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      • User-Generated-Text의 키워드 정보를 활용한 혈당 예측 연구

        박소형,조성준,성연,양혁용 대한산업공학회 2023 대한산업공학회 춘계학술대회논문집 Vol.2023 No.5

        최근 건강한 삶에 대한 관심이 높아지면서 당뇨 관련 질환을 가지고 있지 않은 사람들에게도 혈당 관리에 대한 관심이 높아지고 있다. 혈당은 대사 관련 질환, 체중 등의 건강 상태를 포함하여 생산성과 직결된 경제적 가치에도 영향을 미칠 수 있어 이를 안정적으로 관리하는 것이 중요하다. 연속혈당측정기(CGM)에 대한 수요가 높아지고 있으며, 관련 헬스케어 서비스도 다수 등장하고 있다. 하지만, 비용이나 불편감 등의 문제로 이를 장기간 착용함에 있어 제약이 따른다. 본 연구에서는 기계 학습 기법을 활용하여 당뇨 질환이 없는 사람들의 혈당 예측을 다룬다. 연속혈당측정기를 착용하고 있는 일반 사용자들의 혈당 패턴을 확인하고, 사용자가 건강 관리를 위해 직접 행동을 기록하는 User-Generated-Text에 포함된 다양한 음식과 관련한 키워드를 추출하여 이를 보조적인 수단으로 활용하고자 한다.

      • KCI등재

        Entire Mitochondrial DNA Sequencing on Massively Parallel Sequencing for the Korean Population

        박소형,조소희,서희진,이지현,김문영,이숭덕 대한의학회 2017 Journal of Korean medical science Vol.32 No.4

        Mitochondrial DNA (mtDNA) genome analysis has been a potent tool in forensic practice as well as in the understanding of human phylogeny in the maternal lineage. The traditional mtDNA analysis is focused on the control region, but the introduction of massive parallel sequencing (MPS) has made the typing of the entire mtDNA genome (mtGenome) more accessible for routine analysis. The complete mtDNA information can provide large amounts of novel genetic data for diverse populations as well as improved discrimination power for identification. The genetic diversity of the mtDNA sequence in different ethnic populations has been revealed through MPS analysis, but the Korean population not only has limited MPS data for the entire mtGenome, the existing data is mainly focused on the control region. In this study, the complete mtGenome data for 186 Koreans, obtained using Ion Torrent Personal Genome Machine (PGM) technology and retrieved from rather common mtDNA haplogroups based on the control region sequence, are described. The results showed that 24 haplogroups, determined with hypervariable regions only, branched into 47 subhaplogroups, and point heteroplasmy was more frequent in the coding regions. In addition, sequence variations in the coding regions observed in this study were compared with those presented in other reports on different populations, and there were similar features observed in the sequence variants for the predominant haplogroups among East Asian populations, such as Haplogroup D and macrohaplogroups M9, G, and D. This study is expected to be the trigger for the development of Korean specific mtGenome data followed by numerous future studies.

      • KCI등재

        연소성 골화 섬유종; 8 증례의 임상병리학적 분석 및 두개얼굴뼈에서 발생하는 섬유골병터와의 비교분석

        박소형,이봉재,이정현,조경자 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.6

        Background : Juvenile ossifying fibroma (JOF) is defined as a variant of the ossifying fibroma, and the latter includes juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF). JOF can be distinguished from other craniofacial fibroosseous lesions by its tendency to recur and its clinical mimicry of malignant bone tumors, but some clinical and histological features of JOF overlap with the other fibro-osseous lesions as well. We aimed to identify the clinicopathologic definition of JOF. Methods : Forty-two cases of fibro-osseous lesions were reviewed and they were classified into JOF, fibrous dysplasia (FD) and ossifying fibroma (OF). Results : JTOF had long, slender and anastomosing trabeculae of osteoid in a fibrocellular stroma, and JPOF had small ossicles resembling psammoma bodies with a thick collagenous rim in the fibrous stroma, which are features that differ from those of FD and OF. Radiologically, JOF and OF showed a well-defined lesion but FD exhibited an ill-defined lesion. Clinically, the average age of the JOF patients was the youngest, followed by OF and FD. For JOF, three cases had rapid growth and two others showed recurrences. JOF mainly occurred in the paranasal sinuses, OF in the mandible and FD in any craniofacial bone. Conclusion : We demonstrated the distinct characteristics of JOF and these features may be helpful for the diagnosis and management of this malady.

      • KCI등재

        조직학적 악성소견을 보이는 소아 부신피질종양 - 1 증례 보고 및 악성 진단기준에 관한 고찰 -

        박소형,김대연,공경엽 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.5

        Adrenal cortical neoplasm, especially carcinoma, is extremely rare in pediatric patients. We describe here a rare pediatric case of adrenal cortical neoplasm. A 2-year-old girl presented with an enlarged clitoris. The other physical findings and laboratory tests were nonspecific. The magnetic resonance imaging showed a 4 cm-sized heterogeneously enhancing soft tissue mass with calcification in the left adrenal gland. The mass was removed by laparoscopic operation. Grossly, several fragments of reddish tan soft tissue were present, and they weighed 19 gm in total. Microscopically, there were capsular invasion, diffuse/solid growth pattern with focal necrosis, high cellularity, cytoplasmic eosinophilia, marked nuclear pleomorphism, high N/C ratio, prominent nucleoli, atypical mitotic figures and calcifications, which all suggested adrenal cortical neoplasm of histologic malignancy. On immunohistochemistrical staining, there were positive reactivities to pancytokeratin, cytokeratin 7/20, CEA, inhibin and p53. The Ki-67 labeling index was about 6%. All these findings were indicative of adrenal cortical neoplasm of histologic malignancy.

      • KCI등재후보

        Hemoperitoneum Resulting From Injuries to Liver with a Benign Vascular Tumor During Acupuncture: A Case Report

        박소형,이한영 대한법의학회 2012 대한법의학회지 Vol.36 No.1

        Various complications following acupuncture have been reported. In most cases,complications occur from the close apposition of vital organs and acupuncture sites. These complications can be avoided if acupuncturists are trained in appropriate medical science such as anatomy. However, our case is somewhat different from the norm. The deceased received acupuncture on the abdomen, provided by an acupuncturist. Unexpected symptoms occurred suddenly and she was transported to a hospital where she died of hemoperitoneum. On the postmortem examination, a well-defined vascular tumor was identified on the front of the liver, which was also cirrhotic;a few localized injuries were identified on the cystic wall of the tumor and surrounding liver parenchyma. We assumed these injuries were complications of acupuncture. Therefore, we present this case to suggest that acupuncturists should be educated to be vigilant for complications following treatment to reduce the risk of these tragedies.

      • KCI등재

        편측 의수 사용 환자에서 Milled Bar와 Attachment를 이용한 임플란트 피개의치 재수복 증례

        박소형,정창모,윤미정,허중보,이소현 대한치과보철학회 2022 대한치과보철학회지 Vol.60 No.2

        완전 무치악 환자의 가철성 보철 수복 치료에서 잔존 치조제의 흡수가 심한 경우 임플란트를 이용하면 부가적인 지지, 유지 및 안정을 제공할 수 있다. 환자의 상태에 대한 정확한 진단 및 평가 없이 보철물을 제작하게 되면 생역학적, 기능적, 심미적으로 불리한 치료 결과를 야기하게 된다. 본 증례의 환자는 개인치과의원에서 상ㆍ하악 임플란트 피개의치를 제작하였으나 연조직 통증 및 기존 의치 유지력 저하로 재치료를 위해 내원하였다. 진단 결과 기존 의치의 수직고경이 다소 낮게 설정되어 있어 이를 거상하고, milled bar와 부가적인 attachment를 이용한 임플란트 피개의치를 제작하였다. 이를 통해 증진된 구강위생과 기능적, 심미적인 면에서 만족할 만한 결과를 얻었기에 보고하는 바이다.

      • KCI등재

        특성화 대안학교 고등학생의 자기조절능력 향상을 위한 집단상담 프로그램 개발

        박소형,조용선,유형근 한국상담학회 2013 상담학연구 Vol.14 No.2

        이 연구의 목적은 특성화 대안학교 고등학생을 대상으로 자기조절능력 향상 집단상담 프로그램을 구안하고, 효과를 검증하는 것이다. 프로그램 개발과정은 박인우(1995)의 체계적인 상담 프로그램 개발 모형에 따라 조사, 분석, 설계, 구안, 적용의 5단계로 이루어졌다. 조사단계에서는 다양한 선행연구 고찰과 연구대상 범위에 있는 113명의 학생들을 대상으로 요구조사를 실시하였다. 분석단계에서는 조사단계의 결과를 바탕으로 프로그램 목적, 회기별 목표, 회기수를 결정하였다. 설계 및 구안단계는 목적, 목표, 회기별 목표에 따른 활동안을 작성하였고 이론전문가 및 현장전문가의 자문과정과 예비검사과정을 거쳐 수정․보완하여 최종 프로그램을 구안하였다. 적용단계에서는 전라남도 Y특성화 대안학교 학생 30명을 실험집단 15명과 통제집단 15명을 배치하여 프로그램을 처치하고, 프로그램 전․후 자기조절능력 검사(이순규, 1995)를 실시하고 혼합변량분석(Mixed Anova)으로 분석하였다. 분석결과, 실험집단의 자기조절능력의 변화가 통제집단과 유의한 차이가 있었다. 따라서 이 연구를 통해 개발된 특성화 대안학교 고등학생의 자기조절능력 향상을 위한 집단상담 프로그램은 특성화 대안학교 고등학생의 자기조절능력을 향상시키는데 긍정적인 영향을 주는 것으로 나타났다. The purpose of this study was to improve the self-regulation competence for the alternative high school students. This group counseling program to enhance school resilience is researched, analyzed, designed, developed and applied. It surveyed 113 alternative high school students for actual requirement. It developed final program by pilot, experts of theories, on-the-spot experts. To verify the hypotheses, The test tool was The test tool was the scale standardized by Lee Soon-Gyu(1995) from the self-control evaluation scale developed by Kendall & Wilcox (1979). The data was submitted to SPSS/Windows 12.0 for the mixed ANOVA and analysis of the students' experience reports and counselor observation contents was accompanied to supplement the limitations of quantitative results. The results obtained from this research are as follows. there was significant difference between the experimental group who participated in the program and the control group in the change in self-regulation competence and the results from the analysis on the experience reports and observational data showed that the program has a positive effect on the improvement of self-regulation competence for the alternative high school students.

      • KCI등재

        Fatal Case of Acute Pulmonary Embolism due to Venous Thrombosis after COVID-19 Vaccination: Based on Forensic Postmortem Examination

        박소형,원유진,이수경 대한법의학회 2021 대한법의학회지 Vol.45 No.2

        We present an unexpected fatal case of pulmonary embolism due to venous thrombosis after vaccination for coronavirus disease 2019 (ChAdOx1 nCov19). The deceased was a 64-year-old woman with Alzheimer disease. The deceased had fever shortly after vaccination, and presented sudden dyspnea and died 8 days after vaccination. On postmortem examination, pulmonary embolism and venous thrombosis were noted in deep veins of both lower legs. Even though the psychomotor function of the deceased became fragile due to Alzheimer disease, the deceased was not bed-ridden, and major known risk factors related to venous thrombosis were not explicit in this case. Because there are not enough data related to vaccination and thrombosis, we hope that this case would be helpful in unraveling pathogenesis of venous thrombosis after vaccination and in determining whether there is any association between thrombosis and vaccination.

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