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활동성폐결핵환자에서 말초혈액단핵구의 Th1 및 Th2 cytokine 분비양상
박성학(Sung Hak Park),이상학(Sang Hak Lee),이숙영(Sook Young Lee),문화식(Hwa Sik Moon),현대성(Dae Sung Hyun),신윤(Yoon Shin),최지현(Gee Hyun Choi),여동승(Dong Seung Yoe),김석찬(Suk Chan Kim),송정섭(Jeong Sup Song) 대한내과학회 1999 대한내과학회지 Vol.56 No.4
N/A T cell mediated immunity amlifies macrophage capacities to kill and digest the bacilli through production of interferon-γ (IFN-γ). The secreted cytokines of Th1 and Th2 cells can mutually regulate and inhibit each other's function. Therefore, the fine balance between the secreted cytokines is important for the resulting nature of tuberculosis. In this study, activation marker and cytokine production profiles were compared in patients with active tuberculosis and healthy control, and according to degree of radiographic extent and pleural involvement. Method:Forty-four patients with active pulmonary tuberculosis and 25 normal controls were recruited. We measuerd soluble interleukin-2 receptor(sIL-2R), IFN-r, IL-4 and IL-5 produced from blood mononuclear cells in vitro stimulation with phytohemagglutinin by ELISA. Results:The sIL-2R and IFN-γ from patients with active pulmonary tuberculosis were significantly lower than normal control, while IL-4 and IL-5 were not different between two group. The sIL-2R and IFN-r decreased in proportion to the extent of pulmonary involvement, and the sIL-2R and IFN-r from pulmonary tuberculosis with pleural effusion were significantly lower than those without pleural effusion. Conclusion:At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 response.
부순모래 사용에 따른 원전 구조물용 콘크리트의 기초적 특성
박성학(Sung-Hak Park),김경환(Kyung-Hwan Kim),최병걸(Byung-Keol Choi),최연왕(Yun-Wang Choi) 한국건설순환자원학회 2017 한국건설순환자원학회 논문집 Vol.5 No.2
본 연구에서는 원전 구조물용 콘크리트의 잔골재로 부순모래를 사용하기 위한 연구의 일환으로 기존의 부순모래 생산공정에서 임팩트크러셔(Impact crusher)의 성능(회전수)을 높여 입형을 개선하고 ASTM C 33에 적합하도록 입도를 조정한 부순모래의 입형 및 입도 특성을 검토하였으며, 강모래에 대한 치환률에 따라 콘크리트를 제조하여 콘크리트 배합 특성, 굳지 않은 콘크리트 특성 및 경화한 콘크리트 특성을 검토하였다. 실험결과, 대부분의 콘크리트 특성이 강모래만을 사용한 콘크리트와 동등한 수준으로 나타났지만, 강모래에 대한 치환률 50% 이상일 경우, 치환률 증가에 따라 허용 범위 내에서 공기량, 압축강도 및 인장강도는 다소 감소되는 것으로 나타났다. This study, as a research for using crushed sand as a fine aggregate of concrete for nuclear structures, we improved the performance of impact crusher in the existing crushed sand production process and adjusted grain size to conform to ASTM C 33 The shape and grain size characteristics of a crushed sand were examined and concrete was prepared according to the substitution ratio of the sand to investigate the properties of fresh concrete and hardened concrete. The experimental results show that most of the concrete characteristics are equivalent to those of concrete using only heavy sand. However, when the substitution rate of steel sand exceeds 50%, the amount of air, compressive strength and tensile strength are somewhat reduced.