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박성운,이승현,차원철,허규연,김재현,이문규,박성민,진상만 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.1
Background: We aimed to describe the outcome of a computerized intravenous insulin infusion (CII) protocol integrated to the electronic health record (EHR) system and to improve the CII protocol in silico using the EHR-based predictors of the outcome. Methods: Clinical outcomes of the patients who underwent the CII protocol between July 2016 and February 2017 and their matched controls were evaluated. In the CII protocol group (n=91), multivariable binary logistic regression analysis models were used to determine the independent associates with a delayed response (taking ≥6.0 hours for entering a glucose range of 70 to 180 mg/dL). The CII protocol was adjusted in silico according to the EHR-based parameters obtained in the first 3 hours of CII. Results: Use of the CII protocol was associated with fewer subjects with hypoglycemia alert values (P=0.003), earlier (P=0.002), and more stable (P=0.017) achievement of a glucose range of 70 to 180 mg/dL. Initial glucose level (P=0.001), change in glucose during the first 2 hours (P=0.026), and change in insulin infusion rate during the first 3 hours (P=0.029) were independently associated with delayed responses. Increasing the insulin infusion rate temporarily according to these parameters in silico significantly reduced delayed responses (P<0.0001) without hypoglycemia, especially in refractory patients. Conclusion: Our CII protocol enabled faster and more stable glycemic control than conventional care with minimized risk of hypoglycemia. An EHR-based adjustment was simulated to reduce delayed responses without increased incidence of hypoglycemia.
Systemic Amyloidosis Manifested by Gastric Outlet Obstruction
박성운,이현웅,조은정 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.5
Amyloidosis is characterized by extracellular deposition of insoluble protein fibrils that stain with Congo red application and appear apple green under polarized light. The presenting symptoms result from the involvement of many affected, nonspecific and generalized organ systems. Our patient was an 80-year-old woman with no medical history. She presented with a 2-week history of nausea and vomiting. An esophagogastroduodenoscopy showed erythematous and edematous mucosa on the antrum with pyloric stenosis. Histopathologic examination of the biopsy specimen showed the deposition of amorphous, homogeneous, and acidophilic material in the gastric mucosa. Amyloidal protein was proven by positive Congo red stain. A serum and urine immunfixation electrophoresis showed lambda light chain band. She developed symptoms of repeated greenish color vomiting. A follow-up esophagogastroduodenoscopy showed progressed antral obstruction. However, she refused further evaluation and treatment and was managed conservatively. She later died of disease progression after 34 hospital days.
박성운,이길호 대한요로생식기감염학회 2012 Urogenital Tract Infection Vol.7 No.1
일반적으로 인간이나 동물 생존에 영향을 미치는 항생제 내성을 지닌 세균의 등장과 전파는 피할수 없지만 여러가지 적절한 방법을 동원한다면 인간의 영향력 아래에서 조절할 수 있다. 이러한 항생제 내성을 가진 세균에 대한 이해를 넓히고, 내성 문제의 해결을 위한 미래의 접근 방안을 논의하기 위해 학계와 산업계를 대표하는 과학자 30명이 2011년 5월 8일 미국 뉴욕 Cold Spring Harbor의Banbury Conference Centre에 모였다. 아래 서술된 내용은 그 때 토의 내용을 정리한 것이다.
박성운,김민지,서윤정,강다현,김영기,노현인,배재룡,이재원,이진원,최근욱,류재환,Park, Sung-woon,Kim, Min-ji,Seo, Yoon-jeong,Kang, Da-hyun,Kim, Young-ki,Noh, Hyun-in,Bae, Jae-ryong,Lee, Jae-won,Lee, Jin-won,Choi, Geun-wook,Lew, Jae-hwan 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2
Objectives: This clinical study reports on the effects of Yukgunja-tang on aspiration pneumonia.Method: This case examined a comatose male patient who suffers from continuous regurgitation. He showed symptoms of aspiration pneumonia with accompanying gastroesophageal reflux. We gave the patient Yukgunja-tang for 28 days and observed any changes in symptoms.Results: During the period when the patient was given Yukgunja-tang, he defecated on his own without glycerin enema, regurgitation occurred less frequently, and the aspiration pneumonia symptoms improved.Conclusion: Yukgunja-tang helped the patient's bowel movements move more quickly and smoothly through his colon. As a result, Yukgunja-tang appears to have prevented regurgitation and aspiration pneumonia.
박성운,이길호 대한요로생식기감염학회 2012 Urogenital Tract Infection Vol.7 No.2
In 2010, the infectious disease surveillance system of Korea was faced with a series of changes. For sexually transmitted infections (STIs) such as syphilis, gonorrhea, chlamydia, chancroid, genital herpes,condyloma accuminata or acquired immunodeficiency syndrome (AIDS), every case had to be reported according to the Infectious Disease Prevention Law passed in 2003. But the reporting system for STIs was changed to a ‘Sentinel Surveillance System' in 2010, except for syphilis and AIDS, due to the fact that reporting every case was not practically possible and their occurrences should be continuously monitored to ensure the early detection and control of these diseases. In addition, the public health improvement or control activities of medical personnel need regular feedback of the surveillance results. However, the efficient reporting or surveillance of STIs has yet to be successfully carried out because of special requirements such as the need to protect patient's privacy. Therefore, to set up countermeasures and research to prevent the spread of STIs, first line medical personnel should be active and familiar with the reporting system so that the nationwide surveillance system can be successfully managed.
고지방식이유도 실험용 Rat에서 Statin 및 한약 2종(후박, 하수오) 투여에 따른 혈중 지질, 조직 변화 비교 연구
박성운,서윤정,최현정,유재환,Park, Sung-woon,Seo, Yoon-jeong,Choi, Hyun-jeong,Lew, Jae-hwan 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.3
Objective: The goal of this preclinical study was to compare the dyslipidemic effect of pravastatin with that of herbal medicine in rats. Methods: In total, 40 rats were divided into 4 groups: Normal (10 rats), Control (10 rats), Statin alone (10 rats), and the MO-PM-S group (10 rats), which was given the powder of the cortex of Magnolia officinalis Rehd. et Wils., the root of Polygonum multiflorum Thunb, and pravastatin. The Control group, the Statin alone group, and the MO-PM-S group were all given a high-fat (45%) diet that made them obese. After 2 weeks of drug administration, the dyslipidemic effect of pravastatin was compared with that of herbal medicine in rats by analyzing the lipid profiles, measuring the body weights, and taking biopsies (liver, aorta). Results: The herbal medicine and the statin complex group got a much lower TG level and a slightly higher HDL-cholesterol level than the other groups. However, it got a higher total cholesterol and LDL-cholesterol level than the other groups. In biopsies, 30% of the Statin alone group and 10% of the MO-PM-S group showed mild histopathologic findings in the liver. Conclusion: The cortex of the Magnolia officinalis Rehd. et Wils. and the root of Polygonum multiflorum Thunb have dyslipidemic effects from the perspective of a TG level and HDL-cholesterol. However, the herbal mixture has a raising effect on both the LDL-cholesterol and the total cholesterol levels. Therefore, we cannot conclude that the herbal mixture helps to prevent dyslipidemia. In liver biopsies, the group administered with both the herbal mixture and the statin showed less histopathologic findings than the group administered with statin alone. This means that the herbal mixture helps to prevent fatty degeneration of the liver.