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증례 : 류마티스 ; 강직성 척추염 환자에서 발생한 갑상선자극호르몬(TSH) 분비 뇌하수체 선종 1예
박지혜 ( Ji Heh Park ),이승근 ( Seung Geun Lee ),박은경 ( Eun Kyoung Park ),구동완 ( Dong Wan Koo ),김보현 ( Bo Hyun Kim ),김인주 ( In Joo Kim ),김근태 ( Geun Tae Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.6
저자들은 강직성 척추염을 진단받고 외래에서 추적관찰중인 환자에서 동반된 갑상선자극호르몬 분비 뇌하수체 선종을 TRH 자극검사, 갑상선자극호르몬 α-아단위 측정 및 자기공명영상으로 진단하고 수술로 치료하여서 호전된 드문증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 두질환과의 상호 연관성에 대해서는 추가적인 연구가 필요할 것으로 판단된다. A thyrotropin (TSH)-secreting pituitary adenoma is a rare cause of hyperthyroidism, with an incidence of one case per million. Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease of the axial skeleton. Extra-articular manifestations, such as anterior uveitis, may also be prominent features in AS but little is known about the association between AS and thyroid diseases including TSH-secreting pituitary adenomas. We present a case study of a 26-year-old male AS patient who was diagnosed with a TSH-secreting pituitary adenoma using a thyrotropin releasing hormone stimulation test, measurement of the TSH α-subunit, and magnetic resonance imaging, and subsequently treated with a transsphenoidal tumor resection. (Korean J Med 2015;88:737-741)
원발쓸개관경화증에서 발생한 갑상샘유두암과 혼합결합조직병 1예
구동완 ( Dong-wan Koo ),이승근 ( Seung-geun Lee ),박은경 ( Eun-kyoung Park ),박지혜 ( Ji-heh Park ),이규민 ( Kyu-min Lee ) 대한내과학회 2017 대한내과학회지 Vol.92 No.1
A 40-year-old female previously diagnosed with primary biliary cirrhosis was referred to the hospital complaining of muscle weakness, arthralgia, Raynaud`s phenomenon, and thick skin. After work-up, she was diagnosed with both mixed connective tissue disease (MCTD) and papillary thyroid cancer (PTC), based on the Alarcon-Segovia criteria and pathological examination, respectively. High-dose glucocorticoid and azathioprine were introduced to treat active myositis of MCTD, and total thyroidectomy was performed to treat PTC. This report highlights the possible association between MCTD and thyroid cancer, and suggests that MCTD is associated with PTC, similar to other autoimmune diseases including Sjogren`s syndrome, systemic sclerosis, and systemic lupus erythematosus. (Korean J Med 2017;92:103-107)