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남재희 ( Jae Hui Nam ),이가영 ( Ga Young Lee ),박수홍 ( Soo Hong Park ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.9
Spindle cell hemangioma is an uncommon variant of vascular tumor, and it was first described as a unique vascular lesion that`s characterized by cavernous blood vessels separated by spindle cells. It is recently thought to be a benign hemangioma with a reactive process. It mostly affects the distal extremities and it present as single or multiple lesions that are often painful. Histologically, thin-walled cavernous vessels are seen to be intermixed with varying proportions of bland spindle cells with vesicular nuclei. We report here on an interesting case of spindle cell hemangioma in a 39-year-old woman. (Korean J Dermatol 2009;47(9):1102∼1104)
남재희 ( Jae Hui Nam ),양유진 ( You Jin Yang ),최영준 ( Young Jun Choi ),김희정 ( Hee Jung Kim ),이가영 ( Ga Young Lee ),박수홍 ( Soo Hong Park ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.10
Angioleiomyoma is a deep dermal or subcutaneous, benign tumor that originates from the vascular smooth muscle. It commonly presents between the third and sixth decades of life and it has a female preponderance. It mainly develops on the limbs and especially the lower legs. We experienced a case of angioleiomyoma that occurred on the chin, and this clinically mimicked hemangioma. (Korean J Dermatol 2009;47(10):1206∼1208)
남재희 ( Jae Hui Nam ),최영준 ( Young Jun Choi ),김태환 ( Tae Hwan Kim ),이가영 ( Ga Young Lee ),박수홍 ( Soo Hong Park ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Background: Keloid is one of the most frustrating clinical problems in wound healing. There are numerous treatments for keloids such as surgical excision, steroid injection, radiation therapy, laser, silicone gel application and so on. Surgical excision of a keloid is generally not accepted as a first treatment of choice. However, there have been many reports of successful cosmetic results from specialized surgical treatments such as intra-lesional/intra-marginal excision with or without post surgical adjuvant treatments. Objective: The aims of this study areto evaluate the effectiveness of intralesional excision of keloids, the optimal surgical conditions and the proper adjuvant therapy after surgery. Methods: We analyzed the medical records and clinical photographs of 20 patients who underwent intra-lesional excision of their keloids and who had regular follow-ups for at least for 3 months. The clinical outcomes were assessed by three independent physicians based on their interpretation of the photographs before and after surgery with using a global assessment 5 point scale that ranged from bad, poor, fair and good to excellent. Results: General surgical outcomes after intra-lesional excision: the average improvement score was 4.05 after intra-lesional excision and adjuvant therapy. The average improvement score after intra-lesional excision was 4.71 for ear keloids and 2.83 for keloids in other areas (p=0.000). The average improvement score after intra-lesional excision was 5 for earlobe keloids and 4.42 for ear-helix keloids (p=0.014). The average improvement score was 3.92 for the steroid intra-lesional injection and topical silicone gel combination treatment group after intra-lesional excision and the average improvement score was 4.29 for the single topical silicone gel treatment group (p=0.858). Conclusion: Although surgery is not a first treatment of choice for the management of keloids, large recalcitrant keloids need massive surgical removal for faster clinical results. In this study, we found that surgery, and especially intra-lesional excision, is not an absolute contraindication for treating keloids and this is sometimes considered as the first treatment of choice, and especially for ear keloids. However, a more careful surgical approach is necessary for the case of keloids that develop in other areas. Further studies about the optimal surgical indications for keloids and the recommended adjuvant therapy after surgery are necessary. (Korean J Dermatol 2009;47(6):641∼648)
남재희 ( Jae Hui Nam ),최영준 ( Young Jun Choi ),김태환 ( Tae Hwan Kim ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Sebaceous carcinoma (SC) is a slow-growing, locally aggressive tumor with the high potency of metastatic spread. This neoplasm frequently arises from the sebaceous glands of the eyelid and exceptionally from extraocular sites. Approximately one-quarter of all reported cases of SC are extraocular. We observed a 42-year-old woman with an crusted erythematous to brownish plaque on her scalp. The biopsy specimen showed that multiple lobules were composed of foamy-cytoplasmic cells and sebocytes which show pleomorphism and atypia. For the immunohist-ochemistry, abundant tumor cells (with the expressions of epithelial membrane antigens and cytokeratin) were found within the masses. We present here a case of SC of the scalp arising from a previous lesion clinically compatible with a nevus sebaceous. (Korean J Dermatol 2009;47(3):326∼329)
남재희 ( Jae Hui Nam ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.2
Syringoma is a common, benign, adnexal tumor of eccrine origin. Generalized eruptive syringoma, however, is a rare variant of syringoma which presents as a widespread papular eruption. It occurs in large numbers on the anterior parts of the neck, chest, abdomen, axillae, periumbilical region, or sometimes proximally on the extremities. It is as frequent in prepubertal as in postpubertal age. A 20-year-old woman presented with multiple asymptomatic papules on the face, neck, abdomen, back, upper and lower extremities. Family history showed that her mother had similar lesions on the abdomen. Histologically, numerous ducts are embedded in a fibrous stroma and their walls are lined by two rows of epithelial cells. We report a case of generalized eruptive syringoma. (Korean J Dermatol 2009;47(2):217∼219)
남재희 ( Jae Hui Nam ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.5
Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular tumor. It represents a reactive proliferation of endothelial cells arising in an organized thrombus. And it is histologically characterized by the development of endothelial-lined papillary projections in a vascular lumen. It occurs most frequently in the head and neck region or on the extremities. We report a case of intravascular papillary endothelial hyperplasia developed on the finger. (Korean J Dermatol 2008;46(5):696∼698)
면역억제환자에서 발생한 범발성 편평사마귀를 경구 아시트레틴과 국소 5% Imiquimod Cream 병합요법으로 효과적으로 치료한 1예
임재윤 ( Jae-yun Lim ),김한샘 ( Han-saem Kim ),김정인 ( Jung-in Kim ),민준홍 ( Joon Hong Min ),최영준 ( Young Jun Choi ),남재희 ( Jae Hui Nam ),채승완 ( Seoung Wan Chae ),이가영 ( Ga-young Lee ),김원석 ( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.9
Verruca plana is a subtype of warts, which are one of the most common dermatological diseases. A 37-year-old man presented with multiple asymptomatic skin-colored, 1∼2-mm, flat-topped papules on both arms, neck, and face. The patient had ulcerative colitis, which had been treated with immunosuppressants for 15 years. After skin biopsy, verruca plana was confirmed. The patient was treated with 5% imiquimod cream for 6 months. However, only mild improvement was observed. Acitretin was then added to the treatment regimen. After 44 weeks of treatment, acitretin was stopped. Dramatic and rapid clinical improvement was achieved after 3 weeks of treatment, and no sign of recurrence after treatment cessation has been reported for 60 weeks. Consequently, the combination of oral acitretin and topical 5% imiquimod cream should be recommended for the effective and safe treatment of recalcitrant verruca plana in immunosuppressed patients. (Korean J Dermatol 2017;55(9):597∼601)
대학병원 피부과 외래에 내원한 안드로겐 및 원형탈모증 환자에서의 대표적 Trichoscopic Finding에 대한 고찰
임재윤 ( Jae Yun Lim ),민준홍 ( Joon Hong Min ),최영준 ( Young-jun Choi ),남재희 ( Jae Hui Nam ),이가영 ( Ga-young Lee ),김원석 ( Won-serk Kim ),정호주 ( Ho Joo Jung ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.9
Background: By magnifying the scalp and structure of hair, trichoscopy enables easy differentiation among various hair loss diseases. Objective: To measure the frequency of representative trichoscopic findings in outpatients with androgenetic alopecia and alopecia areata and the frequency of various trichoscopic findings depending on the disease severity of androgenetic alopecia. Methods: This cross-sectional study included 87 patients with androgenetic alopecia (n=57) and alopecia areata (n=30) treated over a year (2014∼2015). Three dermatologists assessed the trichoscopic findings (hair shaft, hair follicle opening, and perifollicular epidermis) in these patients. Results: Vellus hair was observed in 21 of the 30 patients (70%) with alopecia areata and 20 of the 57 patients (35%) with androgenetic alopecia. Among the patients with androgenetic alopecia, as the disease severity increased, the portion of patients with vellus hair, thickness heterogeneity, and honeycomb pigmentation also increased (p<0.05). Conclusion: Trichoscopy is very useful for the diagnosis of androgenetic alopecia and alopecia areata. Additionally, the severity of androgenetic alopecia can be assessed using trichoscopy. (Korean J Dermatol 2016;54(9):699∼705)
CO2레이저와 5% Imiquimod 크림 병합요법으로 치료한 기저세포암
권용현 ( Yong Hyun Kwon ),남재희 ( Jae Hui Nam ),김태환 ( Tae Hwan Kim ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Basal cell carcinoma is the most common skin cancer and surgical treatments like Mohs surgery have been accepted as ideal for it. Although surgical treatments are very effective, non-invasive treatments such as electrocauterization, cryosurgery, CO2 laser and topical 5-fluorouracil cream have been tried because patients need more simple procedures and better cosmetic results. Imiquimod is a Toll-like receptor 7 agonist and which acts as an immune response modifier by inducing several cytokines including interferon. Previously, many reports showed the usefulness of 5% imiquimod cream in treating basal cell carcinoma. However, some local adverse effects, long treatment time and limitation of deep penetration are problems to be resolved. We tried 5% imiquimod cream application after the removal of a visible basal cell carcinoma using CO2 laser, which gave satisfactory results. (Korean J Dermatol 2007;45(11):1187∼1190)
민정 ( Jung Min ),남재희 ( Jae Hui Nam ),정호주 ( Ho Joo Jung ),박지혜 ( Ji Hye Park ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.7
Background: Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, which is commonly treated by a dermatologist but there are few reports about clinical data on cellulitis in Korean literature. Objective: This study evaluated the clinical characteristics of inpatients diagnosed as cellulitis in the recent 5 years. Methods: We reviewed the medical records of 77 patients who were diagnosed as cellulitis and hospitalized at the Kangbuk Samsung Hospital from March 2008 to February 2013. Results: The study included data from 77 patients with cellulitis (mean age, 51.7 years; 44 men, 33 women). There was a positive correlation between age and hospitalized days (p<0.05). Cellulitis most frequently occurred in the foot (32.1%). The most common cutaneous symptoms were erythema, tenderness, and swelling (100%), and the most common systemic symptom was fever (23.4%). Tinea pedis was the most common cause of cellulitis (31.2%). Elevation of C-reactive protein (CRP) was observed in 30 patients (40%) and there were positive correlations not only between CRP and hospitalized days (p<0.05) but also between white blood cell (WBC) count and hospitalized days (p<0.05). First-generation cephalosporin was chosen as the primary antibiotic in 33 patients (40.3%) and the mean duration of antibiotic treatment was 12.4 days. There was no significant difference of hospitalized days between first-generation cephalosporin and other antibiotics (p>0.05). Systemic steroid was administered in 21 patients (27.3%), and was not significantly related to hospitalized days (p>0.05). Conclusion: The clinical course of cellulitis was inversely correlated to the elevation of patient`s age, WBC count, and CRP. (Korean J Dermatol 2014;52(7):479∼485)