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Hijikia fusiforme Protects Against Ovariectomy-Induced Bone Loss in Rats
박상용,이정민,Don-Gil Lee,Heon-Sub Shin,Jung Eun Yang,Eun Ji Yi,Jae Hee Park,Yu Jin Jeon,Da-Eun Nam,이태후 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
The prophylactic effects of Hijikia fusiforme on bone metabolism were examined using in vitro indices of bone formation and resorption. As the indices of bone formation, osteoblast proliferation and differentiation were measured through mitochondrial enzyme activity [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] and bone marker alkaline phosphatase (ALP) activity. The aqueous extract of H. fusiforme stimulated the proliferation of the human osteoblast-like cell line MG63 and the ALP activity of the mouse osteoblast-like cell line MC3T3-E1. Moreover, extracellular matrix mineralization was accelerated by the addition of H. fusiforme. As the indices of bone resorption, differentiation of the murine macrophage/osteoclast precursor cell line RAW 264.7 by receptor activator of nuclear factor-jB ligand (RANKL) was measured as tartrate-resistant acid phosphatase–positive multinucleated cells, which were suppressed by H. fusiforme. Additionally,H. fusiforme lowered the secreted amount of RANKL that is required for the osteoclastic differentiation and activation, but the amount of osteoprotegerin as a decoy receptor for RANKL was not affected. The bone-protective effects of H. fusiforme in estrogen-deficient ovariectomized rats were also investigated. Osteoporosis was induced in female Sprague–Dawley rats by ovariectomy for 15 weeks, and then H. fusiforme was orally administered at a dose of 100 mg/kg of body weight every day for 6 weeks. Bone mineral density in the group orally administered H. fusiforme was increased, compared with ovariectomized rats, but not significantly (P > .05). Oral administration of H. fusiforme improved microarchitecture of bone in terms of bone volume (bone volume/total volume ratio) and trabecular separation (P < .05). The amounts of osteocalcin and C-telopeptide type I collagen in serum were measured as the biomarkers for bone formation and resorption. The level of osteocalcin in serum was increased, but not significantly. However, the level of C-telopeptide type I collagen in serum was significantly decreased (P < .05). When the results are taken together, the present study indicates that H. fusiforme might be useful in the treatment of osteoporosis.
Immunostimulatory Effect of Fermented Red Ginseng in the Mouse Model
박상용,김호빈,김정훈,이주미,김상래,신헌섭,이태후 한국식품영양과학회 2014 Preventive Nutrition and Food Science Vol.19 No.1
In this study, Woongjin fermented red ginseng extract (WFRG) was evaluated for its potential ability to act as an adjuvant for the immune response of mice. For the in vitro study, macrophages were treated with serial concentrations (1 μg/mL, 10 μg/mL, and 100 μg/mL) of WFRG. For in vivo studies, mice were administered different concentrations (10 mg/kg/day, 100 mg/kg/day, and 200 mg/kg/day) of WFRG orally for 21 days. In vitro, the production of nitric oxide and TNF-α by RAW 264.7 cells increased in a dose-dependent manner. In vivo, WFRG enhanced the proliferation of splenocytes induced by two mitogens (i.e., concanavalin A and lipopolysaccharide [LPS]) and increased LPS-induced production of TNF-α and IL-6, but not IL-1β. In conclusion, WFRG has the potential to modulate immune function and should be further investigated as an immunostimulatory agent.
유비쿼터스 컴퓨팅 환경을 위한 에이전트 시스템과 인포메이션 버스 어댑터간 상호 운용성을 위한 기법
박상용,한승욱,윤희용 한국정보처리학회 2006 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.13 No.7
유비쿼터스 컴퓨팅 환경의 관심과 요구가 고조됨에 따라 다양한 상황에 능동적이고 지능적인 에이전트의 역할이 점차 중요시 되고 있다. 이러한 에이전트는 ACL(Agent Communication Language)을 통신 언어로 사용하여 에이전트간 자율적인 상호 운용성 문제를 해결하기 위해 정보를 교환 한다. 본 논문에서는 소프트웨어 에이전트의 국제표준화 단체인 FIPA(Foundation for Intelligent Physical Agents)의 에이전트 프레임워크와 CORBA 이벤트 서비스 기반으로 자체 개발한 인포메이션 버스 어댑터간의 효율적인 통신을 보장하는 상호 운용성 기법을 제안한다. 비에이전트 플랫폼인 인포메이션 버스 어댑터와 JADE 플랫폼간 통신(메시지 교환)을 보장하기 위한 인터페이스인 EMTI(Efficient Message Transport Interface) 설계 및 구현 방법에 대해 살펴보고, 이기종 플랫폼간 다량의 메시지를 송수신하여 그 안정성과 성능에 대해 평가한다. The role of autonomic and intelligent agents in various environments is getting more important as demand on ubiquitous computing grows. The agents exchange information using the ACL (Agent Communication Language) to autonomously solve the problems. In this paper we propose a way of efficient interoperability technique between the agent framework built based on the international standard FIPA(Foundation for Intelligent Physical Agents) and the CORBA event service-based information bus adapter developed by us. The design and implementation of EMTI (Efficient Message Transport Interface) allowing communication between the information bus adapter which is non-agent platform and JADE platform are presented, and its performance is evaluated by letting them exchange a large amount of messages.