통계자료의 비밀보호를 위한익명화 방법들

박원환,황조연 통계청 2004 통계연구 Vol.9 No.2

In this paper, we introduce the disclosure limitation techniques which are used to protect statistical tables and micro data. Techniques for disclosure limitation are cell suppression, random rounding, controlled rounding and confidentiality edit. And techniques for disclosure limitation of micro data are sampling, eliminate identifier, limit geographic detail, limit variables and top or bottom-coding. The techniques introduced in this paper contribute to promote dissemination of macro data and micro data. 통계자료는 매크로 데이터(macro data)와 마이크로 데이터(micro data)로 구분하며, 수집한 자료에 포함된 오류를 바로잡은 유효한 자료(valid data)를 마이크로 데이터, 이를 집계 및 요약한 자료를 매크로 데이터라 한다. 최근 정보기술이 발전하여 대용량의 통계자료를 이용자가 직접 분석할 수 있어 통계자료 이용자는 마이크로 데이터를 확보하여 직접 분석․활용하고자 하는 추세이다. 이로 인하여 통계작성기관은 마이크로 데이터의 보급 확대와 응답자 보호라는 두 가지 과제에 직면하게 된다. 실제 통계자료에는 개인 또는 기업의 민감한 개별정보가 포함되어 있을 수 있으므로 이러한 정보는 보호가 필요하다. 따라서 본 논문에서 통계자료 이용 활성화와 응답자 보호를 위하여 통계자료 특성, 매크로 및 마이크로 데이터 비밀노출 위험(disclosure risk)과 그의 방지 방법들(disclosure limitations)을 소개한다.

血栓症과 打撲性 充血 및 高脂血症에 順氣導痰湯 및 化瘀湯이 미치는 影響

박원환,최달영,文濬典 東國大學校韓醫學硏究所 1993 東國韓醫學硏究所論文集 Vol.2 No.1

To see both Shunqidaotantang(dissipate phlegm and promote vital energy circulation) and Huayutang(blood circulation and disperse blood stasis) influencing on thrombosis, contusion-hyperemia, and hyperlipidemia, at first we measured the density of FDP, the quantity of fibrino-gen, prothrombin time, and the number of platelet of rat taken thrombosis by endotoxin. Secondly we measured the increase-rate of "paw swelling", the number of platelet, the quantity of fibrino-gen, and pothrombin time of rat taken contusion-hypermia. And then we measured the quantity of total cholesterol in serum and of H.D.L-cholesterol and of triglyceride and of phospholipid and of β-lipoprotein, its weight, and the variation of the quantity of electrolyte of rat taken hyperlipidemia by the oral-injection of cholesterol. As a result, we can conclude as follows: 1. Out of the test of thrombosis, we can recognize not only the noticeable increae of the number of platelet and the quantity of fibrinogen, but also the noticeable decrease of prothrombin time and the density FDP in case of Shunqid?otant?ng-injected rat and Huay?t?ng-injected rat. 2. Out of the test of contusion-hypermia, we can recognize not only the noticeable increase of the number of platelet and the quantity of fibrinogen, but also the noticeable decrease of prothrombin time and "increase-rate of paw swelling" in case of Shunqid?otant?ng-injected rat and Huay?t?ng-injected rat. 3. Out of the test of hyperlipidemia, at first we can recognize that test rat's weight increased as close as that of normal rat. And we can recognize the noticeable decrease of the triglyceride and phospholipid and β-lipoprotein. " Also, in case of the variation of electrolyte we can recognize the decrease of calcium and potassium in Shunqidaotantang-injected rat, and of sodium and magnesium in Huayutang-injected rat. Thus, as the above-mentioned, in covering thrombosis, contusion-hypermia, and hyperlipidemia, the effect of Shunqiduotantang and Huay?t?ng can be recognized. Granting that Huayutang reveals its effectiveness in thrombosis and contusion-hyperemia, and Shunqid?otant?ng in hyperlipidemia, it can be inferred that contusion-hyperemia is like "model of blood stasis form" as thrombosis and hyperlipidemia "phlegm-retention diseases form ", and both phlegm-retention and blood stasis have correlation each other.

白鼠의 高脂血症 病態誘發에 관한 實驗的 硏究

박원환 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2

연구배경 : 고지혈증은 혈액속의 지질성분이 보통 이상으로 증가된 상태이며, 고지혈증의 발생원인은 가족성, 원발성, 속발성이 있으며 이로 말미암아 발생한 고지혈증은 과다한 지방 질의 축저으로 동맥경화증, 비만증, 당뇨병등을 초래할 수 있다. 특히 지방질의 이상축적은 동맥경화증의 원인 중에서도 가장 위험한 인자로 알려져 있다. 오늘날 성인병을 유발시키 기는 발병인자중에 고지혈증이 차지하는 비율이 날로 증가하는 추세이므로, 한의학의 담음 어혈이론과 접근을 시키고 한의학적 방법으로 지방질의 축적으로 오는 성인병을 해결하는 것이 연구의 목표이며 이를 위해 우선 고지혈증의 병태모형을 연구하게 되었다. 방법 : 고지혈증 병태모형유발로 많이 이용되고 있는 cholesterol현탁액을 Rat에 경구투여한 것과 고지질사료를 2종류로 제작하여 Rat에 자유섭취시킨 것을 비교연구하기 위하여, 백서의 혈청지질에 포함되어 있는 효소활성도에 대한 영향을 관찰하였다. 결과 : 혈청증 total cholesterol, triglyceride, phospholipid와 β-lipoprotein함량에 미치는 영 향은 정상군에 비해서 대조군,실험군 1에서 모두 증가되는 변화를 나타내었으며, 혈청중 H.D.L-cholesterol에 미치는 영향은 정산군에 비해서 대조군,실험군1,2에서 모두 감소되어 나타났으며, 혈청중 total cholesterol함량에 대한 H.D.L.cholesterol함량의 비율과 total cholesterol함량에 대한 phospholipid함량의 비율은 정상군에 비해서 대조군,실험군 1,2에서 모두 감소의 비율이 나타났다. 결론 : 두 종류의 고지질고형사료를 실험동물에 자유섭취시켜 만들어지는 병태모형이 고지 혈증병태의 유발에 차이있는 성적을 나타내는 것으로 보아서, 고지방성 음식물의 종류에 따른 고지혈증의 연구를 더욱 많이 하여야 한다고 사료된다. Blood lipids are composed of cholesterol, triglyceride, phospholipid and free fatty acid. Hyperlipidemia mainly implies the elevations of cholesterol and triglyceride in the plasma and is closely related to atherosclerosis. As blood lipids are transported in the form of lipoprotein, hyperlipidemia also manifests as hyperlipoproteinemia. It is included in the categoreis of "xuan yun"(vertigo), "tan zhuo"(phlegm syndrome) and others in Oriental medicine. In order to study of the model making of the condition of hyperlipldemia, rats were devided to 4 groups, one group(Control groups)of them was induced by lipid metabolism disorder by the oral-injection of cholesterol colloid liquid for 28 days. 2 groups (Sample 1, 2 groups) of them were induced by lipid metabolism disorder by the high lipid diets for 28 days. and the other one group(Normal group)was not induced. So, each of this groups were compaired and were measured by the quantity of total cholesterol and of H.D.L.-cholesterol and of triglyceride and of phospholipid and of β-lipoprotein, by the rare of total cholesterol vs h.D.L.-cholesterol and of total cholesterol vs phospholipid in serum. As a result, we can conclude as follows: 1. We can recognize the noticeable increase of the quantity of "total cholesterol, triglyceride, phospholipid and β-lipoprotein" in control and sample l groups. and were not noticeable in sample 2 groups. 2. We can recognize the decrease of the quantity of H.D.L.-cholesterol in control and sample 1,2 groups. especialy sample 1 groups were recognized more decrease than control group. and sample 2 groups were not noticeable. 3. Rate of total cholesterol vs H.D.L-cholesterol and of total cholesterol vs phospholipid were decreased in the control and sample 1,2 groups as compaired with the normal groups. Thus, as the above-mentioned, in inducing hyperlipidemia pattern, a model of the condition of disease by high lipid diet can be recognized a noticeable result. Therefore the condition of disease by high lipid diet is likely to have wide application on a study of hyperlipidemia

痰飮에 對한 文獻的 考察

박원환,崔遠永 東國大學校韓醫學硏究所 1992 東國韓醫學硏究所論文集 Vol.1 No.-

平胃導痰湯이 高脂肪食餌性 高脂血症 白鼠에 미치는 影響

朴元煥 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

高脂血症은 血液속의 脂質性分이 보통 이상으로 增加된 狀態이며, 高脂血症의 發生原因은 原發性과 績發性이 있으며 이로 말미암아 發生한 高脂血症은 過多한 脂肪質의 蓄積으로 動脈硬化症, 肥滿症, 糖尿病등을 招來할 수 있다. 특히 脂肪質의 以上蓄積은 動脈硬化症의 原因 중에서도 가장 위험한 仁者로 알려져 있다. 오늘날 成人病을 誘發시키는 發病因子중에 高脂血症이 차지하는 比率이 날로 增加하는 趨勢이므로, 韓醫學의 痰陰·瘀血理論과 接近을 시키고 韓醫學的 方法으로 脂肪質의 蓄積으로 오는 成人病을 解決하는 것이 硏究의 目標이며 이를 위해 高脂血症의 病態模型에 痰濁, 濕濁등의 治療에 많이 活用되며 平胃導痰湯을 復用시킨 후, 高脂肪性高脂血症病態誘發과 이에 대한 治療效果르 硏究하기 위하여, 白鼠의 血淸脂質에 包含되어 있는 酵素活性度에 대한 影響을 觀察하였다. 血淸중 total-cholesterol, triglyceride와 β-lipoprotein 含量에 미치는 影響은 正常群에 비해서 對照群에서 모두 增加되어 나타났으며, 平胃導痰湯을 復用시킨 實驗群에서는 對照群에 비해서 모두 減少되는 變化가 나타났다. 血淸 중 HDL과 phospholipid 含量에 미치는 影響은 正常群에 비해서 對照群에서 모두 減少되어 나타났으며, 平胃導痰湯을 復用시킨 實驗群에서 對照群에 비해서 增加되는 變化가 나타났다. 또한 血淸중 total-cholesterol 含量에 대한 HDL 含量의 比率과 total-cholesterol 含量에 대한 phospholipid 含量의 比率은 正常群에 비해서 對照群에서 모두 減少되었으며, 對照群에 비해서 實驗群에서는 모두 增加되는 比率이 나타났다. 平胃導痰湯은 高脂肪性固形飼料를 自由攝取시켜 만들어지는 白鼠의 高脂血症病態에 有意할 만한 治療效果가 있는 것으로 認定되었으며, 아울러 高脂肪性??食物로 인한 脂質大事障碍나 그로 인한 高脂血症 및 動脈硬化疾患의 治療硏究에 더 많은 應用이 可能하다고 思料된다. Diet is the fundamental condition for human beings to live in good health. An improper diet can affect the physiological functions of the viscera and reduce the organism's resistance to disease. Thus becoming pathogenic factors. In particular, a heavy and fatty diet can increase opportunity for adults to become infected by diseases. Blood lipids are composed of cholesterol, triglyceride, phospholipid and free fatty acids. Hyperlipidemia implies the increased levels of cholesterol and triglyceride in the plasma. It is closely related to atherosclerosis. As blood lipids are transported in the form of lipoprotein, hyperlidemia can also manifest itself as hyperlipoproteinemia. Hyperlipidemia is included in the categoreis of “xuan yun”(vertigo), “tan zhuo”(phlegm syndrome) and others in Oriental medicine. Retention of phlegm and fluid is pathological products in the body, which manifest themselves through the course of illness. When retention of phlegm and fluid developes, it can act directly or indirectly, effect certain tissues or organs in the human body. Thus, causing new phtholoical chagnes, and forming various syndromes. therefore it become also a group of pathogenic factors. In oriental medicine differentiation and treatment of hyperlipidemia are divided into deficiency of the Liver-yin, Kidney-yin and retention of Damp-heat in the interior. Therapeutic principle of deficiency of the Liver-yin and Kidney-yin, is nourishing the liver-yin and kidney-yin. Therapeutic principle of retention of Damp-heat in the lnterior is eliminating pathogenic damness and heat. Pungwidodamtang had used a prescirption for this experiment, and was recorded in “Zung in Mak Chi〈症因脈治〉”. Pungwidodamtang is a comman remedy for the treatment of dampness-phlegm, stomachache, vomiting, nausea, salivation and also applied widly for other uses, This prescription is combined Pungwisan with Dodamtang. Pung-wi-san is a representative prescription for drying dampness evil and promoting the function of the spleen. The action of Pung-wi-san is regulating the function of the spleen and strengthening the stomach and activating circulation of vital energy. Pung-wi-wan has a therapy action which is used for cases due to stagnation of dampness evil in the spleen and stomach and functional disorders of vital energy. Thses can be manifested as abdominal fullness, anorexia, vomiting, nausea, a heavy sensation over the body, tiredness, loose stools, white and thick greasy fur on the tongue, show pulse, etc. The action of Dodamtang is drying dampness, eliminating phlegm and activating vital energy. Do-dam-tang has a therapy action used primarily for cases due to phlegm syndrome accompanied with coma or coldness of extremities. These can be manifested as dizziness, feeling of stagnation over the chest, nausea, vomiting, restlessness, anorexia, while and smooth fur on the tongue, wiry and smooth pulse. Hence, Pungwidodamtang is the prescription to use for invigorating the spleen, and promote diuresis to eliminate the wetness-evil from the lower warmer. Thus it can be used as a clinical application for the treatment hyperlipidemia. In order to study the effects of the Pungwidodamtang on high lipid diet-hyperlipidemia rats, white rats were divided into 4 groups. One group(Control group) was induced by high lipid solid feed for 35 days. Two groups(test 1, 2 groups) were treated Pungwidodamtang for 28 days from experiment-1 week after. The other group(Normal group)was not induced. Then, each of these groups were compaired and measured in the quantity of total-cholesterol, HDL, triglyceride, phospholipid, β-lipoprotein, the rate of total-cholesterol versus HDL and total-cholesterol versus phospho-lipid in their serum. 1. We noticed the decrease in the quantity of “total-cholesterol, triglyceride and β-lipoprotein” in sample-groups 1 and 2 as compaired with the control groups. Particularly noticeably significant results approached during the 3th, 4th, 5th, week in sample-group 1. 2. We noticed the increase in the quantity of HDL and phospholipid in sample-groups 1 and 2. However the quantity of HDL showed an increase in each week of the experiment whereas the quantity of phosopholipid only showed significant increase in the 4th and 5th weeks. 3. Rate of total-cholesterol versus HDL and total-cholesterol versus phospholipid were increased in both sample-groups 1 and 2 as compaired with the control groups. Thus, the change of the quantity of total-cholesterol, triglyceride, phospholipid and β-lipoprotein was influenced with hyperlipid solid and Pung-wi-do-dam-tang. Pung-wi-do-dam-tang had a noticeable therapeutic effect for hyper lipid diet-hyperlipidemia pattern. Therefore, Pung-wi-do-dam-tang can be applied as an effective therapy for disturbance of lipid metabolism induced hyper lipid diet, Hyperlipidemia and atherosclerosis induced disturbance of lipid metabolism.

痰飮病態模型의 開發을 爲한 痰·瘀同源理論의 文獻的 考察

朴元煥 동서의학사 1992 동서의학 Vol.17 No.2

痰飮病態模型의 開發을 爲한 瘀血病態模型의 實驗的 硏究

朴元煥,文濬典 동국대학교 한의학연구소 1994 東國韓醫學硏究所論文集 Vol.3 No.-

白鼠의 高脂血症 病態誘發에 관한 實驗的 硏究(Ⅱ)

朴元煥 동국대학교 경주대학 1995 東國論集 Vol.14 No.-

Blood lipids are composed of cholesterol, triglyceride, phospholipid and free fatty acid. Hyperlipidemia mainly implies the elevations of cholesterol and triglyceride in the plasma and is closely related to atherosclerosis. As blood lipids are transported in the form of lipoprotein, hyperlipidemia also manifests as hyperlipoproteinemia. It is included in the categoreis of "xuan yun"(vertigo), "tan zhuo"(phlegm syndrome) and others in Oriental medicine. In order to study of the model making of the condition of hyperlipldemia, white rats were devided to 4 groups, 3 groups(Sample groups) of them were induced by lipid metabolism disorder by the oral-injection of cholesterol colloid liquid and high lipid diets for 28 days. and the other one group(Control group)was not induced. Sample 1 groups were induced by lipid metabolism disorder by the oral-injection of cholesterol colloid liquid. Sample 2,3 groups were induced by lipid metabolism disorder by high lipid diets. So, each of this groups were compaired and were measured by the quantity of total cholesterol and of H.D.L-cholesterol and of triglyceride and of phospholipid and of -lipoprotein, by the rate of total cholesterol vs H.D.L-cholsterol and of total cholesterol vs phospholipid in serum. As a result, we can conclude as follows : 1. We can recognize the noticeable increase of the quantity of "total cholesterol, triglyceride, phospholipid and β-lipoprotein" in sample 1,2,3 groups. and sample 1,2 groups were noticeable significance, but sample 3 were partially significance. 2. We can recognize the decrease of the quantity of H.D.L.-cholesterol in sample 1,2 groups. Especialy sample 2 groups were recognized more decrease than sample 1 groups. 3. Rate of total cholesterol vs H.D.L.-cholesterol and of total cholesterol vs phospholipid were decreased in the sample 1,2,3 groups as compaired with the control groups. Thus, as the above-mentioned, in inducing hyperlipidemia pattern,a model of the condition of disease by high lipid diet can be recognized a noticeable result. Therefore the condition of disease by high lipid diet is likely to have wide application on a study of hyperlipidemia.

血栓症과 打撲性 充血 및 高脂血症에 順氣導痰湯 및 化瘀湯 미치는 影響

朴元煥,崔達永,文濬典 동국대학교 한의학연구소 1993 東國韓醫學硏究所論文集 Vol.2 No.1

To see both Shunqidaotantang(dissipate phlegm and promote vital energy circulation) and Huayutang(blood circulation and disperse blood stasis) influencing on thrombosis, contusion-hyperemia, and hyperlipidemia, at first we measured the density of FDP, the quantity of fibrinogen, prothrombin time, and the number of platelet of rat taken thrombosis by endotoxin. Secondly we measured the increase-rate of "paw swelling", the number of platelet, the quantity of fibrinogen, and prothrombin time of rat taken contusion-hyperemia. And then we measured the quantity of total cholesterol in serum and of H.D.L-cholesterol and of triglyceride and of phospholipid arid of P-lipoprotein, its weight, and the variation of the quantity of electrolyte of rat taken hyperlipidemia by the oral-injection of choleserol. As a result, we can conclude as follows : 1. Out of the test of thrombosis, we can recognize not only the noticeable increae of the number of platelet and the quantity of fibrinogen, but also the noticeable decrease of prothrornbin tirne and the density of FDP in case of Shunqidaotantang-injected rat and Huayutang-injected rat. 2. Out of the test of contusion-hyperemia, we can recognize not only the noticeable increase of the number of platelet and the quantity of fibrinogen, but also the noticeable decrease of prothrombin time and "increase-rate of paw swelling" in case of Shunqidaotantang-injected rat and Huayutang-injected rat. 3. Out of the test of hyperlipidemia, at first we can recognize that test rat s weight increased as close as that of normal rat. And we can recognize the noticeable decrease of the triglyceride and phospholipid and P-lipoprotein. Also, in case of the variation of electrolyte we can recognize the decrease of calcium and potassium in Shunqidaotantang-injected rat, and of sodium and magnesium in Huayutang-injected rat. Thus, as the above-mentioned, in covering thrombosis, contusion-hypermia, and hyperlipidemia, the effect of Shunqidaotantang and Huayutang can be recognized. Granting that Huayutang reveals its effectiveness in thrombosis and contusion-hyperemia, and Shunqidaotantang in hyperlipidemia, it can be inferred that contusion-hyperemia is like model of blood stasis form as thrombosis and hyperlipidemia "phlegm-retention diseases form", and both phlegm-retention and blood stasis have correlation each other.

담음병태모형(痰飮病態模型)의 개발을 위한 담, 어동원리론(瘀同源理論)의 문헌적 고찰

박원환 경산대학교 제한동의학술원 1992 東西醫學 Vol.17 No.2