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나민균,하티탄훵,안인파,이상명,김영호,이종필,성락선,이경순,배기환,Na, Min-Kyun,Huong, Ha Thi Thanh,An, Ren Bo,Lee, Sang-Myung,Kim, Young-Ho,Lee, Jong-Pill,Seong, Rack-Seon,Lee, Kyong-Soon,Bae, Ki-Hwan 한국생약학회 2000 생약학회지 Vol.31 No.3
Lonicerae Flos, the flower of Lonicera japonica Thunb., has been used as a diuretic, stomachic, antipyretic, analgesic and anti-inflammatory agent in Korea. In order to evaluate the quality of Lonicerae Flos, the method of isolation and quantitative determination of luteolin $7-O-{\beta}-D-glucoside$ as a reference standard compound has been developed. Different specimens of Lonicerae Flos were collected from twenty Korean markets and were analyzed with HPLC using the mobile phase of MeOH-4.5% acetic acid solution (16.5:83.5). The average content of luteolin $7-O-{\beta}-D-glucoside$ from Lonicerae Flos in Korean markets was $0.43{\pm}0.34%$.
나민균,안인파,이상명,홍남두,유재국,이찬복,김진표,배기환,Na, Min-Kyun,An, RenBo,Lee, Sang-Myung,Hong, Nam-Doo,Yoo, Jae-Kuk,Lee, Chan-Bok,Kim, Jin-Pyo,Bae, Ki-Hwan 한국생약학회 2001 생약학회지 Vol.32 No.2
Based on DPPH radical scavenging activity and lipid peroxidation inhibitory activity, the MeOH extracts of 139 crude drugs were screened in order to search for antioxidants. Among tested samples, the extracts from the seed of Nelumbo nucifera, the fruit of Terminalia chebula var. gangetia, the root of Salvia miltiorhiza, the fruit of Ziziphus jujuba var. innermis, the root bark of Paeonia moutan, the fruit of Rubus coreanus, the fruit of Zanthoxylum schinifolium, the lignum of Caesalpinia sappan, the leaf of Pinus densiflora, the rhizome of Alpinia officinarum, the fruit of Syzygium aromaticum, the ramulus and uncus of Uncaria rhynchophylla, the root bark of Lycium chinense, and the fruit of Alpinia katsumadai showed a relatively strong antioxidative activity. Furthermore, the BuOH fraction from the extract of N. nucifera showed a potent activity in each assay. The isolation of bioactive compounds has been carried out and will be reported in the next paper.
나민균,최승열,김동희,김진표,이찬복,김경동,Na, Min-Kyun,Choi, Seung-Youl,Kim, Dong-Hee,Kim, Jin-Pyo,Lee, Chan-Bok,Kim, Kyung-Dong 대한한방피부미용학회 2005 대한한방피부미용학회지 Vol.1 No.1
(1) Objectives: To discover natural skin-lightening agents, we have evaluated the inhibitory activity of EtOH extracts from 20 medicinal plants against mushroom tyrosinase. (2) Methods: Tyrosinase activity was determined by the dopachrome method using L-tyrosine as the substrates. (3) Results: Of the plant extracts tested, the extracts of 4 plants, Albizzia julibrissin, Curcuma longa, Anethum graveolens and Sophora flavescens, exhibited potent inhibitory activity (> 50%) in mushroom tyrosinase assay. Four plant extract, extracts of Agrimonia pilosa, Paeonia moutan, Magnolia obovata and Eugenia caryophyllata also showed relatively strong inhibitory (> 40%) against mushroom tyrosinase. (4) Conclusion: These active medicinal plants may be useful for the development of skin-whitening agents. Since the active medicinal plants may contain effective tyrosinase inhibitors even more than kojic acid, further study to identify the active constituents from the plants is expected.
나민균,박진영,안인파,이상명,김영호,이종필,성락선,이경순,배기환,Na, Min-Kyun,Park, Jin-Young,An, Ren Bo,Lee, Sang-Myung,Kim, Young-Ho,Lee, Jong-Pill,Seong, Rack-Seon,Lee, Kyong-Soon,Bae, Ki-Hwan 한국생약학회 2000 생약학회지 Vol.31 No.3
Polygoni Multiflori Radix, the root of Polygonum multiflorum Thunb., has been used as a tonic, and in the inflammation and constipation in Korea. In order to evaluate the quality of Polygoni Multiflori Radix, the method of isolation and quantitative determination of emodin as a reference standard compound has been developed. Different specimens of Polygoni Multiflori Radix were collected from twenty Korean markets and were analyzed with HPLC using the mobile phase of MeOH-water (64:36). The average content of emodin from Polygoni Multiflori Radix in Korean markets was 0.021%.
Natural Compounds with Antioxidant Activity: Recent Findings from Studies on Medicinal Plants
나민균,Phuong Thien Thuong,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Reactive oxygen species potentially cause damage to cellular components including lipids, protein and DNA; this oxidative damage plays a key role in the pathogenesis of neurodegenerative disease, cardiovascular disease, metabolic disease and cancer. On the basis of the oxidative stress hypothesis, a number of studies have been performed to search for an efficient and safe antioxidant. Although in vitro studies have provided promising results, only a limited number of natural and synthetic antioxidants have been developed for clinical application due to their low efficacy and side-effects. Thus, the discovery of new antioxidants with marked efficacy and safety has attracted worldwide attention in recent decades. Since plants are recognized as important sources of natural antioxidants, our research has focused on the discovery of new naturally occurring antioxidants from medicinal plants. The purpose of this review is to open a new prospect in the field of search for natural antioxidants from medicinal plants by summarizing our recent findings. Using in vitro bioassay systems such as 2,2-diphenyl-1-picrylhydrazyl, superoxide radical scavenging tests and lipid peroxidation models, we have tested over than 350 species of medicinal plants for their antioxidant activity and selected several of them for further investigation. During the research on the discovery of effective natural antioxidants from the medicinal plants selected, we have isolated several new and known antioxidant compounds that include stilbene glycosides, phenolic glycosides, flavonoids, oligostilbenes, and coumarins. Our results suggest that the presence of antioxidant compounds in the medicinal plants might be associated with the traditional use to treat inflammation, cardiovascular disease and various chronic diseases.