사물탕(四物湯) 및 구성(構成) 약물(藥物)이 가토(家兎)의 수축혈관(收縮血管)에 미치는 영향(影響)

남창규,배성한,Nam, Chang-Gyu,Bae, Seong-Han 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Objectives : To analyze the effects of Samul-Tang and combinations of constituent herbs on arterial contraction. Method : In order to investigate the effects, Angelicae gigantis Radix, Cnidii Rhizoma, Rehmanniae Radix, Paeoniae Radix, in which one of them, three of them, and all of them, were used to exam. Results : Samul-Tang significantly inhibited the contraction of artery induced by PE(phenylephrine), accordingly as the concentration of Samul-Tang increased and inhibited in both with intact and removed endothelium. Among the constituent herbs of Samul-Tang, Paeoniae Radix and Paeoniae Radix-Cnidii Rhizoma combination inhibited the PE-induced contraction of artery the most. Conclusions : Samul-Tang and constituent herbs of Samul-Tang inhibit the contraction of artery.

사물탕(四物湯)이 혈관내피세포(血管內皮細胞)에 미치는 영향(影響)

남창규,김영균,문병순,Nam, Chang-Kyu,Kim, Young-Kyun,Moon, Byung-Soon 대한한방내과학회 1999 大韓韓方內科學會誌 Vol.20 No.1

This study is designed to investigate the effects of Samul-Tang extract on the response of lactic dehydrogenase(LDH) release, cellular activity, lipid peroxidation, DNA synthesis and the changes of total protein of bovine pulmonary artery endothelial cells(PAEC) from hydrogen peroxide$(H_2O_2)$-induced injury. The results are as follows : 1. Samul-Tang significantly decreased $H_2O_2$-induced release of LDH from injured bovine PAEC. 2. Samul-Tang significantly repressed $H_2O_2$-induced cellular activity from injured bovine PAEC. 3. Samul-Tang significantly repressed $H_2O_2$-induced lipid peroxidation from injured bovine PAEC. 4. Samul-Tang significantly stimulated DNA synthesis in bovine PAEC. 5. Samul-Tang significantly repressed $H_2O_2$-induced changes of total protein volume from injured bovine PAEC. Above results suggest that Samul-Tang can protect bovine PAEC from $H_2O_2$-induced injury. These results can be effectively applied to the prevention and cure of cardiovascular and cerebrovascular diseases.

황련해독탕(黃連解毒湯)이 가토(家兎)의 혈관긴장성조절(血管緊張性調節)에 미치는 영향(影響)

남창규,김호현,정찬길,성현제,권오율,Nam Chang-Gyu,Kim Ho-Hyun,Jeong Chan-Gil,Sung Hyun-Jea,Kwon Oh-Yul 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Objective : The purpose of this study was to analyze the effects of HwangRyunHaeDok-Tang and combinations of constituent herbs on the arterial contraction. Methods : In order to investigate the effects Scutellariae Radix. Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus, in which one of them, two of them, and all of them, were used to exam. Results : The results were summarized as follows; 1. HwangRyunHaeDok-Tang significantly inhibited the contraction of artery induced by Norepinephrine(NE). However the atonic effect was slightly blunted when the vascular endothelial cell was removed. No significant change in the atonic effect of HwangRyunHaeDok-Tang was found when $_L-NNA$ was used as a preliminary treatment. These results indicate that the vascular atonic effect by HwangRyunHaeDok-Tang is slightly dependent on the endothelial cell, and that the HwangRyunHaeDok-Tang works directly to the vascular smooth muscle in creating the vascular atonic effect. 2. The pretreatment of HwangRyunHaeDok-Tang extract significantly inhibited the contractile response to additive application of $Ca^{2+}$ in the strips which were contracted by NE in $Ca^{2+}$-free solution. 3. HwangRyunHaeDok-Tang extract increased the contraction of arterial smooth muscle induced by KCl. Therefore, it can be concluded that HwangRyunHaeDok-Tang may block the NE-receptor or receptor-operated $Ca^{2+}$ channel. 4. It was determined that Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex among the ingredients of HwangRyunHaeDok-Tang have a vascular atonic effect. In addition, those ingredients plays a role in strengthening the atonic effect by working with other herbal medicines. Gardeniae Fructus causes the blood vessel to contract. but it does not influence the atonic effects of other herbal medicines. However Gardeniae Fructus tends to inhibit the vascular atonic effect of Phellodendri Cortex. Conclusion : Based on the above results, it can be said that HwangRyunHaeDok-Tang can be applied to cure hypertension considering those three herbs have significant effects of relaxation.

중풍(中風)에 활용(活用)된 자락요법(刺絡療法)에 대(對)한 문헌적(文獻的) 고찰(考察)

남창규,이진섭,Nam, Chang-Gyoo,Lee, Jin-Seop 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.2

A Literature study was done for identifying the effects of Bloodletting on C.V.A. The major results of the study were as follows. 1. The frequency of points of Bloodletting on C.V.A. were in order Twelve well point, Ship son, Gold SalivaJade Fluid, Paekoe, Chungchung, Sugu, Sosang, Taechu, Wijung, Kwanchung, etc. 2. The frequency of meridians of Bloodletting on C.V.A. were in order Extra-point, Tongmaek-kyong, Su-gworum-Shimpo-Kyong, Susoyang-Samcho-Kyong, Sutaeum-Pye-Kyong, Choktaeyang-Panggwang-Kyong. ete. 3. The frequency of the site of points of Bloodletting on C.V.A. were in order four extremities, face, neck and head, etc. 4. The effects of Bloodletting on C.V.A. is clear away heat and alleviate pain, therapy for waking up a patient from unconsciousness, dredge the meridian passage, expel wind-evil and promote blood circulation, emergency treatment for collapse, etc, 5. The effects of Bloodletting on the early stage of C.V.A. were wake up the patient from unconsciousness by clearing away the heat and The effects of Bloodletting on sequence of C.V.A. were dredge the meridian passage, 6. The frequency of points and meridians of Bloodletting on Hemiplegia were in order Twelve well point, Kyonjong, Extra-point, Chok soyang-Tam-Kyong, etc. 7. The frequency of points and meridians of Bloodletting on Aphasia were in order Gold Saliva Jade Fluid, Amun, Extra-point, Tongmaek-Kyong, etc. 8. The frequency of points and meridians of Bloodletting on Quadriplegia were in order Ship son, Twelve well point, Koktaek, Wijung, Extra-point, Chok soyang-Tam-Kyong, etc. 9, The frequency of points and meridians of Bloodletting on Vertigo were in order Four Gods Cleverness, Tuyu. Chanjuk, Paekoe, Taeyang, Extra-point, Yang-Kyong, etc. 10. The frequency of points and meridians of Bloodletting on Headache were in order Taeyang, Paekoe, Taechu, Extra-point, Tongmaek-Kyong, Yang-Kyong, etc. 11. The points and meridians of Bloodletting on Bells palsy were Chichang, Hyopko in Yangmyong-Kyong.

重患者室에서 氣管內 揷管後 退院한 患者의 臨床統計 考察

南昌圭(Chang-Gyu Nam),文炳淳(Byung-Soon Moon) 대한한의학회 1996 대한한의학회지 Vol.17 No.1

苦蔘이 家免의 血管收縮抑制에 미치는 影響

권오율,남창규,정찬길 世明대학교 한의학연구소 1999 韓醫學硏究所 論文集 Vol.2 No.-

The purpose of this study was to analyze the effect and mechanism of Sophorae Radix on arterial experimental section contracted by PE(phenyl-ephrine). The results were summarized as follows; 1.Sophorae Radix significantly ingibited the PE-induced contraction of artery, accordingly as concentration of Sophorae Radix increased. 2.Sophorae Radix significantly ingibited the PE-induced contraction of artery both with intact endothelium and removed endothelium. 3.The ingibiting effect of Sophorae Radix on contracted strips was not changed by the pretreatment of NLA(Nω-nitro-L-arginine). 4.Sophorae Radix more significantly inhibited the PE-induced contraction of artery than KCI-induced. 5.The mechanism of inhibition of Sophorae Radix on contracted strips is suggested that Ca++ was blocked from the external medium.

枾根이 PE로 유발된 家兎의 수축혈관에 미치는 영향

김희철,남창규 世明대학교 한의학연구소 2002 韓醫學硏究所 論文集 Vol.4 No.-

This study was undertaken to define the effect of Diospyros Kaki L. Radix on the phenylephrine-induced arterial contraction and the mechanism of Diospyros Kaki L. Radix-induced relaxation. In order to investigate the effect of Diospyros kaki L. Radix on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Diospyros kaki L. Radix induced relaxation, Diospyros kaki L. Radix extract infused into contracted arterial strips induced by phenylephrine after treatment of indomethacin, N_(t) nitro-_L-arginine, or tetraethylammonium chloride, and Ca^++ infused into contracted arterial strips by phentlephrineafter treatment of Diospyros kaki L. Radix in a CA^++ free solution. Diospyros kaki L. Radix relax arterial strip with or without endothelium contracted by phenylephrine, but in the strips without endothelium, Diospyros kaki L. Radix-induced relaxation was significantly inhibited. The endothelium-dspendent relaxtion induced by Diospyros kaki L. Radix was decreased by the pretreatment of N_(t) nitro-_L-arginine, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When Ca^++ was applicated the strips which were contracted by phenylephrine in a Ca^++ free solution, arterial contraction was increased. But pretreatment of Diospyros kaki L. Radix inhibited contractile response to Ca^++. We suggest that Diospyros kaki L. Radix may directly suppress influx of extra-cellular Ca^++ and indirectly suppress influx of extra-cellular Ca^++ though the formation of nitric oxide in the vascular endothelial cells.

刺人參이 PE로 유발된 토끼의 수축혈관에 미치는 영향

권오율,남창규 世明대학교 한의학연구소 2002 韓醫學硏究所 論文集 Vol.4 No.-

This study was undertaken to define the effect of Oplopanacis Cortex on the phenylephrine-induced arterial contraction and the mechanism of Oplopanacis Cortex-induced relaxation. In order to investigate the effect of Oplopanacis Cortex on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Oplopanacis Cortex-induced relaxation, Oplopanacis Cortex extract infused into contracted arterial strips induced by phenylephrine after treatment of indomethacin, tetraethylammonium chloride or N_(t) nitro-_L-arginine. The relaxation of Oplopanacis Cortex was dependent on the presence of endothelium, showing that Oplopanacis Cortex-indeced relaxation was not observed in the strips damaged endothelium. The endothelium-dependent relaxation induced by Oplopanacis Cortex was suppressed by the pretreatment of N_(t) nitro-_L-arginine, but it was not observed in the strips pretreated or tetraethylammonium chloride. These result demonstrated that Oplopanacis Cortex may inhibit phenylephrine-induced constraction through the production of nitric oxide in the vascular endothelial cells.

뇌전산화단층촬영(CT)상 확진된 120예의 뇌졸중환자에 대한 임상적 고찰

배성한,남창규,Bae, Sung-Han,Nam, Chang-Gyu 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

Clinical Observation was made on 120 Cases of CVA that were confirmed through brain CT of Oriental Medical hospital of Se-Myung University from July in 1997 to June in 1998. 1. The CVA cases were classified into the following kinds : cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage(SAH), and the greatest in number among them were the cases of cerebral infarction. 2. The most cases were 50 of age in all cases, in cerebral infarction were over 70 of age. There is no significant difference in the frequency of strokes between the male and female. the ratio was 1.07 : 1. 3. The frequency of strokes seems to have no relation to month and season. 4. The course of entering hospital, most patients visited this hospital directly(not through any other hospital) within 24hours. 5. The first attack was noted in 80.8%, the recurrance attack in 19.2% and the cerebral infarction had high recurrance ratio compared with cerebral hemorrhage. 6. The average duration of hospitalization was 25.2 days. 7. The most ordinary preceding disease was hypertension. 8. The common symptoms were motor disturbance and dysphasia. 9. The most frequent location of the lesion in cerebral infarction was parietal lobe, in cerebral hemorrhage was basal ganglia. 10. According to electrocardiography findings, abnormality was noted in cerebral infarction more than cerebral hemorrhage, subarachnoid hemorrhage. 11. The hypercholesterolemia and hypertriglyceridemia were found more frequently in cerebral infarction than cerebral hemorrhage, subarachnoid hemorrhage. 12. The average time to start physical theraphy was 7.76 days after admission. 13. The most common complications were pneumonia and bed sore.

후각장애 환자에서의 麗澤通氣湯 치험 1례

김희택,남창규,배성한 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5

Smell is one of the six human senses and for some individuals is a very important sense and means a great deal more than inst the ability to taste and enjoy food. In order to understand the cause of the taste and smell dysfunction a detailed, specific medical history is necessary and it is well known that olfactory dysfunction relates to many etiologies such as obstructive nasal and sinus diseases, upper respiratory tract infections, head trauma, aging, congenital anomalies, endocrine diseases, drugs and so forth. Among these, the most common causes of olfactory disturbance were upper respiratory infectiom and nasal or sinus disease. We report the case of a 55-year-old male patient who had anosmia before several day and the most obvious and primary complaint is that food no longer has a taste, We treated this case(Olfactory disturbance) with Ryetaktongi-tang and Acupunture, and were improved. so we report it.