent lymph vessels were observed but there was no extensive subcapsular and medullary sinuses. These sinuses were filled with erythrocytes. The stroma of hemolymph nodes was composed of reticular cells and fibers, and many lymphocytes, granulocytes, erythrocytes, plasma cells, macrophages and megakaryocytes were supported by the reticular network. The above findings suggest that the hemolymph nodes of SD rats may take part in blood formation, blood filtration and immune reaction.

Diethyl maleate가 N-methyl-N'-nitro-N-nitrosoguanidine에 의해서 유발되는 랫드 위암 발생에 미치는 영향에 관한 병리학적 연구

박철범,이준섭,Park, Cheol-bom,Lee, Joon-sup 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.4

This study was carried out to investigate the effects of diethyl maleate(DEM) on the carcinogenesis of forestomach and pyloric glandular stomach in rats caused by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). A total of 60 male 6-week-old Wistar rats were given twice intragastric injection of MMNG(200mg/kg BW), then were given diets containing 5% NaCl for 3 weeks until 4th week of the experiment. And then the animals of groups of 1 and 2 were placed on diets containing 0.2% DEM for 16 weeks until the end of 20 weeks of the experiment. On the other hand, the animals of groups of 3 and 4 were placed on basal diets for the same periods. The tissues of forestomach and liver of each group were frozen in liquid nitrogen and the activities of quinone reductase(QR) were determined by measurement of the dicoumarol-sensitive reduction of dichloro-indophenol by NADPH at 600nm. All rats were sacrificed at the end of 20 weeks of the experiment. Every animal was fasted for 24 hrs prior to sacrifice. The forestomach was fixed in 10% neutral phosphate buffered formalin for histology and the pyloric gland was fixed in sublimated formalin for immunohistochemistry of pepsinogen 1 altered pyloric gland(PAPG). The final body weight of the group given MNNG and treated with 5% NaCI and DEM was significantly decreased compared with that of the group 4(p<0.05). Food and water consumption rates were not significantly changed. The preneoplastic and neoplastic lesions of the forestomach given MNNG and treated with 5% NaCI and DEM were significantly increased compared to those of the group 4(p<0.0l). The incidence of PAPG in the groups treated with 0.2% DEM was significantly increased compared with that of the group 4(group 1:p<0.01, group 2:p<0.05). The activities of QR of forestomach in the groups treated with 0.2% DEM were significanitly increased compared with those of the group 4(p<0.001), but those of liver were not significant. These results indicate that DEM exert the enhancing effect of forestomach and glandular stomach carcinogenesis in rats pretreated with MNNG and NaCl.

CB6F1-rasH2 transgenic mice를 이용한 발암성 시험 대체법

박은진 ( Eun Jin Park ),박선희 ( Sun Hee Park ),박찬성 ( Chan Sung Park ),김영선 ( Young Seon Kim ),김은애 ( Eun Ae Kim ),강종구 ( Jong Koo Kang ),서동석 ( Dong Suk Seo ),박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2008 동물실험대체법학회지 Vol.2 No.1

Alternative carcinogenecity test on CB6F1-rasH2 transgenic mice(rasH2) were conducted. Both sexes of rasH2 and wild type mice were orally administered at the dose of 1.44, 5.75 and 23 mg / kg of sibutramine mesilate and 20 mg / kg of sibutramine hydrochloride for 26 week. Incidence rate of tumor per mice and number of tumor were very low and not significantly different between control and treatment group. It means that sibutramine mesilate and sibutramine hydrochloride has no carcinogenecity on rasH2 mice and this result predicted that 2-year carcinogenecity of sibutramine mesilate would be negative. Based on these results, rasH2 transgenic mice has useful model for alternative of 2-year carcinogenecity test.

피부/안자극시험 대체시험법 연구

박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2008 한국동물실험대체법학회 학술대회집 Vol.2008 No.1

Reconstructed skin provides advantages to single cell culture testing and leads to promising results as shown by different validation studies. In this study we investigated the efficacy of "KeraskinTM" compared with "EPI-200" and in vivo test. We conducted endpoint analysis including cell viability (MTT reduction, CCK-8) and IL-1 alpha release. Twenty chemical were investigated using keraskinTM model and compared with Epiderm model. Results of MTT assay and CCK-8 assay were not different between EPI-200 and KeraSkinTM, but IL-lα levels of some test items different between EPI-200 and KeraSkinTM. We concluded that this KeraSkinTM model is useful for alternative skin irritation test, although other tests should be conducted for many other chemicals in international validation study.

주택가격 변화가 소비에 영향을 미치는 경로에 대한 고찰 : 한국의 패널 데이터 분석

박철범(논평) ( Cheolbeom Park ) 한국금융연구원 2019 韓國經濟의 分析 Vol.25 No.1

한국의 재정패널 데이터를 이용하여 주택가격 변화가 어떠한 경로를 거쳐 소비의 변화에 영향을 미치는지를 살펴보았다. 평균적으로 주택가격 변화에 대한 소비의 반응은 작게 나타났지만, 가구들에 따라서 반응이 상이하게 나타났다. 주택 소유자가 고령인 가구와 다주택 소유의 가구는 주택가격이 상승할 때 소비를 증가시키지만 무주택 가구 또는 1주택 소유 가구는 소비를 감소시키거나 반응이 유의하지 않았는데, 이러한 결과는 주택자산 효과(Housing wealth effect) 가설과 부합하는 것으로 보인다. 또한, 정부가 총부채상환비율(Debt-to-income ratio)를 강화할 때, 주택가격이 상승하더라도 차입제약이 강화되어 해당 규제를 받는 가구들은 소비를 감소시키는 현상도 발견하였는데, 이러한 결과는 주택가격 변화가 차입제약 경로를 통하여서도 소비에 영향을 미칠 수 있음을 암시한다. 마지막으로, 주택과 소비에 동시에 영향을 미치는 거시경제적 공통 요인(Common factor)이 중요하다는 증거는 발견할 수 없었다. Utilizing household-level panel data, this study examines the relation between house price changes and consumption changes. Although the overall impact of house price changes on consumption is small, the responses of consumption to housing price changes are heterogeneous across households. Old homeowners and households owning multiple houses raise consumption in response to house price changes whereas young homeowners and households with one house do not. These results indicate the relevance of housing wealth effect hypothesis to understand the relation between house price changes and consumption changes. In addition, when borrowing constraint is tightened by tightening debt-to-income ratio, households reduce the consumption even with an increase in the house price, which is also consistent with the borrowing constraint hypothesis.

전후 자본주의경제의 동향에 관한 고찰

박철범(Park, Chul-Bum),김광표(Kim, Kwang-Pyo) 조선대학교 지식경영연구원 1999 기업과 혁신연구 Vol.22 No.2

Asset Prices, Heterogeneous Expectations, and Limited Short Sales

CHEOLBEOM PARK(박철범) 고려대학교 미래성장연구소 2016 미래성장연구 Vol.2 No.1

This paper extends the Harrison-Kreps model by allowing limited short sales and finite wealth. The main results of this paper are: (1) investors always pursue short-term gains (or participate in single-period speculation) when perceiving heterogeneous expectations; (2) important properties of the equilibrium price in the Harrison-Kreps model still hold even when limited short sales and finite wealth are allowed; (3) an increase in short-sale costs raises the risky asset price; and (4) an increase in the dispersion of expectations about future dividends also raises the risky asset price when the risky asset is held by a minority of investors.

Physostigmine과 procyclidine으로 구성된 유기인제 중독 복합예방제에 대한 4주 반복투여 독성평가

이종성(Jong-Sung Lee),황재식(Zai-Zhi Huang),강현구(Hyun-Gu Kang),박선희(Sun-Hee Park),박철범(Cheol-Beom Park),박종일(Jong-Il Park),김왕수(Wang-Soo Kim),피택산(Taek-San Phi),최은경(Ehn-Kyoung Choi),황석연(Seock-Yeon Hwang),강종구(Jong 한국실험동물학회 2003 Laboratory Animal Research Vol.19 No.4