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Endoscopic Ultrasound-Guided Fine Needle Aspiration in Submucosal Lesion
문정섭 대한소화기내시경학회 2012 Clinical Endoscopy Vol.45 No.2
A submucosal lesion, more appropriately a subepithelial lesion, is hard to diagnose. Endoscopic ultrasonography is good to differentiate the nature of submucosal lesion. For definite diagnosis, tissue acquisition from submucosal lesion is necessary, and many methods have been introduced for this purpose mainly by endoscopic ultrasonography, such as endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), EUS-guided Trucut Biopsy (TCB), and EUS-guided fine needle biopsy (FNB). For EUS-FNA, adequate processing of specimen is important, and for proper diagnosis of EUS-FNA specimen, both cytologic and histologic examinations, including immunohistochemical stains, are important. All gastrointestinal stromal tumors have some degree of malignant potential, so there have been a lot of efforts and methods to increase diagnostic yields of submucosal lesion. We herein review the current hot topics on EUS-FNA for submucosal tumor, such as needles, on-site cytopathologists, immunohistochemical stains, EUS-TCB, EUS-FNB, Ki-67 labelling index, DOG1, and combining EUS-FNA and EUS-TCB.
고추냉이 밭재배에서 근경의 상품성 향상을 위한 재배체계
문정섭,장영직,최동칠,최정식,김형무,최영근 韓國藥用作物學會 2004 한국약용작물학회지 Vol.12 No.6
고추냉이 밭재배에서 강판에 갈아 생식할 수 있는 근경을 생산하는 작부체계를 개발하기 위해 중산간부 지역인 전북 진안군에서 12개월과 7개월간 묘를 육묘하였다. 육묘된 묘는 평야부인 전북 익산지역에 9월 하순에 이식되어 이듬해 5월에 근경수량을 조사하였다. 중산간부에서 7개월간 육묘한 묘에서 근경장 5cm 이상, 근경중 40 g 이상의 상품성 있는 근경이 13.0%의 비율로 생산되었고 72.9 kg/10a의 수량성을 보였으며 근경의 allylNCS 함량도 0.7771 mg/g으로 18개월간 물재배된 근경과 대등한 함량을 보였다. Wasabis (Wasabia japonica Matsum.) have been used as a spice with its petioles and rhizomes, but the production of its rhizomes in upland cultivation was very difficult for the severe damage of rotting disease during summer season. This experiment was carried out to increase the yield of marketable rhizome in wasabi when cultured in upland. Seedlings were raised in sub-alpine area for 7 and 12 months and then transplanted to experimental area on Sept. 20 and the yield was investigated on May 12 of the next year. The marketable rhizome(above 40g/plant) was produced in seedlings raised for 7 months. Production rate of marketable rhizome was 13.3% and total yield was 72.9 kg/10a. The content of allylisothiocyanate in rhizome of upland wasabi was 0.777 mg/g and its content was equal to wasabi cultured in water condition for 18 months. These results suggested that the upland cultivation of wasabi seedlings raised in sub-alpine area for 7 months was possible to product marketable rhizome.
Screening Upper Endoscopy for Early Detection of Gastric Cancer
문정섭 대한의학회 2018 Journal of Korean medical science Vol.33 No.23
Gastric cancer (GC) incidence rate in Korea is very high (52.7 for men and 21.4 for women per 100,000, age-standardized in 2014). Symptoms in early stage of GC are minimal or nonspecific, therefore, GC is usually diagnosed by screening upper endoscopy.1 In everyday life, prevention of GC is important. The primary prevention of GC consists of Helicobacter pylori treatment and modifications of daily life habits to avoid GC development. The secondary prevention of GC consists of early diagnosis of early gastric cancer (EGC) for appropriate treatment. Knowledge of GC screening and surveillance data by literature are important for planning the secondary prevention of GC.
문정섭,유권,전영빈,정원종,양대열,이승진 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4
The granular cell tumor was first described in 1926. Recently, it has been suggested that the tumor is Schwann cell in origin, and this notion has been supported by electron microscopic studies and immunohistochemistry of the S-100 protein. The most frequently involved organs include the tongue, skin, breast, and digestive tract. The esophagus is rarely involved. The treatment of choice for an esophageal granular cell tumor is still controversial. The traditional treatment has been surgical excision, but new therapeutic options, including laser surgery, diathermy loop, and multiple biopsies have recently been tried. An endoscopic esophageal mucosal resection (EEMR) tube, originally designed for resection of early esophageal cancer, is widely used nowadays. A case of a granular cell tumor of the esophagus, which was successfully removed by an EEMR tube, is herein reported.