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박이천,정지윤,지준호,박실비아,안진석,임영혁,박연희 대한암학회 2014 Cancer Research and Treatment Vol.46 No.2
Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastasesin the lung. This patient was a 40-year-old Korean woman who had been diagnosedwith breast cancer (T1N0M0, estrogen receptor/progesterone receptor/HER2+/+/+) and papillary thyroid cancer three years prior and underwent a completesurgical resection followed by appropriate adjuvant treatment with radiation,hormone, and radioactive iodine. She was recently admitted for newly developedpulmonary nodules. Metastasectomy through video-assisted thoracoscopic surgeryrevealed recurrent double primary cancer with two different components (metastaticductal carcinomas from the breast and metastatic papillary carcinomas from thethyroid gland) in each pulmonary nodule in the right upper lobe and right middle lobe. To the best of our knowledge, this is the first report of simultaneous recurrent doublemetastasis in one organ from different primary origins.
박이천,이호섭,이은미,신성훈,김양수 고신대학교(의대) 고신대학교 의과대학 학술지 2016 고신대학교 의과대학 학술지 Vol.31 No.2
Objectives : The both values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were reported as indexes of systemic inflammation and readily available and inexpensive prognostic markers in patients with solid cancer. The objective of this study was to clarify whether the NLR and PLR were significant prognostic markers in Korean diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP as a first line therapy. Methods : We retrospectively collected the clinical data of ninety nine DLBCL patients treated with R-CHOP from 2004 to 2012 and analyzed. NLR and PLR were calculated from complete blood count (CBC) and differential leukocyte count. Results : In univariate analysis, NLR was significantly associated with 5-year progression free survival(PFS) rate (P = 0.039), but not significantly associated with 5-year overal survival (OS) rate (P = 0.276). PLR was not significantly associated with 5-year PFS (P = 0.632) and OS rate (P = 0.855). In multivariate analysis, NLR was not a significant independent prognostic factor for 5-year PFS (P = 0.415) and OS rate (P = 0.991). Conclusion : The NLR can be considered a useful predictor of survival outcome. The PLR is not a valid predictor of survival outcome.
식도근절개술로 치료한 식도이완불능증에서 발생한 Barrett 식도궤양 1예
박효진,박인서,이천균,송준현 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.3
We report a patient who developed a Barrett,s esophageal ulcer 10 years after esophagomyotomy for achalasia. A-59-year-old female was admitted to the hospital with dysphagia for 2 months. In 1982, she had undergone a modified Heller esophagomyotomy for achalsia. After esophagogram, esophageal manometry, 24hr esophageal pH monitoring, esophagoscophy achalasia and Barrett,s esophageal ulcer was diagnosed. So, she had been treated with omeprazole and sucralfate and has been followed up in a asymtomatic state currently. In Barrett,s esophagus, there is a metaplasia of the normal stratified squamous mucosa to columnar epithelium, caused by the reflux of acid. It appears in approximately 10% of patients with chronic gastroesophageal reflux and is associated with increased probability of adenocarcinoma of the esophagus. Among the predis- posing factors of gastroesophageal reflux, there is treatment of esophageal achalsia by forceful dilatation or by the esophagomyotomy. The resultant ralaxation of lower esophageal sphinter, combined with deficient propulsive esophageal peristalsis, predisposed to gastroesophageal reflux. Actually an increased incidence of gastroesophageal reflux, esophagitis and stricture are well-known complications after esophagomyotomy. But in spite of higher risk of gastroesophageal reflux after esophagomyotomy the development of Barrett,s mucosa has been rarely reported and only recently recognized. Diagnosis of Barrett,s esophagus in such patients is difficult and the cumulative effects of achalasia and Barrett's esophagus predispose these patient to higher risk of developing esophageal carcinoma. So, high index of awareness and regular endoscopic surveillance are required.
박인서(In Suh Park),강진경(Jin Kyung Kain),김충배(Choong Bai Kim),박효진(Hyo Jin Park),문병수(Byung Soo Moon),이천균(Chun Kyun Lee) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
Three patients with epiphrenic diverticula were reviewed with foci on esophageal dysfuntion and its relation to treatment. All cases were identified by bariurn esophagogram and confirmed by endoscopy. Manoetric studies of esophagus documented as diffuse esophageal spasm-like disorder in 1 case, and nonspecific motor disorder in 2 cases. One case was managed surgically, and the other 2 were treated conservatively. We found that epiphrenic diverticulum were associated with esophageal motility disorders. Treatment should be considered to focus on associated motility disorders as well as a diverticulum. (Korean J Gastroenterol 1997;29:687-693)
스쿼시 동호인들의 운동중독이 근 손상 생물표지인자에 미치는 영향
박석,이천호,이영준,김정석,유영준,정윤철,조영웅,이상규,홍인숙,김동아 한국웰니스학회 2012 한국웰니스학회지 Vol.7 No.1
The purpose of the study was to examine the influence of exercise addiction on??muscle injury markers in squash club members. In order to achieve this purpose, a questionnaire survey was??conducted with 217 squash club members residing in Seoul and Kyonggi. Exercise addiction participants were??divided into 3 groups, that is, non-addicted, over-use, and addicted group by the exercise addiction scales. In this??study, heat shock protein 70, creatine kinase and lactate dehydrogenase were measured to confirm the level of??muscle injury. There was significant difference in heat shock protein 70, creatine kinase and lactate??dehydrogenase between exercise addiction levels(p<0.05). The results represent that muscle injury is more affected by??high level of exercise addiction. In summary, these results suggest that muscle injury markers (heat shock??protein 70, creatine kinase and lactate dehydrogenase) might increase as the exercise addiction level increases.
심장이식후 발생한 대장기종 ( Pneumatosis Cystoides Intestinalis )
이천균(Chun Kyun Lee),송시영(Si Young Song),이용찬(Yong Chan Lee),장병철(Byung Chul Chang),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
Pneumatosis cystoides intestinalis(PCl) is a rare disease of undetermined etiology which is characterized by multiple gas-filled cysts in the wall of the small or large intestine or both. It is associated with various medicosurgical conditions including organ transplantation. Fewer than 50 cases of PCI occurring after organ transplantation including 4 cases of cardiac transplantation have been reported in the world literatures. We report a 47-year-old man of PCI who suffered from right lower quadrant abdomina) pain for 1 week. He was taken heart transplantation due to acute myocardiac infarction and ischemic cardiomyopathy 1 year ago. On plain abdominal X-ray revealed the multiple clustered localized collections of gas in the ascending and hepatic flexure of colon. Co]onoscopy showed the typical finding of PCI, which was multiple variable size protruding masses which apperared as round, soft, and somewhat bluish colored cysts. After the puncture of the above cystic mass using endoscopic injection needle, we can observe the deflation of the above ass. This is the first case in Korea. (Korean J Gastroenterol 1995;27: 732 - 737)
박세기,이천,김무성,Park, Se-Ki,Lee, Cheon,Kim, Moo-Sung 한국전기전자재료학회 1996 電氣電子材料學會誌 Vol.9 No.3
Non-ozone layer destructive Chlorofluorocarbon(CFC) altematives(CHCIF$_{2}$ and $C_{2}$H$_{2}$F$_{4}$) have been initially used for laser-induced thenrmochemical etching of GaAs. High etching rate up to 188.mu.m/sec and an aspect ratio of 2.7 have been achieved by a single scan of laser beam, respectively. The etching rate at constant ambient gas pressure was found to saturate for beam power. The chemical compositions of the reaction products deposited on the etched groove were measured by Auger electron microscopy(AES). Etched profile, depth and width were observed by scanning electron microscope(SEM).