The Ancient Mariner 에 나타난 죽음과 再生의 神話 : 달(月), 뱀(蛇), 비(雨)의 象徵을 中心으로

朴敬一 경희대학교 언어연구소 1982 언어연구 Vol.3 No.-

A Giant Left Atrium in Rheumatic Mitral Stenosis

박경일,김형관,박영배 대한심장학회 2010 Korean Circulation Journal Vol.40 No.11

Enlargement of left atrium (LA) is not infrequently observed in patients with rheumatic mitral stenosis. We recently met a patient who had a giant LA associated with severe mitral stenosis. The right ventricle had almost collapsed due to compression by the LA. Mitral valve surgery was performed for mitral stenosis and the postoperative course was uneventful. Thus, we suggest that clinicians should not delay corrective surgery for severe mitral stenosis solely on account of a huge LA.

Normal Ranges and Physiological Changes of Midwall Fractional Shortening in Healthy Korean Population

박경일,장성아,김형관,박효은,나상훈,김용진,손대원,오병희,박영배 대한심장학회 2010 Korean Circulation Journal Vol.40 No.11

Background and Objectives: Left ventricular (LV) midwall fractional shortening (FSmw) reflects systolic function more accurately than LV endocardial fractional shortening (eFS) in patients with increased LV wall thickness. Although the normal reference ranges of LV-FSmw have been suggested in Western population studies, its reference values and age-related physiological changes in Eastern populations remain unknown. Subjects and Methods: Conventional echocardiographic parameters, LV-FSmw, and stress-corrected LV-FSmw were assessed in 160 healthy and clinically normal subjects with a mean age of 45 (range, 11-72 years; 104 males, 56 women), all of whom were confirmed to be free of disease, based on laboratory investigations, clinical and physical examination findings and computed tomographic coronary angiographic examinations. Results: LV-FSmw was higher in women compared to men. However, the differences were without statistical significance (18.2±1.5% for male gender and 19.4±2.5% for female gender, p=0.07). In contrast to LV-eFS that progressively increased with age (p=0.001), LV-FSmw and stress-corrected LV-FSmw was not influenced by changes in age (p=0.88 and 0.29, respectively). The results remained unchanged when analyses were performed adjusting for gender. Conclusion: The results of this study provide normal reference values for LV-FSmw and stress-corrected LV-FSmw and their natural physiological changes with advancing age. These measures can be used as reference standards for research on LV systolic function in the setting of pressure or volume overload.

Assessment of Immune Parameters of Manila Clam Ruditapes philippinarum in Different Physiological Conditions using Flow Cytometry

박경일,Ludovic Donaghy,강현실,홍현기,김영옥,최광식 한국해양과학기술원 2012 Ocean science journal Vol.47 No.1

Cellular and humoral immune parameters are often used as biomarkers to trace environmental and physiological stresses in marine bivalves. In this study, we compared various immune parameters of Manila clams (Ruditapes philippinarum) under normal conditions and under a high level of desiccation,using flow cytometry. The immune parameters analyzed included, total hemocyte count, hemocyte mortality, hemocyte DNA damage, reactive oxygen species (ROS) production, and phagocytosis activity. Total hemocyte count, hemocyte DNA damage, and hemocyte mortality were significantly elevated among clams under high desiccation stress, while phagocytosis activity and spontaneous ROS production were significantly lower compared to those parameters of the control clams (p<0.05). These data suggest that the immune parameters analyzed in this study well reflect the physiological status of clams.

Effect of Intravenous Infusion of G-CSF-Mobilized Peripheral Blood Mononuclear Cells on Upper Extremity Function in Cerebral Palsy Children

박경일,이영호,나위진,조승휘,박시복,한승훈,고한이,서진영,음장수,최은혜,박운진,김미정 대한재활의학회 2017 Annals of Rehabilitation Medicine Vol.41 No.1

Objective To investigate the effect of intravenous infusion of peripheral blood mononuclear cells (mPBMC) mobilized by granulocyte-colony stimulating factor (G-CSF) on upper extremity function in children with cerebral palsy (CP).Methods Fifty-seven children with CP were enrolled. Ten patients were excluded due to follow-up loss. In total, 47 patients (30 males and 17 females) were analyzed. All patients’ parents provided signed consent before the start of the study. After administration of G-CSF for 5 days, mPBMC was collected and cryopreserved. Patients were randomized into two groups 1 month later. Twenty-two patients were administered mPBMC and 25 patients received normal saline as placebo. Six months later, the two groups were switched, and administered mPBMC and placebo, respectively. Quality of Upper Extremity Skills Test (QUEST) and the Manual Ability Classification System (MACS) were used to evaluate upper motor function.Results All subdomain and total scores of QUEST were significantly improved after mPBMC and placebo infusion, without significant differences between mPBMC and placebo groups. A month after G-CSF, all subdomain and total scores of QUEST were improved. The level of MACS remained unchanged in both mPBMC and placebo groups. Conclusion In this study, intravenously infused mPBMC showed no significant effect on upper extremity function in children with CP, as compared to placebo. The effect of mPBMC was likely masked by the effect of G-CSF, which was used in both groups and/or G-CSF itself might have other neurotrophic potentials in children with CP.

지중해담치내 미세플라스틱의 축적에 관한 조직학적 관찰

박경일,박준우,최진수 한국패류학회 2017 The Korean Journal of Malacology Vol.33 No.4

Microplastics discharged from human daily activities are not decomposed by sewage treatment but are introduced into the oceans through land-water systems, and are accumulated in filter-feeding bivalves. This study aimed to investigate microplastic accumulation in Mytilus galloprovincialis artificially exposed to microplastics. The mussels were exposed to fluorescent microplastics made of polypropylene (diameter of 53-63 μm) for 21 days at concentrations of 50 mg/L, 0.5 μg/L, and 0 μg/L. Microplastic distribution and concentration in mussel tissues were analyzed by histology and image processing, respectively. In our study, the microplastics used were partially decomposed into nano-sized particles during the experiment. Thus, two types of micro-particles were investigated in the present study: microplastics (φ < 5 mm) and nanoplastics (φ < 20 μm). Micro/nano-sized plastics were found only in the mussels exposed to the 50 mg/L concentration; the gill, stomach, stylus sac, secondary duct, and intestine of the mussels were the organs of accumulation. Pathological symptomssuch as hemocyte infiltration and digestive tubule atrophy were found around micro/nano-sized plastics, suggesting that these particles cause physiological disorders in mussels.

사회복지행정 교재의 검토와 교육의 방향

박경일 한국사회복지교육협의회 2008 한국사회복지교육 Vol.4 No.1

This study focused on the proposal for the improvement of textbook contents and a better directions of education in social welfare administration. This article analyzed textbooks on social welfare administration and a subject guideline on social welfare administration in social welfare curriculum. According to this study results, I founded that the books on social welfare administration are increased in comparison to reforming of social welfare laws and growing in students of the department of social welfare. Especially, many textbooks on social welfare administration have been published to prepare a qualifying examination of the first degree social worker after 2000. In conclusion, the Implications for future directions of education on social welfare administration call for new approaches to developing learning materials and textbook contents. These include: publishing of the textbook or casebook related to the blance between knowledge and skills, writing of human service management, developing of the techniques and skills of human service management, publishing many translation on social welfare administration. 본 연구는 2005년 현재까지 출간된 사회복지행정 관련 저서들의 시기별 특성과 사회복지행정 교재와 교과목 지침서의 구성과 내용을 검토 분석하여 사회복지 행정교육의 방향과 교재의 질적 향상을 제언하는데 있다. 검토 결과 사회복지행정 교재는 사회복지관계 법령의 변화와 사회복지학과 및 학생 수가 증대함에 따라 비례하여 관련 저서들의 출간이 증대되었음을 알 수 있었고 특히 사회복지사 1급시험이 실시되는 2000년 이후부터 행정 교재의 집필이 활발하게 이루어졌음을 알 수 있었다. 아울러 사회복지행정 교재와 지침서에 수록된 내용과 구성이 실제 사회복지 현장에서 직접적으로 활용되어질 수 있는 행정 기술과의 연계성이 부족하다는 것도 알 수 있었다. 따라서 연구자는 사회복지행정의 질적 향상을 위한 교육의 방향과 교재의 개발로서 이론과 실천현장이 연계된 사회복지행정의 교육과 교재 출간, 사회복지(서비스)관리론에 대한 저서 집필, 사회복지실천 현장에 적합한 서비스 관리기법의 개발과 적용, 대학원에 복지매니져먼트 전공 개설, 사회복지사 재교육의 강화, 그리고 사회복지행정 번역서의 출간과 지원 등을 제언하였다.

휴대용 유세포분석기를 이용해 바지락 서식장에서 측정한 바지락의 세포성 면역력

박경일 한국패류학회 2017 The Korean Journal of Malacology Vol.33 No.3

To elucidate the immune response of the Manila clam Ruditapes philippinarum in a habitat, 20 clams were collected from the west coast of Korea; and immune parameters, including total hemocyte counts (THC), reactive oxygen species (ROS), cell necrosis, apoptosis, and DNA damage within hemocytes were investigated using a portable flow cytometer. The measurements were conducted immediately after sample collection in the field. The analyzed immune parameters were also compared with those measured in the clams kept at 4 °C for 12 h. The immune parameters of the field-collected clams were 737,568/ml of THC, 0.553% of DNA damage, 41.962 A.U. of ROS, 0.121% of necrosis rate, and 0.055% of apoptosis rate, respectively. These values significantly increased when the clams kept at 4 °C for 12 h in the present study, suggesting that a significant modulation of immune responses might have occurred during transformation from sampling site to laboratory. Therefore, in order to investigate the immunity of clam in habitat, it is necessary to consider measures to reduce the change of immunity that may occur during transportation to laboratory after sampling.

수종 한약재 및 죽염 함유치약이 치태 및 치은염에 미치는 영향에 관한 임상적 연구

박경일,최유진 ( Kyung Ill Park,Eu Gene Choi ) 대한예방치과·구강보건학회 1994 大韓口腔保健學會誌 Vol.18 No.1

나팔꽃의 꽃과 종자 착색에 관여하는 유전자의 동정과 특성

박경일 한국화훼산업육성협회 2012 화훼연구 Vol.20 No.1

I. purpurea의 야생형 FP39는 진한 자주색 꽃과 흑 갈색의 종자가 맺히는 반면, 자연변이종인 KK-1과 W-4는 안토시아닌 색소가 결핍된 꽃을 피우고 아이보 리색의 종자를 맺는다. 이들 변이종에서는 조사된 안토 시아닌 생합성 유전자의 발현률이 떨어졌는데, 이는 나 팔꽃식물의 전사조절인자 변이종인 ivs, c1 및 ca 계 통에서 관찰된 결과와 유사하였다. 분자분석을 통해 꽃 과 종자에서 동시에 관찰되는 착색변이는, bHLH 단 백질을 암호화하고, 꽃과 종자의 착색을 포함한 식물의 표피세포에서 나타나는 여러가지 형질에 관여하는, 애 기장대의 TT8과 페튜니아의 AN1유전자와 상동성이 있 는 나팔꽃의 IVS 유전자에 DNA형 전이인자가 삽입됨 으로써 유전자의 기능이 상실된 결과였다. KK-1과 W-4계통은 bHLH2의 변이형질인 ivs-m1과 ivs-stb를 각각 가지는데 두 대립형질의 IVS 전사산물 축적은 전이인자의 exon 영역 삽입에 의해 감소되었다. 전이 인자의 삽입을 제외하더라도, ivs-m1과 ivs-stb는 exon 및 intron 영역에서 각각 26 및 165부분에서 DNA 염기서열 차이를 보였다. 그 차이는 추정 아미노산 서 열에서14개의 아미노산 차이로 나타났는데, 이러한 결 과로 이 두 대립형질이 같은 종 내에서 서로 다른 생 태역사를 가질 것이라는 것을 알 수 있다. While the wild type plant FP39 of Ipomoea purpurea, displays deep purple flowers and darkbrown seeds, spontaneous mutants KK-1 and W-4 produce flowers deficient in anthocyanin pigments and ivory seeds. In these mutants, the expression of anthocyanin biosynthetic genes tested was reduced, which resembles with results of the ivory-seed (ivs), c1 and ca mutants harboring mutations in transcriptional regulatory genes in Ipomoea species. Molecular analyses showed that the phenotypic defect in both flower and seed pigmentation is caused by insertion of DNA-type transposons into the IVS gene, which encodes a basic helix-loop-helix (bHLH) protein and is homologous to Arabidopsis transparent testa 8 and petunia anthocyanin 1 that regulate various plant epidermal traits containing flower and seed pigmentation. KK-1 and W-4 carry the ivs mutable 1 (ivs-m1) and the ivs stable (ivs-stb) alleles, respectively, and accumulation of the IVS gene transcripts in both alleles seems to be largely reduced by insertion of transposons into exon regions. In addition to the transposon insertions, 26 and 165 DNA sequence alteration in exon and intron regions, respectively, could be detected between two alleles, ivs-m1 and ivs-stb, which results in difference of 14 amino acids predicted in coding region. This suggests that the ivs-m1 and ivs-stb alleles seem to have different ecological history each other.