심근 성형술 1례 보고

박국양,박철현,현성열,김주이,권진형,최인석,이현재,임창영,Igor Dubrovski, Ph.D. 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.4

A 25-year-old man with viral cardiomyopathy and chronic active hepatitis successfully underwent dynamic cardiomyoplasty for the first time in Korea on July 30, 1996. The patient had been intermittently dyspneic for 5 years and was admitted to our center twice because of heart failure. For the past 2 years, he was NYHA functional class III status with a left ventricular ejection fraction(LVEF) of around 30%. The patient was born with scoliosis and showed a short stature. The liver function showed elevated liver enzymes, and hepatitis B antigen was positive. The liver biopsy revealed chronic active hepatitis. The preoperative echocardiogram showed decreased left ventricular function with grade II mitral and grade II tricuspid regurgitation with dilated left and right atrium. Recently his symptoms worsened and we decided to perform a dynamic cardiomyoplasty. The left latissmus dorsi muscle(LDM) was mobilized and tested with lead placement on his right lateral decubitus position. The patient was positioned into supine and, after median sternotomy, the heart was wrapped with the mobilized muscle. The Russian made cardiomyostimulator(EKS-445) and leads (Myocardial PEMB for heart and PEMP-1 for LDM) were used. The total operation time was 8 hours and there were no perioperative episodes. Postoperatively the LDM had been trained for a 10 week period and currently the stimulation ratio is maintained at 1:4. The postoperative LVEF did not increase with the value of 30-35%. However, the patient feels better postoperatively with slightly increased activity. 25세된 말기 심부전 환자에게 한국에서는 최초로 광배근을 이용한 심근 성형술이 성공적으로 실시되었다. 환자는 약 심근수축력이 30%인 상태로 94년과 96년에 한차례씩 심부전으로 입원한 적이 있으며 수술직전 임상상태는 NYHA functional class III 였다. 간조직 검사상 만성 활동성 간염으로 판명되었으며 환자는 간염 항원이 양성으로 심장이식대상에서 제외되었다. 1996년 7월 30일 좌측 광배근을 이용하여 심근 성형술을 실시하였다. 측와위로 광배근을 박리한후 자극전극을 설치하였으며 흉골 정중 절개로 심장을 노출한 후 광배근으로 심장을 감싸주고 심근 전극을 설치한 후 좌상부 복부에 심장근육자극기를 설치하였다. 총 수술시간은 약 7시간 30분이 소요되었으며 환자는 수술후 일시적인 심방 조동(atrial flutter)을 보여 심도자실에서 동율동으로 환원시킨 것외에는 특별한 합병증은 없었다. 환자는 수술후 6주째 자극기의 빈도가 1:4인 상태에서 퇴원하였으며 통원치료중 1:1로 근육훈련을 마친 후 현재는 수술후 6개월째 자극빈도가 1:4인 상태에서 외래 추적중이다. 심초음파상 수축력의 차이는 없으나 환자의 임상 활동은 수술전보다 양호해진 상태이다.

4첨 대동맥판막 환자에서 발생한 대동맥 판막폐쇄부전 -1례 보고-

박국양,김성철,김창호,Park, Guk-Yang,Kim, Seong-Cheol,Kim, Chang-Ho 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.3

A 11 year-old girl with quadricuspid aortic avlve associated with regurgitation left superior vena cava and chromosomal anomaly is presented. The quadricuspid valve was unexpectedly found during operation for aortic valve replacement. The aortic valve consisted of 4 equal-sized cusps and retrospective review of the aortogram revealed the aortic valve to have 4 cusps also. To the best of our knowledge, this combination of anomalies has not been reported in Korea previously.

좌심실우심방 단락치험 2

박국양 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.2

As OHS is prevalent on whole world, LV-RA shunts once thought as quite rare congenital heart disease are reported frequently. Two cases of LV-RA shunts were operated at N.M.C. in 1983: One of them combined VSD, the other membranous ventricular septal aneurysm protruding into right atrial chamber. In case 1, which was diagnosed correctly, right atriotomy was enough to close the defect under ECC, but in case 2, which was misdiagnosed as ASD preoperatively, atriotomy was added to ventriculotomy. The LV-RA defects were closed by U-shaped direct suture with Teflon felt pledget. Postoperative course was uneventful in both of them.

유두근 파열 수술 치험 1례

박국양 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.1

A 69-year-old patient with rupture of anterolateral papillary muscle following non-Q-wave myocardial infarction is described. Transesophageal echocardiography was useful in making the diagnosis. Mitral valve replacement was performed 22 days after the onset of acute myocardial infarction. The patient was discharged in his good condition and coronary angiography is scheduled.

한국의 심장이식 현황

박국양 인제대학교 1999 仁濟醫學 Vol.20 No.1S

한국에서의 심장이식은 1992년 11월 11일 중앙병원 송명근 등에 의해 최초로 실시되었으나, 역시 일반인에 대한 홍보의 부족, 의료계 내부의 심장이식에 대한 인식의 부족 등으로 인해 이식건수는 크게 증가하지 못한 것이 사실이다. 그러나 1994년 의사협회의 뇌사에 관한 선언이 있었고 KBS 인기 연기자 중 한명이 드라마 촬영도중 뇌사가 되어 전신 장기를 기증하는 등 홍보효과로 인해 장기기증이 급증하였고 심장이식안해도 한 해 20예가 넘게 되었다. 현재 우리나라에서의 심장이식은 그 중례가 한 해 약 20~30예에 이르고 있으며 그 술 후 성적역시 외국의 경우와 크게 다르지 않다. 중앙병원에 이어 서울대학병원에서는 1994년 3월에, 그리고 부천 세종병원에서는 같은 해 4월에 각각 심장이식에 성공하였으며 이후 1999년 1월 3일 현재까지 10개 병원에서 총 128예의 심장이식이 실시되었다.

심장-폐이식 1례보고

박국양,김주이,박철현,김상익,김정철,현성열,심현자,정미진,권진형 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.6

12세된 여자 환자에서 한국에서는 처음으로 심장-폐 동시이식이 성공적으로 이루어 졌다. 환아는 심실 중격결손증이 없는 폐동맥 폐쇄증으로 좌폐부전과 함께 우심실의존성 관상동맥혈류를 가지고 있었으며 개심술에 의한 일반적인 심장 수술은 불가능하였다. 장기 제공자는 9세된 남아로 교통사고에 의한 뇌출혈이 사망의 원인이었다. 심장폐이식은 1997년 4월 20일 이루어 졌다. 이식시 수술 방법은 소위 아리조나 방법으로 양측 폐문부를 환아의 횡격막 신경위로 놓는 방법을 사용하였는데 수술시 지혈에 큰도움이 되었다. 수술후 환자는 두가지 큰 합병증이 발생하였는데 하나는 발열이고 둘째는 기관 문합부위 협착을 들수가 있다. 수술후에 계속되었던 발열은 결핵약 투여후 극적으로 소실되었으며 기관 협착에 의한 호흡 곤란은 수술후 제 71일째 실시한 금속성 그물망에 의한 확장으로 치유 되었다. 환자는 수술후 7개월째 호흡 곤란은 보이지 않고 있으며 운동 및 일상 생활에 지장이 없이 양호한 상태로 지내고 있다. The first heart-lung transplantation in Korea was successfully performed. The recipient was a 11 year old girl with pulmonary atresia with intact ventricular septum. She had been catheterized at the ages of 4 months, 3 years, 7 years and 10 years, which revealed that neither Fontan nor biventricular repair was feasible. The donor was a traffic accident victim, a 9 year-old boy with the same blood type. The donor was pronounced dead according to the guidelines of the Korean Medical Association's Brain Death Committee. The operation was performed on April 20, 1997. The native heart-lung block was explanted segmentally and donor one was placed above the phrenic nerve using the Arizona technique. After the tracheal anastomosis with single continuous 4-0 prolene, both vena cavae were anastomosed, followed by aortic anastomosis. The graft ischemic time was 145 minutes. The postoperative course was complicated by fever and tracheal stenosis at the anastomosis site. The fever was controlled by anti-tuberculous medications and the tracheal stenosis was relieved by stent(Palmaz 8 mm, 30 mm in length) placement on POD #71. The patient is doing well and is very active in her 7th postoperative month.

여호와의 증인의 심장이식 - 1례 보고 -

박국양,박철현 대한흉부심장혈관외과학회 1997 Journal of Chest Surgery (J Chest Surg) Vol.30 No.5

An orthotopic cardiac transplantation was successfully performed in a 40 year-old Jehovah's witness without use of any blood product. Preoperatively, the patient had been on coumadin to prevent left atrial thrombi and the INR(Internation Normalized Ratio)of prothrombin titre was 2.4. During the operation, cell saver was used for shed blood and aprotinin was admini tered intravenously for platelet function. Total postoperative drainage was 860cc and the lowest hemoglobin was 12.2 gmldl. Postoperative course was complicated by central nervous system infection by wisteria monocytogenes and two episodes of rejection, both of which were effectively treated. The patient is on his 5th postoperative month and doing well. 40세된 한 여호와의 증인 환자에게 혈액제제의 사용없이 심장이식이 성공적으로 실시되었다. 환자는 수술 전 심방세동을 보여 항응고제를 사용중이었는데 프로트롬빈치가 Hm기준으로 2.4의 상태에서 수술을 시행하였다. 이 환자의 수술후 총 출혈양은 860cc 였으며 최소 헤모글로빈치는 12.2gm/이전로 수술전의 13.8 glen에 비해 불과 1.6 gm/이밖에 감소 하지 않았다. 환자는 수술후 12시간 만에 호흡기를 제거할 수 있었으며 수술후 5개월이 지난 현재까지 경과는 매우 양호한 상태이다. 본 환자에 있어서 성공적인 무혈 수술의 원인은 여러 가지가 있겠지만 이중 cell saver의 사용, 정맥내 aprotinin의 처치, 그리고 수술중 지혈의 세밀함이 중요한 요소라고 본다.

심내막염 환자의 수술적 치료

박국양 대한흉부심장혈관외과학회 1988 Journal of Chest Surgery (J Chest Surg) Vol.21 No.1

During one year period from Sep. 1986 to Sep. 1987, we have experienced 6 cases of infective endocarditis requiring surgical interventions. All 6 patients had class IV or V cardiac disability at the time of surgery. The indication for surgery was rapidly progressive congestive heart failure in all cases. Four patients underwent aortic valve replacement including one double valve replacement. Two other patients required other surgical procedures, removal of large left atrial vegetation mass in one patient and excision of destroyed pulmonary valve and aortic vegetation in the other patient. Two patients died; one of mitral annulus rupture after release of aortic clamp and the other of mediastinal bleeding 3 months after replacement of aortic valve. Three out of 4 survivors are in NYHA Class I and the remaining patient is in Class II. We emphasize that early operative intervention is life-saving in patients with persistent or progressive congestive heart failure, irrespective of the activity of the infective process or the duration of antibiotic therapy.

심장이식후 발생한 아스페르길루스증-2례 보고-

박국양,김희정 대한흉부심장혈관외과학회 1997 Journal of Chest Surgery (J Chest Surg) Vol.30 No.3

아스페르길루스 감염증은 드물기는 하지만 면역 억제된 상황에서는 비교적 잘 발생하며 치사율도 높은 것으로 알려져 있다. 경구 또는 정맥내 치료제가 있기는 하지만 합병증이 많고 장기간 사용해야 하기 때문에 치료효과는 크게 기대할 수 없는 경우가 많다. 따라서 환자에 따라서는 외과적 요법을 병행하여 치료효과를 높이는 방법도 사용하고 있다. 세종병원에서는 지금까지 실시한 15례의 심장이식환자중 2 례의 폐 아스페르길루스증을 경 험하였기 에 보고하는 바이다. 두 환자 모두 나이와 수술시기가 비슷하였 으며 수술후 약 3주후 외래에서 흉부 X-선상 폐병변을 발견하였다 경피적 천자생검상 Aspergillus fumigatus로 확인되어 정맥내 Amphotericin B와 경구용 Itraconazole을 병용한 항진균제요법을 실시하 였으며 두번째 환자는 병변이 우하엽에 국한되어 외과적 절제술을 병용하였다. 첫번째 환자는 이식후 14개월째 양호한 상태로 추적중이며 두번째 환자는 치료 완료후 3개월째 비세포성 거부반응으로 사망하였다. Aspergillus Infection is a major.cause of mortality in individuals with depressed cell-mediated immunity. Despite therapy with intravenous amphotericin B and oral antifungal agents, high mortality has been reported among heart transplant recipients. We experienced two cases of pulmonary aspergillosis among 15 heart transplantation cases. Both cases were similiar in terms of age, time of diagnosis, and medication. Percutaneous needle aspiration biopsy revealed Aspergillus fumigatus in both cases. The thirst case showed multiple aspergilloma on both lung fields and were treated by IV Amphotericin B and oral itraconazole. After completion of treatment, the lesion completely disappeared and he has been followed up for more than one year in his good condition. The second case showed a single nodule on his right lower lung field and were treated by both medication and surgery. The patient recovered well and had been doing well until 4th postoperative month when he developed humoral rejection and expired.

수직추락후 발생한 복부대동맥 협착 1례 보

박국양,이홍섭,김창호,Park, Guk-Yang,Lee, Hong-Seop,Kim, Chang-Ho 대한흉부심장혈관외과학회 1987 Journal of Chest Surgery (J Chest Surg) Vol.20 No.1

We have recently experienced a rare case of abdominal aortic injury caused by deceleration force during fall in upright position. The patient was 43-year-old brick-layer fell from 12 meter height and sustained compression fracture of the spine and both legs. The aortic injury was unnoticed at that time. About 2 years later, marked stenosis of the distal abdominal aorta was found together with clinical manifestations of ischemia of both legs. Aorto-femoral bypass on both sides has completely relieved the symptoms, Similar type of abdominal aortic injuries could not be found in the literatures.