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윤택준 ( Taek Joon Yoon ),문원국 ( Won Kook Moon ),이광호 ( Kwang Ho Lee ) 한국식품영양학회 2007 韓國食品營養學會誌 Vol.20 No.3
In experimental lung metastasis of colon26-M3.1 carcinoma cells, we found that the prophylactic or therapeutic administration of Inonotus obliquus extracts significantly inhibited lung metastasis. In an in vitro cytotoxicity analysis, the extracts did not affect colon26-M3.1 cell growth at concentrations up to 1000 ㎍/㎖. Peritoneal macrophages that were stimulated with the extracts produced TNF-α. These data suggest that Inonotus obliquus extract has antitumor activity to inhibit tumor metastasis, and its antitumor effects are partially associated with macrophages activation.
문한규,허윤,송철수,이동완,강필중,문원국,양웅석,송수복 대한내과학회 1990 대한내과학회지 Vol.39 No.5
Sparganosis, an infection transmitted to humans by sparganum, was first reported by Manson at 1882. Many cases have been reported in korea, the sites are subcutaneous tissue, fascia, body cavities, urinary tract, orbit, brain, and spinal canal. This 59-year-old male, who had a history of having eaten snakes frequently 15-20 years ago, suffered from right upper quadrant pain and intermittent fever and chills. An abdominal ultrasound revealed an echolucent area on the right lower lobe of the liver. Aspiration was done, and through a drainage tube, the parasite was expelled. On parasitologic evaluation, sparganum was confirmed. It was the first report of sparganum found in liver parenchyme in korea. We report a case of sparganosis combined with liver abscess with a review of the literature,
이민기,신영기,박순규,허재영,도창호,조군제,임홍섭,문원국,최장락,이헌직 대한내과학회 1990 대한내과학회지 Vol.39 No.2
Tuberculous osteitis of the skull is an uncommon condition, first reported by Reid of Erlangen, who described two cases in 1842. By 1933. only 220 cases had been recorded in world literature (Strauss). It occurs in approximately 1%. of all patients with tuberculous osteitis and is diagnosed by clinical manifestation, skull roentgenogram, smear and culture of aspirated pus, and biopsy of granulation material. It responds readily to chemotherapy and the prognosis is favorable. To the best of our knowledge, the condition has not been previously reported in Korea. But recently we experienced a case of tuberculous osteitis of the skull in an 18-year-old male patient who complained of dyspnea, chest pain, multiple swelling of scalp and right eye proptosis. The patient was treated with antituberculous medication and discharged with his condition improved.
겨우살이(Viscum album)와 칡뿌리( Pueraria radix) 추출물의 NF - κB활성 억제 및 항산화 효과
송희순(Hee Sun Song),박연희(Yeon-Hee Park),김승균(Seung-Kyoon Kim),문원국(Won-Kuk Moon),김동우(Dong-Woo Kim),문기영(Ki-Young Moon) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.10
다양한 생리활성을 지닌 천연물 겨우살이와 칡뿌리 추출물의 인체피부조직세포에서 NF-κB 활성에 대한 조절효과와 이들 추출물의 지질 과산화물 생성 억제 및 라디칼 소거활성, reducing power와 관련된 항산화적 활성을 조사하였다. 본 실험에 사용한 모든 시료들은 세포독성을 보이지 않는 수준에서 NF-κB 활성을 억제했다. 칡뿌리 추출물은 0.5 ㎎ 농도에서 35%로 vitamin C 10 mM(8.8 ㎎, 53%)과 함께 유의적인 NF-κB활성 억제효과를 보였다(p<0.05). 또한 칡뿌리 추출물은 겨우살이 추출물보다 상대적으로 더 높은 NF-κB활성 억제 효과를 보였다. 겨우살이 추출물의 NF-κB활성 억제 효과는 10%로 낮았지만, 지질 과산화물에 대한 항산화 효과는 5 ㎎ 이상의 농도에서 63% 이상으로 칡뿌리 추출물보다 높았다. 겨우살이와 칡뿌리 추출물은 동일 농도 10 ㎎에서 vitamin C의 항산화 효과, 48%보다 각각 유의적으로 높은 86%와 75%의 항산화 활성을 보였다. 라디칼 소거활성에 대하여 칡뿌리 추출물이 겨우살이 추출물보다 동일농도에서 더 강한 소거활성을 나타냈다. 잘 알려진 항산화제 vitamin C와 비교해 볼 때, DPPH test에서 이 두 추출물은 vitamin C만큼 강한 라디칼 소거활성을 보이지는 않았다. 그러나 NO test에서 칡뿌리 추출물의 SC_(50)은 88 ㎍으로 vitamin C(SC_(50), 77 ㎍)만큼 강한 항산화 활성을 보였다(p<0.05). 칡뿌리 추출물의 항산화 활성은 reducing power 측정에서도 겨우살이 추출물보다 높게 나타났으나, vitamin C의 환원력보다는 매우 낮은 활성을 보였다. 본 연구의 전체 결과를 통해서, 강한 라디칼 소거활성을 지닌 칡뿌리 추출물과 상대적으로 높은 지질 과산화 억제 효과를 보인 겨우살이 추출물은 천연 항산화제로 제안될 수 있는 것으로 판단되었다. 또한 vitamin C와 칡뿌리 추출물의 결과처럼 천연 추출물의 인체피부조직세포에서 NF-κB활성 조절 효과의 일부는 이들 천연 추출물이 지닌 라디칼 소거활성 또는 reducing power의 항산화 활성의 역할에 의한 것으로 제안되었다. Effects of mistletoe (Viscum album) extract and pueraria (Pueraria radix) extract on cellular NF-κB activity were evaluated in human malignant keratinocytes (SCC-13) to elucidate the possible correlation of NF-κB with antioxidant activity. The antioxidant activities of these natural extracts were examined in four different evaluation methods, i.e., lipid peroxidation value (POV) evaluation test, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), nitric oxide (NO) scavenging test, and reducing power assay. Pueraria extract (0.5 ㎎) and mistletoe extract (5 ㎎) downregulated the cellular NF-κB activation up to 35% and 10% compared to the control, respectively, although their effects were lower than the known NF-κB downregulator, vitamin C (8.8 ㎎, 53%) in a cell-based NF-κB activity assay system. In the POV test, relative antioxidant activities of mistletoe extract (86%) and pueraria extract (75%) were significantly higher than the known antioxidant, vitamin C (48%) at the same concentration (10 ㎎) and the degree of activity increased in a dose-dependent manner. Pueraria extract showed more potential radical scavenging activities than those of mistletoe extract evaluated in both DPPH and NO test. Especially, the NO radical scavenging activity of pueraria extract (SC_(50), 88 ㎍) was comparable to that of vitamin C (SC_(50), 77 ㎍). Even pueraria extract possessed a much less reducing power compared to vitamin C, it also revealed higher reducing power than that of mistletoe extract. These results indicate that mistletoe extract and pueraria extract may serve as an useful natural antioxidant agents, and led to suggest the hypothesis that compounds having an antioxidant activity, i.e., radical scavenging activity or reducing power may be correlated with the downregulation of NF-κB activation in human keratinocytes.