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Lipoxygenase 및 Cyclooxygenase Inhibitor가 뇌수막종세포의 성장에 미치는 영향
박용석,구태헌,이정훈,이영배,이규춘,목진호,김한식,Park, Yong Seok,Koo, Tae Heon,Lee, Jung Hoon,Lee, Young Bae,Lee, Kyu Chun,Mok, Jin Ho,Kim, Han Sik 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.1
Object : To verify the effect of the lipoxygenase inhibitor and cycloxygenase inhibitor on meningioma cell proliferation. Method : Using two meningioma cell lines, cell proliferation was determined at 96 hrs after adding inhibitor (AA861, Nordihydroguaiaretic acid(NDGA), Indomethacin, acetyl-11-keto-beta-boswellic acid(AKBA) into medium by methyl tetrazolium salt/phenazine methosulfate(MTS/PMS) non-radioactive cell proliferation assay. We checked optical density with 490nm wavelength UV and this value was used as a proliferative index. The percent of inhibition was also calculated from this value. Conclusion : Indomethacin and NDGA showed no effect on meningioma proliferation. AA861 also showed no significant inhibitory effect, but AKBA demonstrated a significant inhibitory effect on meningioma cell proliferation.
지렛대 원리를 이용한 성게 껍질 분할기 작업 능률 분석
박용석 ( Young Seok Park ),김병엽 ( Byung Yeob Kim ),이창헌 ( Chang Heon Lee ) 한국어업기술학회 2014 수산해양기술연구 Vol.50 No.1
A new shell divider was manufactured according to the principle of the lever in order to improve working efficiency in collecting the gonad of Sea Urchin, Anthocidaris crassispina, around the coast of jeju. It was composed of three parts of a pair of handles for grasping power, a fulcrum and a pair of knives for action with 21cm in length and 13cm in width. The operating efficiency of the shell divider was tested out in three place of Jeju coast. Statistical significances of differences of working time between test groups were calculated according to the t-test with the level of significance. In dividing the shell of sea urchin, the average of about 3 seconds of working time by the shell divider was less than that by a knife. At the result of t-test, the statistical significance in the working time existed between the divider group and the knife group. On the other hand, the working time among the divider operators showed no significant differences. It is concluded that the shell divider is more efficient than a knife in traditional operating.
원발병소가 갑상선인 전이성 두개골 종양 2례 - 증례보고 -
강한석,박용석,이영배,이규춘,목진호,김한식,Kang, Han Sug,Park, Yong Seok,Lee, Young Bae,Lee, Kyu Chun,Mok, Jin Ho,Kim, Han Sik 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10
The authors present two cases of lytic skull metastasis from thyroid carcinoma. The first case is a 62-year-old female who was diagnosed as thyroid cancer one year ago. She complained a mass over the right parietal area but showed no neurological abnormalities. The mass didn't invade the dura, and was completely removed. Histopathological examination revealed the insular thyroid carcinoma, composed of undifferenciated cells that were responded to thyroglobulin in immunohistochemical staining. The second case is a 75-year-old female who complained a mass over the right parietal and neck area without any neurological abnormality. The mass was confined to the epidural region which was associated with osteolytic change of skull. It was also completely removed. Histopathological examination of mass revealed the follicular thyroid carcinoma.
이재석,한거름,박용석,서주태,Lee, Jae-Seok,Han, Keo-Reum,Park, Young-Seog,Seo, Ju-Tae 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.2
Objective: We investigated whether serum testosterone to estradiol ratio was decreased in infertile men and whether this condition can be corrected with oral aromatase inhibitor. Method: The serum testosterone to estradiol ratio of 26 men with testicular failure were compared with those of normal semen analysis parameter, 89 control reference group. All of 26 testicular failure group were diagnosed with the previous testicular biopsy. Then 46 men with oligospermia and/or asthenospermia were selected and treated with 1 mg of the aromatase inhibitor anastrozole ($Arimidex^{(R)}$) orally once daily for 3 months. Testosterone to estradiol ratio and semen analyses were evaluated during anastrozole therapy. Results: The testosterone level of testicular failure group was significantly lower and the testosterone to estradiol ratio was more decreased than normal semen parameter group. Forty six on-anastrozole group had significantly lower testosterone (4.6 versus 5.7 ng/ml, p<0.01) and higher estradiol (15.9 versus 23.4 pg/ml, p<0.01) than pre-anastrozole group, resulting in a decreased testosterone to estradiol ratio ($0.21{\pm}0.07$ versus $0.39{\pm}0.15$, p<0.01). Semen analyses before and during anastrozole treatment revealed significant increases in sperm count (35.5 versus 52.2 million sperm per ml, p<0.01) and motility (22.9% versus 29.3%, p<0.01). Conclusions: We identified infertile men with testicular failure had hormonal changes characterized by a decreased serum testosterone to estradiol ratio. The ratio can be corrected with aromatase inhibitor, resulting in a significant improvement in semen parameters.