류머티스 관절염과 골관절염 환자에서 Transforming grwoth factor β의 발현 양상

김채기,윤원찬,송용호,김상경,최정윤 Official Journal of the Korean society for immunol 2001 Immune Network Vol.1 No.3

류머티스 관절염과 골관절염 환자에서 Transforming growth factor β의 발현 양상

김채기,윤원찬,송용호,김상경,최정윤,Kim, Chae-Gi,Yoon, Wern Chan,Song, Yong-Ho,Kim, Sang-Gyung,Choe, Jung-Yoon 대한면역학회 2001 Immune Network Vol.1 No.3

The transforming growth $factor-{\beta}$ ($TGF-{\beta}$) is a multifunctional cytokine modulating the onset and course of autoimmune disease as shown in experimental models. In synovial inflammation, there is a potential role for $TGF-{\beta}$ in repairment, the inhibition of cartilage and bone destruction, and the down-regulation of immune response. The biologic effects of $TGF-{\beta}$ depend on the cell type, the isoform and the availability of active $TGF-{\beta}$. We investigated $TGF-{\beta}$ expression in patients with rheumatoid arthritis (RA) and compared to those of osteoarthritis (OA). And we determined a correlation between $TGF-{\beta}1$ and $TGF-{\beta}2$, and also the relationships between each $TGF-{\beta}$ isoform and the parameters for disease activity of RA. Methods: The study population consisted of 20 patients with RA and 20 patients with OA. The commercial ELISA kit was used to study $TGF-{\beta}1$ and $TGF-{\beta}2$ levels in peripheral blood (PB) and synovial fluids (SF). Results: 1) While PB $TGF-{\beta}1$ level was of no difference between RA and OA patient groups, SF $TGF-{\beta}1$ level was higher in RA group than OA group. Similarly, PB $TGF-{\beta}2$ levels of RA and OA groups was not different, but SF $TGF-{\beta}2$ levels was higher in RA group than OA group. 2) In patients with RA, the $TGF-{\beta}1$ levels were higher than $TGF-{\beta}2$ in both the PB and SF, while in patients with OA, there showed higher readings for $TGF-{\beta}1$ than $TGF-{\beta}2$ in SF but no difference between $TGF-{\beta}1$ and $TGF-{\beta}2$ levels in PB. 3) In patients with RA, there were no correlations between PB $TGF-{\beta}1$ and PB $TGF-{\beta}2$ levels, nor between SF $TGF-{\beta}1$ and SF $TGF-{\beta}2$ levels. At the same way, there was no correlation between PB $TGF-{\beta}1$ and SF $TGF-{\beta}1$ levels, nor between each levels of $TGF-{\beta}2$ in patients with RA. 4) There was also no correlation between each $TGF-{\beta}$ isoform and the parameters for disease activity such as ESR, CRP, tender joint count, swollen joint count, rheumatoid factor, and the duration of morning stiffness except between in PB $TGF-{\beta}1$ and disease duration of RA (r=0.637, p<0.01). Conclusion: Each $TGF-{\beta}$ isoforms were higher in synovial fluid of patients with RA than that of patients with OA. The data from the RA patients demonstrated different patterns of expressions of the isoforms depending on which compartment (PB or SF) was investigated. The quantification of different $TGF-{\beta}$ isoform is thought to be important when $TGF-{\beta}$ is measured under disease conditions of RA.

직업축구선수의 최대운동부하 심폐기능

김채기,김이근,김지희,김태석,최지용,장성국,한춘덕,정태훈,박의현 대한순환기학회 1996 Korean Circulation Journal Vol.26 No.3

수도권 화물차량 기ㆍ종점자료 신뢰도 향상 방안

김채만,김락기 경기연구원 2008 정책연구 Vol.2008 No.10

코로나19 이후 대중교통을 바꾸어야 한다

김채만,김병관,한아름,김현주 경기연구원 2021 이슈&진단 Vol.- No.462

도시외곽순환고속도로를 운행하는 순환버스 운영방안

김채만,조응래,Kim, Chae-Man,Jo, Eung-Rae 대한교통학회 2009 교통 기술과 정책 Vol.6 No.1

화성시 무상교통 정책 고도화 방안 연구

김채만,류시균,김지영 경기연구원 2022 정책연구 Vol.- No.-

This study proposes an answer to the question, How should the city of Hwaseong, which is implementing a free public transportation policy, develop this policy in the future?‘ Economic goods are classified into public goods, private goods, common goods, and collective goods on the basis of exclusion and competition. Commons include city parks and public transport. The logic of the free public transportation policy begins with the question, ‘Why is public transportation provided for a fee when city parks are provided free of charge?’ Free public transportation is also available. A survey was conducted on the free transportation policy of Hwaseong City, which is well received by citizens. As a result of the survey, citizens evaluation of the free policy was positive, and the most necessary bus policy for Hwaseong City was expansion of bus supply, and for the 24-64 year old fare policy, discounting public transportation fares at a certain rate, free As a policy to be pursued in parallel with the transportation policy, it was found that selection of trunk bus routes and management of service quality was the most preferred. By collecting the survey results and expert opinions, 8 policies to be implemented along with the free transportation policy in Hwaseong were selected. As a result, ① free transportation for low-income families, ② free transportation for the disabled, ③ free transportation by volunteers, ④information on environmental improvement effects, ⑤ public transportation day in Hwaseong, ⑥ improvement of parking feeding system, ⑦ cash payment of parking subsidy for commuters, ⑧ cash refund of public transportation fees for frequent users to be. Two implementation plans are presented as scenarios for implementing this policy. Implementation Plan A requires KRW 7.91 billion annually to implement six policies, and Implementation Plan B requires KRW 10.77 billion annually to implement seven policies. For the successful implementation of Hwaseong Citys free transportation advancement policy, we propose three things. First, new policies should be implemented in stages and gradually. Second, citizens should be involved in the decision-making process of making policies and setting priorities. Third, a free transportation local government consultative body (tentative name) should be formed and operated.

양극성 장애, 조증 삽화 입원 환자에서 조증 증상 경과 예측과 관련있는 임상 변인 연구

김채리(Chae-Ri Kim),박진완(Jin-Wan Park),백두현(Doo-Hyun Pak),이연정(Yeon-Jung Lee),한상우(Sang Woo Hahn),우성일(Sungil Woo),황재욱(Jaeuk Hwang) 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.3

Objectives:This study was aimed to investigate clinical factors associated with the prediction of symptom improvement in hospitalized patients with bipolar disorder, manic episode. Methods:We performed a retrospective observational study based on the medical records review of 53 bipolar disorder manic patients, who had been hospitalized in the psychiatric ward. During the hospitalization, Young Mania Rating Scales(YMRS) have been measured periodically. Demographic information and clinical characteristics including medications and history of prior hospitalization have been collected in each patient. Linear mixed effect model has been used to assess the effect of clinical factors on the changes of YMRS over time. Selection of clinical factors was conducted using backward elimination with the minimization of Akaike Information Criterion. Results:Mean days of hospitalization were 29.74±16.96. Mean YMRS at the admission was 33.64±7.57. Effective factors for the model included YMRS at baseline, combination of mood stabilizer, and the history of prior hospitalization. Predicted YMRS at the discharge was 10.43(95% confidence interval 7.13–13.72). Conclusion:The current findings suggest the model which may predict the clinical course of the bipolar disorder manic patients. It would be useful to establish the treatment plan for the patients.

임상미술치료가 분리불안 및 부적응 유아의 행동변화에 미치는 영향

김채리 ( Chae Ri Kim ) 대한임상미술치료학회 2014 임상미술치료학연구 Vol.9 No.2

본 연구는 임상미술치료가 분리불안 및 부적응 유아의 행동변화에 어떠한 긍정적인 영향을 미칠 수 있는지에 관한 연구를 한 것이다. 연구의 대상자는 경기도 인천광역시 내 위치한 S 유치원 7세(만 5∼6세) 유아 중 대상으로 분리불안 과 부적응 문제를 가지고 있는 유아들을 재 선별하였다. 선별된 대상자들은 2014년 3월부터 5월까지, 3개월간 주1∼2 회, 평균 50∼60분씩 총 11회에 걸쳐 임상미술치료 프로그램을 실시하였다. 검사도구로는 C-TRF(한국판 유아행동 평 가척도-교사용), K-CBCL(한국판 유아행동 평가척도-부모용)와 동적학교생활화(KSD), 집-나무-사랍(HTP) 그림검사를 사용하였다. 수집한 자료의 양적 분석을 위하여 SPSSWIN 18.0 프로그램을 사용하였고, 비모수 검정 방법인 Wilcowon 부호순위 검정(Wilcown signed rank test)을 실시하였으며 통계적 검증을 위한 유의수준은 a=.05에서 실시하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 첫째, 임상미술치료가 분리불안 및 부적응 유아의 행동적 변화에 미치는 영향에 대해 살펴본 결과 양적 분석에서 유 의한 효과가 입증되었다. 둘째, 임상미술치료가 분리불안 및 부적응 유아의 정서적 변화에 미치는 영향에 대해 살펴본 결과 양적 분석에서 유 의한 효과가 입증되었다. 셋째, 임상미술치료가 분리불안 및 부적응 유아의 회기별 부적응 횟수 기록변화에 대해 살펴본 결과 유의한 효과가 입증되었다. 넷째, 집-나무-사람(HTP)검사를 실시한 결과 임상미술치료 프로그램이 분리불안 및 부적응 유아의 정서적 안정감 에 긍정적인 영향을 주는 것을 확인하였다. 다섯째, 동적 학교 생활화(KSD)검사를 실시한 결과 임상미술치료 프로그램이 분리불안 및 부적응 유아의 사회적 관계에 긍정적인 영향을 주는 것을 보여 주었다. 이상의 연구 결과를 통해 임상미술치료는 분리불안 및 부적응 유아의 행동적, 정서적 변화에 긍정적인 영향을 준다 는 것을 확인할 수 있었으며, 회기별 부적응 행동변화에서도 긍정적인 변화를 이끌어 낼 수 있다는 것을 확인하였다. 이상의 결과를 바탕으로 임상미술치료의 분리불안 및 부적응 유아의 치료가치가 기대되며, 향후 대규모의 임상연구와 유아의 발달과정에 따른 차후의 연구가 필요하다. This study examines how positively clinical art therapy can influence the behavioral change of children showing separation anxiety and maladjustment. This research selected as its subjects children with problems of separation anxiety and maladjustment among 5- or 6-year-old children attending S Kindergartens located in Gyeonggi-do and Incheon Metropolitan City. The selected subjects received the clinical art therapy program with total 11 sessions, for 50 to 60 minutes averagely, once or twice a week, for three months from March till May, 2014. As the testing tools, C-TRF (the Korean edition for teachers), K-CBCL (the Korean edition for parents), Kinetic School Drawing (KSD), and Human-Tree-Person (HTP). To conduct quantitative analysis on the data collected, SPSSWIN 18.0 was employed, and Wilcown Signed Rank Test, one of the nonparametric tests, was utilized, and the significant level for statistical verification was fixed as a=.05. The findings of this study can be summed up as below: First, according to the results of examining the effects of clinical art therapy on the behavioral change of children showing separation anxiety and maladjustment, it was proved to exert significant effects in quantitative analysis. Second, according to the results of examining the effects of clinical art therapy on the behavioral change of children showing separation anxiety and maladjustment, it was proved to have significant effects in quantitative analysis. Third, according to the results of examining how clinical art therapy influenced the records of maladjustment frequency of children showing separation anxiety and maladjustment by sessions, it was proved to show significant effects. Fourth, according to the results of conducting HTP, the clinical art therapy program exerted positive effects on the emotional stability of children showing separation anxiety and maladjustment.Fifth, according to the results of conducting KSD, the clinical art therapy program had positive effects on the social relationship of children showing separation anxiety and maladjustment. Based on the above results, it was possible to verify clinical art therapy exerted positive effects on the behavioral and emotional change of children showing separation anxiety and maladjustment and also it indicated positive effects on their maladjusted behavior, too, by sessions. The above findings imply clinical art therapy is expected to have therapeutic value on children showing separation anxiety and maladjustment and follow-up study based on large-scale clinical research will be needed according to a child’s developmental process afterwards.

교통카드 자료가 알려주는 대중교통 이야기

김채만,한아름 경기연구원 2019 정책연구 Vol.- No.-

본 연구는 수도권 교통카드 자료를 이용하여 사람들이 궁금해 하는 “대중교통 이야기”를 만들었다. 대중교통 이야기는 “2018년 경기도 대중교통 이야기”, “2018년 시․군의 대중교통 이야기”, “지난 9년간의 경기도 대중교통 이야기”로 구성된다. 본 연구 결과는 분석대상 시간과 항목을 결합하여 총 58개의 이야기를 만들었다. “2018년 경기도 대중교통 이야기”는 29개의 이야기로 구성하였다. 경기도 대중교통 목적통행 발생량이 가장 많은 시·군, 읍·면·동, 전철역, 버스정류소, 버스노선을 제시하였다. 연구는 3가지의 의미 있는 결과를 도출하였다. 첫째, 경기도는 서울시에 비해서 대중교통수단을 운영하기 위한 환경이 매우 열악하다. 이 근거는 경기도 주민등록인구 100인당 대중교통 목적통행 발생량이 39로 서울시 94의 41%수이고, 경기도 출근시간 목적통행 집중률이 30.1%로 서울시 23.1%보다 높다. 둘째, 출근시간에 경기도에서 서울시로 가는 대중교통 이용자는 통행시간 단축을, 퇴근시간에 서울시에서 경기도로 이동하는 대중교통 이용자자는 편리함을 추구한다. 이 근거는 출근시간 경기도→서울시 대중교통 목적통행의 환승률은 53.3%이나, 퇴근시간 서울시→경기도 환승률은 47.4%이다. 셋째, 경기도 주말 대중교통 통행량은 평일의 83.1%이고, 경기도 5개 시·군(가평군, 양평군, 동두천시, 과천시, 연천군)은 주말 대중교통 목적통행량이 평일보다 많다. 이들 5개 시․군은 주말 관광지이며, 수도권 전철이 연결되어 있다. “2018년 시․군의 대중교통 이야기”는 14개의 이야기로 구성하였다. 전철역에 대하여 지표들을 결합하여 의미 있는 2가지 이야기를 도출하였다. 첫째, 경기도 전철역의 평일대비 주말 통행량 비율은 95%이고, 평일보다 주말 통행량이 많은 전철역은 50개 역(약 23%)이다. 둘째, 경기도 전철역의 직승대비 환승(버스+전철) 통행량 비율은 28%이며, 직승보다 환승 통행량이 많은 전철역은 9개역(약 4%)이다. “지난 9년간, 경기도 대중교통 이야기”는 15개 이야기로 구성된다. 대중교통 목적통행량의 시계열 분석을 통해 4가지 의미 있는 결과를 도출하였다. 첫째, 지난 9년 동안 경기도의 대중교통 목적통행량은 2014년을 정점으로, 그 이후에는 감소 추세에 있다. 둘째, 지난 9년간 대부분의 경기도내 시·군은 대중교통 목적통행량이 증가하였으나, 6개 시․군(안산, 안양, 과천, 포천, 동두천, 연천)은 감소하였다. 셋째, 지난 9년 동안 출근시간 대중교통 목적통행량의 경기도↔서울시간 방향별 불평등 지수가 증가한 것으로 나타났다. 넷째, 경기도 대중교통 목적통행량은 복합수단 이용률이 증가하고, 복합수단 중에서는 버스-전철의 이용률이 증가하고 있다. This study made “public transportation story” using the transportation card data of the metropolitan area. The public transport story consists of “2018 Gyeonggi-do Public Transport Story”, “2018 City and County Public Transport Story” and “Last 9 Years of Gyeonggi-do Public Transport Story”. The results of this study made 58 stories combining analysis object time with items. The “2018 Gyeonggi-do Transit Story” consists of 29 stories. The cities, counties, towns, towns and villages, subway stations, bus stops, and bus routes with the highest traffic volume for public transportation are presented. The study produced three meaningful results. First, Gyeonggi-do has a very poor environment for operating public transportation compared to Seoul. The reason for this is that the amount of public transport purpose traffic per 100 population in Gyeonggi-do is 39, which is 41% of 94 in Seoul, and the concentration rate of the purpose of traffic in Gyeonggi-do is 30.1%, higher than 23.1% in Seoul. Second, public transportation users from Gyeonggi-do to Seoul during the morning rush hours seek to reduce travel time, but convenience for public transportation users moving from Seoul to Gyeonggi-do during the evening rush hours.. The reason for this is that the transfer rate from the time of commuting to Gyeonggi-do → Seoul public transportation is 53.3%, while the rate of transfer from Seoul to Gyeonggi is 47.4%. Third, Gyeonggi-do"s weekend traffic volume is 83.1% of weekdays, and Gyeonggi-do"s five cities and counties (Gapyeong-gun, Yangpyeong-gun, Dongducheon-si, Gwacheon-si, and Yeoncheon-gun) have more traffic on weekends than weekdays. These five cities and counties are weekend tourist destinations and are connected by Seoul metropolitan subway lines. The 2018 City and County Public Transport Stories consisted of 14 stories. By combining the indicators of the subway station, two meaningful stories were drawn. First, the ratio of weekend traffic to weekdays is 95% in Gyeonggi-do, and 50 stations (about 23%) have more weekend traffic than weekdays. Second, the ratio of transit (bus + train) to direct transfers in Gyeonggi-do is 28%, and 9 stations (about 4%) have more transit traffic than direct transfers. “The story of Gyeonggi-do public transport for the last 9 years“ consists of 15 stories. Four meaningful results were obtained through time series analysis of the purpose of public transport traffic. First, for the past nine years, Gyeonggi-do"s public transportation traffic peaked in 2014 and after that it has declined. Second, most cities and counties in Gyeonggi-do have increased in public transportation for the past nine years, while six cities and counties (Ansan, Anyang, Gwacheon, Pocheon, Dongducheon, and Yeoncheon) have decreased. Third, the inequality index by the direction of Gyeonggi-do and Seoul time of public transport purpose traffic volume during the morning rush hour has increased for 9 years. Fourth, Gyeonggi-do"s public transportation purpose traffic volume has increased in the use of multi-purpose vehicles, and among the multi-purpose vehicles, the usage rules of bus-trains have increased.