남자 만성 정신분열병환자에서 Haloperidol과 Nimodipine의 병합사용이 혈장 HVA와 5-HIAA에 미치는 영향

김형섭,최애경,지성학,김수동,박성덕,김광현,Kim, Hyeong-Seob,Choi, Ai-Kyung,Jee, Sung-Hak,Kim, Soo-Dong,Park, Sung-Deok,Kim, Kwang-Hyeon 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

본 연구는 난치성 만성 정신분열병 남자환자 20명을 대상으로 항정신병약물인 haloperidol 올 2주간 일정량으로 유지한후 중추신경계에 비교적 선택적으로 작용하는 칼슘차단제인 nimodipine을 5주간 병합투여하였고 BPRS, Simpson-Angus Scale Averse events-Somatic Symptoms 등을 이용하여 nimodipine투여전, 투여후 1주, 3주, 5주에 임상반응을 평가하고 혈장 HVA, 5-HIAA농도를 투여전과 투여후 1주, 3주, 5주에 측정하여 다음과 같은 결과를 얻었다. 1) Nimodipine과 haloperidol의 병합투여시 전체 BPRS점수 및 사고소검사점수, 편집성소검사점수는 용량에 관계없이 기간에 따라 감소하는 추세를 보였으나, 특히 nimodipine 90mg을 병용투여하는 군의 경우 nimodipine투여전과 비교하여 3, 5주째에서 통계적으로 의미있게 감소하는 결과를 나타냈다(p<0.05). 2) Nimodipine과 haloperidol의 병합투여에 따른 부작용등은 통계적으로 의미는 없었으나 기간에 따라 감소하는 추세를 보였고, 임상적으로 관찰된 소견상 추체외로증상, 안구동통, 정서적 불안정, 심혈관계 부작용 등의 심각한 부작용은 없었다. 3) Nimodipine의 투여량 및 기간에 따른 혈장 HVA와 5-HIAA의 농도변화는 없었다. 4) BPRS점수가 20% 이상 감소하는 경우를 호전된 것으로 간주했을때 호전군과 비호전군간의 혈장 HVA 및 5-HIAA는 차이를 나타내지 않았고, 각 군에서 측정시기에 따른 차이도 보이지 않았다. 상기 결과로 보아 nimodipine이 혈장 HVA와 5-HIAA의 농도변화에 영향을 미치지 않으나 임상적인 호전은 나타내는 바 난치성 정신분열병환자, 노인환자나 항정신병 약물에 대해 부작용이 심한 정신분열병환자에서 nimodipine 병합사용이 유용할 것으로 사료된다. In an open labeled study, two fixed doses of nimodipine(45mg and 90mg daily) were added to the usual antipsychotic drug treatment (Haloperidol : mean dose=25mg/day) in 20 male chronic schizophrenics for 5 weeks. The purposes of this study were to evaluate the therapeutic effects and the effect an the changes of plasma homovanillic acid(HVA) and 5-hydroxyindoleacetic acid(5-HIAA) levels. The results were as follows : 1) Total BPRS score and thought cluster, paranoid cluster subscores showed linear decreasing trend over the course of the study(P<0.05). Especially the thought cluster and paranoid cluster subscores were significant difference between 45mg and 90mg dose of nimodipine(P<0.05). The improvement rates were 45,45% of 90mg and 11.11% of 45mg, but there was no significant difference between the 45mg and 90mg dose of nimodipine. 2) The scores of extrapyramidal symptoms and adverse events-somatic symptoms showed a linear decreasing trends over the course of study. 3) The changes in the mean plasma HVA and 5-H1AA concentrations by the dosages and durations of combining of nimodipine were not statistically significant. 4) There was no statistical significance in plasma HVA and 5-HIAA of the improved, non-improved goroup. Nimodipine has a possibility os on adjunctive agent for treatment resistant schizophrenics, elderly patients and liable patients for the Side effects to usual antipsychotic drugs. So we suggest that the dosage of nimodipine must be above 90mg/day in the treatment of schizophrenia.

폴리에틸렌, 폴리프로필렌, 폴리스티렌 이성분 혼합물의 유변학적 성질 및 다이 팽윤

김형섭,김상용,전붕수,Kim, Hyeong-Seop,Kim, Sang-Yong,Jeon, Bung-Su 한국섬유공학회 1994 한국섬유공학회지 Vol.31 No.10

A study has been made on the die-swell and rheological properties of bicemponent polymer blends of low density polyethylene(PE), polypropylene(PP) and polystyrene(PS); PE/PP, PE/PS, and PP/PS. In the case of PE/PP blends the continuous phase transferred from PE to PP at the PE content of 60wt%. Meanwhile the PE/PS and PP/PS blends the continuous phase transferred from PE to PS and from PP to PS at the PS content of 60wt%. respectively. The die-swelling ratio. normal stress difference(N1) and dynamic shear viscosity of PE/PP blends appear, to show same tendency by chaneine the blend-ratios. For the cases of both PE/PS and PP/PS blends, where PE and PP are in the continuous phase, the die-swelling ratios increase as the N1 increases but decrease as the dynamic shear viscosity increases. But N1 of the PS has been found not to contribute to the die-swelling ratios when PS is in the continuous phase.

『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 따른 대시호탕(大柴胡湯) 투여와 압출치료를 병행하여 호전된 성인 여드름 증례보고

김형섭,Kim, Hyeong-Seop 대한상한금궤의학회 2017 대한상한금궤의학회지 Vol.9 No.1

Objectives : The purpose of this case report is to report the effect of Daesiho-tang on adult acne by Shanghanlun provisions with extrusion therapy. Methods : According to diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung Gyeolhyung and treated by Daesiho-tang with extrusion therapy. The result of administrations were evaluated by Korean Acne Grading System(KAGS), Korean Skindex-29, and change of clinical symptoms. Results : After administration of Daesiho-tang for 150 days with weelky extrusion therapy, KAGS improved from grade 4 to grade 1, Skindex-29 improved from 67.93 to 15.51, and patient was very satisfied with the treatment. No serius treatment-related adverse events were reported. Limitations : This case is only one case that the level of evidence is weak. Two interventions were used together and the duration of photo was uneven. Conclusions : The patient almost recovered from acne treated by Daesiho-tang according to diagnostic system based on Shanghanlun provisions with extrusion therapy. This is the first case report that suggests '熱結在裏' on the number 136 provision of Shanghanlun means fever that is always present in chronic skin lesions.

한국인의 상악 유치악 치열 및 무치악 치조제에 관한 삼차원적 연구

김형섭,신상완,Kim Hyeong-Seop,Shin Sang-Wan 대한치과보철학회 2005 대한치과보철학회지 Vol.43 No.2

Statement of problem. In Korea, the preliminary impression trays for dental and edentulous maxillae are manufactured on the base of the statistical value of Westerners. There had been less study on the dental and edentulous arches of Koreans. Purpose. The purpose of this study was to evaluate an average dental cast, preliminary impression trays, three-dimensional relation of dental and edentulous maxilla of Koreans Material and methods. The subjects for this study were 173 dental casts of maxilla (dental: 52, edentulous : 146) with ages $18\{\sim}60$ years old. Each of the master casts was measured 69 measuring points on the dental cast or maxilla, and 46 measuring points on the edentulous cast of maxilla with three-dimensional digital measuring machine. Each measuring points were analysed and were overlapped, that three dimensional dental graphic manufactured by CAD/CAM system. Results. 1. A standard of distribution to alveolar bone were width between left and right buccal border lines of the standard 3/4 line. The mean value of dental and edentulous casts were 67.27mm, 63.49mm respectively. 2. Morphological classification of dental casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 17%, 16%, 67%, respectively. Dimensional classification of the dental casts were divided into five groups of less than 63mm, 63 up to 65mm, 65 up to 67mm. 67 up to 69mm, more than 69mm, respectively. 3. Morphological classification of edentulous casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 18%, 17%, 65%, respectively Dimensional classification of the edentulous casts were divided into five groups of less than 57mm, 57 up to 61mm, 61 up to 65mm, 65 up to 69mm, more than 69mm, respectively. 4. Mean dental and edentulous cast of maxilla were overlapped, the proportion of bone resorption to alveolar bone is higher than that of palatal bone, its difference were higher anterior 2/4 area than posterior 3/4 area. Conclusion. It obtains information of preliminary impression trays for dental and edentulous maxilla of Koreans.

원전 운영 - 한국형 신형 원전의 최초 발전소 신고리원자력 3호기

김형섭,Kim, Hyeong-Seop 한국원자력산업회의 2018 원자력산업 Vol.38 No.1

고효율 필터의 입자포집 거동에 관한 연구

김형섭,진동식,조광수,서문호,Kim Hyungsup,Jin Dong Sik,Cho Kwang-Soo,Seo Moon Hwo 한국섬유공학회 2005 한국섬유공학회지 Vol.42 No.4

The filtration behaviors of glass filters were studied by measuring the air permeability, pressure drop and SEM images of five HEPA grade filter material. Based on the observations, the filtration mechanism was described in terms of fiber diameter, packing density and filter depth. The results indicate that the finer fibers and fibers on/near the filter media surface show better filtration performance. Also the captured particles on the fibers formed dendrites, which influenced further filtration.

『상한론(傷寒論)』 처방에서 감초(甘草) 용량의 안전성 및 임상 사용에 대한 문헌 고찰

김형섭,이숭인,Kim, Hyeong-Seop,Lee, Soong-In 대한상한금궤의학회 2016 대한상한금궤의학회지 Vol.8 No.1

Objectives : The purpose of this paper is to find out the safe dose and clinical use for administration of Glycyrrhizae Radix in Shanghanlun(傷寒論). Methods : Web-databases(OASIS, NDSL, Pubmed, Google) were searched with keywords including 'Licorice', 'Pseudoaldosteronism', 'Glycyrrhizin', 'Testosterone' on 14/10/2016. The searched about 40 papers and books were reveiwed. Results : Glycyrrhizin(GL) and 3-monoglucuronyl glycyrrhetinic acid(3MGA) in Glycyrrhizae Radix are found to be the main compounds vulnerable for inducing pseudoaldosteronism. The dose range of Glycyrrhizae Radix in Shanghanlun prescriptions is from 0.25 g to 12 g as a daily administration, and this dose satisfies the guidelines of WHO, European Union, ABC etc. And risk factors contributing for personal sensitivities are old age(>60), female sex, liver dysfunction, hypokalemia, prolonged gastrointestinal transit time, anorexia nervosa, decreased 11-${\ss}$-hydroxysteroid dehydrogenase-2 activity and hypertension. Conclusions : As a result, dose of Glycyrrhizae Radix in Shanghanlun(傷寒論) is safe. However, the personal sensitivity and unexpected drug interactions are independent from doses of GL, so doctors should monitor those risk factors and symptoms of pseudoaldosteronism when administering Glycyrrhizae Radix.

이온보조반응법으로 처리한 알루미나 코아의 인장결합강도에 관한 연구

김형섭,우이형,권긍록,최부병,최원국,Kim, Hyeong-Seob,Woo, Yi-Hyung,Kwon, Kung-Rock,Choi, Boo-Byung,Choi, Won-Kook 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.5

This study was undertaken to evaluate the tensile bond strength of In-Ceram alumina core treat-ed by ion assisted reaction(IAR). Ion assisted reaction is a prospective surface modification technique without damage by a keV low energy ion beam irradiation in reactive gas environments or reactive ion itself. 120 In-Ceram specimens were fabricated according to manufacturer's directions and divided into six groups by surface treatment methods of In-Ceram alumina core. SD group(control group): sandblasting SL group: sandblasting + silane treatment SC group: sandblasting + Siloc treatment IAR I group: sandblasting + Ion assisted reaction with argon ion and oxygen gas IAR II group: sandblasting + Ion assisted reaction with oxygen ion and oxygen gas IAR III group: sandblasting + Ion assisted reaction with oxygen ion only For measuring of tensile bond strength, pairs of specimens within a group were bonded with Panavia 21 resin cement using special device secured that the film thickness was $80{\mu}m$. The results of tensile strength were statistically analyzed with the SPSS release version 8.0 programs. Physical change like surface roughness of In-Ceram alumina core treated by ion assistad reaction was evaluated by Contact Angle Measurement, Scanning Electron Microscopy, Atomic Force Microscopy; chemical surface change was evaluated by X-ray Photoelectron Spectroscopy. The results as follows: 1. In tensile bond strength, there were no statistically significant differences with SC group, IAR groups and SL group except control group(P<0.05). 2. Contact angle measurement showed that wettability of In-Ceram alumina core was enhanced after IAR treatment. 3. SEM and AFM showed that surface roughness of In-Ceram alumina core was not changed after IAR treatment. 4. XPS showed that IAR treatment of In-Ceram alumina core was enabled to create a new functional layer. A keV IAR treatment of In-Ceram alumina core could enhanced tensile bond strength with resin cement. In the future, this ion assisted reaction may be used effectively in various dental materials as well as in In-Ceram to promote the bond strength to natural tooth structure.

치주질환과 용해소체효소;치주질환 활성에 관한 실험적 연구

김형섭,Kim, Hyong-Seop 대한치주과학회 1989 Journal of Periodontal & Implant Science Vol.19 No.2

제 2 발표장 : 나노결정 구리의 기계적 성질의 복합재료모델에 관한 연구

김형섭,조성석,천병선 ( H . S . Kim,S . S . Cho,B . S. Chun ) 한국복합재료학회 1996 한국복합재료학회 학술발표대회 논문집 Vol.- No.2