http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
당뇨 흰쥐에서 음경발기 양상과 신경원성 Nitric Oxide Synthase의 관계
문기학,정희창,박동춘,이융창,허근,박종민,서준규 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-
Diabetes mellitus (DM) is an important cause of organic impotence in man. The exact pathogenesis remains debatable although it has been focused on cavemosal neuropathy and/or endothelial dysfunction. This study was designed to investigate the effect of DM on penile erection, especially in association with nitric oxide synthase (NOS) in corpus cavrnosum of diabetic rats. Nos studies of rat penis were performed in diabetic (DM was induced for 3, 6, 9, 12 weeks, respectively, by intraperitoneal administration of streptozotocin, 60mg/kg), in control and neurotomy group (3 weeks after bilateral cavrnous nerve transection). The experiments consisted of nicotinamide dinucleotide phosphate (NADPH) diaphorase activity with spectrophotometric assay for NOS catalytic activity, NADPH diaphorase staining for the identification of NOS containing nerve fibers, and Western blotting analysis with anti-brain NOS antibody for the expression of neuronal NOS. Finally, these results were compared with erectile response to cavemous nerve stimulation in diabetic and in control rats. In assay of NADPH diaphorase activity, NOS activity decreased significantly in penis of diabetic rat as compared to that of controls. Between the diabetic groups, NOS activity was not seen significantly different, and in neurotomy groups it was similar to that of diabetic groups. On histochemical staining of penile tissues, the number of NADPH-positive nerve fibers in control group (a mean of 127±6 fibers recorded in 4 random fields on each corporal side) contrasted significantly with that of the bilateral cavernous nerve ablation group (a mean of 12±2). In diabetic group, the number of NOS-containing nerve fibers was gradually reduced along with duration of diabetes (from 92±3 at 3 weeks to 28±3 at 12 weeks). In addition, analysis of blot density of neuronal NOS by Western blotting showed similar findings: 16% at 3 weeks and 8% at 12 weeks in diabetic group, 5% in neurotomy group and 27% in controls, based on the density of the rat cerebellum. Furthermore, erection response to cavernous nerve stimulation was also decreased in diabetic rats along with DM duration. The results indicated that reduction of cavernous NOS, particularly, its neuronal form at the level of NO production plays an important role on the pathogenesis of erectile impotence in diabetic rats although the role of endothelial NOS in DM remains to be elucidated. Furthermore, cavernosal NADPH diaphorase staining and/or NOS activity may allow to characterize certain pathological condition, which comprise neurogenic impotence.
1P-701 수막 집진기를 이용한 분진 및 고점도 액적 처리
문기학,권진홍,김태영,김재용 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
산업발달로 최근 미세먼지 등 대기오염물질에 대한 처리방법이 활발히 연구되고 있다. 그중에서도 최근 산업현장의 대기오염물질에 대한 연구에 관심이 높아지고 있는데, 이러한 오염물질들은 장치의 성능 저하 및 전체 공정 효율을 떨어뜨리기 때문에, 분진 및 가스상 물질들의 효율적인 처리가 필요하다. 본 연구에서는 DUAL로 CYCLONE SCRUBBER에 함진 가스를 양방향으로 인입하여 수막을 형성시켜 미세먼지 및 액적, 백연을 제거하고자 하였다. 실험결과 수막형성 후 PM10은 99%, PM2.5는 97%, PM1은 90%까지 제거되었고 액적 및 백연은 95%까지 제거되는 것을 확인하였다.
Display 제조공정 배출가스 처리를 위한 휘발성 유기화합물 전처리 장치 개발
문기학,김재용 한국공업화학회 2019 공업화학 Vol.30 No.5
본 연구에서는 최근 반도체 및 display 산업이 발달함에 따라 문제가 되고 있는 휘발성 유기화합물의 전처리에 관해조사하였다. 일반적인 VOCs 처리 설비인 직접연소장치에 사용되는 농축기는 display 제조 공정 내 배출가스에 의해쉽게 오염되어 성능저하를 일으키며 결과적으로 VOCs의 처리 효율을 떨어뜨린다. 배출가스 성분 분석 결과 고비점, 고점도, 고분자량의 Alcohol류 및 Oil 성분이 다량 검출되었다. 이에 전처리 설비 내 열교환기를 이용하여 농축기 성능저하 물질을 응축시켜 처리하고자 하였고, 대부분의 물질을 90% 이상 처리하였다. 또한 열교환기에서 재 비산되는고분자 Oil 등은 후처리 설비로 Grease Filter를 장착하여 대부분 처리할 수 있는 것으로 확인되었다.
문기학,송필현,양대열,박남철,김수웅,이성원,김세웅,문두건,박종관,안태영,박광성 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.5
Purpose: To evaluate the efficacy and safety of silodosin 8 mg once daily in a 12-week treatment of subjects with severe lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Materials and Methods: A total of 100 subjects from 10 urology centers in Korea were included in this study. The inclusion criteria were as follows: age ≥50 years, International Prostate Symptom Score (IPSS) ≥ 20, quality of life (QoL) score ≥3, urine volume ≥120 mL and maximal urinary flow rate (Qmax) <15 mL/s, and postvoid residual volume (PVR) <100 mL. We assessed the improvement of LUTS with change in IPSS, QoL score, Qmax, PVR, and adverse events at baseline and 4 and 12 weeks after treatment with silodosin 8 mg once daily. Results: The IPSS values were 23.27±3.34, 15.89±6.26, and 13.80±6.31 at baseline, 4, and 12 weeks, respectively, with significant improvements (p<0.0001, p=0.0214, respectively). QoL scores were 4.44±0.85, 3.38±1.20, and 3.04±1.20 at baseline, 4, and 12 weeks, respectively, and the differences were statistically significant (p<0.0001). There was a significant difference in Qmax between baseline and 12 weeks (p<0.0001) but not in PVR (p=0.9404) during the clinical trial. The most frequent adverse event in this study was ejaculation failure with 13 cases. However, no subject dropped out because of ejaculation failure, and in 12 of the 13 cases it was fully resolved without further treatment. Conclusions: Silodosin 8 mg once daily may be effective and safe in Korean patients with severe LUTS associated with BPH.