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음주 습관에 따른 혈중 지질 농도의 차이 비교에 대한 단면연구: 제 7기 국민건강영양조사 자료 활용
박창윤,김형숙 대한지역사회영양학회 2023 대한지역사회영양학회지 Vol.28 No.5
Objectives: This study compared serum lipid concentration according to drinking habits. Methods: We analyzed data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES VII). The study included 8,525 adults (3,651 males and 4,874 females), aged 30–59years. Results: There were differences in age, gender, education level, smoking status, physical activity, and waist circumference between drinkers and abstainers. The serum low-density lipoprotein-cholesterol (LDL-C) level of the drinkers was lower than those of the abstainers (P < 0.05). The serum triglyceride (TG) and high-density lipoprotein-cholesterol (HDL-C) concentrations were highest in the group that consumed alcohol ‘more than twice a week’ relative to the other groups (P < 0.001). The LDL-C and atherogenic index (AI) levels were lowest in the ‘more than twice a week’ drinking group compared to the other groups (P < 0.001). The serum TG and HDL-C concentrations were the highest in the ‘7 glasses/ time’ group (P < 0.001). The serum LDL-C concentration was the lowest in the ‘7 glasses/ time’ group (P < 0.001). Notably, the higher the frequency of binge drinking (7 glasses or more), the higher the concentration of TG (P < 0.001). The serum HDL-C concentration was significantly higher in the ‘no binge’ and ‘more than once a week’ groups compared to the other groups (P < 0.001). The serum LDL-C concentration and AI score were the lowest in the ‘more than once a week’ group (P < 0.001). Conclusions: As the quantity and frequency of drinking increased, the serum TC con- centration increased. Moreover, an increase in the serum HDL-C concentration led to a decrease in AI. The factors exacerbating cardiovascular disease increased simultaneously due to drinking. Our results suggest that for individuals with hypertriglyceridemia and patients with low HDL-cholesterolemia, separate guidelines based on the quantity and frequency of alcohol consumption are warranted.
朴昌潤,朱炅煥,林漢鍾 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3
The purpose of this study was to evaluate the therapeutic effect of praziquantel (Embay8440, Biltricide®) on human cerebral cysticercosis. The praziquantel is a broad spectrum anthelmintic agent and has a high activity against cestodes and trematodes. Before and after the treatment with oral administration of the praziquantel the changes in structure of Cysticercus cellulosae biopsied in subcutaneous tissue were studied by scanning and transmission electron microscope, and cerebral cysticercosis by computerized tomographic scanning. The results were as follows : 1. The findings of the observations on subcutaneous Cysticercus biopsied after treatment were compared with those of before treatment. At the early stage of the treatment, small vacuoles were scattered along the basement layer in the tegumental syncytium of the scolex and neck regions. In the scanning electron microscopic observation, marked surface changes were present in the neck region with many bleb-like structures formed by the bursting of the large vacuoles in the tegumental syncytium. In the specimens biopsied at 2 or 5 weeks after treatment, the degenerations and necrosis of the tegumental syncytium were seen in all part of cysticercus. 2. The scanning electron microscopic findings of Cysticercus cellulosae obtained from the 4th ventricle of the cerebral cysticercosis patients by the surgical operation were identical with those of subcutaneous tissues. 3. In 12 cases of cerebral cysticercosis treated with prziquantel in dosage of 3×25 ㎎/㎏ for 3 or 4 consecutive days, there were no cessations of the convulsive seizures during the 6 months follow up. Among them 9 cases were given again with the same doses of the drug for 4 or 7 days. In 7 of 9 cases, no more convulsive seizure was experienced over one or two years after the second treatment. At the same time the lesions of the brain C.T. scanning were disappeared, decreased in size or calcified. In the other 3 cerebral cysticercosis cases, the complete cure was also obtained after the oral medication of praziquantel with the doses of 3×25 ㎎/㎏ for 7 consecutive days. 4. In the treatment of cerebral cysticercosis with praziquantel, it was found that the combined oral medication of dexamethasone during the course of treatment was effective on preventing and minimizing the side effects.
열공성 경색 환자에서 경사에코 자기공명영상상 보이는 미세출혈과 Matrix Metalloproteinases-9과의 관계
박창윤,김현영,고성호,이규용,이영주,김주한,김승현,구대림 대한신경과학회 2006 대한신경과학회지 Vol.24 No.4
Background: Hypointense cerebral lesions on T2*-weighted gradient-echo MRI (GRE) have been known to be related with microbleeds or advanced microangiopathy with potential for further bleeding. It has also been suggested that matrix metalloproteinases (MMPs) may play a role in blood brain barrier disruption, edema formation and hemorrhagic transformation. In this study, we investigated the relationship between microbleeds detected by GRE, MMPs and neurological worsening in acute lacunar infarctions. Methods: Eighty-eight patients with acute lacunar infarctions, defined by TOAST classification, were included. GRE (1.5T, TR 500 ms TE 15 ms) was performed within 48 hours after stroke symptom onset. MMPs were measured by standard quantitative sandwich enzyme-linked immunosorbent assays (ELISA). Clinical characteristics, neurologic scale and MMP-9 levels were compared between groups with or without hypointense lesions in GRE (microbleeds). Neurological worsening was defined as deterioration from baseline in the score on the NIHSS by one or more points 14 days after the onset of a lacunar infarction. Results: Eleven of 88 patients (12.5%) undergoing GRE demonstrated evidence of microbleeds in the ischemic region. In the groups with microbleeds, the ESR level (p=0.048) and MMP-9 activity (p=0.001) were significantly increased, and neurological worsening was more prominent (p=0.018). Conclusions: This study suggests that microbleeds detected by GRE are related with elevated MMP-9 and neurological worsening. Therefore, the finding of microbleeds in GRE, increased MMP-9 activity and elevated ESR level might be useful factors for predicting the progression of acute lacunar infarctions.