특별강연 및 일반연제 발표 : 장기 복막 투석 환자에서 후기당화산물이 복막의 기능과 섬유화에 미치는 영향

박민선 ( Park Min Seon ),나명희 ( Na Myeong Hui ),이현아 ( Lee Hyeon A ),황승덕 ( Hwang Seung Deog ),이희발 ( Lee Hui Bal ) 대한신장학회 1999 춘계학술대회 초록집 Vol.18 No.2

일본전통도시주택 町家(마찌야)의 주동관계에 관한 연구 - 근린형 주상복합으로서 교토시의 마찌야 활용사례를 중심으로 -

박민선(Park Min-Seon),김영훈(Kim Young-Hoon) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

The purpose of this study was to analysis a planning character to ensure the territoriality of dwelling and commercial part. For this approach of study with the Japanese traditional urban housings (Machiya) and their examples which came out from each type, I analyzed the relations between separating dwelling part form commercial part, and improving effect for the environment of dwelling. As the result, it was proved that insurance of the territory according to separating dwelling part form commercial part has an influence on the improvement of the urban dwelling environment.

인지질/세라마이드 혼합물의 상호적 자가회합 특성을 활용한 수화 액정형 베시클 제조

박민선 ( Min Seon Park ),최정원 ( Jeong Won Choi ),이설훈 ( Seol-hoon Lee ),진병석 ( Byung Suk Jin ) 한국공업화학회 2020 공업화학 Vol.31 No.5

인지질과 세라마이드 간 상호적 자가회합 특성을 활용하여 수화 액정형 베시클 제조를 시도하였다. 인지질과 세라마이드의 혼합지질에 에지 액티베이터를 첨가하면 난용성의 세라마이드를 고 함량으로 함유하는 베시클 제조가 가능하였다. 본 연구에서는 인지질, 세라마이드, 에지 액티베이터의 혼합 조성에 따른 수화 액정상의 구조적, 열적 특성 등의 변화를 관측하고, 혼합 조성을 달리하여 만든 베시클의 입자크기 및 베시클 분산액의 안정성을 비교하였다. 실험 결과, 인지질과 세라마이드 간 혼합에서 세라마이드 비율을 최대 70%까지 늘려서, 베시클 분산액 전체 대비 세라마이드를 3.5 wt% 함유되는 제형을 제조할 수 있었다. An attempt was made to prepare hydrated liquid crystalline vesicles by utilizing a mutual self-assembly between phospholipid and ceramide. When an edge activator was added to the mixture of phospholipid and ceramide, it was possible to prepare a vesicle containing a high content of poorly soluble ceramide. In this study, we investigated changes in structural and thermal behaviors of the hydrated liquid crystalline phase according to the mixed composition between phospholipid, ceramide, and sodium deoxycholate. Also, both the droplet size of the vesicles with different composition and stability of the vesicle dispersion solution were observed. From results of the experiments, by increasing the ratio of ceramide up to 70% in the mixture between phospholipid and ceramide, a formulation containing 3.5 wt% of ceramide in the vesicle dispersion solution could be obtained.

한국인에서 적절하게 처방된 가스투과경성콘택트렌즈 직경에 여러 안구계측치들이 미치는 영향

박민선(Min Seon Park),박영기(Young Kee Park),이상목(Sang-Mok Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.9

Purpose: To compare the differences of parameters of 9.3 mm and 8.8 mm rigid gas permeable lenses (RGP lenses) that were prescribed by trial lens fitting. Methods: Ninety-three eyes of 49 patients were prescribed RGP contact lenses (YK spherical lens, Lucid Korea, Bonghwa, Korea) by a single ophthalmologist at the same hospital. We analyzed the differences of parameters of 9.3 mm and 8.8 mm rigid gas permeable lenses (RGP lenses) that were prescribed by trial lens fitting. Steep keratometric value (Ks), flat keratometric value (Kf), and corneal astigmatism (Kast) were measured by keratometer. Simulated steep keratometric value (Sim Ks), simulated flat keratometric value (Sim Kf), simulated corneal astigmatism (Sim Kast), white to white corneal diameter (WTW), and eccentricity were measured by corneal topography. We also analyzed the differences of back optic zone radius (BOZR) and lens power between the two groups. Results: In this study, 40 eyes wearing 8.8 mm lenses and 53 eyes wearing 9.3 mm lenses were included. Keratometric value and eccentricity were significantly higher in the 8.8 mm lens group, while WTW and BOZR were significantly lower. Corneal astigmatism (Kast, Sim Kast) and lens power were not significantly different between the groups. Conclusions: RGP lenses with a smaller diameter were likely to be prescribed to patients with higher keratometric value, higher eccentricity, and shorter WTW, and the average BOZR of the prescribed RGP lenses with a smaller diameter was likely to be steeper. J Korean Ophthalmol Soc 2017;58(9):1031-1035

안와주위에 발생한 결절근막염 3예

박민선(Min Seon Park),권미정(Mi Jung Kwon),이민정(Min Joung Lee) 대한안과학회 2016 대한안과학회지 Vol.57 No.12

목적: 안와주위에 발생한 종괴를 주소로 내원하여 결절근막염을 진단 받은 3예를 보고하고자 한다. 증례요약: 18세 남자 환자가 3개월 전에 발견한 왼쪽 눈썹 옆 관자놀이 부위의 종괴를 주소로 내원하였다. 이학적 검사상 20 mm 크기의 피부밑 종괴가 촉지되었다. 자기공명영상에서 T1에서 isointensity, T2에서 hyperintensity를 보이며 조영증강이 잘 되는 고형 종괴로 나타났다. 36세 남자가 6개월 전부터 시작된 우측 위눈꺼풀 종괴를 주소로 내원하였다. 이학적 검사상 우측 눈썹 중앙부 아래로 15 mm 크기의 피부밑 종괴가 촉지되었다. 안와 전산화 단층촬영에서 균일하고 주변조직과 구별이 잘 되는 종괴로 나타났으며, 중등도의 조영증강을 보였다. 3세 남자 환자가 4개월 전 시작된 우측 위눈꺼풀의 종괴로 내원하였다. 안과 검사상 위안와연 내측에 10 mm 크기의 종괴가 촉지되었다. 자기공명영상에서 조영증강이 잘 되는 부정형의 종괴를 나타내었다. 세 증례 모두 절제 생검을 시행하였고 병리조직검사 상에서 특징적인 방추형 세포의 증식과 함께, 면역조직화학검사에서 smooth muscle actin 양성, S-100 음성, CD34 음성 등의 특징을 보여 결절근막염으로 확진하였다. 각각 수술 후 4개월, 3개월, 48개월까지 경과관찰하였을 때 재발은 관찰되지 않았다. 결론: 결절근막염은 드물지만 안와 주위에 발생할 수 있으며, 특히 소아 및 청장년층에서 비교적 이환 기간이 짧은 피부밑 종괴의 감별진단으로 염두에 두어야 한다. Purpose: Herein, we report 3 cases of nodular fasciitis presenting with periorbital mass. Case summary: An 18-year-old male presented with a mass in his left lateral temple area 3 months in duration. On physical examination, a subcutaneous mass approximately 20 mm in size was palpable with upper eyelid swelling. Orbital magnetic resonance imaging (MRI) showed T1 isointensity and T2 hyper intensity and a well-circumscribed enhancing lesion. A 36-year-old male presented with a 6-month history of a bump under his right upper eyelid. External examination revealed a 15 mm-sized subcutaneous mass in the right central sub-brow area. Orbital computed tomography showed a homogenous, well-circumscribed mass with moderate enhancement. A 3-year-old boy presented with a mass in his right upper eyelid 4 months in duration. A subcutaneous mass approximately 10 mm in size was palpated at the medial superior orbital rim. Orbital MRI revealed an enhanced mass of irregular shape. Surgical excision was performed for all cases. Histopathological examination showed pathognomonic proliferation of spindle cells and immunohistochemical stains showed the spindle cells were positive for smooth muscle actin, negative for S-100 and negative for CD34, consistent with nodular fasciitis. Recurrence of the tumors after excision in the 3 cases was not observed after 4 months, 3 months and 48 months, respectively. Conclusions: Nodular fasciitis is rare but can occur at the periorbital region. In particular, nodular fasciitis should be considered as a differential diagnosis of a subcutaneous mass short in duration in children or young adults.

치위생(학)과 학생의 감성지능과 문화 역량과의 관련성

박민선 ( Min-seon Park ),장종화 ( Jong-hwa Jang ) 한국치위생학회(구 한국치위생교육학회) 2018 한국치위생학회지 Vol.18 No.3

Objectives: The study was a cross-sectional research to examine dental hygiene students' multi-cultural experiences, emotional intelligence and cultural competency and to understand the correlations among them. Methods: The study was conducted from September 1st to October 31st 2016, based on the survey of 449 students in the department of dental hygiene at 7 Universities. The questionnaire consisted of 57 questions including general characteristics (n=7), multi-cultural experiences (n=7), emotional intelligence (n=16) and cultural competency (n=27). Results: Each score of students' emotional intelligence and cultural competency is 3.43 and 3.01 respectively in 5-point scale. An analysis of correlations between emotional intelligence and cultural competency shows that the higher the emotional intelligence, the higher the cultural competency (r=0.342). The factors affecting the cultural competency include use of emotions (β= 0.327, p<0.001), control of emotions (β=0.254, p=0.001), frequency of multi-cultural media (β=0.221, p<0.001) and experience of multi-cultural class (β=0.221, p=0.002). The modified explanatory power in this model is 28.2% (F=10.856, p<0.001). Conclusions: There was a positive correlation between emotional intelligence and cultural competency, and the contacts with multi-culture and experience of class are identified as the affecting factors. Dental hygiene students should acquire theoretical experiences regarding the multi-culture through curriculum or continuous educations and it is necessary to promote such educations in order to develop and apply the programs for the enhancement of emotional intelligence.

금속 이물질에 의한 육아종으로 의심되는 전방내의 색소성 종괴

박민선(Min Seon Park),최상열(Sang Yul Choi),이상목(Sang-Mok Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.2

목적: 금속 이물질에 의한 육아종으로 의심되는 전방내 색소성 종괴 1예를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. 증례요약: 63세 남자 환자가 수년 전부터 발생한 우안 흐려보임을 주소로 내원하였다. 우안 상비측 각공막 경계부위 지름 2 mm 정도의 동심원상의 갈색침착과 함께, 전방내 일부 흰색 부분이 섞여 있는 균질한 갈색 직육면체모양(2 x 0.6 x 0.3 mm)의, 표면이 매끄럽고, 혈관이 없는 상비측의 종괴가 전방각경을 통해 관찰되었다. 종괴가 홍채를 약간 누르고 있어 동공은 상비측 쪽으로 끌리는 타원형 모양이었다. 전안부빛간섭단층촬영상 전부 각막기질과 내피세포층을 포함하는 후부 각막기질에 두 층의 분리된 고음영이 관찰되었다. 전산화단층촬영상 조영증강전검사에서 오른쪽 눈 전안부의 상비측에 지름 약 3.0 mm 크기의 대칭적인 원형의 높은 밀도의 고음영이 관찰되었다. 공막층판절개를 통한 절제생검을 고려하였으나, 환자의 좌안 시력이 좋지 않아 우안에 의존한 상태였으며, 여러 가지임상적 소견이 홍채흑색종보다는 육아종으로 판단되어 조직검사를 시행하지 않았다. 19개월의 경과관찰 기간 동안 종괴의 크기, 동공모양 등의 변화는 관찰되지 않았다. 결론: 전방내 색소성 종괴가 발견되면 홍채의 양성, 악성 종양 및 육아종 등의 감별진단이 필요한데, 안내종양의 경우 조직학적 진단을 얻기 어려운 경우가 있으므로 환자의 정확한 병력과 악성과 양성 종양을 구별한 수 있는 형태학적인 특성을 염두에 두고 진단에 활용하는 것이 중요하다. Purpose: To report on a patient with a brown pigmented mass in the anterior chamber suspected of a granuloma caused by a metallic foreign body and to review the relevant literature. Case summary: A 63-year-old man presented with blurring in his right eye, which had initially began several years prior. Concentric corneoscleral brown pigmentation about 2 mm in diameter was found in the superonasal limbal area. A rectangular parallelepiped mass was observed in the superonasal anterior chamber, which was an even brown color with a small white portion, smooth-surfaced, and non-vascularized. The pupil was oval and dragged superonasally, possibly due to mild compression of the iris caused by the mass. In pre-enhanced orbital computed tomography, a round high signal intensity with a diameter of 3.0 mm was found in the superonasal anterior segment. Though excisional biopsy using the lamellar scleral flap was considered for exact diagnosis, this was not performed considering the clinical features are more indicative of granuloma than iris melanoma. Neither changes in the size of the mass nor the shape of the pupil were observed during the follow up period until 19 months after the first visit. Conclusions: When a pigmented mass in the anterior chamber is detected, benign and malignant iris tumors and granulomas should be considered for a differential diagnosis. The patient’s exact past medical history and clinical features differentiating malignant and benign masses are important for proper diagnosis due to the difficulty in obtaining tissue diagnoses in some cases.

심포지엄 : 인종에 따른 복막투석 예후의 차이

박민선 ( Park Min Seon ) 대한신장학회 2003 추계학술대회 초록집 Vol.22 No.2

‘저항굴곡MS운동’이 류마티스 관절염 통증에 미치는 영향

박민선(Park Min Seon ),최성옥(Choi Sung Ok) 한국콘텐츠학회 2018 한국콘텐츠학회 종합학술대회 논문집 Vol.2018 No.5

가용화제를 활용한 세라마이드 고함량의 수화 액정형 베시클 개발

박민선 ( Min Seon Park ),진병석 ( Byung Suk Jin ) 한국공업화학회 2021 공업화학 Vol.32 No.5

세라마이드와 인지질, 콜레스테롤 등과의 상호적 자가회합이 가능한 최적의 조성을 구성하여 세라마이드 고함량의 수화 액정형 베시클을 제조하였다. 혼합조성을 달리하여 다양한 베시클을 제조한 결과, 에지 액티베이터인 sodium deoxycholate (SDOC)와 가용화제인 PEG-60 hydrogenated castor oil (HCO 60)을 혼합하여 베시클을 만들었을 때, 가장 작은 나노 사이즈의 입자가 만들어지고, 베시클 분산액은 약산성이면서 가장 안정한 상태를 유지하였다. 또한 편광현미경과 열분석을 통해 SDOC와 HCO 60의 첨가가 세라마이드 등 지질 성분의 결정성 억제에 영향을 미치는 것으로 확인되었다. 베시클 분산액은 8주 동안의 고온의 장기 보관에서도 외관 및 점도의 변화없이 안정성이 그대로 유지되었다. Hydrated liquid crystalline vesicles containing a high content of ceramide were prepared by constituting an optimal composition in which ceramides can be mutually self-associated with phospholipid and cholesterol. From the result of manufacturing various vesicles with different component composition, when the edge activator sodium deoxycholate (SDOC) and the solubilizer PEG-60 hydrogenated castor oil (HCO 60) were mixed to form vesicles, the smallest nano-sized particles were produced and the vesicle dispersion solution was weakly acidic and maintained the most stable state. In addition, it was confirmed through polarized light microscopy and thermal analysis that the addition of SDOC and HCO 60 had an effect on the inhibition of crystallinity of lipid components such as ceramide. The stability of the vesicle dispersion solution was maintained without change in appearance and viscosity even after long-term storage at high temperature for eight weeks.