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健腦飮이 海馬損傷白鼠의 記憶 및 學習機能 恢復에 미치는 영향
노상용,엄현섭,지규용 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2
In order to make the efficient prescription and cope with various senile dementia, learning and memory functions of Sprague-Dawley model rats were tested with Morris water maze at first. And to evaluate the effects of the sample drug(GM) on choline acetyltranferase and acetylcholine esterase, immunoreactive measurement and-enzymatic activity measuring were carried out. Rats were injected with ibotenic acid through hippocampus CA1 and CA3 area. The results are as following. GM improves the learning ability in the acquisition test and memory function in the retention test significantly. And GM increases the level of ChAT which is synthesizing acetylcholine in CA3 area, and at the same time it increases the level of AChE which is resolving acetylcholine. These results show that GM improve the cholinergic catabolism and anabolism, and the increment of metabolic activity of cholinergic system contributes to the recovery of damaged learning and memory function by ibotenic acid. So it can be concluded that GM will be helpful to cholinergic brain disease induced by primary or senile reduction of acetylcholine secretive activity.
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노상용,엄현섭,지규용 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
This paper is aimed at explaining about logical structures between the nature(性) and emotions(情) in philosophical concept and the pathological mechanisms in traditional medicine. This research was made through 2 textbooks written by Lee Je-Ma. At first, we propose some Dongmoo's allegations, and after that show some reasons from 〈Yellow Emperor's Medical Classics〉rooting for that pathological viewpoint. On the logical basis at first, Dongmoo classified the nature and emotions with harmonious(中節) or disharmonious and virtuous or vicious, not with manifested already or not. So the nature contains 2 conceptions, one is the attribution of pure virtue, and the other is the energy(性氣) of the nature having various actions. And emotions have 2 aspects of virtual nature and emotional energy too. Second, 4 main categories of the nature and emotions are sorrow·rage·pleasure·enjoyment, and those are corresponded with ears·eyes·nose·mouth and lungs·pancreas·river·kidney. When the 4 elements are manifested onto body, there must be specific movement and be related with the movement of energy of the 4 viscera. Next, the 4 natural energy and emotional energy are corresponded with chin·chest·navel·abdomen and head·shoulder·waist·buttock respectively, so various good and evil or affluent and deficient states, eg. pathological change of these parts can be explained by the 4 energy's activation degrees. Third, more complicated pathologic mechanisms are explained by the theory of concurrent or reverse movement of 4 each energies, eg. upper and lower or anterior and posterior part of body can be damaged successively or concurrently.
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