각종(各種) 소화기(消化器) 증장(症狀)에 대(對)한 HPS-A의 임상(臨床) 치험(治驗)

문구,김세길 대한한방신경정신과학회 1992 동의신경정신과학회지 Vol.3 No.1

消化性潰瘍의 治法 및 運治方 活用에 對한 考察

文九,林圭庠,崔賢 圓光大學校 漢醫科大學 1989 圓光漢醫大論文集 Vol.- No.6

After finding out cure-all method by analyzing and synthesizing of Peon-Zheng-Shi-Chi(辨證施治) and clinical character of peptic ulcer, forming a cure-all prescription, attempting to conform the modificatory method of Kun(monarch). Shin(minister). Zhoa(assistant). Sha(guide) of forming drugs by Peon-Zheng(辨證) and modificatory drugs with Peon-Zheng-Shi-Chi(辨證施治) of Oriental medicine and pharmacologic effect of Western medicine, the author obtained conclusion as below. 1. The cure-all method based on the method of Peon-Zheng-Shi-Chi(辨證施治) are So-Kan-Hai-Wul (疏肝解鬱), Hoa-Wei (和胃), Hoal-Heol-Sang-ki (活血生肌), Hai-Keong-Zhin-Tong (解痙鎭痛), Jhei-San(制酸)(antacid). 2. The forming drugs of cure-all prescripiton are Radix paeoniae, Radix Glycyrrhizae, Rhizoma Cyperi, Radix Aucklandiae, Radix Linderae, Rhizoma Atracyodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Os Sepiae, Rhizoma Corydalis, Resina Myrrhae, Radix Astragali, Radix Adenophorae, Ramulus Cinnamomi. 3. The main durgs of each Peon-Zheng(辨證) are Rhizoma Cyperi, Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Aucklandiae, Radix Linderae in the symptoms of Ki-Chei(氣滯) Caused by Kan-Ki-Hoing-Yeog(肝氣橫逆) ; Radix Astrageli, Ramulus Cinnamomi, Radix Paeoniae Alba in the symptoms of Ki-Chei(氣滯) of Mog-Pul-So-To (木不疏土) caused by Kan-Ki-Her (肝氣虛) ; Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae in the symptoms of Her-Han(虛寒);Radix Adenophorae, Radix Paeoniae Alba in the symptoms of Wei-Yeum-Her(胃陰虛) and Wul-Yeol(鬱熱) ; Rhizoma Cyperi, Rhizoma cotydalis, Resina Myrrhae in the symptoms of Yer-Heol(瘀血) ; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis in the symptoms od Tam-Kuel(痰厥). On the other hand, classifying and using the modification and utility method by the character of drug in order to coinside with Peon-Zheng (辨證) and pharmacologic effect, and finding out the therapeutic methods and prescriptions to protect the sideaction, it is considered that the better therapeutic effect will gain.

항장요법에 의한 白毛藤의 즉각형 과민반응 억제효과

문구,문석재,원진희,김태균,배남규,이종덕,임미양 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5

The Solanum Iyratum Thunb. (Solanaceae) has been used against allergic disease for generations, and it still occupies an important place in traditional oriental medicine. In this study, the author investigated the effect of an aqueous extract of Solanum Iyratum on immediate-type hypersensitivity by anal administration. Anal administration of Solanum Iyratum showed a marked inhibition rate in systemic hypersensitivity with a dose of 0.1, 1 g/kg 1 hr before intraperitoneal injection of compound 48/80. Anal administration of Solanum Iyratum significantly reduced plasma histamine contents induced by compound 48/80. Anal administration of Solarium Iyratum (0.1 g/kg) also inhibited to 61.2%(P〈0.01) local allergic reaction activated by anti-dinitrophenyl (DNP) lgE significantly. In addition, Solanum Iyratum dose-dependency inhibited the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE, When Solanum Iyratum was added, the level of cAMP in peritoneal mast cells transiently and significantly increased compared with that of basal cells. These results provide evidence that anal therapy of Solanum Iyratum may be beneficial in the treatment of systemic and local immediate-type hypersensitivity by inhibition of histamine release from mast cells in vivo and in vitro.

積聚 處方에 對한 文獻的 考察

문구,조성각 대한한방종양학회 1996 대한한방종양학회지 Vol.2 No.1

Canser is one of the most important cause of death. So recently, investigation of cancer progress prosperously all over the world. Cancer in the present medicine correspond to You-Am, Sin-Am, Youg-Soon, Sel-Gyun, Sil-Young, Young-Lyoo, Seg-Je, Seg-Young, Seg-Ha, Jerk-Chuo(積聚), Jing-Ha, Oel-Gyek, Ban-Oui, Bi-Gi, Bok-Lyang, Jang-Dan, Hyen-Bek in the oriental medicine. Among thes, generally Jerk-Chui(積聚) is expressed to cancer. So to develop of new drugs of cancer in the present medicine, bibliographic investigation of mass-prescriptions was stodied in the oriental medicine-bodks. According to the bibliographic study of Jerk-Chui-prescriptions, the results rus as follows. 1. According to the analyses of three hundred sixty eight Jerk-Chui-prescriptions in the twenty-seven kinds of literature, the frequency number of the used drugs were Perivarpium Citri Nobilis Viride 140 times, Pericarpium Citri Reticulatae 135 times, Rhizoma Scirpi 124 times, Radix Aucklandie 115 times, Rhizoma Zedoariae 114 times, Cortex Magnoliae Officinalis lll times, Radix Glycyrrhizae 106 times, Rhizoma Zubguberis 100 times, Rhizoma Coptidis 94 times, Radix Ginseng 93 times, Poria 86 times, Rhizoma Pinelliae 85 times, Semen Arecae 83 times, Rhizoma Cyperi 82 times, Radix Angelicae Sinensis 80 times, Rhizonma Atractylodis 74 times, Massa Fermentata Medisinalis 67 times, Radix Et Rhizoma Rhei 66 times, Fructus Aurantii 62 times, Fructus Hordei Germinatus 55 times, Cortex Cinnamomi 54 times, Fructus Evodiae 51 times, Fructus Aurantii Immaturus 49 times, Fructus Crataegi 49 times, Rhizoma Cnidii 46 times, Radix Platycoi 44 times, Semen Tiglii 44 times, Radix Aconiti 43 times, Fructus Amoni 38 times, Semen Raphani 37 times, Radix Aconiti Praeparata 36 times, Radix Scutellariae 35 times, Pericarpium Zanthoxyli 35 times, Rhizoma Corydalis 33 times, Rhizoma Acori Graminei 31 times, Carapax Amydae 31 times, Fructus Foeniculi 31 times, Semen Persicae 30 times, Radix Bupleuri 30 times. 2. The frequency number of the most important used drugs in the Jerk-Chui-prescriptions were Rhizoma Coptidis 41 times, Rhizoma Scirpi 35 times, Radix Et Rhizoma Rhei 31 times, Pericarpium Citri Reticulatae 30 times. Rhizoma Zedoariae 37 times. Rhizoma Cyperi 22 times, Cortex Magnoliae Officinalis 22 times, Rhizoma Atractylodis 22 times, Pericarpium Citri Nobilis viride 21 times, Rhizoma Pinelliae 20 times, Semen Arecae 20 times, Fructus Crataegi 18 times, Rhizoma Zingiberis 17 times, Carapax Amydae 16 times, Semen Pharbitidis 13 times, Poria 12 times, Radix Angelicae Sinensis 10 times, Semen Persicae 10 times, Fructus Evodiae 10 times, Radix Aconiti 10 times, Radix Glycyrrhizae 9 times. Massa Fermentata Medisinalis 9 times, Fructus Aurantii 9 times, Fructus Hordei Germinatus 8 times, Radix Aucklandie 8 times, Rhizoma Atractylodis 8 times, Radix Bupleuri 8 times, Radix Ginseng 7 times, Semen Raphani 7 times, Radix Astragali 7 times, Cortex Cinnamomi 6 times, Frctus Aurantii Immaturus 6 times, Rhizoma Cnidii 6 times, Radix Aconiti Praeparate 5 times, Fructus Foeniculi 5 times, Lacca Sinica Exsiccata 5 times, Radix Aconiti 5 times, Rhizoma Zingiberis 5 times. 3. The clinical-botanic classifications of the used drugs in the drugs in the Jerk-Chui-prescriprions were regulating the flow of Qi drugs, warm-heating drugs, promoting blood circulation drugs, killing mass drugs, resolving drugs, purgative drugs, Qi and blood tonics drugs, heat clearing drugs, removing dampess by promoting diuresis drugs, phlegm eliminating drugs, allaying pain drugs. 4. According to the nature and taste in the drugs, warm and heating recipes were used most, heat-clearing recipes were used a few times assistantly. 5. The Jerk-Chui-prescription used frequently was Bun-Don-Tang, Which was used 13 times ; Bok-Oyang-Hoan 12 times, Bi-Gi-Hoan(肥氣丸) 12 times, Sik-Boon-Hoan 12 times, A-Uie-Hoan 12 times, Bi-Gi-Hoan(肥氣丸) 12 times, Dai-Cil-Gi-Tang 8 times, Sik-Boon-Hoan 12 times, A-Uie-Hoan 12 times, Bi-Gi-Hoan(肥氣丸) 12 times, Dai-Cil-Gi-Tang 8 times, San-Cuie-Tang 8 times, Guye-Gyen-Tang 6 times, On-Baig-Won 5 times, So-Jek-Jeng-Ouen-San 5 times, Jin=In-Hoa-Cel-Tang 5 times. Byel-Gab-San 5 times, Sng-Hong-Hoan 5 times, Ji-Sil-San 4 times, So-A-Oie-Hoan 4 times, Hyang-Rng-Hoan 4 times.

팔진탕합화적환(八珍湯合化積丸)과 Adriamycin의 병용처리시 나타나는 synergistic 항종양(抗腫瘍) 효과(效果)에 관(關)한 작용기전 연구(硏究)

문구,문석재,원진희,조정연,박상구,송봉길,박래길,이병구,Moon, Gu,Moon, Seok-Jae,Won, Jin-Hee,Cho, Jung-Yun,Park, Sang-Gu,Song, Bong-Gil,Park, Rae-Gil,Lee, Byung-Gu 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

Objective : This study was designed to evaluate the synergistic effect on cytotoxicity of combination with adriamycin and Palginhonhapwhajucwhan, a traditional prescription for cancer treatment in oriental medicine, in Chang, HL-60, Hep-3B and Alexander cells. Methods : We observed cell viability in Chang, HL-60, Hep-3B, and Alexander cells by crystal violet staining. Those cells were treated with various concentrations of adriamycin alone, Palginhonhapwhajucwhan alone and combination of two medications for 10 hr. On condition of $0.5{\mu}l/ml$ adriamycin alone, $15.6{\mu}l/ml$ Paljintanghapwhajucwhan alone and combination of two medications, at first, we observed colony forming of Chang and HL-60 cells. Second, we observed DNA fragmentation by agarose electrophoresis in Chang, HL-60, Hep-38 and Alexander cells. Third, we measured the catalytic activation of caspase-1, 2, 3, 6, 8, and 9 protease in Chang cells and caspase-3 protease in Chang, HL-60, Hep-3B and Alexander cells by using fluorogenic substrate. Finally, we isolated mRNA of Fas in Chang, HL-60, Hep-38 and Alexander cells and observed that Fas gene was amplified by RT-PCR Results : 1. The combination of adriamycin and Palginhonhapwhajucwhan synergistically augmented the cytotoxicity of Chang and HL-60 cells whereas did not in Hep-38 and Alexander cells. 2. Cotreatment of two drugs also markedly inhibited the colony forming ability both in Chang and HL-60 cells. 3. The cytotoxicity of these medicatons was revealed as apoptosis characterized by high molecular wight DNA fragmentaton. 4. The apoptotic cytotoxicity was mediated by activation of caspase-3 protease in Chang cells. 5. Synergistic increase in apoptotic cytotoxicity by combination of two medications was dependent on the expression of Fas in cancer cells. Conclusions : Combination of adriamycin and Palginhonhapwhajucwhan significantly augmented apoptotic cytotoxicity of Fas-positive cells such as Chang and HL-60 cells via acticaton of apoptosis signaling pathway.

적취(積聚) 처방(處方)에 대(對)한 문헌적(文獻的) 고찰(考察)

문구,조성각,Mun, Gu,Jo, Seong-Gak 대한암한의학회 1996 大韓癌韓醫學會誌 Vol.2 No.1

Cancer is one of the most important cause of death. So recently, investigation of cancer progress prosperously all over the world. Cancer in the present medicine correspond to You-Am, Sin-Am, Young-Soon, Sel-Gyun, Sil-Young, Young-Lyoo, Seg-Je, Seg-Young, Seg-Ha, Jerk-Chui(積聚), Jing-Ha, Oel-Gyek, Ban-Oui, Bi-Gi, Bok-Lyang, Jang-Dan, Hyen-Bek in the oriental medicine. Among these, generally Jerk-Chui(積聚) is expressed to cancer. So to develop of new drugs of cancer in the present medicine, bibliographic investigation of mass-prescriptions was studied in the oriental medicine-books. According to the bibliographic study of Jerk-Chui-prescriptions, the results run as follows. 1. According to the analyses of three hundred sixty eight Jerk-Chui-prescriptions in the twenty-seven kinds of literature, the frequency number of the used drugs were Pericarpium Citri Nobilis Viride 140 times, Pericarpium Citri Reticulatae 135 times, Rhizoma Scirpi 124 times, Radix Aucklandie 115 times, Rhizoma Zedoariae 114 times, Cortex Magnoliae Officinalis 111 times, Radix Glycyrrhizae 106 times, Rhizoma Zingiberis 100 times, Rhizoma Coptidis 94 times, Radix Ginseng 93 times, Poria 86 times, Rhizoma Pinelliae 85 times, Semen Arecae 83 times, Rhizoma Cyperi 82 times, Radix Angelicae Sinensis 80 times, Rhizoma Atractylodis 74 times, Massa Fermentata Medisinalis 67 times, Radix Et Rhizoma Rhei 66 times, Fructus Aurantii 62 times, Fructus Hordei Genninatus 55 times, Conex Cinnamomi 54 times, Fructus Evodiae 51 times, Fructus Aurantii Immaturus 49 times, Fructus Crataegi 49 times, Rhizoma Cnidii 46 times, Radix Platycodi 44 times, Semen Tiglii 44 times, Radix Aconiti 43 times, Fructus Amoni 38 times, Semen Raphani 37 times, Radix Aconiti Praeparata 36 times, Radix Scutellariae 35 times, Pericarpium Zanthoxyli 35 times, Rhizoma Corydalis 33 times, Rhizoma Acori Graminei 31 times, Carapax Amydae 31 times, Fructus Foeniculi 31 times, Semen Persicae 30 times, Radix Bupleuri 30 times. 2. The frequency number of the most imponant used drugs in the Jerk-Chui-prescriptions were Rhizoma Coplidis 41 times, Rhizoma Scirpi 35 times, Radix Et Rhizoma Rhei 31 times, Pericarpium Citri Reticuiatae 30 times, Rhizoma Zedoariae 27 times, Rhizoma Cyperi 22 times, Cortex Magnoliae Officinalis 22 times, Rhizoma Atraclylodis 22 times, Pericarpium Citri Nobilis Viride 21 times, Rhizoma Pinelliae 20 times, Semen Arecae 20 times, Fructus Crataegi 18 times, Rhizoma Zingiberis 17 times, Carapax Amydae 16 times, Semen Pharbitidis 13 times, Poria 12 times, Radix Angelicae Sinensis 10 times, Semen Persicae 10 times, Fructus Evodiae 10 times, Radix Aeoniti 10 times, Radix Glycyrrhizae 9 times, Massa Fennenlata Medisinalis 9 times, Fructus Aurantii 9 times, Fructus Hordei Genninatus 8 times, Radix Aueklandie 8 times, Rhizoma Atractylodis 8 times, Radix Bupleuri 8 times, Radix Ginseng 7 times, Semen Raphani 7 times, Radix Astragali 7 times, Cortex Cinnamomi 6 times, Fructus Aurantii Immaturus 6 times, Rhizoma Cnidii 6 times, Radix Aconiti Praeparata 5 times, Fructus Foeniculi 5 times, Lacca Sinica Exsiccata 5 times, Radix Aconiti 5 times, Rhizoma Zingiberis 5 times. 3. The clinical-botanic classifications of the used drugs in the Jerk-Chui-prescriptions were regulating the flow of Qi drugs, warm-heating drugs, promoting blood circulation drugs, killing mass drugs, resolving drugs, purgative drugs, Qi and blood tonics drugs, heat clearing drugs, removing dampness by promoting diures is drugs, phlegm eliminating drugs, allaying pain drugs. 4. According to the nature and taste in the drugs, warm and heating recipes were used most, heatclearing recipes were used a few times assistantly. 5. The Jerk-Chui-prescription used frequently was Bun-Don-Tang, which was used 13 times ; Bok-Oyang-Hoan 12 times, Bi-Gi-Hoan(肥氣丸) 12 times, Sik-Boon-Hoan 12 times, A-Uie-Hoan 12 times, Bi-Gi-Hoan 12 times, Dai-Cil-Gi-Tang 8 times, San-Cuie-Tang 8 times, Guye-Gyen-Tang 6 times, On-Baig-Won 5 times, So

항장요법에 의한 白手?의 즉각형 과민반응 억제효과

문구,문석재,원진희,김태균,배남규,이종덕,임미양 한의병리학회 2001 동의생리병리학회지 Vol.15 No.5

각종(各種) 소화기(消化器) 증상(症狀)에 대(對)한 HPS-A의 임상(臨床) 치험(治驗)

문구,김세길,Mun Gu,Kim Se-Gil 대한한방신경정신과학회 1992 동의신경정신과학회지 Vol.3 No.1

The effectiveness, the safety and the usefulness of HPS-A(An Jung San with Chyag Yag Kam Cho Tang), herbal digestive, was examined on 32 patients complained digestive symptoms. This medicine was administered 1 package per 1 time 3 times per 1 day, during 2 weeks. From the examination of the improvemnt and the safety mainly by subjective symptoms, the usefulness was gained. The results were as follows ; 1. In the improvement rate of susbjective symptoms, high rate symptoms was gastric distension, anorexia, heart burn, gastric discomport, dyspepsia, acrid eructation, indigestion, nausea. 2. The improvment over moderate effective was 85.7% after 1 week 96.4% after 2 weeks. The 4 cases breaked medicine during experimental period were all over moderate offectiveness. 3. There weren't any cases complaind particular problem about safety except for 1 case complained mild pushing up of heat. There weren't also any side effect of medicine on common blood count, blood chemistry and urinalysis. 4. In the dicision of usefulness, 19cases(59.4%) were usefulnesss, 12cases(37.5%) were moderate usefulness, 1 case was uselessness(3.1%). So the cases over moderate usefulness were 31 and rate was 96.9%. 5. The usefulness rates according to physical features were all over 95.5% in sturdiness, middle feature and infirmity. So the rates were no relations with the features. 6. The usefulness rates over moderate usefulness according to total seriousness were all over 90% in high, middle, and mild cases. So the rates were no relations with the seriousness. Totally HPS-A was a medicine that was highly effective, safe and useful to patients complained various digestive symptomes.

좌골부 및 전자부 욕창의 재건을 위한 후대퇴근막 피판술

문구현,방사익 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 욕창은 장기적으로 반복되는 압박으로 인해 피부 및 연부조직에 생긴 괴사를 말하며 이는 주로 골 돌출부 주위에 잘 발생한다. 이러한 욕창은 교통사고 및 산업재해의 증가로 척추손상 및 지체마비 환자가 늘어나고 집중 치료를 요하는 의식불명, 만성병증의 환자수가 증가하면서 그 발생 빈도도 증가 하고 있다. 그리고 욕창은 천골부, 대전자부 및 좌골부 등에서 호발한다. 추후에 보행이 가능한 환자의 경우 근피판보다는 근육을 보존할 수 있는 근막피판을 사용하는 것이 수술 후 보행에 더 도움을 줄 수가 있다. 그러므로 기존에 수술적 치료를 시행한 환자의 경우나, 욕창의 크기가 큰 경우, 추후에 보행이 가능한 환자에게 있어서 사용할 수 있는 술식의 유용성을 확인하고자 했다. 대상 및 방법 : 1999년 9월부터 2000년 8월까지 본원에 입원 중이던 6 례의 전자부 욕창과 5례의 좌골부 욕창을 가진 남자환자 7명, 여자환자 4명을 대상으로 하였으며, 원인별로 볼 때는 하반신 마비가 가장 많았다. 하둔부동맥 및 대퇴 심동맥의 제 1, 2 심부관통동맥으로부터 혈액공급을 받는 후대퇴근막피판을 작성한 후 피판을 전위하는 방법을 사용하였다. 결과: 피부 괴사등의 합병증 없이 모른 예에서 결손 부위을 막을 수가 있었으며 적당한 연부조직을 함께 전위 시켜줌으로 해서 추적관찰 기간 동안 욕창의 재발을 방지 할 수 있었으며 보행이 가능한 환자에 있어서도 보행에 문제가 없었다. 결론: 하둔부동맥 및 대퇴 심동맥의 제 1, 2 심부관통동맥으로부터 혈액 공급을 받는 후대퇴근막피판술은 수술이 쉽고, 출혈이 비교적 적으며 수술시간이 짧고, 피판 공여부의 봉합이 쉬우며, 보행 가능한 환자에서는 하지 근육의 기능을 보존할 수 있고, 만약 욕창이 재발 시 피판을 재거상 하여 전진시킴으로서 치료가 가능하며, 근육의 손상을 주지 않으므로 재발시 다른 수술 적 방법을 고려할 수 있는 여러가지 장점이 있는 술식이라 판단된다. Purpose : Pressure sore is an area of ischemic tissue loss resulting from prolonged or often repeated pressure, usually over a bony prominence of body. There has been recent reports describing superior durability of fasciocutaneous flap in sore reconstruction over musculocutaneous flap. Contrary to common musculocutaneous flap using gluteus & harmstring muscle, posterior fasciocutaneous flap does not incorporate any muscle, making it useful especially in ambulatory patients. Material and Methods : From September 1999 to October 2000 we have used posterior thigh fasciocutaneous flap for coverage of six trochanteric sores and five ischial sores. Posterior thigh fasciocutaneous flap is perfused by first & second profunda femoris perforating arteries. Results: All the patients recovered without any serious complications. Three cases developed minimal hematoma but it was corrected by simple evacuation. During the follow up period none of the patients were recurred and for those patients who were able to walk, there was no problem in walking. Conclusion : Posterior thigh fasciocutaneous flap has several advantages. It is easier to elevate, less operation time, less hematoma formation, good donor site morbidity and making possible to preserve the muscle component.

IMT-2000에서 이동국의 수신시스템을 위한 파라메터 분석

문구선(Gu-Seon Mun),천종훈(Jong-Hun Chun),이철희(Cheul-Hee Lee),이광재(Kwang-Je Lee),박종안(Park Jong An) 한국통신학회 2001 한국통신학회 학술대회논문집 Vol.2001 No.7