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박진수 ( Chin Su Park ),황요순 ( Yo Sun Hwang ),구성태 ( Sung Tae Koo ) 경락경혈학회 2011 Korean Journal of Acupuncture Vol.28 No.3
Objectives : We have examined and analyzed patents regarding acupuncture point stimulating methods in order to understand the stimulation technology and research trends of acupuncture points. Methods : We searched and analyzed the total of 135 on-line DB based patents under time limit of Dec, 2010. Results : According to the analyzed results, non-invasive method is used more than invasive method. Electric stimulation is used more than any other method, such as magnetic, ionic, laser, light, ultrasonic, water, Far IR and thermal stimulation. There are numbers of cases such as rejected during screening procedure, waived before the screening, of failed to renew its registrational status which outnumber those patents registered and maintained. Conclusions : These data suggest that we need to move away from using one side method such as non-invasive and electrical method. Thus follow-up service is recommended.
다제내성결핵 균주에서 Reverse Hybridization Assay를 이용한 Fluoroquinolone, Kanamycin 신속 내성 검사의 유용성
박진수 ( Chin Su Park ),성낙문 ( Nack Moon Sung ),황수희 ( Soo Hee Hwang ),전재현 ( Jae Hyun Jeon ),원영섭 ( Young Sub Won ),민진홍 ( Jin Hong Min ),김천태 ( Cheon Tae Kim ),강형석 ( Hyung Seok Kang ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.1
Multidrug-resistant tuberculosis (MDR-TB) is an increasing public health problem and poses a serious threat to global TB control. Fluoroquinolone (FQ) and aminoglycoside (AG) are essential anti-TB drugs for MDR-TB treatment. REBA MTB-FQ? and REBA MTB-KM? (M&D, Wonju, Korea) were evaluated for rapid detection of FQ and kanamycin (KM) resistance in MDR-TB clinical isolates. M. tuberculosis (n=67) were isolated and cultured from the sputum samples of MDR-TB patients for extracting DNA of the bacilli. Mutations in genes, gyrA and rrs, that have been known to be associated with resistance to FQ and KM were analyzed using both REBA MTB-FQ? and REBA MTB-KM?, respectively. The isolates were also utilized for a conventional phenotypic drug susceptibility test (DST) as the gold standard of FQ and KM resistance. The molecular and phenotypic DST results were compared. Sensitivity and specificity of REBA MTB-FQ? were 77 and 100%, respectively. Positive predictive value and negative predictive value of the assay were 100 and 95%, respectively, for FQ resistance. Sensitivity, specificity, positive predictive value and negative predictive value of REBA MTB-KM? for detecting KM resistance were 66%, 94%, 70%, and 95%, respectively. REBA MTB-FQ? and REBA MTB-KM? evaluated in this study showed excellent specificities as 100 and 94%, respectively. However, sensitivities of the assays were low. It is essential to increase sensitivity of the rapid drug resistance assays for appropriate MDR-TB treatment, suggesting further investigation to detect new or other mutation sites of the associated genes in M. tuberculosis is required.
황요순 ( Yo Sun Hwang ),박진수 ( Chin Su Park ),구성태 ( Sung Tae Koo ) 경락경혈학회 2012 Korean Journal of Acupuncture Vol.29 No.4
Objectives: The aim of the study is to find out whether effect of acupuncture is depending on the diameter of needle, which is a possible component of dose of acupuncture needling. Methods: To compare acupuncture effects in different diameters of needle, we measured the changes in muscle fatigue recovery using surface electromyogram(sEMG) in healthy 8 volunteers. Muscle fatigue was induced by 20 times sit-up for 1 min. Immediately after induction of muscle fatigue, acupuncture needle was inserted into ST36 or ST25 for 10 min by diameters of 0.20 mm, 0.30 mm, or 0.40 mm needles. The sEMG recording was followed by acupuncture for 30 min. As a control group, sEMG was recorded for the same period at rest after muscle fatigue induction. Results: In both of ST 36 and ST 25, stimulation with 0.4 mm diameter needle showed significant rapid recovery followed by short period of muscle fatigue increase. Stimulation with 0.2 mm diameter significantly suppressed the increase of muscle fatigue. Conclusions: These data suggest that acupuncture effect is, at least in part, dependent on diameter of needle. Therefore, diameter of needle is also considered to achieve effective outcome of acupuncture.
뇌로 전이된 원발성 피부 미만 B대세포 림프종, 다리형
김윤미 ( Yun Mi Kim ),김성근 ( Sung Keun Kim ),이상훈 ( Sang Hoon Lee ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),황규왕 ( Kyu Uang Whang ),진수지 ( Su Sie Chin ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.10
In the WHO-EORTC (World Health Organization-European Organization for Research and Treatment of Cancer) classification, the primary cutaneous B-cell lymphomas were divided into 4 groups: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center cell lymphoma, primary cutaneous diffuse large B-cell lymphoma, other, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT). PCLBCL LT is known to have more aggressive clinical behavior and a worse prognosis than the other groups of primary cutaneous B-cell lymphomas. We report here on a case of PCLBCL LT in a 55-year-old male who presented witha multiple erythematous nodules on the right leg. After chemotherapy, the skin lesions had almost cleared, but afterward the tumor was revealed to have metastasized to the brain during 1 year. (Korean J Dermatol 2009;47(10):1149∼1153)