Effect of Post-Baking Treatment Conditions on the Interfacial Adhesion Energy between Electroless-Plated Ni and Polyimide Films

민경진,박성철,이규환,정용수,박영배 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.3

The effects of post-baking treatment conditions on the interfacial adhesion energy between electroless-plated Ni and polyimide film were systemically analyzed by using a 180˚ peel test. The measured peel strength monotonically decreased from 38.6±0.5 g/mm to 26.8±1.1 g/mm for post-baking treatment temperatures from 80℃ to 180℃. Wet chemical pretreatment of the poly- imide surface produced not only pinholes but also carboxyl and amide functional groups, which are closely related to the interfacial bonding mechanism between electroless-plated Ni and polyimide films. The peel strength seemed to be controlled by carbonyl oxygen bonding near the cohesive failure region during the post-baking treatment.

Clinical guideline for 9-valent HPV vaccine: Korean Society of Gynecologic Oncology Guideline

민경진,권상훈,김기동,김성훈,김현정,성석주,송용중,이근호,이신화,이정원,장석준,주웅,김영탁,이재관 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2

In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy of 9-valent HPV vaccine, the ideal age of 3-dose schedule vaccination, the efficacy of 9-valent HPV vaccine in middle-aged women, the efficacy of the 2-dose schedule vaccination, the safety of 9-valent HPV vaccine, the possibility of additional 9-valent HPV vaccination, and crossvaccination of 9-valent HPV vaccine. So, Korean Society of Gynecologic Oncology (KSGO) developed a guideline only for 9-valent HPV vaccine.

Desmear 습식 표면 전처리가 무전해 도금된 Cu 박막과 FR-4 기판 사이의 계면 접착 기구에 미치는 영향

민경진,박영배,Min, Kyoung-Jin,Park, Young-Bae 한국재료학회 2009 한국재료학회지 Vol.19 No.11

Embedding of active devices in a printed circuit board has increasingly been adopted as a future electronic technology due to its promotion of high density, high speed and high performance. One responsible technology is to embedded active device into a dielectric substrate with a build-up process, for example a chipin-substrate (CiS) structure. In this study, desmear treatment was performed before Cu metallization on an FR-4 surface in order to improve interfacial adhesion between electroless-plated Cu and FR-4 substrate in Cu via structures in CiS systems. Surface analyses using atomic force microscopy and x-ray photoemission spectroscopy were systematically performed to understand the fundamental adhesion mechanism; results were correlated with peel strength measured by a 90o peel test. Interfacial bonding mechanism between electrolessplated Cu and FR-4 substrate seems to be dominated by a chemical bonding effect resulting from the selective activation of chemical bonding between carbon and oxygen through a rearrangement of C-C bonding rather than from a mechanical interlocking effect. In fact, desmear wet treatment could result in extensive degradation of FR-4 cohesive strength when compared to dry surface-treated Cu/FR-4 structures.

역대기저자가 에스라-느헤미야서도 썼는가?

민경진 부산장신대학교 2002 부산장신논총 Vol.2 No.-

Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate

민경진,권택규 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.1

Epigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea. EGCG exhibits a variety of activities, including anti-inflammatory, antidiabetes, antiobesity, and antitumor. In this review, we focus on the antitumor effects of EGCG. EGCG inhibits carcinogen activity, tumorigenesis, proliferation, and angiogenesis, and induces cell death. These effects are associated with modulation of reactive oxygen species (ROS) production. Although EGCG has a dual function of antioxidant and pro-oxidant potential, EGCG-mediated modulation of ROS production is reported to be responsible for its anticancer effects. The EGCG-mediated inhibition of nuclear factor-κB signaling is also associated with inhibition of migration, angiogenesis, and cell viability. Activation of mitogen-activated protein kinases activity upregulates the anticancer effect of EGCG on migration, invasion, and apoptosis. In addition, EGCG could also induce epigenetic modification by inhibition of DNA methyltransferase activity and regulation of acetylation on histone, leading to an upregulation of apoptosis. Although EGCG promotes strong anticancer effects by multiple mechanisms, further studies are needed to define the use of EGCG in clinical treatment.

물 중에서 일부 농약의 생분해성에 관한 연구

민경진,차춘근 한국식품위생안전성학회 2001 한국식품위생안전성학회지 Vol.16 No.2

The present study was conducted to investigate biological degradability of phosphamidon and profenofos. In the biodegradation test of two pesticides by the modified river die-away method from May 20 to July 29, 1999, the biodegradation rate was determined in Nakdong (A) and Kumho(B) River. The residual percentages of phosphamidon were 74.9%, 68.8% and 62.7% in control, A and B samples 7 days after application, respectively. Biodegradation constants and half-lives of phosphamidon were 0.0005 and 58.6 days in A, 0.0012 and 23.8 days in B, respectively. The residual percentages of profenofos were 25.1%, 21.9% and 11.9% in cotrol, A and B samples 7 days after application. Biodegradation constants and half-lives of profenofos were 0.0005 and 58.4 days in A, 0.0013 and 21.6 days in B, respectively. The biodegradation rates of phosphamidon and profenofos were higher in the Kumho River(B) than in the Nackdong River(A). The strains of microorganisms for the degradation of phosphamidon and profenofos were identified as Klebsiella pneumoniae, Aeromonas hydrophila and Acinetobacter calcoaceticus, all Gram-negative bacteria. In order to identify biodegradate products, the extracts of cultivates were analyzed by GC/MS. The mass spectra of biodegradate products of phosphamidon were at m/z 153 and 149, those of the profenofos were at m/z 208 and 240, respectively. It was suggested that the biodegradate metabolites of phosphamidon were O, O-dimethyl phosphate (DMP) and N, N-diethylchloroacetamide, those of profenofos were 4-bromo-2-chlorophenol and O-ethyl-S-propyl phosphate.

급성 충수염으로 진단된 예측 불가 염증성 맹장 종물에 대한 외과적 고찰

민경진,백무준,채만규,김성용,이문수,김창호,김재준,송옥평 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: An unexpected inflammatory cecal mass of uncertain etiology was encountered during surgery for presumed appendicitis. In this case, the surgeon couldn't exclude differential diagnosis which were severe appendicitis involving the cecal region, diverticular disease, other inflammatory bowel diseases, and neoplasm. Therefore, this finding leads to a therapeutic dilemma for the surgeon, when making surgical decisions during the operation. The aim of this study was to resolve this dilemma, a retrospective review was undertaken in this study. Methods: A retrospective study was performed to review the management of this problem at Soonchunhyang University Chunan Hospital for eight and half years from July 1991 to December 1999. A review of the emergency operation records identified 50 patients who had undergone ileocecal resection or right hemicolectomy for an inflammatory ileocecal mass of uncertain etiology when operated on for probable appendicitis. Results: Altogether, 39 patients underwent ileocecal resection, and 11 patients underwent right hemicolectomy. The final pathologic diagnosis was appendiceal abscess in 32 patients (63%), cecal diverticulitis in 7 patients (14%), neoplasm in 6 patients (12%), appendiceal phlegmon in 3 patients (6%), ileal tuberculosis in 1 patient (2%) and Anisakiasis in another patient (2%). The neoplasm of the 6 neoplasm patients was ascending colon cancer for 4 patients and cecal cancer for 2 patients. There was no mortality in this group. Conclusion: Although most inflammatory cecal masses are caused by benign disease, all cases in which the intraoperative diagnosis is unclear, any pathologic diagnosis including neoplasm cannot be ruled out. So this suggest ileocecal resection or right hemicolectomy to remove a possible underlying malignancy, and to decrease morbidity and mortality.

Flexible PCB용 무전해 도금 Ni 박막/Polyimide 계면파괴에너지 평가

민경진,박성철,이지정,이규환,이건환,박영배,Min, Kyoung-Jin,Park, Sung-Cheol,Lee, Jee-Jeong,Lee, Kyu-Hwan,Lee, Gun-Hwan,Park, Young-Bae 한국마이크로전자및패키징학회 2007 마이크로전자 및 패키징학회지 Vol.14 No.1

폴리이미드 표면에 대한 습식 개질 전처리 조건에 따른 폴리이미드와 무전해 도금 Ni 박막사이의 계면파괴에너지를 $180^{\circ}$ 필 테스트를 통해 정량적으로 구하였다. KOH 처리시간이 1분인 경우 계면파괴에너지는 24.5 g/mm에서 5분 처리 시 33.3g/mm로 증가하였고, EDA처리 시간이 1분인 경우 31.6 g/mm에서, 5분 처리 시 22.3g/mm로 저하되었다. 이러한 습식 개질전처리 조건에 따른 폴리이미드 표면 거칠기 변화는 매우 작아서, 기계적 고착 효과는 계면파괴에너지 변화에 기여하지 못했음을 알 수 있다. KOH는 carboxyl기, EDA는 amine기를 폴리이미드 표면에 형성시켜 Ni과 강한 화학적 결합을 이루어, 폴리이미드 내부의 cohesive 박리거동을 보였다. 습식 개질전처리 조건에 따른 계면파괴에너지의 거동은 파면 부근에 형성된 O=C-O 결합과 매우 밀접한 연관성이 있는 것으로 판단된다. It is investigated how KOH and Rthylenediamine(EDA) treatment conditions on Polyimide film surface affect the interfacial fracture energy between electroless plated Ni and Polyimide film by $180^{\circ}$ peel test. Estimated values of interfacial fracture energy were 24.5 g/mm and 33.3 g/mm for the KOH treatment times under 1 and 5 minutes, respectively, while, those were 31.6 g/mm and 22.3 g/mm for EDA treatment times under 1 and 5 minutes, respectively. Interfacial bonding between electroless plated Ni and Polyimide seems to be dominated by chemical bonding effect rather than mechanical interlocking effect. It is found that chemical treatment produces carboxyl and mine functional groups which are closely related the interfacial bonding mechanism. Finally, it is speculated that interfacial fracture energy seems to be controlled by O=C-O bonding near cohesive failure region.

흰쥐를 이용한 Methidathion의 경구투여 및 피부도포 후 뇨 중 대사물질 측정

민경진,김화선,차춘근 한국식품위생안전성학회 2003 한국식품위생안전성학회지 Vol.18 No.3

Methidathion을 흰쥐에 경구투여 및 피부도포 후 뇨 중 대사물질을 GC/MS로 분석하였고, 투여경로에 따른 뇨 중 대사물질의 차이를 비교하였으며, 뇨 중 dialkyl phosphate의 시간별 배설량과 그 외 대사물질을 측정하여 다음과 같은 결과를 얻었다. Methidathion을 경구 투여 및 피부도포 후 뇨 중 대사물질을 측정한 결과 유기인계 농약의 공통적이 대사물질인 dialkyl phosphates 중 세 가지 물질인 DMP, DMTP 및 DMDTP로 동일하게 배설되었다. GC/MS로 주요조간이온을 확인한 결과 DMP는 m/z=153,127, 109, DMTP는 m/z=198, 169, 142, 109 그리고, DMDTP는 m/z=158, 125, 93에서 분자이온을 확인할 수 있었다. Methidathion을 경구투여 및 피부도포 후 뇨 중 dialkyl phosphates의 시간별 배설량을 측정한 결과 경구투여의 경우 DMP는 12시간 이내에 79.2%, DMTP는 24시간 이내에 93.3% 그리고, DMDTP는 12시간 이내에 83.0%가 배설되었고, 피부도포의 경우 DMP는 24시간 이내에 71.1%, DMTP와 DMDTP는 48시간 이내에 각각 82.8%, 87.7%가 배설되었다. 이 결과 경구투여 한 실험에서는 48시간 이내에 뇨 중 dialkyl phosphates가 완전히 배설되는 반면 피부도포 한 실험에서는 각 개체의 상태에 따라 대사물질들이 늦게는 168시간까지 배설이 지연됨을 알 수 있었다. 이상의 결과를 종합하면, 흰쥐에 methidathion을 경구투여 및 피부도포 후 뇨 중 대사물질을 측정한 결과 dialkyl phosphate 중 DMP, DMTP 및 DMDTP로 검출되었으며, 경구투여와 피부도포 시 뇨 중 etkanfwlf의 차이는 없었으나, 경구투여보다 피부도포의 경우 배설이 더 지연되었다. 결론적으로, methidathion의 뇨 중 대사물질인 DMP, DMTP 및 DMDTP는 이 농약의 생체모니터링 지표물질로서 사용될 수 있을 것으로 생각된다. This study was performed to determine the urinary metabolites of methidathion in rats. Urine samples were collected for 24 hours in metabolic cages following after oral administration and dermal application of methidathion to rats. The urinary methabolites were identified by GC/MS and the excretion time courses of urinary dialkyl phosphate metabolites were analyzed by GC/FPD. The result obtained are summarized as follows: Three dialkyl phosphate metabolites, DMP, DMTP, and DMDTP, were detected in the rat urine. Urinary dialkyl phosphate metabolites were identified on the basis of their mass spectra by GC/MS. The molecular ions of DMP, DMTP, and DMDTP, were identified at m/z 153, m/z 198, and m/z 158, respectively. A comparison of excretion time courses of urinary dialkyl phosphate metabolites between the orally administrated and dermally applicated rats were also established. After oral administration, 79.2% of DMP, 93.3% DMTP, and 83.0% DMDTP were excreted into the urine by 12, 24, and 12 hours, respectively. After dermal application, 71.1% of DMP, 82.8% of DMTP, 87.7% of DMDTP were excreted into the urine by 24, 48, 48 hours, respectively. Consequently, almost all of the dialkyl phosphates in oral administration were excreted within 48 hours. However, the metabolites in dermal application were excreted up to 168 hours. In this study, three urinary metabolites of methidathion, DMP, DMTP and DMDTP, were detected in the rat both after oral administration and dermal application with methidation. And the urinary excretion in dermal application was more delayed than that in oral administration. Based on the results, it is suggested that three urinary dialkyl phosphates, DMP, DMTP, and DMDTP, could be used as the biomarkers of exposure for methidation.

Invasive Squamous cell carcinoma of Vagina with Cerebellar Metastasis

민경진,오영택,소경아,이상훈,김재원,홍진화,송재윤,이낙우,이재관 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Primary vaginal cancer is an uncommon tumor, representing only 1% to 2% of malignant neoplasms of the female genital tract. Due to early diagnosis and technical advances of brachytherapy in radiotherapy, the outcome for patients has improved over the past several decades. Distant metastases occur most commonly to lungs and liver. We describe a case of a 72-year-old woman with an invasive vaginal squamous carcinoma, who underwent chemo-radiation initially. Initially, there was no evidence of distant metastasis. However, the patient exhibited nausea, vomiting, slurred speech, and dizziness for several days at 1-year follow-up. Brain MRI was performed to check the lesion, and the suspected metastases were found in right cerebellum. Multiple lung metastases were found in chest x-ray. Conservative management was executed due to the patient`s poor general condition, such as Karnofsky performance status scale (KPS) 50, and refusal to treatment. Cerebellar metastasis should be considered in patients with neurological symptoms despite its rareness in vaginal carcinoma. Patients with multiple brain metastases and poor performance status as in our patient may not benefit from any type of therapy. The treatment plan for CNS metastases should be made on an individual basis, with careful consideration of the ultimate purpose of the treatment.