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급성(急性) 신부전(腎不全)이 동반(同伴)된 근양사(筋壤死)에 있어서의 $^{99m}Tc$-MDP 골주사(骨走査)
문희범,한진석,김삼용,조보연,이정상,고창순,조경삼,Moon, H.B.,Han, J.S.,Kim, S.Y.,Cho, B.Y.,Lee, J.S.,Koh, C.S.,Cho, K.S. 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2
We studied four patients with muscle necrosis associated with acute renal failure to evaluate the diagnostic value of the bone scan in this disease. The illness followed carbon monoxide poisoning in two patients, acute physical exertion in one and contaminated intramuscular injection in the other. Whole-body rectilinear bone scans using technetium 99m-methyldiphosphonate were done. In all patients, increased muscle labelling at the regions of suspected muscle injury was showed, and in one, it was after normalization of serum muscle enzyme levels. In one patient, the bone scan was rechecked 8 months later and showed no residual abnormality. Above all, the site and precise extent of muscle injury could be detected and the degree of muscle labelling seemed to correlate with the severy of muscle injury. These findings suggest that isotope scanning may be useful in the diagnosis of patients with acute muscle necrosis.
마우스 B세포에서의 Interleukin 4에 의한 IgGI 및 IgE 생산조절에 관한 연구
문희범 대한천식알레르기학회 1991 천식 및 알레르기 Vol.11 No.5
Mouse interleukin 1(IL-4) is a T cell-produced lymphokine with multiple effects on different cell types of the hematopoietic lineages. IL-4 has pronounced effects on B lymphocytes, where it induces high levels of IgG1 and IgE secretion in lipopolysaccharide (LPS)-stimulated cultures that would otherwise secrete predominantly IgG3 and IgG2b. An important question which been adked is how IL-4 exerts its effect. Two main possibilities exist; (a) 1L-4 instructs uncommitted B lymphocytes to produce IgG1 and IgE; (b) IL-4 selects and expands an already precommitted B cell. In this study, the limiting dilution analysis showed that IL-4 dramatically increased the precursor frequency of IgG1 and IgE-secreting cells with no significant effect on the clone size, and it clearly suggested that IL-4 instructs uncommitted B cells to switch to IgG1 and IgE. The characteristics of IL-4-regulated Ig isotype production in LPS-stimulated splenic B cell cultures also were studied with emphasis on the comparison between the IgG1 and IgE responses. The results showed that the kinetics for the appearance of IgG1 and IgE isotypes was similar, but the dose of IL-4 required for the induction of an IgE response is 3 to 10 times higher than that for an IgG1 response. No requircment for T cells was found for the induction of either isotype IL-4 alone was sufficient to induce an IgG1 response when cells were recultured with LPS from day 1 to day 6. However, the simultaneous presence of both IL-4 and LPS for more than 24 hours was required for a detectable IgE response. For an optimal IgE response, IL-4 needed to be present for more than 72 hours in LPS-activated cultures. The possible reasons for the,different regulation of IgG1 and IgE responses are discussed.