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김해영 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20
Purpose) Bilious vomiting in the neonatal period may be a serious surgical problem. Intestinal malrotation has a variable clinical presentation and is one of the most important diseases to be diagnosed differently in such situations. This study was performed to analyze the clinical characteristics of patients with intestinal malrotation. Subject and Methods) A retrospective review of 11 patients who had intestinal malrotation and received operation at the Pusan National University Hospital from Jan 2001 to Dec 2005 was done. Results) Among 11 cases of intestinal malrotation, there were 8 males and 3 females with male predominance. At the time of operation, 10 patients(90.9%) were in the neonatal period. According to clinical manifestations, the most common symptom was bilious vomiting that was seen in 11 cases(100%). Ultrasonographic examination was performed in all symptomatic cases and a abnormal location of SMA/SMV or 'whirl-pool' sign was seen in them. According to operative findings, malrotation only was 6 cases(54.5%) and malrotation with midgut volvulus was 5 cases(45.5%). After a definite procedure, adhesive intestinal obstruction was developed in 3 cases and among them one case required re-operation. There was no mortality case. Conclusions) Intestinal malrotation could be concerned preferentially for patients presenting bilious vomiting at the neonatal and infantile period. And proper diagnostic attempts and early surgical management will show a good result.
지터에 강건한 딥러닝 기반 프로파일링 부채널 분석 방안
김주환(Ju-Hwan Kim),우지은(Ji-Eun Woo),박소연(So-Yeon Park),김수진(Soo-Jin Kim),한동국(Dong-Guk Han) 한국정보보호학회 2020 정보보호학회논문지 Vol.30 No.6
딥러닝 기반 프로파일링 부채널 분석은 신경망을 이용해 부채널 정보와 중간값의 관계를 파악하는 공격 방법이다. 신경망은 신호의 각 시점을 별도의 차원으로 해석하므로 차원별 가중치를 갖는 신경망은 지터가 있는 데이터의 분포를 학습하기 어렵다. 본 논문에서는 CNN(Convolutional Neural Network)의 완전연결 층을 GAP(Global Average Pooling)로 대체하면 태생적으로 지터에 강건한 신경망을 구성할 수 있음을 보인다. 이를 입증하기 위해 ChipWhisperer-Lite 전력 수집 보드에서 수집한 파형에 대해 실험한 결과 검증 데이터 집합에 대한 완전연결 층을 사용하는 CNN의 정확도는 최대 1.4%에 불과했으나, GAP를 사용하는 CNN의 정확도는 최대 41.7%로 매우 높게 나타났다. Deep learning-based profiling side-channel analysis is a powerful analysis method that utilizes the neural network to profile the relationship between the side-channel information and the intermediate value. Since the neural network interprets each point of the signal in a different dimension, jitter makes it much hard that the neural network with dimension-wise weights learns the relationship. This paper shows that replacing the fully-connected layer of the traditional CNN (Convolutional Neural Network) with global average pooling (GAP) allows us to design the inherently robust neural network inherently for jitter. We experimented with the ChipWhisperer-Lite board to demonstrate the proposed method: as a result, the validation accuracy of the CNN with a fully-connected layer was only up to 1.4%; contrastively, the validation accuracy of the CNN with GAP was very high at up to 41.7%.
김해영,강단비,박원,조주희,박혁곤,김은주,최두호,조원경,전병준,이경태 한국유방암학회 2021 Journal of breast cancer Vol.24 No.2
Purpose: In this study, we examined the impact of reconstruction using tissue expander insertion (TEI) on the risk of radiation dermatitis in patients undergoing postmastectomy radiotherapy (PMRT). Methods: Between August 2015 and March 2019, patients with breast cancer who had received systemic chemotherapy and PMRT were prospectively included. Skin parameters, including melanin, erythema, hydration, sebum, and elasticity, were measured using a multiprobe instrument at 6 time points: before the initiation of radiotherapy (pre-RT), at weeks 1, 3, and 5 during radiotherapy (weeks 1–5), and 1 and 3-month after radiotherapy (post-RT1m and post-RT-3m). Patient-reported outcomes (PROs) were assessed at each time point. Changes in biophysical parameters and PRO were compared between patients with and without TEI (TEI+ vs. TEI−). Results: Thirty-eight patients, including 18 with TEI+ and 20 with TEI-, were analyzed. The pattern of time-course changes in biophysical parameters and PRO did not differ between TEI+ and TEI− patients. The melanin index was highest at post-RT-1m, while the erythema index was highest at week 5. At post-RT-3m, TEI+ patients presented higher melanin values than TEI- patients, with no statistical significance (coefficient, 47.9 vs. 14.2%; p = 0.07). In all patients, water content decreased throughout the measurement period. At post-RT-3m, TEI+ patients demonstrated a further decrease in water content, while the TEI- group nearly recovered the water content to pre-RT status (coefficient, −17.1, −2.5; p = 0.11). The sebum and elasticity levels were not altered by TEI. Conclusion: In patients undergoing PMRT, TEI did not significantly affect the changing patterns of skin biophysical parameters and PRO during radiotherapy.
지속성 진통작용 물질인 Capsaicinoids의 흰쥐 척수내 Substance P 함량 및 생합성에 미치는 영향
김해영,손여원,이상섭,이승기,Kim, Hai-Young,Sohn, Yeo-Won,Lee, Sang-Sup,Lee, Seung-Ki 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.2
강력한 지속적 진통 효과를 나타내는 것으로 알려진 capsaicin은 작용기전은 밝혀져 있지 않으나 dorsal spinal cord와 dorsal root ganglia에 작용하여 신경전달물질이라 생각되는 substance P(SP)를 선택적으로 감소시키므로 지속적인 진통효과를 나타낼 것이라고 제시된 바 있다. 따라서, 본 연구에서는 capsaicin과, 그 analogue로 capsaicin과는 달리 신경 독성이 거의 없는 6-paradol이 척수내 신경조직에 존재하는 SP 농도변화에 미치는 효과 및 SP-mRNA 생합성에 미치는 영향을 분석하여, 이들 capsaicinoids의 진통 효과와 SP-생합성에 미치는 영향과의 상관관계를 규명코자 하였다. 생후 6주된 Sprague-Dawley male rat에 6-paradol(80, 500, 1000 mg/kg) 또는 capsaicin(80 mg/kg)을 ether 마취상태에서 피하주사하고 3시간, 1일, 5일 후에 척수내 SP 함량을 radioimmunoassay 방법으로 측정한 결과, 3시간부터 vehicle 투여군에 비해 capsaicin과 6-paradol 투여군에서 용량 의존적으로 유의성 있는 SP 함량 감소를 보였고, 그 효과가 5일까지도 유지되었다. 또한 이들 약물의 SP-유전자 전사활성에 미치는 영향을 분석하기 위해 slot blot hybridization 방법으로 SP-mRNA의 농도를 측정한 결과, capsaicin 투여군에서는 SP-mRNA 농도가 3시간에 유의적으로 61%로 감소하였으나 1일 후에 90%로 회복되었다. 그러나 6-paradol(1000 mg/kg) 투여군에서는 3시간에는 유의적 감소를 보이지 않았고 1일 후에 49%로 감소하였다. 본 연구 결과는 capsaicinoids 투여 후 초기의 척수내 SP 함량의 감소는 신경조직으로부터의 SP 유리에 따른 것이고, 그 다음의 지속적인 SP의 신경세포내 감소현상은 감각신경에서의 SP 생합성과정 중 SP-mRNA 합성단계에서의 억제효과 때문이라는 가설을 뒷받침하는 결과로 판단된다. We aimed in this study to evaluate the effects of capsaicinoids on the cellular concentration of substance P(SP) and substance P-mRNA in rat spinal cord. This study was based on the fact that long-lasting analgesic, capsaicin caused depletion of SP from primary afferent neurons in dorsal root ganglia. After administration of 6-paradol (80, 500, 1000 mg/kg) or capsaicin (80 mg/kg) in rats, the cellular concentration of SP and its mRNA in spinal cord were analyzed by radioimmunoassay and slot blot hybridization analysis respectively. 6-Paradol, like capsaicin, reduced in dose-dependent manner the content of SP in rat spinal cord. Additionallv, SP-mRNA concentration was also reduced to 61% of the control level at 3 h after capsaicin administration and was restored to the control level after 1 day. In 6-paradol treated group, substance P-mRNA concentration was not detectably reduced at 3 hours but significantly reduced to 49% of the control level at 1 day after 6-paradol treatment. These results support for the previous notion suggesting that the action mechanism of capsaicinoid analgesia may be primarily based on the depletion of SP from primary afferent neurons. These results also suggest that capsaicinoid analgesics may play a role at the transcription level of SP synthesis in rat spinal neurons.
Distributions of BRCA1 and BRCA2 Mutations in Asian Patients with Breast Cancer
김해영,최두호 한국유방암학회 2013 Journal of breast cancer Vol.16 No.4
Breast cancer is the most prevalent cancer in Asian females, and the incidence of breast cancer has been increasing in Asia. Because Asian patients develop breast cancer at a younger age than their Caucasian counterparts, the contributions of BRCA1and BRCA2 (BRCA1/2) mutations in Asians are expected to be different than in Caucasians. The prevalence of BRCA1/2 mutations in the Asian population varies among countries and studies. Most Asian studies have reported more frequent mutations in BRCA2 than in BRCA1, with the exception of studies from India and Pakistan. In addition, the contribution of large genomic rearrangements of BRCA1/2 genes is relatively small in Asian populations in comparison to other ethnic populations. Various statistical models for the prediction of BRCA1/2 mutations have underestimated the risk of having these genetic mutations in Asians,especially in predicting BRCA2 gene mutation. Until recently,BRCA1/2 mutation analyses in Asia were mostly conducted by independent single institutions with different patient selection criteria and using various genotyping methods. However, a couple of Asian groups have initiated nationwide studies collecting BRCA1/2 mutational data. These national collaborative studies will help a comprehensive understanding of the prevalence of BRCA1/2 mutations in the Asian population.
김해영,정광호,배훈식,이미연,김경주,한태진,강세권,박소아,황태진,윤재웅,김이수 한국유방암학회 2014 Journal of breast cancer Vol.17 No.1
Purpose: This study was performed to assess frequency, timingsof occurrence, and predictors of radiologic lung damage (RLD)after forward-planned intensity-modulated radiotherapy (FIMRT)for whole breast irradiation. Methods: We retrospectively reviewedmedical records of 157 breast cancer patients and each of theirserial chest computed tomography (CT) taken 4, 10, 16, and 22months after completion of breast radiotherapy (RT). FIMRT wasadministered to whole breast only (n=152), or whole breast andsupraclavicular regions (n=5). Dosimetric parameters, such asmean lung dose and lung volume receiving more than 10 to 50Gy (V10–V50), and clinical parameters were analyzed in relation toradiologic lung damage. Results: In total, 104 patients (66.2%)developed RLD after whole breast FIMRT. Among the cases ofRLD, 84.7% were detected at 4 months, and 15.3% at 10 monthsafter completion of RT. More patients of 47 or younger were foundto have RLD at 10 months after RT than patients older than theage (11.7% vs. 2.9%, p=0.01). In univariate and multivariateanalyses, age >47 and V40 >7.2% were significant predictors forhigher risk of RLD. Conclusion: RLD were not infrequently detectedin follow-up CT after whole breast FIMRT. More detected casesof RLD among younger patients are believed to have developedat later points after RT than those of older patients. Ageand V40 were significant predictors for RLD after whole breast intensity-modulated radiotherapy.
김해영,임로 한국보훈학회 2019 한국보훈논총 Vol.18 No.3
The way that the Korean-chinese minority ethnics love and value education is no less than the Jews, wheras the Korean-chinese minority ethnics are not quite the same as the Jews for they don’t have an overall nationwide steady, unified and long-term religion belief. That is closely related to the unique and individualized culture and history of the Korean-chinese minority ethnics. They had been tried to save the Korean nation and the Korean people through education to pursue their liberity and freedom. They also wished to change the society through education for the Korean-chinese minority ethnics are not just an issue of cultivating people, but an essential way related with the nation’s survival and the development of the society as well as to keep the truth and the justice. This study tries to go back to the original point of the migrating Korean-chinese minority ethnics. A deep-rooted thought has been taken onto unique religion of education to Korean-chinese minority ethnics, along with far-reaching significance of education to Korean-chinese minority ethnics and Yanbian area, to reveal the ethnic groups’unique cognition process of education, as well as their connotation and characteristics. 중국에서 살고 있는 한민족-조선족은 유대인에 못지않은 교육열을 자랑하고 있다. 유대인처럼 전 민족적이고 안정적, 통일적, 장기적인 종교 신앙이 없음에도 불구하고 조선족은 보기 드문 특유의 교육에 대한 정신적 신앙을 일관해왔다. 이는 조선족의 독특하고도 개성이 다분한 문화 및 역사적 경험과 밀접한 관련이 있다. 그들은 교육을 통해 민족의 운명을 개선하고자 했고 민족해방과 자유의 도모를 교육에 기탁했다. 또한 교육을 통한 사회변혁을 희망하기도 했는바 교육은 그들에게 있어 단순한 인재양성의 문제만이 아닌 민족의 존폐와 사회의 안정 및 발전을 도모하고 진리와 정의를 수호하는 가장 중요한 도경이었다. 본 연구에서는 조선족이 이주한 원점으로 돌아가 근원으로부터 조선족의 독특한 교육에 대한 신앙과 교육이 조선족 내지는 북간도지역에 대한 의미를 파악, 한 민족의 교육에 대한 독특한 인식과정 및 그 함의와 특징을 밝히고자 한다.
김해영,김수산,이지성,윤재선,윤현조,신혁재,이정언,이세경,정일용,정소연,최영진,조지형,우상욱 대한암학회 2023 Cancer Research and Treatment Vol.55 No.2
Purpose This study aimed to evaluate the incidence and prognosis of second non-breast primary cancer (SNBPC) among Korean survivors of breast cancer. Materials and Methods Data from the Korean National Health Insurance Service were searched to identify women who received curative surgery for initial breast cancer (IBC) between 2003 and 2008 (n=64,340). Among them, patients with the following characteristics were excluded: other cancer diagnosis before IBC (n=10,866), radiotherapy before IBC (n=349), absence of data on sex or age (n=371), or male (n=248). Accordingly, data of 52,506 women until December 2017 were analyzed. SNBPC was defined as a newly diagnosed SNBPC that occurred 5 years or more after IBC diagnosis. Results The median follow-up time of all patients was 12.13 years. SNBPC was developed in 3,084 (5.87%) women after a median of 7.61 years following IBC diagnosis. The 10-year incidence of SNBPC was 5.78% (95% confidence interval [CI], 5.56 to 6.00). Higher SNBPC incidence was found in survivors with the following factors: old age at IBC diagnosis, low household income, and receiving combined chemotherapy with endocrine therapy, whereas receiving radiotherapy was related to a lower incidence of SNBPC (hazard ratio, 0.89; p < 0.01). Among the patients with SNBPC, the 5-year survival rate was 62.28% (95% CI, 65.53 to 69.02). Conclusion Approximately 5% of breast cancer survivors developed SNBPC within 10 years after IBC diagnosis. The risk of SNBPC was associated with patient’s age at IBC diagnosis, income level, and a receipt of systemic treatments.