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박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.
박정란,김미혜,우정민,이승재,송경은 대한진단검사의학회 2008 Annals of Laboratory Medicine Vol.28 No.6
Background : Saliva is increasingly being used as a specimen for systemic disease as well as for oral health status. Especially, salivary amylase has been studied as an excellent index for psychological stress. Authors evaluated the measurement of salivary amylase activities collected by Salivettes (Sarstedt, Germany). Methods : Saliva specimens were collected from 13 healthy adults between 10:00 and 11:00 a.m. Participants were asked to gently chew tampons of Salivettes for 1 min. Immediately after collection, all specimens were stored frozen. On the day of testing, they were centrifuged after thawing and diluted with distilled water. Amylase was measured by Dimension RxL Max (Dade Behring Inc.,USA). We evaluated precision, linearity, and recovery rate of Salivette. Amylase activities between collection of saliva by Salivette and passive drool were compared, and also the changes of amylase by the storage temperature were evaluated. Results : Intra-run CVs for three levels of amylase were excellent. Between-day CVs and total CVs were good only for mid and high levels. A good linear relationship was found at all diluted levels. Dosing Salivettes with 2 mL, 1.5 mL, and 1 mL yielded sample recovery 85.5±2.4%, 82.4±1.5%, and 72.2±3.1%, respectively and amylase recovery 78.9±10.9%, 74.1±13.7%, and 37.3±26.9%, respectively. Amylase by Salivette and passive drool were correlated well (r=0.757), although they showed a significant difference. Amylase activity was not affected by the storage temperature. Conclusions : Measurement of salivary amylase using Salivette could be a useful test having good intra-run CVs and linearity. More than 1.5 mL of saliva would be needed to have more than 70% recovery of Salivette. (Korean J Lab Med 2008;28:438-43)
박정란,손장원 한국디지털건축·인테리어학회 2008 한국디지털건축인테리어학회 논문집 Vol.8 No.1
This paper intends to predict characteristic of the balcony space composition in apartment that residents want by analyzing floorplans utilizing balcony that is directly described by housewives in competitions. According to change of age, Modern's lifestyle is variously changed and future housing life may undergo changes continuously. Therefore, development of apartment housing plans is reflected by grasping and collecting space residents desire. Purpose of study is 1) arrangement characteristic of balcony space housewives prefer 2) relations characteristic between balcony and room adjoining balcony 3) characteristic of balcony space composition Through this study, the public space that family use together prefer facing the front side and the kitchen is required to face the front side. Balcony adjoining bedroom is utilized according to user of the bedroom, and independent space like hobby room do not have distinctive relationships with adjacent space. Recent trend that space is reflected in various lifestyle of resident require needs that exercise room for well-being life and other room for various functions. Based upon the study, the results show the basic information and understanding how the plans are supposed to change, particularly to facilitate the usage of the balcony.