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RISS 인기검색어
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- 저자 : 박명재 ( Myungjae Park ) (검색결과 2 건)
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LPS로 염증유도된 RAW 264.74 세포에 대한 흑삼 첨가 경옥고의 항염증 효과
박명재 ( Myungjae Park ),김정수 ( Jeong-soo Kim ),이아름 ( Ahreum Lee ),노성수 ( Seong-soo Roh ),권오준 ( Ojun Kwon ),서영배 ( Young-bae Seo ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.3
Objectives : The aim of this study was to examine effect of anti-oxidant and anti-inflammation activity of the Kyeongok-go with various processing methods that was manufactured by heating mantle. Methods : Commercial Kyeongok-go (K0) was purchased and Kyeongok-go with ginseng (K1), Kyeongok-go with black ginseng (BK), ginseng fermentation Kyeongok-go (KF), black ginseng fermentation Kyeongok-go (BKF) were manufactured by heating mantle. To examine anti-oxidant effect, DPPH radical and production of NO and ROS in RAW 264.74 cell were used. Furthermore, to determined anti-inflammation effect, measured pro-inflammatory mRNA such as NOS-II, COX-2, IL-1β, IL-6, TNF-α in RAW 264.74 cell treated with K0, K1, KF, BK, and BKF. Result : K1 scavenged DPPH radical effectively than K0. The most DPPH radical scavenging activity was BKF. In the RAW 264.74 cells stimulated with LPS, NO and ROS production were measured. As a results, K1 was decreased NO, ROS production compared with K0, and BKF was reduced similarly to cyclosporine A (positive control). Expression of pro-inflammatory mRNA such as NOS-II, COX-2, IL-1β, IL-6 showed a significant decrease in BK or BKF. But, there was no significant in expression of TNF-α in all extract treatmetn groups. Conclusions : According to the above results, it is considered that Kyeongok-go with fermented black ginseng (BKF) manufactured by heating mantle is effective material that have anti-inflammation and anti-oxidant activities. Our finding indicate that BKF may be an effective agent for anti-inflammation through anti-oxidant effect.
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우슬(牛膝)의 증숙(蒸熟)에 따른 항산화 효능 및 고지혈증 유발 흰쥐에 대한 고지혈증 개선 효능에 대한 연구
김정수 ( Jeong-soo Kim ),박명재 ( Myungjae Park ),김수지 ( Suji Kim ),신미래 ( Mi-rae Shin ),이아름 ( Ahreum Lee ),박해진 ( Hae-jin Park ),노성수 ( Seong-soo Roh ),서영배 ( Young Bae Seo ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.6
Objectives : This study was conducted to compare the effect of Achyranthis Bidentatae Radix on antioxidant changes and antihyperlipidemics in hypercholesterolemic rats according to changes in the number of steams. Methods : The experimental animals were divided into six groups: normal (Nor), high cholesterol diet (Veh), high cholesterol diet with Simvastatin 5 ㎎/㎏ (Sim), high cholesterol diet with AR0 extract 200 ㎎/㎏ (AR0), high cholesterol diet with AR6 extract 200 ㎎/㎏ (AR6) and high cholesterol diet plus AR9 extract 200 ㎎/㎏ (AR9). I measured HDL, LDL TC, TG contents and ROS from each serums and compared them. I analyzed antioxidantrelated protein expressions and cholesterol-related protein expressions in each liver tissues. I also performed optical microscopic analysis through liver tissue staining. Results : The Antioxidant activity of Achyranthis Bidentatae Radix was increased by steaming processes. In vivo, AR0 decreased liver weight in hyperlipidemic rats. LDL TC, TG, AI and CRF were decreased but HDL was increased in AR0. AST, ALT, creatinine, and BUN were decreased in AR0. ROS was decreased in AR0, AR6, and AR9. SOD, catalase and GPx were decreased by steaming processes. p-AMPK was decreased but SREBP-2, p-ACC, and HMGCR were increased by steaming processes. Histologic analysis showed that AR0 decreased liver fat accumulation. Conclusion : In conclusion, AR0 can be developed as a treatment for hyperlipemia. And it is required to research on antioxidant effect changes among different times steamed Achyranthis Bidentatae Radix.
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