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아스코르빈산 디팔미테이트의 경피흡수에 미치는 연고기제의 영향
문용구,이완하,Moon, Yong-Koo,Lee, Wan-Ha 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.2
Six different O/W cream bases containing 4% ascorbic acid dipalmitate and two different O/W cream bases containing 1% ascorbic acid were prepared. Percutanceous absorption of ascorbic acid as well as safety were determined using rabbits. The stability of the creams was also tested at room temperature. Ascorbic acid concentrations in urines varied depending on the characteristics of cream bases used. The absorption of ascorbic acid was increased and sustained with the cream bases containing branched chain esters of fatty acid instead of natural oils used currently. The excretion level of ascorbic acid in urine was high with the cream base including nonionic surfactants and a small quantity of natural oils. The creams containing nonionic surfactants showed excellent stability, while those containing anionic surfactants were not stable in terms of pH, odor and coloring test at room temperature during six months. But, the two creams containing ascorbic acid were unstable. All the cream bases tested showed good safety.
문용구(Moon Yong-Koo),권순오(Kwon Soon-Oh),김태영(Kim Tai-Young) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(계획계)
This study is the research on the continuous actual condition of the Old-building of Dae-gu Dong-san hospital designated as modern architectural properties. First of all, we tried to make the Check-list by the architectural planning for this research. To analyze the plan scale and the change of function, we intend to know the difference between the architectural plans, and the continuous actual condition of Hospital. The following is the difference between architectural plans by analysis of Check-list, 1)Dimension of inpatient wards is much smaller than the area requirements of current architectural planning that is 10∼13㎡ per bed. 2)Corridor width is 2,200㎜ less than the minimum width of 2,400㎜ and Ceiling height is lower than the 2,800㎜ to 2,450㎜. 3)Size of the window is required 1/3 to 1/4 in the floor area, but the window size of Old-building as 1/5∼1/8 does not satisfy in the current architectural planning.
아스코르빈산 디팔미테이트의 경피흡수에 미치는 연고기제의 영향
이완하,문용구 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.2
Six different O/W cream bases containing 4% ascorbic acid dipalmitate and two different O/W cream bases containing 1% ascorbic acid were prepared. Percutanceous absorption of ascorbic acid as well as safety were determined using rabbits. The stability of the creams was also tested at room temperature. Ascorbic acid concentrations in urines varied depending on the characteristics of cream bases used. The absorption of ascorbic acid was increased and sustained with the cream bases containing branched chain esters of fatty acid instead of natural oils used currently. The excretion level of ascorbic acid in urine was high with the cream base including nonionic surfactants and a small quantity of natural oils. The creams containing nonionic surfactants showed excellent stability, while those containing anionic surfactants were not stable in terms of pH, odor and coloring test at room temperature during six months. But, the two creams containing ascorbic acid were unstable. All the cream bases tested showed good safety.