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Cardiovascular Diseases after Kidney Transplantation in Korea
정종철,노한,황영환,이한규,하종원,안규리,양재석 대한의학회 2010 Journal of Korean medical science Vol.25 No.11
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease,cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient’s age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95%CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665]respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.
S-529 Change of bone densitometry after kidney transplantation
조기범,김애진,노한,정지용,장제현,이현희,정우경 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Numerous studies have shown that osteoporosis is common in kidney transplant recipients. However, change of bone densitometry after kidney transplantation (KT) is not fully understood. / Methods: Twenty-two kidney transplant recipients (14 males, 8 females) with bone densitometry at pre-transplant and 24 month after KT were reviewed. / Results: Recipients’ median age (43.5 years, range 21.3 ~61.7) and dialysis duration before KT (2.6 years, range 0.04~12.3) were recorded. T score after KT did not show significant change (p=0.710 in lumbar spine, p=0.138 in femur neck). T score of lumbar spine or femur neck at 24 month after KT was positively associated with T score at pretransplant (p=0.001 in lumbar spine, p=0.001 in femur neck). However, change of T score during 24 months (delta T score) of lumbar spine was negatively associated with T score at pretransplant (p=0.001 in lumbar spine). Recipients with osteopenia (T score of femur neck ≤ -1.0) increased at 24 month after KT (p=0.048). / Conclusions: Careful follow-up of bone densitometry for KT recipients was needed.
박혜인조,김치원,노한,오국환,김연수,이정상,인용후,재환준,정진욱,안규리,황영환,문주영 대한의학회 2009 Journal of Korean medical science Vol.24 No.1
Polycystic liver is the most common extra-renal manifestation associated with autosomal dominant polycystic kidney disease (ADPKD), comprising up to 80% of all features. Patients with polycystic liver often suffer from abdominal discomfort, dyspepsia, or dyspnea; however, there have been few ways to relieve their symptoms effectively and safely. Therefore, we tried transcatheter arterial embolization (TAE), which has been used in treating hepatocellular carcinoma. We enrolled four patients with ADPKD in Seoul National University Hospital, suffering from enlarged polycystic liver. We embolized the hepatic arteries supplying the dominant hepatic segments replaced by cysts using polyvinyl alcohol particles and micro-coils. The patients were evaluated 12 months after embolization for the change in both liver and cyst volumes. Among four patients, one patient was lost in follow up and 3 patients were included in the analysis. Both liver (33%; 10%) and cyst volume (47.7%; 11.4%) substantially decreased in two patients. Common adverse events were fever, epigastric pain, nausea, and vomiting. We suggest that TAE is effective and safe in treating symptomatic polycystic liver in selected ADPKD patients.