국내 폐암에 대한 한약물의 최신 실험연구 경향

박승찬,유화승,조종관,이연월,Park, Seung-Chan,Yoo, Hwa-Seung,Cho, Chong-Kwan,Lee, Yeon-Weol 대한암한의학회 2008 大韓癌韓醫學會誌 Vol.13 No.1

Objectives: The purpose of this study is to suggest better directions in experimental researches about finding new drug derived from herbs in South Korea. Methods: We investigated available manuscripts on anti-lung cancer herbal extracts which is used in South Korea by using available electric library, and made diagrams. Results: Many herbs are used in treatment of lung cancer based on traditional oriental medical theory. In Korea, researches for this field have been activated since 2000. But we haven't found the substance showing remarkable anti-tumor effect on lung cancer. And many of the experiment have been designed similar way and also have similar weak points in explanation about the apoptotic mechanism. Conclusions: From this results, we have found 10 herbs, 4 pharmacopunctures and 13 herbal decoctions to be conducted experimental studies for lung cancer from 2000 to 2008 in South Korea.

맥진기 판독의 신뢰도 및 파형의 재현성 연구

박승찬,이지혜,이혜윤,조민경,김도형,김소연,최준용,한창우,박성하,홍진우,이인,권정남,Park, Seung-Chan,Lee, Ji-Hye,Lee, Hye-Yoon,Cho, Min-Kyoung,Kim, Do-Hyung,Kim, So-Yeon,Choi, Jun-Yong,Han, Chang-Woo,Park, Seong-Ha,Hong, Jin-Woo,Lee, In 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.3

Objectives : This study was performed to evaluate inter-rater and intra-rater reliability of interpretation and reproducibility of a pulse analyser (MAXMAC27-Plus). Methods : 38 of 40 volunteers completed the pulse analysis consecutively. Three Korean medical doctors who had at least 2 years of clinical experience interpreted the pulse waves for 3 aspects of size, depth and shape, then inter-rater reliability and crude agreement was obtained. Reinterpretation was done 2 weeks later and intra-rater reliability and crude agreement was obtained. Intra-rater reliability and crude agreement between 1st and 2nd measurement was calculated. Cohen's weighted kappa for size, Cohen's kappa for depth and shape were used as statistical analysis. Results : Inter-rater reliability of size, depth and shape among 3 raters was 0.598, 0.604, and 0.312, respectively, showing moderate to substantial agreement. Average intra-rater reliability between 1st and 2nd interpretation of size, depth and shape was 0.806, 0.705, and 0.638, respectively, showing substantial to almost perfect agreement. However, intra-rater reliability between consecutive measurements of size, depth and shape was 0.221, 0.121, and 0.194, respectively, which showed only poor to fair agreement. Conclusions : Intra-rater and inter-rater reliability of one pulse wave showed relatively high concordance. Training by a clinical expert may effect better concordance among raters. Test-retest reliability showed poor agreement. Improvement of measurement technique and device performance will be needed.

생산구조와 수출전략

박승찬,Park, Seung-Chan 한국과학기술단체총연합회 1974 과학과 기술 Vol.7 No.5

양한방 협진을 통한 뇌전이 동반 말기 폐암환자 치험 1례

박승찬,김도형,한창우,박성하,이인,최준용,Park, Seung-Chan,Kim, Do-Hyung,Han, Chang-Woo,Park, Seong-Ha,Lee, In,Choi, Jun-Yong 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.2

이번 증례에서 뇌전이가 동반된 IV기 비소세포성 폐암 환자에 대해 양한방 치료를 병행하여 VAS, FACT-L, FACIT-fatigue 등을 통하여 그 경과를 관찰한 바 방광자극증상 및 수면 등 삶의 질의 개선을 관찰할 수 있었다. 하지만 원활하지 못한 협진 체계로 인하여 환자 관리에 있어 문제점을 발견할 수 있었다. 향후 한방 치료를 통한 암환자 관리를 위해서는 접근성이 뛰어난 양한방 협진체계의 구축이 필수적인 것으로 사료된다. Objectives : This study reports one case of a patient diagnosed with non-small cell lung cancer with brain metastasis. Methods : A 79 year-old male patient diagnosed with non-small cell lung cancer with brain metastasis was treated chemotherapy for 3 months and quitted it due to poor general condition. He transferred to Korean medicine hospital and was treated herbal medicine(Saengmaek-san plus Baekhapgogeum-tang gagam), acupuncture, moxibustion, interferential current therapy. To evaluate the patient, we measured of Visual Analogue Scale (VAS), Functional Assessment of Cancer Therapy-Lung (FACT-L), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue). Results : Patient's outcomes were improved during the 1st week regarding VAS (41${\rightarrow}$25), FACT-L (81.2${\rightarrow}$90), FACIT-fatigue (25${\rightarrow}$10). However, dyspnea and cough were was aggravated in the 2nd week. Conclusions : Treatment with Korean medicine therapy may have substantial benefit for patients with end-stage lung cancer. But, Integrated medicine therapy is necessary for proper management of end-stage cancer patients.

태음인(太陰人) 청심연자탕(淸心蓮子湯)의 항(抗)allergy 작용(作用)에 대(對)한 실험적(實驗的) 연구(硏究)

박승찬,Park, Seung-Chan 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

In order to evaluate the antiallergic effects of CSYJT, studies were done. We measured the cytotoxic activity for cytokines transcript expression, production of IL-4, IgE, $IFN-{\gamma}$, proliferation of B cell in HRF plus anti-CD40mAb plus rIL-4 stimulated murine splenic B cells. and cytokines transcript expression of IgE in Mast cell The results were obtained as follows: 1. CSYJT decreased the expression of IL-4 in mast cell significantly. 2. CSYJT decreased the production of IL-4 significantly. 3. CSYJT decreased the expression of IgE in mast cell significantly. 4. CSYJT decreased the production of IgE significantly. 5. CSYJT increased the appearance of $IFN-{\gamma}$. The facts above prove that CSYJT is effective against the allergy. Thus, I think that we should study on this continuously.

고사목에서 발견되는 저병원성 소나무재선충 및 이의 인공접종에 의하여 유도되는 소나무의 저항성

박승찬,문일성,김동수,Park, Seung-Chan,Moon, Yil-Sung,Kim, Dong-Soo 한국응용곤충학회 2014 한국응용곤충학회지 Vol.53 No.2

Pinewood nematode (PWN: Bursaphelenchus xylophilus) is known to kill pine tree species that are indigenous to countries where the pest was inadvertently imported, but some cultures from the extraction of dead pines do not damage trees. Experiments were conducted to examine the effect of pre-inoculation of these low-pathogenic pinewood nematode on resistance of pine trees against the pest species. The pre-inoculated pine saplings showed induced resistance which lasted for a year, and repeated inoculation of these low-pathogenic nematodes enhanced tree resistance. All nematode samples extracted from dying or dead pines that had been killed not more than three months before the extraction were pathogenic, and most of those extracted from pines that had been killed 2-3 years before were low-pathogenic. When inoculated in pine saplings, number of low-pathogenic nematodes settled, as studied two days after inoculation, was not different from that of pathogenic ones. However, as studied after 30 days of inoculation, rate of reproduction in low-pathogenic nematodes was far lower than that of pathogenic nematodes. The rate of reproduction of several nematode isolates growing on fungal mat media of Botrytis cinerea varied, but three of four low-pathogenic isolates showed same level of reproduction rates as pathogenic ones. 소나무재선충은 현재까지 도입된 국가의 토착수종인 소나무류를 모두 치사시키는 것으로 알려져 있으나, 고사목으로부터 추출 배양된 계통 중에는 소나무에 피해를 주지 않는 계통이 존재한다. 이러한 저병원성 계통 선충의 사전접종이 고병원성 소나무재선충에 대한 소나무의 저항성에 미치는 영향을 조사하기 위하여 연구가 수행되었다. 치수에 저병원성 소나무재선충을 선접종한 결과, 선접종에 의하여 소나무재선충에 대한 저항력이 유도되었다. 그 유도저항성은 1년 후까지 유지되었으며, 저병원성 선충의 반복 감염은 보다 저항성 유도 효과가 큰 것으로 나타났다. 소나무재선충에 의하여 고사한 후 경과기간이 3개월 이하인 피해목 및 피해진행목에서 분리된 선충은 모두 고병원성이었으며, 고사 후 2-3년이 경과한 벌채목에서 분리된 선충 5계통 중 4계통은 저병원성이었다. 저병원성 선충이 소나무 치수에 인공접종 되었을 때 초기 정착률은 고병원성 선충과 차이가 없었으나, 접종 30일 후에 수목내의 부위별 개체수를 조사한바 저병원성 선충의 증식률은 고병원성보다 현저히 낮았다. 저병원성 선충의 잿빛곰팡이병 균사배지에서의 선충증식 속도는 계통에 따라 차이가 있었으며, 증식속도가 빠른 계통은 대체로 고병원성 선충의 증식속도와 차이가 없었다.

한국전자 공업의 현황

박승찬,Park, Seung-Chan 한국과학기술단체총연합회 1972 과학과 기술 Vol.5 No.10

김수환 추기경 평화 사상의 인문학적 배경 -아우구스티누스와의 관련성을 중심으로-

박승찬 ( Park¸ Seung-chan ) 한국가톨릭철학회 2018 가톨릭철학 Vol.0 No.31

‘평화’ 개념은 일상에서 가장 많이 사용되면서도 깊이 있게 성찰되지 못하고 있다. 그런데 이미 김수환 추기경은 현실의 절박한 상황에 대한 구체적인 성찰을 토대로 심오한 평화 사상을 제시한 바 있다. 과연 그는 어떻게 그렇게 깊이 있는 성찰에 도달할 수 있었을까? 여러 교회 문헌이 일차적인 자료였을 것으로 추정되지만, 우리는 더 깊은 근원을 찾아 아우구스티누스의 평화 사상과 비교해보았다. 이를 통해 보편적인 평화의 추구, 참 평화와 거짓 평화의 구별, 평화를 정의의 실현과 사랑의 결실로 보는 것 등 중요한 내용과 구조는 매우 유사하다는 점을 확인했다. 그렇지만 두 사상가 사이에는 평화를 위한 폭력 허용 여부, 인간을 바라보는 관점, 현세에서 평화가 이루어질 가능성 등에서 차이점도 존재했다. 그렇기 때문에 그들의 유사점과 차이점이 함께 성찰될 때 실천과 이론의 긴밀하게 연결된 더 균형 잡힌 평화 사상이 완성될 것이다. 이를 통해서 여전히 분단 현실에서 살아가고 있는 우리가 평화를 어떻게 이해해야 하며, 평화로 나아가는 구체적인 방법에 대한 영감을 얻을 수 있기를 기대해 본다. The concept of peace is the one of the most referred to in everyday life, but it is not reflected upon deeply. However, Cardinal Kim Sou-hwan has proposed a profound idea of peace rooted in a concrete reflection on the desperate situation of reality. How could he reach such a deep reflection? Although it was presumed that various church documents would be the primary research material, we looked for other sources of Cardinal Kim’s thinking, which was compared to Augustine’s notions of peace. This confirmed that the important content and structures are very similar, regarding the pursuit of universal peace, the distinction between true peace and false peace, and a view of peace as the realization of justice and the fruit of love. There were also differences between the two thinkers, including their views on the human experience, the possibile use of violence for peace, and the potential for peace in this world. Therefore, when we compare and reflect on the thought processes of Cardinal Kim and Augustine, a more balanced perspective on peace as it pertains to both practice and theory may be reached. The goal, through this study, is for those who are in living in our divided country to gain a fuller understanding of peace and how we may achieve it.

김수환 추기경의 공동체 영성을 통한 5·18 정신의 계승

박승찬(Park, Seung-Chan) 광주가톨릭대학교 신학연구소 2019 神學展望 Vol.- No.205

2019년 고(故) 김수환 추기경 선종 10주년을 기념하는 다채로운 행사는 5·18 민주화 운동을 폄훼하는 망언이 난발하며 먹구름이 드리워졌다. 진보와 보수를 떠나 많은 한국인의 존경을 받던 김수환 추기경은 5·18을 ‘민족사의 비극이요 수치’라고 부르며 개인적으로 가장 큰 마음의 고통을 겪었다고 회상했다. 아직까지 진상 규명이 제대로 이루어지지 않았고, 끊임없이 이를 정치적 이유로 왜곡하려는 망언이 계속되는 상황 때문에 본고에서는 김수환 추기경의 5·18 광주항쟁에 대한 입장을 재조명해 보았다. 우선 김수환 추기경은 광주항쟁이 진행되는 동안 최선의 노력을 다했지만 잔혹한 폭력 사태를 막지 못해 매우 안타까워했다. 이후에도 구속자 석방과 진상 규명, 피해자들의 증언을 경청하고 공감함으로써 광주항쟁 피해자들의 이웃이 되어 주었다. 이와 같은 태도는 인간을 존중하고, 정의와 평화를 추구하며, 사랑과 나눔을 실천했던 김수환 추기경의 공동체 영성에 기반한 것이었다. 이러한 영성은 ‘세상을 위한 교회’라는 제2차 바티칸 공의회의 정신에 기초하고 있었다. 5·18항쟁 동안 광주에서는 김수환 추기경이 추구하던 공동체 영성의 핵심 내용이 실현되는 놀라운 일이 일어났다. 신군부 세력에 의해서 자행된 인간 존엄성에 대한 심각한 침해는 정의의 실천에 기반한 평화를 파괴했고, 이는 곧 창조주를 모독하는 행위였다. 그럼에도 광주의 ‘체험공동체’는 주먹밥을 나누고, 타인을 위해 자신의 생명을 희생하는 ‘성사’라고 불릴 만한 사랑과 나눔을 실천했다. 이후에도 침묵과 왜곡을 일삼는 가해자들에 대항해서 진실을 밝히려는 교회의 노력은 제한적이나마 지속되었다. 체험공동체의 아픔에 공감하고 이들의 진실 어린 증언을 경청하는 김수환 추기경은 진정한 치유와 화해를 위해서 ‘기억 공동체’가 어떤 방향으로 나아가야 할지 분명하게 보여 주는 모범이 되었다. 김수환 추기경의 공동체 영성에 따라 5·18공동체가 인간 존중과 참된평화를 위해 노력할 때, 5·18에 대한 기억은 우리나라의 한계를 넘어 모든 고통받는 이들에 대한 치유에 기여하게 될 것이다. The colorful event commemorating the 10th anniversary of the late Cardinal Stephen Kim Sou-Hwan’s death in 2019 was clouded by absurd remarks denouncing the 5·18 pro-democracy movement. Cardinal Kim, who was respected by many Koreans, regardless of progressivism or conservatism, recalled that he personally suffered the biggest pain in his heart, calling 5·18 “a tragedy of national history, a shame.” Due to the fact-finding efforts so far and the absurdity of constantly trying to distort them for political reasons, this paper reexamins Cardinal Kim’s position on the 5·18 Gwangju uprising. First of all, Cardinal Kim did his best during the Gwangju uprising, but he was very sad that he could not prevent the brutal violence. Afterward, he became a neighbor of victims of the Gwangju uprising by listening to and sympathizing with those arrested, and finding out the truth and testimonies of the victims. This attitude was based on Cardinal Kim’s spirituality of community, respect for humanity, pursuit of justice and peace and practice of love and sharing. This spirituality was based on the spirit of the Second Vatican Council, the “Church for the World.” During the 5·18 uprising, a marvelous thing happened in Gwangju where the core content of the spirituality of community pursued by Cardinal Kim was realized. The serious violation of human dignity committed by the new military forces destroyed peace based on the practice of justice, which was an act of blasphemy against the Creator. Nonetheless, Gwangju’s “experience community” practiced love and sharing that would be called a “sacrament” by sharing rice balls and sacrificing their lives for others. Even after that, the church"s efforts to uncover the truth in opposition to the perpetrators of silence and distortion continued to be limited. Listening to the pain of the experience community and to their sincere testimony, Cardinal Kim set a clear example of where the “memory community” should go for real healing and reconciliation. As the 5·18 community strives for human respect and true peace in accordance with Cardinal Kim’s spirituality of community, the memory of 5·18 will go beyond the limits of our country and contribute to healing all people who suffer.

중소기업협동조합 구성원의 네트워크 협력, 교육훈련이 사내기업가정신 간의 관계에서 만족도에 미치는 영향

박승찬 ( Seung Chan Park ),김영수 ( Young Soo Kim ),김진성 ( Jin Sung Kim ) 한국유통경영학회 2021 유통경영학회지 Vol.24 No.4

Purpose: The purpose of this study was to examine the relationships among network cooperation, educational training, corporate entrepreneurship, and satisfactions of SME cooperative members. Research design, data, and methodology: This study was conducted according to the procedure of preliminary and main survey, descriptive statistics, reliability and validity test, and verification of the research model using SEM. A survey was conducted on 219 SME cooperatives members working in South Korea. The study verified the hypotheses related to the effect of network cooperation and educational training on satisfactions in the relationship between corporate entrepreneurship by using SEM. First, an exploratory factor analysis was performed to confirm the reliability and validity. Second, a confirmatory factor analysis was conducted based on the result of reliability and exploratory factor analysis. Third, we compared the average variance extracted(AVE) and correlation values to confirm the discriminant validity of the latent variables. Fourth, the hypotheses were confirmed using the path analysis. Results: First, the relationship between network cooperation and corporate entrepreneurship was found to be positive. Second, the relationship between educational training and corporate entrepreneurship was also found to be significant. Third, there was a significant and positive relationship between corporate entrepreneurship and satisfactions. Implications: The implications of this study are as follows. First, we verified that network cooperation and educational training are important variables that can improve satisfaction and performance in SME cooperatives. Second, it showed that SME cooperative require a process of sharing trust and knowledge and cooperation through educational training. In addition, it suggests that corporate entrepreneurship, which has an important mediating effect, can be promoted through educational training.