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박재선 고신대학교(의대) 고신대학교 의과대학 학술지 1993 고신대학교 의과대학 학술지 Vol.9 No.1
-Abstract- During the past two decades, a dramatic progress has been made in the treatment of childhood acute lymphoblastic leukemia(ALL). The long-term survival of childhood acute ALL has been improved from around 20% in the beginning of 1970' to as high as 60-70% currently. It is largely due to the improved combination chemotherapy, preclinical treatment of the most sanctuary area, the central nervous system, improved survival of poor-prognosis subgroup by intensive chemotherapy and salvage of relapsed patients with better chemotherapy regimens and with bone marrow transplantation. To date, the use of other therapeutic approach than multiple combination chemotherapy has been unconceivable. Consequently, review of important outcomes of recent chemotherapeutic regimens will give us a future direction and help to refine present treatment protocol.
유지 혈액 투석환자의 혈중 포도당 농도 변화에 관한 연구
박재선,선휘경,박봉건,이상준,김은순,김희숙,정우경,권인순,고행일,정귀원 인제대학교 2000 仁濟醫學 Vol.21 No.2
Objectives: The study was done to investigate the changes of serum glucose concentrantion and glucose loss during hemodialysis with and without glucose in the dialysate. Method and Materials: Authors studied 23 patients(11 non-diabetes and 12 diabetes) with end-stage renal disease undergoing long-term maintainence hemodialysis. Hemodialysis was performed with glucose free and glucose containing dialysate. Each blood and dialysate outlet fluid sample was drawn for glucose concentration every hour. Results: 1) In non-diabetes and diabetes, serum glucose concentration was decreased during hemodialysis with glucose free dialysate. 2) Net glucose loss during the four hours of hemodialysis was 50-7lg. 3) There was no change in serum glucose concentration during hemodialysis with glucose containing dialysate in non-diabetic endstage renal disease. But, in diabetes, the serum glucose concentration was decreased during hemodialysis with glucose containing hemodialysate. Conclusion: This study suggested that blood glucose concentration was decreased during hemodialysis because of glucose loss in dialysate outlet fluid. Therefore, the addition of glucose to dialysis fluid may help the prevention of hypoglycemia and energy balance. But, in diabetes, further study is needed.
The Combination of Real-Time PCR and HPLC for the Identification of Non-Tuberculous Mycobacteria
박재선,최정인,임지훈,안종준,Yangjin Jegal,서광원,나승원,전재범,이선호,김성렬,정조셉,정윤성 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.5
We used HPLC and AdvanSure real-time PCR (LG Life Sciences, Korea) to retrospectively analyze non-tuberculous mycobacteria (NTM) in 133 clinical specimens. The specimens were culture-positive for NTM and the HPLC method identified 130 strains of mycobacteria from the cultures (97.7%) at the species level. Among the isolates, 48 Mycobacterium. kansasii (36.1%), 39 M. intracellulare (29.3%), 17 M. avium (12.8%), 16 M. abscessus (12.0%), 6 M. fortuitum (4.5%), 2 M. szulgai (1.5%), 2 M. gordonae (1.5%), and 3 unclassified NTM strains (2.3%) were identified. The real-time PCR assay identified 60 NTM-positive specimens (45.1%), 65 negative specimens (48.9%), and 8 M. tuberculosis (TB)-positive specimens (6.0%). The real-time PCR assay is advantageous because of its rapid identification of NTM. However, in our study, the real-time PCR assay showed relatively low sensitivity (45.1%) when using direct specimens including sputum and bronchoalveolar lavage (BAL) fluid. HPLC is useful as it discriminates NTM at the species level, although it is time-consuming and requires specific equipment and technical expertise. A combination of both methods will be helpful for the rapid and accurate identification of mycobacteria in clinical laboratories.