Comparison of Focal and Conventional Verteporfin Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

노성래,강민석,김기영,김응석,유승영 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.6

Purpose: To evaluate the efficacy of focal verteporfin photodynamic therapy (PDT) in patients diagnosed withchronic central serous chorioretinopathy (CSC). Methods: This study enrolled 52 eyes of 52 patients with chronic CSC who had received verteporfin PDT. Thelaser spot size of 26 eyes covering only the localized hyperfluorescent area in indocyanine green angiographywas classified as focal PDT. The PDT spot size of the other 26 eyes covered the total area of retinal pigmentepithelial detachment including the leaking point and was defined as conventional PDT. The central subfieldthickness and subfoveal choroidal thickness were measured using Heidelberg Spectralis optical coherencetomography before PDT and at months 1, 3, 6, and 12 after PDT. Results: The mean spot size of the PDT was 1,995 μm in the focal group and 2,995 μm in the conventionalgroup. Central subfield thickness steadily decreased in both groups. The mean baseline subfoveal choroidalthickness for the two groups was 334.95 and 348.35 μm, respectively, with no significant difference (p = 0.602). Subfoveal choroidal thickness decreased significantly to 304.20 μm at 1 month, 284.85 μm at 3 months,271.60 μm at 6 months, and 265.95 μm at 12 months in the focal group (p < 0.001, p < 0.001, p < 0.001, andp < 0.001, respectively, compared with baseline). In the conventional group, subfoveal choroidal thicknessdecreased significantly to 318.75, 300, 284, and 272 μm at 1, 3, 6, and 12 months, respectively (p < 0.001,p < 0.001, p < 0.001 and p < 0.001 compared with baseline). There were no significant differences betweenthe two groups in subfoveal choroidal thickness based on PDT spot size at 1, 3, 6, and 12 months (p = 0.633,p = 0.625, p = 0.676, and p =0.755, respectively). Conclusions: Focal verteporfin PDT for CSC significantly decreased the subretinal fluid and sufoveal choroidalthickness to the same extent as conventional PDT.

산란종계 육성기 사료의 에너지 및 단백질 수준이 육성기 성장에 미치는 영향

노성래,우상원,유선종,김은집,안병기,강창원 한국가금학회 2002 한국가금학회 정기총회 및 학술발표회 Vol.19 No.-

산란종계 육성기 사료의 에너지 및 단백질 수준이 성장에 미치는 영향

노성래,유선종,김성권,김은집,안병기,강창원 한국가금학회 2003 韓國家禽學會誌 Vol.30 No.2

본 연구는 산란종계 육성 사료 내의 에너지 및 단백질 수준이 육성기 성장에 미치는 영향을 규명하고자 실시하였다 .8일령의 Hy-Line Variety Brown 갈색 산란종계 암평아리 360수를 5개 처리에 처리당 4반복, 반복당 18수씩 완전 임의 배치하여 에너지와 단백질 수준이 다른 실험 사료를 9주간 급여하였다 .실험 기간 중 2주 간격으로 사료섭취량과 공시계의 생체중, 정강이 길이를 개체별로 측정하였고, 성장 균일도를 조사하였다. 실험 종료 시에 반복별로 평균체중에 해당하는 개체를 2수씩 희생시킨 후 우측 경골을 적출하여 경골 중량, 길이, 파쇄 강도 및 경골 내 회분 함량 등을 조사하였다 .실험종료 시, 증체량과 정강이 길이에서는 대조구에 비해 단백질 함량을 증가시킨 처리구에서 유의하게 증가하는 (P<0.05) 결과가 관찰되었다 사료섭취량에서는 처리간에 큰 차이가 없는 것으로 나타났다. 경골 길이 및 중량은 성장 성적의 증가와 상응해 증가하는 결과가 관찰되었고, 경골 강도 및 경골 내 회분 함량 역시 에너지 및 단백칠 수준의 증가에 따라 증가하는 결과 (P<0.05) 가 나타났다. 성장 균일도는 에너지 및 단백질 수준이 높은 처리구에서 실험 종료시인 10주째 증가하는 경향이 관찰되었으나, 처리간에 통계적 유의성 있는 차이는 인정되지 않았다. 본 연구에서 국내의 산란종계 병아리의 육성에서 NRC(1994) 사양표준의 권장 수준보다 대사에너지와 단백질 수준을 높인 육성 사료 또는 종계회사의 권장 수준에 가까운 에너지 및 단백질 수준의 육성 사료가 산란종계 병아리의 성장에 가장 적합한 영양 수준인 것으로 나타났다. 즉 Phase I 은 에너지 2800 ∼ 2950 kcal/kg, 단백질 19% 정도인 T3 구가 육성초기 가장 적합한 영양수준이고, Phase II에서도 T3, 즉 에너지 2800 ∼ 2950 kcal/kg, 단백질 16%수준이 가장 육성중기 병아리 발달에 가장 적합한 영양수준인 것으로 사료된다. This experiment was conducted to investigate the effects of dietary energy and protein levels on the growth rate of egg breeder pullets. A total of 360 Hy-Line Brown pullets aged 2 to 6 weeks (Phase I) were fed 5 rations differing in dietary protein (17, 19 and 20%) and energy (2,800, 2,950 and 3,050 kcal/kg, TMEn) leveIs for a period of 5 weeks and those aged 6 to 10 weeks (Phase II) were fed 5 rations differing in dietary protein (15, 16 and 17%) and energy (2,800, 2,900 and 3,000 kcal/kg, TMEn) levels in order to evaluate the optimum dietary energy and protein leveIs for egg breeder pullets reared in cages. Their body weight gains were significantly influenced by the dietary protein levels (P<0.05). The dietary energy levels did not greatly affect the growth performances throughout the experimental period. The low energy and protein regimen based on NRC requirement (control) was found to produce smaller pullets and lower tibia bone measurements as compared to the higher regimen groups. With the increase in dietary energy and protein levels, tibial bone strength and ash content also gradually increased (P<0.05). There were no significant differences in the flock uniformity among the treatments. These results indicate that increases in dietary energy and protein levels above the NRC requirements appeared to be more effective in obtaining the optimal growth and bone developments of egg breeder pullets reared in cage.

1P-187 공용매 Dichloro methane이 사용된 RESS공정을 이용한 PLLA의 미립화

노성래,유성식 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.0

인터벌 트레이닝에 따른 홍삼 및 가시오가피 복합섭취가 지구성 능력에 미치는 효과

노성래,박해찬 한국자료분석학회 2013 Journal of the Korean Data Analysis Society Vol.15 No.4

The purpose of this study is to know the effects of endurance exercise performance and blood elements as person who trains his body ingestion red ginseng and acanthopanax senticosus. For this purpose, taking chinese medicines and interval training were executed for 6 weeks. The experiments were executed to twenty five adolescent boys who have trained their body for 24 weeks to improve aerobic endurance exercise performance. They were randomly assigned into four groups as follows; RI : red ginseng+interval training (n=6), AI : acanthopanax senticosus+interval training (n=6), MI : mixture of red ginseng and acanthopanax senticosus+interval training (n=7), IT : interval training (n=6). According to the result of experiments, time on exhaustion and hemoglobin figure showed significant difference for RI, AI, and MI. However, VO2max, anaerobic threshold, red blood cell, and hematocrit figures did not show significant difference among four groups. For conclusion, it is thought that ingestion of red ginseng, acanthopanax senticosus, and mixture of red ginseng and acanthopanax did not have positive influence on improvement of exercise performance with aerobic energy metabolism, but have influence on improvement of exercise performance with anaerobic energy metabolism and improve endurance exercise performance. 본 연구는 청소년 남성의 인터벌 트레이닝과 홍삼, 가시오가피, 복합물(홍삼+가시오가피) 섭취가 지구성 운동수행능력과 혈액성분에 미치는 영향을 알아보기 위해서 6주간의 한약재 섭취와 트레이닝을 병행하여 실시하였다. 본 연구의 대상자는 24주 동안 인터벌 트레이닝을 실시한 청소년 남성을 네 그룹; RI: 홍삼+인터벌(n=6), AI: 가시오가피+인터벌(n=6), MI: 복합물+인터벌(n=7), IT: 인터벌(n=6)로 나누어 실험을 실시하였다. 연구 대상자는 안정시 심박수, 혈압 등의 검사를 실시하였고, 체중을 측정한 후 지구성 운동수행능력을 측정하기 위해서 실험 전․후 트레드밀을 이용한 운동부하 검사를 실시하여 최대산소섭취량, 무산소성 역치, 탈진시간을 측정하였다. 또한 운동수행시 혈액성분의 변화를 알아보기 위해서 안정시와 운동직후 혈액을 채취하여 적혈구, 헤모글로빈, 헤마토크리트의 변화를 측정하였다. 본 연구의 결과에서 최대산소섭취량과 무산소성 역치 지점은 모든 그룹에서 유의한 차이가 없었다. 탈진시간은 각 그룹 내 시점 간 RI, AI, MI에서 유의한 차이가 있었고, IT은 유의한 차이가 없었다. 운동수행시 적혈구와 헤마토크리트는 실험을 실시한 모든 그룹에서 유의한 차이가 없었다. 하지만, 운동수행시 헤모글로빈은 각 그룹 내 시점 간 RI, AI, MI에서 유의한 차이가 있었고, IT은 유의한 차이가 없었다. 이러한 본 연구의 결과로 인터벌 트레이닝을 한 청소년 남성에 대한 홍삼과 가시오가피의 복합 섭취는 산소를 조직에 운반하는 헤모글로빈 농도를 증가시키고 탈진시간을 증가시킨다고 할 수 있다.

초임계 유체와 공용매를 이용한 미세전자기계시스템 웨이퍼의 식각, 세정을 위한 최적공정조건

노성래,유성식 한국반도체디스플레이기술학회 2017 반도체디스플레이기술학회지 Vol.16 No.3

This study aims to select suitable co-solvents and to obtain optimal process conditions in order to improve process efficiency and productivity through experimental results obtained under various experimental conditions for the etching and rinsing process using liquid carbon dioxide and supercritical carbon dioxide. Acetone was confirmed to be effective through basic experiments and used as the etching solution for MEMS-wafer etching in this study. In the case of using liquid carbon dioxide as the solvent and acetone as the etching solution, these two components were not mixed well and showed a phase separation. Liquid carbon dioxide in the lower layer interfered with contact between acetone and Mems-wafer during etching, and the results after rinsing and drying were not good. Based on the results obtained under various experimental conditions, the optimum process for treating MEMS-wafer using supercritical CO2 as the solvent, acetone as the etching solution, and methanol as the rinsing solution was set up, and MEMS-wafer without stiction can be obtained by continuous etching, rinsing and drying process. In addition, the amount of the etching solution (acetone) and the cleaning liquid (methanol) compared to the initial experimental values can be greatly reduced through optimization of process conditions.

Development of osmotic repulsive potential using lattice fluid model on ligand capped metallic nanoparticles in gas expanded liquid system

노성래,유성식 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6

Not only obtaining nano-sized particles, but controlling mono-dispersed nanoparticles has been regarded as one of the important techniques to employ nano-engineering in many disciplines. To fractionate the nanoparticles synthesized, the gas expanded liquid system (GXLs) has proven to be very useful and effective. Many researchers considered the total interaction energy model comprised as a summation of van der Waals attractive potential, the elastic repulsive potential, and the osmotic repulsive potential as a promising thermodynamic model. In previous models, osmotic contribution was modeled based on the rigid lattice model. Consequently, it was impossible to consider the effect of pressure on GXL operation because osmotic repulsive potential based on rigid lattice modal intrinsically could not reflect the pressure influence. We applied a lattice fluid model in the presence of holes to derive better osmotic repulsive potential. Thus, the effect of pressure on nanoparticle synthesis in GXL process has been successfully investigated. A nanoparticle size predicted using this improved model is in a better agreement to that obtained experimentally.

미디어 산업의 구조적 변화에 관한 연구

노성래(Noh, Seong Rae),김용희(Kim, Yong Hee),최정일(Choi, Jeongil) 한국서비스경영학회 2015 서비스경영학회지 Vol.16 No.4

The objective of this study is to examine the structural changes of the Korean broadcasting communication service industry by analyzing foreign and domestic cases of business diversification and also connecting the business diversification and de-diversification behaviors of the CJ Group and SK Telecom with the market condition. This study found that business diversification is not more superior to de-diversification and vice-versa. It means that both strategies have become the business trend that could work in a competitive or complementary manner. Unusually, in the pay-TV market of Korea, both strategies are expected to occur at the same time to derive mutual benefits.

신경 복사 필드를 사용한 텍스트 기반 3D 건물 생성

노성래(Seongrae Noh),강형엽(Hyeongyeop Kang) 한국정보과학회 2023 한국정보과학회 학술발표논문집 Vol.2023 No.12

배양된 인간영양배엽세포에서 PGE2 와 Prostacyclin 이 혈관내피 성장인자와 염기성 섬유아세포 성장인자의 발현에 미치는 영향

노성래(Sung Rae Roh),김동주(Dong Joo Kim),안현영(Hyun Young Ahn),강미지(Mi Ji Kang),이방현(Bang Hyun Lee),이지현(Ji Hyun Lee),오민정(Min Jeong Oh),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8

N/A Background : Several angiogenic factors such as bFGF and VEGF have been shown angiogenesis of placenta. PGE2 and PGI2 may be important in successful establishment of pregnancy. Objective : We studied to investigate whether PGE2 and PGI2 regulate expression of VEGF and bFGF gene in the cultured human trophoblast cells. Methods : Human trophoblasts were isolated from the placenta of early gestation (6-12 weeks). Isolated trophoblasts were cultured in the different concentration of PGE2 and PGI2 and according to the different cultured time of PGE2 and PGI2, respectively. Total RNA was extracted and RT-PCR was performed. Result : Expression of bFGF was increased in 10-7M and 10-6M of PGE2 and was always increased in the all different concentration of PGI2. Four isoforms (VEGF121, VEGF165, VEGF189, VEGF206) were always expressed in the all different PGE2 and PGI2 concentration compared to the control group. However, there was no significant difference in the all different PGE2 and PGI2 concentration. In both PGE2 and PGI2 treatment group, expression of bFGF was decreased at 60 min compared to the control group and was gradually increased in time-dependent pattern. At 180 min, its expression was similar to the control group. Conclusion : Our data suggest that the expression of bFGF gene is influenced by cultured time and concentration of PGE2 and PGI2, although the expression of VEGF gene is not influenced.