I269S와 I224S 이중변이 알코올 탈수소효소의 특성

류지원(Ji Won Ryu),이강만(Kang Man Lee) 대한약학회 1997 약학회지 Vol.41 No.6

Ile-224 in I269S mutant horse liver alcohol dehydrogenase isoenzyme S (HLADH-S) was mutated to serine by site-directed mutagenesis in order to study the role of the residue in coenzyme binding to the enzyme. The specific activity of the I269S and I224S mutant enzyme to ethanol was increased 6-fold and all Michaelis constants(Ka, Kb, Kp, and Kq) were larger than those for the wild-type and I269S enzyme. The substitution decreased the afffinity to coenzymes and increased the specific activity of the enzyme. The mutant enzyme showed the highest catalytic efficiency for octanol among the primary alcohols. But it didn`t have activities on retinoids and 5-beta-cholanic acid-3-one. From these results, it was confirmed that the hydrophobic interaction of Ile-224 residue with coenzyme was related to coenzyme affinity in ADH reaction. The substitution also affected the substrate affinities to the enzyme.

HEC-RAS를 이용한 하천의 식생분포에 따른 1차원 흐름해석

류지원(Ryu, Ji Won),장은경(Jang, Eun-Kyung),지운(Ji, Un),배인혁(Bae, In Hyeok) 대한토목학회 2022 대한토목학회 학술대회 Vol.2022 No.10

KLAM_21을 활용한 바람생성기능 평가분석 연구 -대구시를 대상으로-

류지원 ( Ji Won Ryu ),정응호 ( Eung Ho Jung ),김대욱 ( Dae Wuk Kim ),차재규 ( Jae Gyu Cha ),손경수 ( Kyung Su Son ) 한국지리정보학회 2008 한국지리정보학회지 Vol.11 No.2

본 연구는 KLAM_21을 활용한 바람형성기능 평가분석에 관한 연구로서 대구시를 사례대상지로 실제 도시공간상에서 지형조건과 토지이용에 따라 어떻게 바람이 유동하고 있는지를 살펴보았다. 먼저, 신천상류 가창골 일대의 계곡과 주변산지 경사면에서 형성된 찬공기는 신천상류를 따라 북쪽으로 유동되어 확장되고 있었으며, 시간이 경과함에 따라 찬공기의 양과 높이 그리고 유속 및 방향 등에 있어서도 점점 증가하는 추세를 보이고 있었다. 이는 이 지역의 공간적 특성이 찬공기가 생성되고 유동하는데 있어서 매우 양호한 조건을 가지고 있음을 알 수 있다. 한편, 앞산공원지역에서는 앞산공원일대를 가로지르는 고가도로와 바람의 유동을 방해하는 대규모의 아파트단지 밀집, 그리고 공원내의 건축물 등의 도시개발의 행위로 인하여 찬공기의 생성 및 유동이 크게 방해를 받고 있는 것으로 나타났으며, 찬공기의 양과 높이에 있어서도 미약하게 나타나고 있다. 결국, 바람길의 공간적 효과를 극대화시키기 위해서는 바람길생성의 기본 형태인 찬공기 형성 및 유동, 그리고 찬공기 축적 및 유지지역이 공간적으로 연계되어야 하며, 이러한 공간적 연계는 지역의 공간적 특성과 밀접한 관계가 있음을 알 수 있다. This study, the one concerning the evaluation analysis of the function of the wind generation using KLAM_21, has examined closely how the wind really flows on the space of the city, working with the object of case location. In the first place, the cold air formed at upper stream of Sincheon river, a ravine of whole area of Gachang gully and an inclined plane of neighboring mountainous district, flows to the north and expands itself along the upper stream of the Sincheon river, and as the time passes, it is tending upwards in the change of the volume and height as well as of the velocity and direction, of the cold air. It was learned that this phenomenon has made it clear that the spatial features of this area give rise to very good condition in generating and flowing the cold air. Meanwhile, it has been shown that in the area of park in the Ap-mountain, the generation and flow of the cold air are much interrupted because of the overpass traversing the whole area of the park of Ap-mountain, the congested area of large-scaled apartments and the urban development activities constructing the building in the park, and the volume and height of the cold air has been grown very small. In conclusion, It has been learned that for maximization of the spatial effect of the wind corridor, the areas where the cold air is generated, flowed, accumulated, and maintained, have to be connected spatially, and this spatial connection has a close relation with spatial features of the area.

대구의제21 주체들의 참여활성화 방안에 관한 연구

류지원(Ji-Won Ryu),김학윤(Hak-Yoon Kim),정응호(Eung-Ho Jung) 계명대학교 낙동강환경원 2010 環境科學論集 Vol.14 No.1

Agenda21 is a set of national and local practice plans and conduct guidelines for sustainable development. Every local government has planned to confer with local residents to promote their own Local Agenda21. For the past ten years, meaningful experiments and practices were developed in a variety of fields, but general performance has not reached the high initial objectives and expectations of the plan, when compared to the dedication of its diverse participants' As such, this study examined various plans at this point 10 years after the initial Daegu Agenda 21 was enacted and proclaimed. Daegu Agenda21 was established to meet the demand for the preparation of a new agenda following local conditions and changes in circumstances, and to encourage the main participants in the Daegu Agenda 21, such as citizens, companies and administrations, to enhance their roles. The results are as follows. Above all, as a local government, Daegu City, needs to sympathize with the necessity of the Local Agenda21, to establish a promotional base such as the formation of a promotion agency, and extend administrative and financial support, centering on the promotion conference and the executive office, to deliberate how to be connected with the range of involved areas, including the economic, social and environmental fields, and to prepare a practical department to control and supervise the aforementioned works. Subsequently, Daegu City needs to develop a variety of events and programs in which citizens may actively participate and make a part of their daily lives. It must explore financial support, so that citizens can share meaning and value in their local area. Finally, the city should provide companies with incentives to engage their participation, promoting eco-friendly companies and preparing means by which companies can participate, based on systematic strategies.

산전 초음파에서 구강 내 종괴 소견을 보인 선천성 치은종

류지원 ( Ji Won Ryu ),권자영 ( Ja Young Kwon ),남가현 ( Ka Hyun Nam ),박용원 ( Yong Won Park ),김영한 ( Young Han Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.2

Congenital epulis, a kind of hamartoma, is a very rare tumor, which appears in front of maxillary alveolar ridge in most cases, and accompanies no malformations. As the tumor protrudes from the oral cavity, it may lead to respiratory difficulties and feeding problems. Therefore it is important for pregnant women to receive comprehensive prenatal counseling with accurate diagnosis of the fetal oral tumor. We report a rare case of prenatal detection of oral tumor with a brief review of literatures, which was confirmed to be a congenital epulis or granular cell tumor after birth.

증례 : 신장 ; 혈액투석 환자의 심낭삼출의 치료에 시도한 흉강경을 이용한 심낭막 개창술

류지원 ( Ji Won Ryu ),이주현 ( Ju Hyun Lee ),홍현석 ( Hyun Suk Hong ),이주학 ( Joo Hark Yi ),전순호 ( Soon Ho Chon ),한상웅 ( Sang Woong Han ),김호중 ( Ho Jung Kim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.2

저자들은 투석에 반응하지 않는 요독성 심낭삼출에 대해서 진단 및 치료 목적으로 직경 2~3 mm 미세흉강경을 이용해 심낭흉막개창술을 시술한 후 42개월 추적관찰 동안 심낭삼출의 재발 및 시술에 따른 합병증 없이 없었고, 외관상 흉터가 거의 남지 않는 장점을 경험하여 보고하는 바이다. With the advent of 2-and 3-mm endoscopic instruments, a thoracoscopic pericardiectomy can be performed with relative ease and with almost no postoperative scar. We report a case of a 40-year-old woman with end-stage renal disease who had a large volume of

연구논문 : 남성의 메이크업, 헤어스타일이 인상지각에 미치는 영향

류지원 ( Ji Won Ryu ),김재숙 ( Jae Sook Kim ) 한국미용학회 2007 한국미용학회지 Vol.13 No.3

The purposes of this study were to found out the effects of male make-up and hair style on the impression perception of the stimulus person with person perception theory as the research background. The study consisted of a survey and a quasi-experiment. The experimental materials used for this study were 18 stimuli, 7-point semantic differential scales of bi-polar adjectives. The sampling method was a convenient sampling. The subjects consisted of 940 male and female undergraduate students aged from 18 to 51, in three areas including Daejoen, Cheongyang and Nonsan provinces. The data collection was conducted between May 1 and June 30, 2004. The results of this study were as follows: First, use of make-up significantly affected on impressional dimensions of salience and evaluation. No make-up wearers received more positive impression than make-up wearers. Second, the hair style of stimulus person significantly affected on four impressional dimensions of salience, potency, evaluation, and dynamic in the order of importance. Of models with straight hair style received more positive impression on potency, evaluation, salience, and dynamic dimensions than models with weak waved or strong waved hair style.

여성의 메이크업 수준과 안경착용 및 안경형태, 지각자 특성이인상형성과 선호도에 미치는 영향

류지원 ( Ji Won Ryu ) 한국미용학회 2014 한국미용학회지 Vol.20 No.1

The purposes of this study were to found out the effects of female`s make-up level and eyeglasses shape, perceiver`s characteristics on the impression formation and attraction with person perception theory as the research background. The study consisted of a survey and a quasi- experiment. The experimental materials used for this study were 7-point semantic differential scales of bi-polar adjectives. The sampling method was a convenient sampling. The subjects consisted of 340 male and female under graduate students aged from 18 to 51, resident in areas including Daejoen and Cheongyang. The data collection was conducted between June 13 and June 17, 2011. The validity of the measuring instruments were confirmed by pre-tests and judge group discussions, and reliability was evaluated by Cronbach` alpha analysis. Main gradients and varimax spin method were used to show the factor of facial image and demographic structure. According to independent variables, analysis and Duncan range test are implemented to see the difference of facial image. T-test is implemented to see difference of facial image with demographical characteristics. The female`s make uplevel(no make-up, light make-up heavy make-up) and eyeglasses shape(no eyeglasses, square shape eyeglasses, round shape eyeglasses), perceiver`s characteristics(sex, age, whether of wear eyeglasses(non wear eyeglasses, wear eyeglasses) and experience, make-up interest, make-up satisfaction) had a significant influence on impression formation was trifling hypothesis and an subject`s treats(sex, age, major, appearance interest) had a significant influence on impression formation and attraction. From the above results, female`s make up level and eyeglasses shape, perceiver`s characteristics are used as clues of perception of female. The result of this survey shows image making and make-up, wear eyeglasses in addition to it can applied as the guidance of real evidence for ideal beauty coordination

단일 기관에서의 질식분만과 제왕분만의 장단점에 대한 분석

류지원 ( Ji Won Ryu ),노영호 ( Young Ho Rho ),한상원 ( Sang Won Han ),하현용 ( Hyun Yong Ha ),김의혁 ( Euy Hyuk Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6

목적: 분만방법에 따라 분만 후 산모와 태아에 대한 영향과 부작용에 대해 비교 분석하기 위해 시행되었다. 연구방법: 본원에서 2007년 1월부터 2009년 7월까지 36주 이후에 단태아를 분만한 총 528명의 환자들을 후향적으로 분석하였다. 그들 중 질식분만을 한 군을 그룹 A군, 계획된 제왕절개술을 한 군을 그룹 B군, 그리고 응급 제왕절개술을 받은 군을 그룹 C군으로 나누었다. 우리는 분만 전과 분만 후에 혈색소 수치를 비교하였고 내외과적 소파술 여부와 항생제 추가 사용에 대해 평가하였다. 태아 결과 평가를 위해서는 1분 5분 아프가 점수, 신생아 중환자실 입원 여부와 태변 흡입 여부를 조사하였다. 결과: 분만 후 혈색소 감소치와 분만 후 입원 기간은 각 그룹 간에 통계학적으로 의미 있게 차이가 있었다(1.28 g/dL vs. 1.88 g/dL vs. 2.58 g/dL, 3.5일 vs. 5.9일 vs. 6.6일; P<0.001). 외래 방문수는 그룹 C군에서 그리고 외래에서의 항생제 사용은 그룹 A군에서 통계학적으로 의미 있게 가장 많았다. 신생아의 관점에서 볼 때 1분 5분 아프가 점수가 그룹 B군에서 가장 높았으며 신생아집중치료실 입원율과 태변흡입증후군 비율 역시 그룹 B군에서 가장 낮았다(8.0% vs. 3.2% vs. 16.3%, P=0.002; 4.5% vs. 0% vs. 7.5%, P=0.001). 결론: 질식분만은 출혈량, 재원기간 그리고 퇴원 후 외래 내원 횟수 면에서 좋은 결과를 가진다. 계획된 제왕절개술은 다른 분만 방법에 비해 산모의 심각한 부작용이 적고 태아의 좋은 결과를 가진다. Objective: To compare the postpartum maternal and neonatal effects and complications according to delivery modes. Methods: Five hundred twenty eight singleton pregnant women, who delivered after 36 gestational weeks in National Health Insurance Corporation Ilsan Hospital between July 2007 and July 2009, were retrospectively analyzed. They were categorized into 3 groups: group A, vaginal delivery; group B, elective cesarean delivery; and group C, emergent cesarean delivery. We evaluated the difference in hemoglobin decrement and postpartum hospital stays, medico-surgical curettage, and antibiotics usage. From the view point of neonates, 1 and 5 minute Apgar scores and Neonatal Intensive Care Unit (NICU) admission rates and meconium aspiration rates were evaluated. Results: Postpartum hemoglobin decrement and postpartum hospital days were statistically different among the groups, which results were 1.28 vs. 1.88 vs. 2.68 g/dL and 3.5 vs. 5.9 vs. 6.6 days, respectively (P<0.001). Number of out-patient-department follow-up was highest in group C and additional antibiotics usage was highest in group A with statistical signifi cance. The Apgar score was highest in group B (8.0% vs. 3.2% vs. 16.3%, P=0.002). NICU admission rate and meconium aspiration were also lowest in group B (4.5% vs. 0% vs. 7.5%, P=0.001). Conclusion: Although vaginal delivery showed advantage over blood loss related to procedure, hospital days and number of follow up, elective cesarean delivery has advantage carrying less severe complication of mother and better outcome for the baby than other delivery methods.

남성의 이미지형성에서 지각자의 내적 특성, 착용자의 인상 차원 및 호감도간의 상관관계

류지원 ( Ji Won Ryu ) 한국미용학회 2008 한국미용학회지 Vol.14 No.4

본 연구는 대인지각이론을 배경으로 하여 남성의 이미지형성에서 지각자의 내적 특성, 착용자의 인상차원 및 호감도간의 상관관계를 알아보고자 수행되었다. 연구방법은 준 실험연구로 설계되었다. 연구에 사용된 측정도구는 착용자의 인상차원을 알아보기 위한 18장의 자극물과 7점 등간척도로 구성된 의미미분척도, 7점 리커트 척도로 구성된 지각자의 GBI, 유행관심과 호감도에 관한 척도로 구성되었다. 피험자는 대전 및 청양, 논산에 거주하는 18세부터 39세의 남·녀 대학생 940명으로, 편의표집되었다. 자료 수집은 2005년 5월~6월에 이루어졌으며, 측정도구와 자극물에 대한 타당성은 전문가 집단과의 토의에 의하여, 신뢰도는 Cronbach`α 분석을 통하여 검증하였다. 자료의 분석은 요인분석, 분산분석, t-검정을, Pearson의 적률 상관관계분석을 실시하였다. 연구의 결과에서 착용자의 인상차원 및 지각자의 내적특질, 착용자에 대한 호감도 사이에는 유의한 상관관계가 나타났다. 첫째, 착용자의 매력성, 역능성, 평가성, 현시성, 역동성의 5가지 인상차원 사이에는 모두 유의한 정적 상관관계가 존재하였으며 그 중 매력성과 현시성, 매력성과 역동성, 역능성과 역동성 인상차원 사이에는 부적 상관관계를 나타냈다. 둘째, 지각자의 수동적, 능동적 GBI특질은 지각자의 유행관심과 부(負)적 상관관계를 나타냈다. 셋째, 호감도는 착용자의 매력성, 역능성, 평가성 인상차원과 정(正)적 상관관계를 나타냈으며, 역동성 인상차원과 능동적 GBI특질과는 부(負)적 상관관계를 나타냈다. 넷째, 매력성, 역능성, 평가성, 현시성, 역동성의 5가지 차원의 인상요인은 착용자의 호감도에 유의한 영향을 미쳤다. 본 연구의 결과는 형태주의이론과 내현성격이론을 지지하며, 남성의 토털 이미지 메이킹의 지침을 제공함과 함께 남성 패션 마케팅의 기초 및 응용자료로 활용될 것으로 기대된다.