춘계학술대회 : 포스터전시 ; HBV와 HCV 감염과 연관된 말기 간질환 환자에서 간이식후 재발되는 C형간염 치료 1예

남성민,유찬란,우현영,정승원,배시현,최종영,윤승규 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)

Dynamic analysis during internal transition of a compliant multi-body climbing robot with magnetic adhesion

남성민,오종균,이기욱,김종원,서태원 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.12

The control of a robot is optimized to improve its energy efficiency and stability in a geometrically complex environment. For thispurpose, analysis is performed on the dynamic modeling of a multi-body robot that can transition its position on corners where horizontalground and a vertical wall intersect. The robot consists of three bodies that can be attached to the wall by permanent magnetic adhesionand connected by links with two types of compliant joints: a passive type with a torsion spring and an active type with a torque-controlledmotor. A dynamics model is derived using the Lagrangian formulation, and investigated in the case of internal corner. Difficulties in theanalysis of dynamics for this wall-climbing robot came from how to manage external forces. The external forces acting on the wallclimbingrobot result from the wall and the magnets, which change the acting points of the forces. Experiments were conducted to determinethe magnetic force with respect to distance. Simulation was then performed to verify the dynamic model. The obtained dynamicmodel can offer a competent tool for the design and control of the autonomous wall-climbing robot, which can be used for the inspectionof heavy-industry buildings, and oil tanks where the geometrically horizontal surface and the vertical wall intersect.

분할 췌와 동반된 유두상 점액성 종양 (Intraductal Papillary Mucinous Neoplasm) 1예

남성민,정우철,진형민,이강문,이보인,장우임,양진모,최규용,정인식 대한소화기내시경학회 2006 Clinical Endoscopy Vol.33 No.3

Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions that require a surgical resection. IPMN can cause abdominal pain or pancreatitis as a result of either mucin production or a papillary growth, resulting in a ductal obstruction. Most IPMNs arise from the main pancreatic duct. However, IPMNs arising from the accessory pancreatic duct are extremely rare. Pancreatic divisum occurs when the ventral and dorsal ducts of the pancreas fail to fuse during organogenesis. It is the most common congenital variant of pancreatic-ductal development, and occurs in approximately 10∼14% of individuals. Although pancreatic divisum has no clinical relevance, some patients present with acute recurrent or chronic pancreatitis. In most cases, it is discovered incidentally during an examination of pancreatitis, and is occasionally accompanied by a pancreatic tumor. We report the first case of IPMN in a patient with an incomplete pancreatic divisum in Korea. (Korean J Gastrointest Endosc 2006;33:191-196) 유두상 점액성 종양(intraductal papillary mucinous neoplasm, IPMN)은 전암성 병변으로 외과적 절제가 원칙이다. 많은 양의 점액과 유두상 종양의 성장으로 췌관이 막히면서 급성 췌장염과 유사한 증상을 일으키거나 만성적인 복통, 체중 감소를 보이기도 하지만 증상이 없는 경우도 있다. 대부분의 IPMN는 주췌관에서 발생하고, 부췌관에서 생기는 경우는 매우 드물다. 분할 췌(pancreatic divisum)는 태생기에 복측 췌관과 배측 췌관이 융합되지 않아 발생하는 가장 흔한 췌장의 선천성 기형으로 서양 보고에 따르면 부검 소견에서 10~14% 정도가 발견된다. 비록 분할 췌의 임상적 의의에 대해서는 논란이 많지만, 일부 환자에서 급성 재발성 췌장염, 만성 췌장염, 만성 복통 등의 증상이 나타나기도 하고, 췌장암과 동반되기도 한다. IPMN와 동반된 분할 췌의 경우는 매우 드문 경우이고 이제까지 국내에서는 보고가 없다. 저자 등은 만성 췌장염 증상을 보인 환자에서 불완전형 분할 췌와 동반된 IPMN 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

남성민,김종휘,유대영,최정훈,김우석,정효영,원무호,황인구,성제경,윤여성 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3

Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Eventhough COX-2 levels are high in healthy animals, the function of this factor in adult neurogenesis has not been clearly demonstrated. Therefore,we performed the present study to compare the effects of pharmacological and genetic inhibition of COX-2 on adult hippocampal neurogenesis. Physiological saline or the same volume containing celecoxib was administered perorally every day for 5 weeks using a feeding needle. Compared to the control, pharmacological and genetic inhibition of COX-2 reduced the appearance of nestin-immunoreactive neural stemcells, Ki67-positive nuclei, and doublecortin-immunoreactive neuroblasts in the dentate gyrus. In addition, a decrease in phosphorylatedcAMP response element binding protein (pCREB) at Ser133 was observed. Compared to pharmacological inhibition, genetic inhibition ofCOX-2 resulted in significant reduction of neural stem cells, cell proliferation, and neuroblast differentiation as well as pCREB levels. Theseresults suggest that COX-2 is part of the molecular machinery that regulates neural stem cells, cell proliferation, and neuroblast differentiationduring adult hippocampal neurogenesis via pCREB. Additionally, genetic inhibition of COX-2 strongly reduced neural stem cell populations,cell proliferation, and neuroblast differentiation in the dentate gyrus compared to pharmacological inhibition.

Generation of 3D Microparticles in Microchannels with Non-rectangular Cross Sections

남성민,김기범,강일석,박욱,이원희 한국바이오칩학회 2019 BioChip Journal Vol.13 No.3

Flow lithography in a conventional rectangular microchannel is limited to fabrication of particles for which only the shapes of top perimeters are controlled. We present a flow lithography technique for fabrication of microparticles of diverse 3D shapes and multiple layers using non-rectangular microchannels with designed cross sections that allow the creation of complex shapes and diverse cross- sectional shapes. Variations in cross-sectional shape allow high-throughput, on-demand production of microparticles in unconventional shapes such as tetrahedrons and pyramids. Multilayered 3D particles were generated in an enlarging triangular channel combined with on-chip PDMS valves, which allow particle alignment and fluid exchange. These 3D microparticles are expected to further expand the wide variety of applications of microparticles, especially in drug delivery and tissue engineering fields.

Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes

남성민,권현정,김우석,김종휘,한규리,정효영,김대원,유대영,성제경,황인구,윤여성 한국실험동물학회 2018 Laboratory Animal Research Vol.34 No.4

In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus of Zucker diabetic fatty (ZDF) rats and their control littermates (Zucker lean control; ZLC). In the ZLC group, body weight steadily increased with age; the body weight of the ZDF group, however, peaked at 30 weeks of age, and subsequently decreased. Based on the changes of body weight, animals were divided into the following six groups: early (12-week), middle (30-week), and chronic (52-week) diabetic groups and their controls. MBP immunoreactivity was found in the alveus, strata pyramidale, and lacunosum-moleculare of the CA1 region, strata pyramidale and radiatum of the CA3 region, and subgranular zone, polymorphic layer, and molecular layer of the dentate gyrus. MBP immunoreactivity was lowest in the hippocampus of 12-week-old rats in the ZLC group, and highest in 12-week-old rats in the ZDF group. Diabetes increased MBP levels in the 12-week-old group, while MBP immunoreactivity decreased in the 30-week-old group. In the 52-week-old ZLC and ZDF groups, MBP immunoreactivity was detected in the hippocampus, similar to the 30-week-old ZDF group. Western blot results corroborated with immunohistochemical results. These results suggested that changes in the immunoreactivity and expression of MBP in the hippocampus might be a compensatory response to aging, while the sustained levels of MBP in diabetic animals could be attributed to a loss of compensatory responses in oligodendrocytes.

도로공사 이수식 쉴드 TBM 굴착토 및 필터케이크 재활용방안 연구

남성민,박서영,안병철 사단법인 한국터널지하공간학회 2022 한국터널지하공간학회논문집 Vol.24 No.6

In order to excavate underground tunnel most safely such as Han river, the slurry shield TBM method is applied to cope with face of high water pressure for many metro projects. In downtown subway project most of excavated soil is discharged externally whereas in road construction excavated soil is used as filling materials so it becomes important factor for success of the project. After excavated soil, weathered rock and soft rock are discharged with bentonite through discharge pipe to slurry treatment plant then those soils are separated in separation plant according to those size. Fine grained soil has been discarded together with filter cake but it is not toxic and can be mixed with coarse aggregate in proper ratio so this study is performed to find use of qualified filling material to meet quality standard. Therefore, in this study, legal standards and quality standards for the utilization of excavated soil of the slurry shield TBM method were examined and test was conducted to derive recycling way for filter cake and aggregate. And a plan for using it as a filling material for road construction was derived. Because bentonite is a clay composed of montmorillonite, and the excavated soil in the tunnel is also non-toxic, disposal of this material can waste social cost so it is expected to be helpful in the underground space development project that carries out the TBM project by recycling it as a valuable resource. 한강과 같은 하저지반을 안전하게 굴착하기 위해서는 고수압 막장면에 대응할 수 있는 이수식 쉴드 TBM 공법을 적용한다. 이수식 쉴드 TBM 공법은 지하철 프로젝트에 널리 활용되어 왔는데 도심지 지하철 공사는 지하에서 연결되기 때문에 굴착토를 대부분 전량 사토해왔으며 필터케이크(벤토나이트)도 폐기물처리를 했다. 이와 달리 도로공사는 절성토의 최적화를 위해 굴착되어 나온 토석을 외부로 반출하는 것이 아니고 대부분 성토재로 활용하는 특징이 있어 굴착토의 활용방안이 프로젝트 성공의 중요한 요소가 된다. 이수식 쉴드 TBM 공법에서 굴착토는 이수재로 사용하는 벤토나이트와 굴착된 토사, 풍화암, 연경암 등이 섞여서 배니관을 통 해 이수처리플랜트로 운송되면 이수처리플랜트에서 처리과정을 거쳐 크기별로 분리 배출된다. 이러한 굴착토 중 세립질의 토사는 필터케이크와 함께 폐기되어 왔으나 그 성분에 독성이 없고 조립토와 적정 비율로 혼합하여 사용하면 성토재의 품질기준을 만족할 수 있어 그 활용방안에 대한 연구를 수행하였다. 본 연구는 이수식 쉴드 TBM 공법의 굴착토의 활용에 있어 제도적 ‧ 기술적 기준을 고찰하여 필터케이크와 골재를 도로공사의 성토재로 활용하는 방안을 도출하였다. 벤토나이트는 몬모릴로나이트로 구성된 점토이며 터널 원지반의 굴착토 또한 독성이 없는 상태로 이를 폐기물 처리하는 것은 사회적 비용이 낭비될 수 있기에 오히려 귀중한 자원으로 재활용하여 향후 이수식 쉴드 TBM 프로젝트를 수행하는 지하공간 개발사업에 도움이 되고자 기대한다.

사용권 없는제3자의 캐릭터 상품화와 부정경쟁방지법 제2조 제1호(가)목의 부정경쟁행위

남성민 한국형사판례연구회 1999 刑事判例硏究 Vol.5 No.-

폴 틸리히의 신학에서 본질, 실존, 그리고 생명의 체계

남성민 연세대학교 신과대학 2008 신학논단 Vol.53 No.-

The purpose of this study is to show the ontological system of analysis on human existence in the theology of Paul Tillich. He analyzed human predicaments in the ontological frame of essence, existence, and life. According to this frame, Person has essential finitude, existential estrangement, and the ambiguity of life as the human predicaments, In this article, I attempted to demonstrate the system of the essence, existence, and life. In first, there is the double relationship of participation and transcendence between human being and Being itself. Thus, in this condition, the ontological question, the question of being is possible, and a existential person can ask and answer. Second, existential person is restricted by non-being, and this restriction is the finitude. Non-being that happens ontological question is divided into absolute non-being(ouk on) and relative non-being(me on). Ouk on is equal to the Being itself on that everything is ground, because both absolute non-being and being itself have no limitation and concrete contents. Me on is the discontinuity between what it is, what it should be and what it actually is. The finitude of human existence is conditioned by these non-beings. Third, this finitude is the essence of human existence. But essence is not a actuality but a potentiality of being. Essence is relative non-being, the potentiality of being, and existence is the actuality of being. There is discontinuity between essence and existence, potentiality and actuality. This discontinuityis the estrangement. Fourth, essence, existence is not concrete but abstract, In the movements of human‘s concrete life such as self-integration, self-creation, self-transcendence, essence and existence are mixed, not divided perfectly. So life is ambiguous. Tillich‘s ontological system of Analysis on human existence is based on christological doctrine of humanity. He divided the areas of good creation and of fallenness. Person experiences the divine, and asks the question of salvation. This question is the ontological question. Tillich’s analysis on human predicaments -essential finitude, existential estrangement, and ambiguous life- is not the theoretical question, the question of "asking about", but the existential question, the question of "asking for" Thus, We should interpret the analysis of human existence in the light of salvation.

유연한 등반 로봇의 동역학 해석

남성민(Sungmin Nam),오종균(Jongkyun Oh),이기욱(Giuk Lee),김종원(Jongwon Kim),서태원(TaeWon Seo) 한국정밀공학회 2012 한국정밀공학회 학술발표대회 논문집 Vol.2012 No.5월