Endoscopic Ear Surgery: Paradigm Shift or Subordinate Role?

문일준,김성헌 대한이비인후과학회 2019 Clinical and Experimental Otorhinolaryngology Vol.12 No.2

Role of Angiogenic Factors in Airway Remodeling in an Allergic Rhinitis Murine Model

문일준,김동영,이재서,이철희,Yang-Gi Min 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.1

Purpose: There is growing evidence that nasal airway remodeling occurs in allergic rhinitis (AR). Although angiogenesis is an important component of airway remodeling in asthma, its involvement in AR has been little studied. Furthermore, information regarding the role of potent angiogenic factors, such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), in the nasal airway remodeling process is limited. This study was conducted to investigate the role of VEGF and PDGF in nasal airway remodeling, and to assess the preventive effects of anti-angiogenic drugs on this process in a murine AR model. Methods: Mice were systemically sensitized and subjected to inhalation of ovalbumin (OVA)twice a week for 3 months. Control mice were challenged with phosphate buffered saline, while the treatment group received SU1498, a VEGF receptor inhibitor, and/or AG1296, a PDGF receptor inhibitor, via intraperitoneal injection 4 hours prior to each OVA inhalation. Staining using hematoxylin and eosin, Masson’s trichrome, and periodic acid-Schiff were separately performed to assess eosinophil infiltration, subepithelial fibrosis, and goblet cell hyperplasia, respectively, in the nasal airway. Immunohistochemical staining for matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) was also conducted. Results: Repetitive intranasal inhalation of OVA resulted in significant increases in eosinophil infiltration, subepithelial fibrosis, goblet cell count, and MMP-9/TIMP-1 expression. Administration of SU1498 or AG1296 prevented these abnormal responses. Conclusions: The results of this study suggest that a causal relationship may exist between angiogenic factors and nasal airway remodeling in AR. Inhibition of VEGF or PDGF receptors may, in turn, suppress the remodeling process through the regulation of MMP-9/TIMP-1expression.

What Is Temporal Fine Structure and Why Is It Important?

문일준,홍성화 대한청각학회 2014 Journal of Audiology & Otology Vol.18 No.1

Complex sound like speech can be characterized as the sum of number of amplitude-modulated signals representing the outputs of an array of narrow frequency bands. Temporal information at the output of each band can be separated into temporal fine structure (TFS), the rapid oscillations close to the center frequency and temporal envelope (ENV), slower amplitude modulations superimposed on the TFS. TFS information can be carried in the pattern of phase locking to the stimulus waveform, while ENV by the changes in firing rate over time. The relative importance of temporal ENV and TFS information in understanding speech has been studied using various sound-processing techniques. A number of studies demonstrated that ENV cues are associated with speech recognition in quiet, while TFS cues are possibly linked to melody/pitch perception and listening to speech in a competing background. However, there are evidences that recovered ENV from TFS as well as TFS itself may be partially responsible for speech recognition. Current technologies used in cochlear implants (CI) are not efficient in delivering the TFS cues, and new attempts have been made to deliver TFS information into sound-processing strategy in CI. We herein discuss the current updated findings of TFS with a literature review.

N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

문일준,김기령,주호석,김세형,정원호 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.1

Objectives. Carboplatin, a platinum-containing anti-cancer drug used to treat a variety of cancers, induces ototoxicity. Since,reactive oxygen species (ROS) and nitric oxide (NO) seem to be responsible for this toxicity, the antioxidant, N-acetyl-L-cysteine (L-NAC), and NO synthetase inhibitor, N-nitro-L-arginine methyl ester (L-NAME) were predicted to have protective effects against carboplatin ototoxicity. The aim of this study was to test for the protective effects of LNAC and L-NAME on cochlear hair cells and spiral ganglion neurons (SGNs). Methods. Cochlear organotypic cultures and dissociated spiral ganglion neuron cultures, from mice postnatal day 5 cultures were used in this study. The cultures were treated with carboplatin alone or in combination with L-NAC or L-NAME,and carboplatin-induced damage was monitored. Results. Treatment with carboplatin induced a significant loss of outer hair cells, while inner hair cells were preserved in the cochlear organotypic cultures. Addition of L-NAC or L-NAME reduced the amount of carboplatin-induced hair cell damage; the differences did not reach statistical significance. However, carboplatin significantly decreased the number of surviving SGNs in dissociated cultures. The toxic effects were significantly reduced by addition of L-NAC or LNAME. In addition, carboplatin induced the loss of neurites from the SGN somata, and this was not blocked with LNAC or L-NAME. Conclusion. The results of this study suggest that ROS and NO are involved in carboplatin-induced damage to hair cells and SGNs, and administration of L-NAC/L-NAME can be used to attenuate the toxicity.

CaO - SiO2 - TiO2 슬랙계를 이용한 가스 / 슬랙 / 용강간 탈질반응의 평형론적 연구

문일준,송효석,김선효,이창희 대한금속재료학회 1993 대한금속재료학회 학술대회 개요집 Vol.1993 No.1

진행된 이상와암의 광범위 수직인후두부분절제술 후 요전완 유리피판을 이용한 재건술 2예

문일준(Il Joon Moon),홍성룡(Sung Lyung Hong),김시환(Si Whan Kim),안순현(Soon Hyun Ahn) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.1

Wide vertical hemilaryngopharyngectomy with immediate glottic and pharyngeal reconstruction using a radial forearm free flap is reported in 1991 by Chantrain et al. This procedure was designed for the preservation of healthy hemilarynx and resection of pharynx with safe oncological margin in especially piriform sinus cancer or supraglottic cancer invading the hypopharynx. In the original paper, they used palmaris longus tendon for reconstruction of neoglottis. In other groups, they used rib cartilage instead of palmaris longus tendon. In this paper, we report two cases of piriform sinus cancer patients who treated with wide vertical hemilaryngectomy with radial forearm free flap reconstruction. In one case, the operation was performed as Chantrain et al described. But in another case, the ipsilateral forearm was impossible due to the positive Allen's test. So the contralateral forearm flap and rib cartilage graft was done. This reconstructive technique make large resection possible. As the dissection of thyroid cartilage and lateral displacement makes direct visualization and manipulation of piriform sinus lesions, sufficient resection margin in lateral and inferior pharyngeal wall cab be obtained.

Changes in the Hearing Aid Market Due to Over-the-Counter Hearing Aids

김가영,문일준 대한이비인후과학회 2023 Clinical and Experimental Otorhinolaryngology Vol.16 No.3

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수술적 방법을 통한 어지럼의 치료

정원호,문일준 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.-

수평반고리관 양성 돌발성 두위 현훈에서누울 때 나타나는 안진의 의의

구자원,문일준,심우섭,유지연,문소영,김지수 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.12

Background and Objectives:Lateral canal benign paroxysmal positional vertigo (LC-BPPV) is characterized by horizontal direction changing nystagmus induced by lateral head turning in supine position. According to the Ewald’s second law, the direction of head turning that creates stronger response represents the affected side of geotropic nystagmus and the healthy side in apogeotropic nystagmus. However, it may not always be possible to lateralize the involved ear only by comparing the intensity of the nystagmus. We studied the values of lying-down nystagmus (LDN) in the lateralization of LC-BPPV. Subjects and Method: We performed a retrospective study of 54 patients who had been diagnosed as having LC-BPPV in Dizziness Clinic of Seoul National University Bundang Hospital from May 2003 to February 2004. The directions of the nystagmus induced by lying down were compared with those determined by the Ewald’s second law. Results:Of the 54 patients, 32 (20 apogeotropic and 12 geotropic) patients showed horizontal nystagmus induced by lying down. The nystagmus was ipsilesional in 16 (80%) apogeotropic and contralesional in 9 (75%) geotropic patients. Conclusion:In LC-BPPV, the LDN mostly beats toward the involved ear in the apogeotropic type, and directs to the healthy ear in the geotropic type. The direction of LDN may help lateralizing the involved ear in LC-BPPV.

일측성 말초전정기능 소실에서 진동유발안진의 임상적 의미

구자원,문일준,홍성룡,문소영,최광동,김지수 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.9

Background and Objectives:Vibration-induced nystagmus(VIN) may be a useful bedside sign for detecting vestibular imbalance.However, the clinical significance of VIN remains unclear. The aim of this study is to analyze the lateralizing value of VINin patients with unilateral vestibular deficit after acute vestibular functional loss. Subjects and Method:Forty patients with peripheralvestibular loss of acute etiology were included. Patients assuming fluctuating or slowly aggravating vestibular dysfunctionwere excluded. VIN was induced by applying 100 Hz vibratory stimuli to both mastoids side by side. Direction and intensity of horizontalnystagmus were analyzed by using video-oculography. Post-head shaking nystagmus(HSN), caloric test and vestibularevoked myogenic potential(VEMP) were also performed. Age matched 25 healthy volunteers were included for control. Results:Of the 40 patients, 37(92.5%) showed contralesional VIN whereas only one exhibited ipsilesional nystagmus. Two patients(2.5%)did not develop VIN. Immediate HSN was present in 31(77.5%) patients. VIN and HSN were present in the same direction in24 patients and in the opposite direction in 5. The intensity of VIN showed significant correlations with the intensity of HSN andthe degree of canal paresis on bithermal caloric test, whereas it did not depend on the presence of VEMP. Conclusion:VIN ismostly contralesional in peripheral vestibulopathies. VIN may be a simple and useful clinical sign for indicating lateralization infixed vestibular loss. (Korean J Otolaryngol 2006;49:897-903)