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문찬희,김소영,Chan Hee Moon,MD,So Young Kim,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.7
Purpose: To report a case of ocular myasthenia gravis in conjunction with thyroid-associated ophthalmopathy in a patient who showed incomitant strabismus and blepharoptosis as well as to discuss the clinical features and tests that may help distinguish these 2 diseases. Case summary: A 46-year-old man without any previous history of systemic and ophthalmic disease presented with binocular diplopia that occured a month earlier. The patient had no other systemic symptoms except a 7 kg weight loss within the last month. The patient was referred to the department of internal medicine and brain magnetic resonance imaging was performed to ascertain the cause of suspected left superior oblique muscle palsy. The patient was diagnosed with Graves’ disease and underwent medical treatment. One month later, the patient presented with consistent diplopia and exophthalmos and showed a swelling of eyelid and ptosis in the right eye. Intravenous high-dose steroid therapy was administered to the patient. After the treatment, symptoms of diplopia and lid swelling were improved, however ptosis persisted. Ocular myasthenia gravis was suspected and various tests were conducted. Anti-acetylcholine receptor antibodies were detected in large amounts and ptosis was improved dramatically by an administration of an anticholinesterase agent. The patient was diagnosed with ocular myasthenia gravis in conjunction with thyroid-associated ophthalmopathy. Conclusions: Ocular myasthenia gravis should be suspected in patients with thyroid-associated ophthalmopathy who have signs or symptoms of ptosis. J Korean Ophthalmol Soc 2012;53(7):1057-1061
Secondary flow mixing of neutralizing reagent induced by U-bent de-ballast pipes
문찬희,김현동,김경천 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.5
This study proposes a secondary flow mixer for neutralizing reagent in a de-ballast pipe. Because the proposed mixer has a U-bent pipe configuration, it can be fabricated using commercially available pipe parts at low cost. Numerical simulations were conducted with four computational domains: one straight pipe (SP) and three U-bent pipes. The normalized coefficient of variation (CoV/CoV 0 ) values of the U-bent pipe outlet for UP1, UP2 and UP3 were 0.096, 0.036 and 0.015 (90.4 %, 96.4 % and 98.5 % degree of mixing, respectively). Instability was observed in the secondary flow motion because of the continuous curvature change of the U-bent pipe series and the density difference between mixing fluids. This instability enhances the mixing performance. Despite the high mixing quality, the Ubent pipe mixer caused a pressure drop of 0.5-2.1 % compared to the backpressure of a ballast water treatment system.
문찬희,최경식,이미리,이성진,Chan Hee Moon,Kyung Seek Choi,Mi Ri Rhee,Sung Jin Lee 대한안과학회 2013 대한안과학회지 Vol.54 No.1
Purpose: To assess the influence of body position on intraocular pressure (IOP) in patients who underwent vitrectomy and intraocular gas tamponade. Methods: Patients who did not undergo any surgery were defined as Group 1. The remaining patients were divided into 3 groups according to the surgery performed (Group 2; cataract surgery, Group 3; vitrectomy and cataract surgery, Group 4; vitrectomy with intraocular gas tamponade and cataract surgery). IOP was measured by a non-contact tonometer, Goldmann applanation tonometer, and Tono-Pen in the sitting, supine, and prone positions. Results: The difference of IOP measured in the sitting position among the 4 groups was not significant. IOP was significantly elevated by 2.04 mm Hg on average when the posture was changed from sitting to supine or prone in all 4 groups. The IOP discrepancy between supine and sitting positions was significantly greater in group 4 by 3.61 mm Hg than the other groups (p = 0.003, ANOVA test). The IOP difference between the prone and sitting position was also significantly higher in group 4 by 3.82 mm Hg than the other groups (p = 0.001, ANOVA test). Conclusions: The patients with vitrectomized gas tamponade eyes had a mean IOP increase of 3.82 mm Hg when the position was changed from sitting to prone. When performing vitrectomy and intraocular gas tamponade on patients in the prone position, an IOP elevation should be monitored thoroughly.
Nestin Expression in the Adult Mouse Retina with Pharmaceutically Induced Retinal Degeneration
문찬희,조희윤,김윤경,박태관 대한의학회 2017 Journal of Korean medical science Vol.32 No.2
The present study investigated the temporal pattern and cellular localization of nestin in the adult mouse retina with pharmaceutically induced retinal degeneration using N-methyl-N-nitrosourea (MNU). After a single intraperitoneal injection of MNU in 8-week-old C57BL/6 mice, the animals were sacrificed at 1, 3, 5, 7, and 21 days (n = 6, in each stage). The eyes were examined by means of immunohistochemical tests using nestin, ionized calcium-binding adaptor molecule (Iba-1), CD11b, F4/80, and glial fibrillary acidic protein (GFAP). Western blot analysis and manual cell counting were performed for quantification. Nestin expression was increased after MNU administration. Nestin+/Iba-1+ cells were migrated into outer nuclear layer (ONL) and peaked at day 3 post injection (PI). Nestin+/CD11b+ cells were also mainly identified in ONL at day 3 PI and peaked at day 5. Nestin+/F4/80+ cells were shown in the subretinal space and peaked at day 3 PI. Nestin+/GFAP+ cells were distinctly increased at day 1 PI and peaked at day 5 PI. The up-regulation of nestin expression after MNU administration in adult mouse retinal microglia, and monocyte/macrophage suggests that when retinal degeneration progresses, these cells may revert to a more developmentally immature state. Müller cells also showed reactive gliosis and differentiational changes.
시야 결손이 있는 뇌하수체샘종 환자에서 수술 후 시야 변화
문찬희,황선철,박태관,Chan Hee Moon,Sun Chul Hwang,Tae Kwann Park 대한안과학회 2011 대한안과학회지 Vol.52 No.6
Purpose: To evaluate visual field (VF) changes in patients with pituitary adenoma after surgical treatment. Methods: The present study retrospectively evaluated 96 eyes of 48 patients with pituitary adenoma who received surgical tumor removal between July 2001 and February 2010. Preoperative and postoperative clinical data including age, tumor volume, logMAR BCVA, surgical technique (transsphenoidal surgery and transcranial surgery), static perimetry scores (mean deviation [MD], pattern standard deviation [PSD], and visual field defect [VFD] scores) were reviewed. Results: The MD (15.79%, p = 0.001) and PSD (3.98%, p = 0.003) improved postoperatively (mean postoperative follow- up period 1.85 months). Transsphenoidal surgery for tumor removal showed significant MD (26.99%, p = 0.000) and PSD (12.92%, p = 0.003) improvements. A multivariate regression analysis of the transsphenoidal surgery patient group revealed that the preoperative MD was related to the postoperative MD (Pearson = 0.762, p = 0.000), but negatively correlated to the amount of postoperative improvement in MD score (Pearson = -0.231, p = 0.046). Transcranial surgery did not significantly improve the MD (p = 0.419), PSD (p = 0.562), VFD score (p = 0.135), or logMAR BCVA (p = 0.708). Conclusions: Visual filed defects in patients with pituitary adenoma improved after neurosurgical treatment. Better postoperative visual field outcomes were achieved in patients who had smaller preoperative visual field defects. Transsphenoidal surgery significantly improved the visual field defects and visual acuity in patients with non-functioning pituitary adenoma, compared to the transcranial surgery patients. J Korean Ophthalmol Soc 2011;52(6):726-733
GIS 분석을 활용한 부산권 버티포트 위치 및 회랑 선정에 관한 연구
문찬희(ChanHee Moon),시하영(HaYoung Shi),구태완(TaeWan Ku),강범수(BeomSoo Kang) 항공우주시스템공학회 2023 항공우주시스템공학회지 Vol.17 No.6
도심 교통 체증과 환경오염이 중요한 대도시 문제로 부각되는 가운데, 최근에는 Urban Air Mobility(UAM)가 효율적인 대책으로 주목받고 있다. 본 연구에서는 부산 지역의 지형 및 인프라 등의 실제 데이터를 고려한 GIS 기반 공간 분석과 군집 알고리즘을 수행하였으며 이를 통해 UAM 운영을 위한 버티포트 위치와 경로를 선정할 수 있었다. 부산권 UAM 인프라 시스템의 중심으로 예상되는 김해국제공항을 기반으로, 목표 지역에서 세 개의 버티포트 위치가 적합하다 판단하였으며, 이후 지상 위험 평가(Ground Risk)를 고려한 A*(A-star) 알고리즘을 이용해 위험도와 거리를 최소화하는 비행경로를 선정하였고, 이를 통해 최소 거리 경로 대비 80.168%의 위험 감소 효과를 확인하였다. As urban traffic congestion and environmental pollution are becoming significant issues in major cities, Urban Air Mobility (UAM) is gaining attention as an efficient solution. In this study, we conducted a geographic information system (GIS)-based spatial analysis and clustering algorithm considering the actual data of the terrain and infrastructure in the Busan area, through which we were able to select the location of vertiports and corridors (flight routes) for the UAM operation. Based on the Gimhae International Airport, which is expected to be the center of the UAM infrastructure system in the Busan region, we judged that three vertiport locations in the target area were suitable. Subsequently, we used the A* (A-star) algorithm considering Ground Risk to select a flight path that minimized both risk and distance. Through this, we confirmed a risk reduction effect of 80.168% compared to the minimum distance route.