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무과립구증과 동반된 Propylthiouracil 에 의한 급성 간염 1 예
김홍자,오화은,이재균 대한내과학회 2001 대한내과학회지 Vol.61 No.1
Hyperthyroidism is a common condition which is initially managed with an antithyroid drug, either propylthiouracil or methimazole. Adverse reactions occur in 1-5% of patients taking antithyroid medications, most commonly transient, benign leukopenia and skin rash. Agranulocytosis and liver dysfunction are reactions which occur infrequently. Severe hepatic toxicity combined with agranulocytosis has been known as rare complication. Experimental studies have demonstrated that immunological mechanisms play an important role. While most patients are completely recovered after stop of medication, some patients can show grave prognosis. We report a case of propylthiouracil induced hepatitis with agranulocytosis. (Korean J Med 61:50-52, 2001)
일본제국주의(日本帝國主義)에 대한 비판의식(批判意識) 고찰(考察) -궁택현치(宮澤賢治) 작품(作品)을 중심으로-
김홍자,추석민 한일군사문화학회 2016 한일군사문화연구 Vol.21 No.-
본고는「축제의 밤」에서는 개인의 도덕적 해이에 대한 비판을, 「고양이 사무소」에서 집단따돌림이라는 소재로 인간에 대한 배척과 멸시 등 집단의 도덕적 해이에 대한 비판을 그려내고 있음을 순차 분석하였다. 이어 군국주의식 일본제국주의 팽배로 국민들의 반발이 극심했던 시기에 집필된「북수장군과 의사 삼형제」는 오랜 세월동안 국가를 위해 전쟁터에서 희생하고 후유증에 시달리는 병사들에게 기본적인 삶의 보장조차 책임지지 않는 국가에 대한 반감표명을 의사 삼형제의 치료과정 장면을 극대화하면서 작품이면에 작가의 비판의식을 내재시켜 놓음으로 분석하였다. 또한 세 작품의 집필시기가 각각 1924년, 1926년, 1931년임에 주목하여 개인의 도덕적 해이에 대한 비판에서 집단의 도덕적 해이에 대한 비판으로, 나아가 제국주의 국가에 대한 비판으로 외연 확장하고 있음을 조명하였다. 즉 개인에서 집단으로, 집단에서 국가로 작가의 비판의식이 비상식적 개인과 사회윤리가 해제된 사회, 군국주의식 일본제국주의인 국가로 그 비판이 대상전이 되고 있음을 고찰하였다. 宮澤賢治が活發に創作活動をしていた時の時代的な狀況は、政治權力による思想彈壓と軍國主義の日本帝國主義という國策が露骨しつつある混亂期であった。のみならず、軍需の景氣好況によっておびただしい富を蓄積した資本家と低賃金で酷似されていた國民の間には對立の意識が目立つようになっていて、經濟界の不況と恐慌の中で、階級鬪爭は持續的に激しくなっていた。博愛主義と平和主義を志向していた賢治は、このような數多い矛盾に煩惱しながら當時の社會現實を强く批判し、日本帝國主義の國策に對する反感を持つしかない必然性で創作していたと思われる。本稿は、第一、「祭の晩」と「猫の事務所」で、「集團いじめ」という共通的な素材で人間に對する排斥と蔑視を批判の觀点から、集團の道德の緩みという觀点で着目していることを照明してみた。ただし、「集團いじめ」において「祭の晩」は、異邦人に對する排斥と輕蔑を素材にしながらも眞實の交感で、「猫の事務所」は劣等人に對する蔑視と姦計を素材にしながら事務所の閉鎖という相反する作品の結末を見せている。このような点においては、同じ素材に違う結末という形で、作品のなかの現實に對する批判意識は共通していることが分かる。第二、軍國主義の日本帝國主義の澎湃で國民たちの反發が激しかった時期に執筆された「北守將軍と三人兄弟の醫者」は、長い間、國のために戰場で犧牲し、後遺症に惱んでいる兵士たちに基本的な生活さえ保障してくれない國に對する反感の表明を三人兄弟の醫者の治療の場面を極大化させながら作品の裏面に作家の批判意識を潛めておいたことが分かる。最後に、「祭の晩」と「猫の事務所」、「北守將軍と三人兄弟の醫者」が執筆された時期を作品の分析の順序通りに1924年、1926年、1931年であることに注目した。個人の道德の緩みに對する批判から集團の道德の緩みに對する批判、そして帝國主義國家に對する批判へに續いていることをその根據にして、個人、集團、國家へにそれがだんだん廣がっていて、 個人と集團から國家へと作家の批判が對象轉移していることを考察した。
Giant Cell Reparative Granuloma 가 합병된 예를 포함한 한국인 골의 파제트병 가계
김홍자,조유숙,송영기,이기업,박중열,김기수,신명진,김선희,조재근 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.4
Paget bone disease(PBD) is usually focal, but can be wide spread disorder of the skeletal remodeling characterized by greatly increased osteoclast size and activity. It has extremely variable prevalence worldwide, being common in England and northern European countries and areas populated by their descendants, but strikingly uncommon in Asia, the middle east, Africa and Scandinavia. It's occurrence also shows familial clustering, some postulates autosomal dominant inheritance. Many studies have shown that paramyxoviruses may play a critical role in the etiology of this disorder. However, the precise etiology of PBD remains unknown. We describe a kindred with PBD in 3 successive generations. The propositus, a 55-year-old man, has panostotic PBD and giant cell reparative granuloma of pagets disease involving his head, mandible, abdomen and ileum, rare tumorous complication of Paget's disease. Bowed limbs were first noticed at age 25 years, and progressed for 20 years. Giant cell reparative granuloma began manifesting at age 45 years, and responded dramatically to high-dose dexamethasone therapy. His pretreatment biochemical finding were remarkable for elevated serum ALP, 765(normal 66-220 u/L) and osteocalcin, 154(normal 6.3-30.7 mg/ml), but normal serum calcium, phosphorous, 250HD and PTH. A nondecalcified iliac crest specimen demonstrated classic histopathologic 25OHD and PTH. A nondecalcified iliac crest specimen demonstrated classic histopathologic changes of PBD on light microscopy. His decreased father had a similar degree of bony deformities beginning at age 20 years, but had not been examined. His two asymptomatic daughters, 20 and 24-year-old, were both found to be affected with widespread PBD by bone scan, radiographic study, and their serum ALP levels, 939 and 435U/L, respectively. This is the first report of familial occurance of PBD and a case of giant cell reparative granuloma of Paget's disease in Korea, where PBD is very rare(J Kor Soc Endocrinol 10: 456-467, 1995).
수업 중 교수자의 언어적 표현이 학습자의 학습동기의 질적 변화에 미치는 영향
김홍자 언어과학회 2019 언어과학연구 Vol.0 No.88
This paper presents very interesting and creative research on relations between teachers' linguistic expressions in lessons and learners' learning motivations to figure out the effects of instructors on their students' learning motivations in a college educational environment. There are few researches like this in this field in the nation, and it has great implications for improved lesson environments in colleges and universities. The study analyzed the effects of instructors' attitudes based on linguistic expressions in lessons on learners' learning motivations and found that their negative linguistic attitude was an influential factor for learners' learning motivations. The study also analyzed connections and relations among the factors, testing its hypotheses.