토끼 고유간동맥에 주입한 Adriamycin과 Cisplatin-Lipiodol 유상액에 의한 간손상에 관한 연구

문태용,이석홍,심문섭,조몽,김창원,김석,문태용,이석홍,심문섭 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.31 No.1

$^{99m}$Tc-MDP 골스캔상 다발성 골전이암의 Batson's Plexus 분포

문태용,이석홍,김병수,정현우,허진도,이영일,박병호,이영준,은충기 대한영상의학회 1998 대한영상의학회지 Vol.39 No.2

간동맥화학색전술로 치료한 간세포암 환자의 생존율 : 수술가능군과 수술불가능군의 비교

문태용 대한영상의학회 1998 대한영상의학회지 Vol.38 No.4

Purpose: To predict the prognosis of hepatocellular carcinoma (HCC) patients who underwent transarterial chemoembolization (TACE). Materials and Methods: The study unvestigated the one- and two-year survival rates of 211patients who were divided into two groups : 74 operable Child's grade A or B cases, and 137 inoperable cases involving Child's grade C or poor prognostic factors such as metastasis, main portal thrombus, and total bilirubin above 2.0mg/dl. Cumulative survival curves were obtained by the Kaplan-Meier method, beginning with the day of the first TACE. Results: The one- and two-year cummulative survival rates were 80.8% and 47.9% for the 74 operable cases and 37.6% and 14.0% for the 137 inoperable cases, respectively(p<0.01). Conclusion: The prognosis of HCC patients who underwent TACE can be predicted by classifying then into two groups, operable or inoperable cases.

면류용 알칼리제 처리가 건면의 조리특성에 미치는 영향

문태용,이성갑 한국기술사회 2000 技術士 Vol.33 No.3

The effects of alkali salts adding on the cooking quality improving in dried noodles were investigated in the good texture maintaining for preventing solid soluble losses ,through chemical analysis and actual manufacturing practice ,the following results were obtained. Experiments were took a special flour of ASW:DNS=70:30, thickening agent(TA) composed of K2CO3 58%, Na2CO3 36% and Na4P2076%, and emulsified oil(EO) mixing of corn oil 44%, polysorbate 23%, emulsifier(ester of glycerin and fatty acids) 21%, soy lecithin 12%. When the mixing ratio of TA and EO to flour, is 0.03 and 1.5%(w/w) or morel than, satisfied the good quality. The water soluble solid matters content of the lowest 3.2% in the treating group that TA and EO is 0.03 and 1.5%(w/w) respectively, comparing to the 7.3% in the control group provides a excellent cooking quality. The research achieves the similar effects at specific gravity, water absorption ratio, weight increasing rate and volume expansion ratio. According to appearance test the more treating of TA turn the noodle into deeper yellow-green color. Turning to the deeper yellow color according to the increasing of EO provides better

토끼 고유간동맥에 주입한 Lipiodol 독성에 관한 실험적 연구

문태용 대한영상의학회 1990 대한영상의학회지 Vol.26 No.3

Lipiodol is iodized ethyl esters of the fatty acids of poppy-seed oil, and has recently been used as a mediator in combination with anticancer drugs or tagging with radioiodine to treat hepatocellular carcinoma because of higher concentration in tumor tissue compared to normal liver tissue. Author assessed toxic effects and lethal dose of Lipiodol when injected directly into the proper hepatic artery(PHA) of New Zealand white rabbits. 38 rabbits with normal liver function(SGOT <50 K.U., total bilirubin <0.1mg/㎗) were divided into one control and three experimental groups according to a dosage of Lipiodol into PHA such as A group (10 rabbits) having as control, B group(10 rabbits) having as 0.15$m\ell$/kg of Lipiodol comparable to the average dose to have used as mediator to treat human hepatocellular carcinoma, C group (12 rabbits) having as 1.58$m\ell$/kg of Lipiodol comparable to the average lethal dose of ethiodol to dogs following intravenous injection and D group(6 rabbits) having as lethal dose to be given Lipiodol injection into PHA to death. And A, B, C groups were also subdivided into two groups such as group 1 with no ligation of PHA and group 2 with ligation of PHA after Lipiodol injection respectively. All rabbits were examined the liver function tests, radiographs and CT, and in D group, serial radiographs were taken to evaluate the spreading of Lipiodol. All rabbits except C2 and D groups were sacrificed 6 hours, 24 hours, 5 days, 15 days and 30 days, and then the liver, lungs and kidneys were removed for histologic examination. The results were as follows : 1. The average lethal dose of Lipiodol administered into PHA of white rabbits was 5.44 $m\ell$/kg, and the cause of death was pulmonary Lipiodol embolism. 2. The mean survival time of rabbits administered in a dose of 1.58 $m\ell$/kg of Lipiodol injection followed by PHA ligation was 25.3 hours, and the cause of death was hepatic failure due to hepatocellular necrosis. 3. On liver function tests, SGOT and t tal bilirubin in group C, and total bilirubin in group 2 were elevfated. 4. Lipiodol injected into PHA induced hepatocellular necrosis and inflammatory reaction of the liver(54.5%, chronic inflammatory reaction of the lungs(36.4%) and glomerular and proximal tubular cell necrosis of the kidneys(50.0%) in both B and C groups. There are concluded that Lipiodol injected into PHA can migrate to systemic circulation, and induce tissue damages of the liver, lungs and kidneys. 1.58 $m\ell$/kg of Lipiodol injected into PHA followed by PHA ligation can induce hepatic failure due to hepatocellular necrosis and 5.44 $m\ell$/kg of Lipiodol injected into PHA can cause death due to pulmonary Lipiodol embolism.

저혈관성과 고혈관성이 동시에 있는 간세포암 1례 보고

문태용,이석홍,이준우,김창원 釜山醫師會 2001 釜山醫師會誌 Vol.37 No.7

간동맥화학색전술후 발생한 화농성농양의 배액술로 치료된 간세포암

문태용,박병호,김창원,지삼룡 釜山醫師會 2001 釜山醫師會誌 Vol.37 No.6

골격계 육종에서 관상골MR과 편평골CT의 유용성

문태용,이영준,정경화,허진도,설미영,권운정,Moon, Tae-Yong,Lee, Young-Joon,Jung, Kyung-Hwa,Hur, Jin-Do,Sol, Mi-Young,Kwon, Woon-Jung 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

목적: 골격을 침해하는 원발성 악성종양으로는 골육종이나 연골육종 같은 간엽성육종과 유윙육종이나 림프종 같은 소원형세포성육종으로 나눈다. 골격육종을 진단하기 위해 관상골 육종은 MR검사를 편평골 육종은 CT검사를 주로 이용한다. MR과 CT는 공히 골파괴병소와 연조직종괴를 잘 나타내지만 무기질침착은 MR에서 식별되기 어렵다. 이에 본저자들은 관상골 MR과 편평골 CT검사의 골파괴 소견으로 간엽성육종과 소원형세포성육종을 감별하고자 하였다. 대상 및 방법: 수술적 조직생검술에 의한 병리조직학적으로 진단되고 관상골 MR 또는 편평골 CT검사를 시행했던 간엽성육종 28례와 소원형세포성육종 26례를 대상으로 하였다. 관상골 MR검사 26례와 편평골CT검사 28례에서 골파괴 병소 소견을 각각 편심성과 중심성으로 나누어 비교 분석하였다. 결과: 관상골 MR검사에서 간엽성육종 16례중 12례(75.0%)가 편심성 골파괴 소견이였고 소원형세포육종 10례는 전례(100.0%)가 중심성 골파괴 소견이었다(p>.01). 편평골 CT검사에서 간엽성육종 12례중 10례(83.3%)에서 편심성 골파괴 소견이었고 소원형세포성육종 16례중 13례(81.3%)가 중심성 골파괴 소견을 보였다(p>.01). 결론: 관상골 MR검사든 편평골 CT검사든 골파괴 양상을 중심성과 편심성으로 나누는 방사선학적 소견은 간엽성육종과 소원형세포성육종을 감별 진단하는데 도움이 되는 소견이었다. Purpose: Primary malignant bone tumors are classified with mesenchymal sarcomas (MS) such as osteosarcoma and chondrosarcoma and small round cell sarcomas (SRS) such as Ewing's sarcoma and lymphoma. Radiological examinations for skeletal sarcoma were using MR scan in tubular bone sarcomas and CT scan in flat bone sarcomas recently. Both MR and CT scans show some findings of bone destruction and soft tissue mass but MR scans don't reveal a finding with mineralization relatively. So we investigated bone destructive pattern of skeletal sarcomas on both MR and CT scans for differentiation of MS and SRS. Materials and Methods: There are 28 MS and 26 SRS examined with MR or CT scans. The findings according to bone destructive pattern were divided to eccentric and concentric in 26 cases of tubular bone sarcomas with MR scan and 28 cases of flat bone sarcomas with CT scan. Results: MR images revealed eccentric destruction in 12 cases of 16 MS and concentric in all cases of 10 SRS (p>.01). CT images showed eccentric destruction in 10 cases of 12 MS and concentric bone destruction in 13 cases of 16 SRS (p>.01) Conclusion: The findings divided to eccentric and concentric bone destructive patterns were useful for differential diagnosis of MS from SRS on both MR and CT scans.

간동맥화학색전술을 이용한 시스플라틴의 간암 재발성 억제효과 : 아드리아마이신 유상액 단독군과 시스플라틴 아드리아마이신 복합군의 비교

문태용 대한영상의학회 1997 대한영상의학회지 Vol.37 No.5

Purpose : To compare the suppressive effects in hepatocellular carcinoma patients of transhepatic arterialchemoembolization by the infusion of adriamycin-lipiodol emulsion and of this plus 10ml of cisplatin solution.Materials and Methods : In a total of 151 cases, the frequency of intrahepatic recurrence was compared withfollow-up angiographic findings after the first and second transhepatic arterial chemoembolization withadriamycin-lipiodol emulsion and adriamycin-lipiodol emulsion plus 10ml of cisplatin solution, respectively.Results : Among 46 patients whose first single infusion was after mean 119 days, the recurrence rate was 22% ; for42 who were given their first multiple infusion after mean 76 days this rate was 5% ; for 35 whose second singleinfusion was administered after mean 147 days, the rate was 34%, and among 28 whose second multiple infusion wasafter mean 110 days, the rate was 43%. Conclusion : During the first trial of transcatheter arterialchemoembolization with adriamycin-lipiodol plus cisplatin solution, hepatocellular carcinoma recurred much lessfrequently, but during the second trial with cisplatin, recurrence was not suppresed.

늑간동맥을 통한 간세포암 화학색전술로 발생한 일과성척수손상 1예

문태용 대한영상의학회 1994 대한영상의학회지 Vol.31 No.1